Pathologic Bone Resorption and New Bone Formation in Inflammatory Arthritis
Bone remodeling is a dynamic and complex process finely orchestrated by cell interactions among bone-degrading osteoclasts, bone-synthesizing osteoblastosteoblasts, T cells, B cells, and natural killer cells. An imbalance between osteoclast and osteoblast activity results in skeletal and joint diseases including osteoporosis, arthritis, and non-union bone repair. These diseases impact the quality of life of patients.

Christopher T. Ritchlin, M.D., M.P.H.
Principal Investigator
Publications
View All Publications- The Function of Efhd1+ Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis.; bioRxiv : the preprint server for biology. 2025 Nov 05.
- Sonelokimab, an IL-17A/IL-17F-inhibiting nanobody for active psoriatic arthritis: a randomized, placebo-controlled phase 2 trial.; Nature medicine. 2025 Oct 06.
- Relationship of radiographic progression status to low disease activity in patients with psoriatic arthritis receiving secukinumab treatment for two years.; Rheumatology (Oxford, England). 2025 Sep 18.
- Inhibition of structural damage progression with the selective interleukin-23 inhibitor guselkumab in participants with active PsA: results through week 24 of the phase 3b, randomised, double-blind, placebo-controlled APEX study.; Annals of the rheumatic diseases. 2025 Sep 16.
Affiliations
News
November 21, 2025
Rangel-Moreno an International Speaker at the Research Seminars in Biological Sciences and International Biomedicine Workshop
October 22, 2025
Jennifer Anolik Presents at Upstate Medical Center Symposium
October 20, 2025
National Scleroderma Foundation Rochester Education Forum Held at URMC
September 29, 2025
Jessica Stern, MD Awarded a Mentored Patient-Oriented Research Career Development Award (K23)
May 23, 2025
AIR Research Presented at the 2025 AAI Meeting
Contact Us
Ritchlin Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642
(585) 442-3214