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Christopher T. Ritchlin, M.D., M.P.H.

Allergy, Immunology & Rheumatology

Clinical Interests

Psoriasis Rheumatology

Contact Information

Phone Numbers

Administrative: (585) 273-3213

Appointment: (585) 486-0901

Fax: (585) 442-3214

Office: (585) 273-2125

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Efforts are focused on the mechanisms of bone resorption and formation, the effect of anti-TNF agents on dendritic cell differentiation and the mechanisms for bone marrow edema in PsA and RA.

Lab: (585) 273-2124

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Research Network

Biography

Dr. Ritchlin's basic science research efforts are directed towards understanding the mechanisms that underlie pathologic bone resorption and new bone formation in psoriatic arthritis and rheumatoid arthritis. Using a translational approach, investigators in his lab are analyzing the cell surface molecules expressed by osteoclast and dendritic cell precursors with the goal to identify susceptibility and response biomarkers in patients with inflammatory arthritis. The lab is also studying the effect of anti-TNF agents on dendritic cell differentiation in RA and PsA patients. In addition, collaborative studies are underway with the lab of Dr. Eddie Schwarz to understand the mechanisms that are responsible for bone marrow edema as recorded on magnetic resonance imaging scans in inflammatory arthritis. The bulk of this work is performed in animal models but insights gained from these studies are applied to the study of human joint diseases such as psoriatic and rheumatoid arthritis. Dr. Ritchlin is also the Director of the Clinical Immunology Research Unit where he is the principle investigator on several clinical trials testing the efficacy of anti-TNF agents and other biologic molecules in the treatment of psoriatic and rheumatoid arthritis and ankylosing spondylitis. In the Clinical Immunology Research Unit, patient oriented research is conducted on multiple levels. Investigator New Drug (IND) trials of novel agents (adalimumab, rituximab) in the treatment of PsA and AS have been completed or are about to start. Additional trials have been performed to study the effect of TNF inhibition on the frequency of osteoclast precursors and enhancing bone marrow edema in PsA. The Unit also conducts multicenter trials with novel biologic agents such as rituximab and abatacept in PsA with special attention directed towards understanding how these agents alter bone remodeling in these disorders. Additional studies underway include microanalysis assays of synovium, skin and intestinal tissues in patients with Immune Mediated Inflammatory Disroders (IMIDs) before and after TNF inhibition. Future plans include the development of ultrasound outcome measures in collaboration with Dr. Ralf Thiele and Dr. Darren Tabechian, to assess synovial, lymph node and periarticular tissue responses to different therapies in inflammatory arthritis.

Research

Dr. Ritchlin's basic science research efforts are directed towards understanding the mechanisms that underlie pathologic bone resorption and new bone formation in psoriatic arthritis and rheumatoid arthritis. Using a translational approach, investigators in his lab are analyzing the cell surface molecules expressed by osteoclast and dendritic cell precursors with the goal to identify susceptibility and response biomarkers in patients with inflammatory arthritis. The lab is also studying the effect of anti-TNF agents on dendritic cell differentiation in RA and PsA patients. In addition, collaborative studies are underway with the lab of Dr. Eddie Schwarz to understand the mechanisms that are responsible for bone marrow edema as recorded on magnetic resonance imaging scans in inflammatory arthritis. The bulk of this work is performed in animal models but insights gained from these studies are applied to the study of human joint diseases such as psoriatic and rheumatoid arthritis. Dr. Ritchlin is also the Director of the Clinical Immunology Research Unit where he is the principle investigator on several clinical trials testing the efficacy of anti-TNF agents and other biologic molecules in the treatment of psoriatic and rheumatoid arthritis and ankylosing spondylitis. In the Clinical Immunology Research Unit, patient oriented research is conducted on multiple levels. Investigator New Drug (IND) trials of novel agents (adalimumab, rituximab) in the treatment of PsA and AS have been completed or are about to start. Additional trials have been performed to study the effect of TNF inhibition on the frequency of osteoclast precursors and enhancing bone marrow edema in PsA. The Unit also conducts multicenter trials with novel biologic agents such as rituximab and abatacept in PsA with special attention directed towards understanding how these agents alter bone remodeling in these disorders. Additional studies underway include microanalysis assays of synovium, skin and intestinal tissues in patients with Immune Mediated Inflammatory Disroders (IMIDs) before and after TNF inhibition. Future plans include the development of ultrasound outcome measures in collaboration with Dr. Ralf Thiele and Dr. Darren Tabechian, to assess synovial, lymph node and periarticular tissue responses to different therapies in inflammatory arthritis.

Credentials

Faculty Appointments

Specialties

  • Internal Medicine - American Board of Internal Medicine
  • Rheumatology - American Board of Internal Medicine

Education

1976
BA | University of Rochester
Biology

1976
B.A. | University Of Rochester
History

1982
MD | Albany Medical College
Medicine

2008
MPH | University of Rochester
Public Health & Clinical Investigation

Post-doctoral Training & Residency

07/01/1982 - 06/30/1983
Internship in Internal Medicine at Albany Medical Center

07/01/1983 - 06/30/1986
Residency in Internal Medicine at Mount Sinai Medical Center

07/01/1986 - 06/30/1989
Fellowship in Internal Medicine: Rheumatology at New York University Langone Medical Center

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Awards

2010 - 2012
Marquis Who's Who

2005
Irene Kohn Teaching Award
Sponsor: Strong Memorial Hospital
Location: Rochester, NY

2004
Irene Kohn Teaching Fellowship Award
Sponsor: Strong Memorial Hospital
Location: Rochester, NY

2003 - 2012
Best Doctors in America

1994
Teacher of the Year Award
Sponsor: Rochester General Hospital
Location: Rochester, NY

1991
Henry Christian Award of Excellence in Clinical Research
Sponsor: American Federation of Clinical Research

1982
Stanley Poole Award for Excellence in Internal Medicine
Sponsor: Albany College
Location: Albany, NY

1981
Alpha Omega Alpha
Sponsor: Albany Medical College
Location: Albany NY

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Patents

Title: Method to Identify Patients That Will Likely Respond to Anti-TNF Therapy
U.S. Serial #: 14/761,408
Filed: Jan 10, 2014
Invented By: BrendanBoyce, ChristopherRitchlin, LianpingXing, YanXiu

Publications

Journal Articles

1/2017
Mease PJ, van der Heijde D, Ritchlin CT, Okada M, Cuchacovich RS, Shuler CL, Lin CY, Braun DK, Lee CH, Gladman DD, . "Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1." Annals of the rheumatic diseases.. 2017 Jan 0; 76(1):79-87. Epub 2016 Aug 23.

11/2016
Chiu YG, Ritchlin CT. "DC-STAMP: A Key Regulator in Osteoclast Differentiation." Journal of cellular physiology.. 2016 Nov 0; 231(11):2402-7. Epub 2016 Jun 14.

9/1/2016
Rahimi H, Bell R, Bouta EM, Wood RW, Xing L, Ritchlin CT, Schwarz EM. "Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential." Arthritis research & therapy.. 2016 Sep 1; 18:194. Epub 2016 Sep 01.

Books & Chapters

2010
Book Title: Pathogenesis of Psoriatic Arthritis
Author List: Ritchlin, CT, McGonagle, DA
Edited By: Hochberg et al
Published By: Elsevier2010 in Philadelphia

2007
Chapter Title: Pathogenesis of Psoriatic Arthritis
Book Title: Psoriatic and Reactive Arthritis
Author List: Ritchlin CT, Fitzgerald O.
Edited By: Ritchlin, CT and Fitzgerald, O.
Published By: Elsevier2007 in Philadelphia

2007
Chapter Title: Epidemiology and Pathogenesis of Psoriatic Arthritis
Book Title: Primer of Rheumatic Diseases
Author List: Ritchlin, C.T.
Published By: Arthritis Foundation2007 in Atlanta

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Videos

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SECOND OPINION | Psoriasis | APT | Webisode