Christopher T. Ritchlin, M.D., M.P.H.

Christopher T. Ritchlin, M.D., M.P.H.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 695
Rochester, NY 14642

Office: (585) 273-2125
Lab: (585) 273-2124
Administrative: (585) 273-3213
Fax: (585) 442-3214

Lab Information

Efforts are focused on the mechanisms of bone resorption and formation, the effect of anti-TNF agents on dendritic cell differentiation and the mechanisms for bone marrow edema in PsA and RA.

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Research Bio

Dr. Ritchlin's basic science research efforts are directed towards understanding the mechanisms that underlie pathologic bone resorption and new bone formation in psoriatic arthritis and rheumatoid arthritis. Using a translational approach, investigators in his lab are analyzing the cell surface molecules expressed by osteoclast and dendritic cell precursors with the goal to identify susceptibility and response biomarkers in patients with inflammatory arthritis. The lab is also studying the effect of anti-TNF agents on dendritic cell differentiation in RA and PsA patients. In addition, collaborative studies are underway with the lab of Dr. Eddie Schwarz to understand the mechanisms that are responsible for bone marrow edema as recorded on magnetic resonance imaging scans in inflammatory arthritis. The bulk of this work is performed in animal models but insights gained from these studies are applied to the study of human joint diseases such as psoriatic and rheumatoid arthritis.

Dr. Ritchlin is also the Director of the Clinical Immunology Research Unit where he is the principle investigator on several clinical trials testing the efficacy of anti-TNF agents and other biologic molecules in the treatment of psoriatic and rheumatoid arthritis and ankylosing spondylitis. In the Clinical Immunology Research Unit, patient oriented research is conducted on multiple levels. Investigator New Drug (IND) trials of novel agents (adalimumab, rituximab) in the treatment of PsA and AS have been completed or are about to start. Additional trials have been performed to study the effect of TNF inhibition on the frequency of osteoclast precursors and enhancing bone marrow edema in PsA. The Unit also conducts multicenter trials with novel biologic agents such as rituximab and abatacept in PsA with special attention directed towards understanding how these agents alter bone remodeling in these disorders. Additional studies underway include microanalysis assays of synovium, skin and intestinal tissues in patients with Immune Mediated Inflammatory Disroders (IMIDs) before and after TNF inhibition. Future plans include the development of ultrasound outcome measures in collaboration with Dr. Ralf Thiele and Dr. Darren Tabechian, to assess synovial, lymph node and periarticular tissue responses to different therapies in inflammatory arthritis.

Awards & Honors (National)

Marquis Who's Who 2010 - 2012
Best Doctors in America 2003 - 2012
Henry Christian Award of Excellence in Clinical Research | American Federation of Clinical Research 1991

Awards & Honors (Local)

Irene Kohn Teaching Award | Strong Memorial Hospital | Rochester, NY 2005
Irene Kohn Teaching Fellowship Award | Strong Memorial Hospital | Rochester, NY 2004
Teacher of the Year Award | Rochester General Hospital | Rochester, NY 1994
Stanley Poole Award for Excellence in Internal Medicine | Albany College | Albany, NY 1982
Alpha Omega Alpha | Albany Medical College | Albany NY 1981


Circulating Osteoclast Precursors as Markers of Bone Resorption in Inflammatory Arthritis

United States Serial NO.: 10/799,345
Filed Date: March 12, 2004
Title: Methods and Compositions Related to Joint Inflammation Diseases
Invented by: Christopher Ritchlin, Sally Haas, Edward Schwarz
Circulating Osteoclast Precursors as Markers of Bone Resorption in Inflammatory Arthritis

United States Serial NO.: 10/548,389
Filed Date: July 26, 2006
Title: Methods and Compositions Related to Joint Inflammation Diseases
Invented by: Christopher Ritchlin, Sally Haas, Edward Schwarz
TRAF3 Protein Levels in Peripheral Blood Monocytes Predict which Patients with Rheumatoid Arthritis and Psoriatic Arthritis will Respond to Anti-TNF Therapy

United States Serial NO.: 14/761,408
Filed Date: January 10, 2014
Title: Method to Identify Patients That Will Likely Respond to Anti-TNF Therapy
Invented by: Brendan Boyce, Lianping Xing, Christopher Ritchlin, Yan Xiu

Recent Journal Articles

Showing the 5 most recent journal articles. 128 available »

2012 Jan
Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT. "Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2012 Jan; 27(1):79-92.
2012 Jan
Hsu S, Papp KA, Lebwohl MG, Bagel J, Blauvelt A, Duffin KC, Crowley J, Eichenfield LF, Feldman SR, Fiorentino DF, Gelfand JM, Gottlieb AB, Jacobsen C, Kalb RE, Kavanaugh A, Korman NJ, Krueger GG, Michelon MA, Morison W, Ritchlin CT, Stein Gold L, Stone SP, Strober BE, Van Voorhees AS, Weiss SC, Wanat K, Bebo BF. "Consensus guidelines for the management of plaque psoriasis." Archives of dermatology. 2012 Jan; 148(1):95-102.
Gossec, L.; Smolen, J.S.; Gaujoux-Viala, C.; Ash, Z., Marzo-Ortega, H.; van der Heijde, D.; FitzGerald, O.; Aletaha, D.; Balint, P.; Boumpas, D.; Ritchlin CT et al. ": European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies. Ann Rheum Dis 2012, 71(1):4-12." Ann Rheum Dis. 2012; 71(1): 4-12.
2011 Dec
Bouta EM, Wood RW, Perry SW, Brown EB, Ritchlin CT, Xing L, Schwarz EM. "Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes." Annals of the New York Academy of Sciences. 2011 Dec; 1240:47-52.
2011 Aug 31
Li J, Zhou Q, Wood R, Kuzin I, Bottaro A, Ritchlin C, Xing L, Schwarz E. "CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice." Arthritis research & therapy. 2011 Aug 31; 13(4):R138. Epub 2011 Aug 31.

Current Appointments

Chief - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)
Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD) - Primary


Internal Medicine - American Board of Internal Medicine
Rheumatology - American Board of Internal Medicine


MPH | Public Health & Clinical Investigation | University of Rochester2008
MD | Medicine | Albany Medical College1982
BA | Biology | University of Rochester1976
B.A. | History | University Of Rochester1976

Post-Doctoral Training & Residency

Fellowship in Rheumatology at New York University Langone Medical Center07/01/1986 - 06/30/1989
Residency in Internal Medicine at Mount Sinai Medical Center07/01/1983 - 06/30/1986
Internship in Internal Medicine at Albany Medical Center07/01/1982 - 06/30/1983