Brain Signature of SARS-CoV-2 Infection and its Impact on Long-Term Cognitive Functioning in Older Adults
Lead Researcher: Giovanni Schifitto
We are recruiting individuals 65 or older to learn more about how Covid impacts our brains!
COVID is caused by a virus that enter many cells including cells of blood vessels. This can make vessels leaky and in the brain this leakage can cause inflammation. The damaged blood vessels are also more likely to form blood clots, causing tiny strokes. The purpose of this study is to understand if after initial COVID infection these leaky brain vessels fully recover or remain permanently damaged. If you decide to take part in this study, you will be asked to come to the Clinical Research Center (CRC) at URMC three different times: Baseline, 12 months, and 24 months - and you will participate in two telephone calls over a 2 year period. At the baseline visit, there is a blood draw and testing to assess your memory, attention, and movement (approximately 2.5 hours) as well as an MRI (approximately 1.5 hours). At the 12 month visit, there is a blood draw and memory tests. At the 24 month visit, there is a blood draw, memory testing, and an MRI.
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Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R, . "Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial." Neurology.. 2010 Feb 2; 74(5):413-20.
Cohen RA, Harezlak J, Schifitto G, Hana G, Clark U, Gongvatana A, Paul R, Taylor M, Thompson P, Alger J, Brown M, Zhong J, Campbell T, Singer E, Daar E, McMahon D, Tso Y, Yiannoutsos CT, Navia B. "Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era." Journal of neurovirology.. 2010 Feb; 16(1):25-32.
Eggert D, Dash PK, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA, Gendelman HE. "Neuroprotective activities of CEP-1347 in models of neuroAIDS." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Jan 15; 184(2):746-56. Epub 2009 Dec 04.
Books & Chapters
Chapter Title: HIV-1-Associated Dementia (HAD)
Book Title: Handbook of Secondary Dementias
Author List: Schifitto G, Mariuz P.
Edited By: R. Kurlan, MD
Published By: Taylor & Francis 2006
Chapter Title: Human Immunodeficiency Virus-Associated Cognitive Impairment
Book Title: Handbook of Neurologic Rating Scales
Author List: Schifitto G, Gaugh MD
Edited By: R. M. Herndon
Published By: Demos Medical Publishing 2006
Chapter Title: HIV-Associated Neuropathy and Myelopathy
Book Title: Principles of Neurologic Infectious Diseases
Author List: Herrmann D, Schifitto G.
Edited By: K. Roos, MD
Published By: McGraw-Hill 2005
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