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Alexander R. Paciorkowski, M.D.

Neurology, Pediatrics

Clinical Interests

Child, Pediatric Neurology; Neurology

Contact Information

Phone Numbers

Appointment: (585) 276-3000

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Biography

Professional Background

My overall career goal is to help improve the care of children with neurologic disability. Early in my training I decided to focus on neurogenetics, as many causes of neurologic disorders in childhood have a genetic basis. After completion of my pediatrics and medical genetics training at the University of Connecticut, I then moved to St. Louis for child neurology training at Washington University. I see patients as part of the Neurogenetics Consultation Service and the Hereditary Ataxia Program.

Research

The Paciorkowski Lab research program is focused on the discovery of genes involved in childhood neurologic disorders, and how those genes affect brain development. Currently, the lab is working on next-generation sequencing approaches to gene discovery in severe pediatric epilepsies such as infantile spasms. We are also studying complex developmental disorders where autistic features, intellectual disability, epilepsy, and movement disorders overlap. A key part of our research program is the creation of new bioinformatics tools to analyze and integrate data.

Credentials

Faculty Appointments

Specialties

  • Clinical Genetics (M.D.) - American Board of Medical Genetics
  • Neurology with Special Qualifications in Child Neurology - American Board of Psychiatry and Neurology
  • Pediatrics

Post-doctoral Training & Residency

07/01/2007 - 06/30/2010
Fellowship in Pediatric Neurology at Washington University School of Medicine

07/01/2005 - 06/30/2007
Residency in Genetics at University of Connecticut

07/01/2005 - 06/30/2007
Residency in Genetics at University of Connecticut

07/01/2007 - 06/30/2010
Fellowship in Pediatric Neurology at Washington University School of Medicine

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Awards

2016
Derek Denny-Brown Young Neurological Scholar Award
Sponsor: American Neurological Association

2014
Kayden R. Vinson Distinguished Scholar Award
Sponsor: Le Bonheur Children's Hospital Neuroscience Institute
Location: Memphis, TN

2013 - Present
K08 Award
Sponsor: NIH / NINDS

2012
Logan Infantile Spasms Award
Sponsor: Child Neurology Foundation

2010
Berg Research Prize in Neurology
Sponsor: Washington University School of Medicine
Location: St. Louis, MO

2009 - Present
Fellow, American College of Medical Genetics

2009
Resident of the Year Award for Teaching
Sponsor: Washington University School of Medicine
Location: St. Louis, MO

2008
Resident of the Year Award for Teaching
Sponsor: Washington University School of Medicine
Location: St. Louis, MO

2004 - Present
Fellow, American Academy of Pediatrics

2001
Outstanding Intern in Pediatrics
Sponsor: University of Connecticut School of Medicine
Location: Farmington, CT

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Publications

Journal Articles

11/29/2017
Yunes-Medina L, Paciorkowski A, Nuzbrokh Y, Johnson GVW. "Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability." Molecular and cellular neurosciences.. 2017 Nov 29; Epub 2017 Nov 29.

11/17/2017
Lee BH, Reijnders MRF, Abubakare O, Tuttle E, Lape B, Minks KQ, Stodgell C, Bennetto L, Kwon J, Fong CT, Gripp KW, Marsh ED, Smith WE, Huq AM, Coury SA, Tan WH, Solis O, Mehta RI, Leventer RJ, Baralle D, Hunt D, Paciorkowski AR. "Expanding the neurodevelopmental phenotype of PURA syndrome." American journal of medical genetics. Part A.. 2017 Nov 17; Epub 2017 Nov 17.

9/2017
Traitruengsakul S, Seltzer LE, Paciorkowski AR, Ghoraani B. "Developing a novel epileptic discharge localization algorithm for electroencephalogram infantile spasms during hypsarrhythmia." Medical & biological engineering & computing.. 2017 Sep 0; 55(9):1659-1668. Epub 2017 Feb 09.

Books & Chapters

2017
Chapter Title: Developmental Encephalopathies.
Book Title: Swaiman's Pediatric Neurology, Principles and Practice. 6th Edition.
Author List: AR Paciorkowski, LE Seltzer, JL Neul.
Published By: Elsevier2017

2017
Chapter Title: Neurogenetics in the Genome Era.
Book Title: Swaiman's Pediatric Neurology, Principles and Practice. 6th Edition.
Author List: K McMahon, AR Paciorkowski, LC Walters-Sen, JM Milunsky, A Bassuk, B Darbro, J Diaz, WB Dobyns, A Gropman.
Published By: Elsevier2017

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