Faculty Appointments
Patient Care Setting
Cancer
Biography
Alissa Huston is a Rochester native who received her medical degree at the University of Buffalo, and went on to complete an Internal Medicine residency at Strong Memorial Hospital. She then attended the University of Pittsburgh for her Hematology/Oncology fellowship, during which time she was involved in research involving bone metastasis in cancer. Currently, she is an Assistant Professor of Medicine at the James P. Wilmot Cancer Institute at the University of Rochester, where her clinical efforts are focused on breast cancer. She is also the Director for Medical Student and Resident Education for the Hematology/Oncology Division. Her research efforts focus on understanding the effects of treatment for breast cancer upon bone health, the role of vitamin D in breast cancer and how improvements in education affect residents and medical students rotating on our inpatient oncology unit. She is a member of the American Society of Clinical Oncology, the American Society of Breast Disease and the American Society for Bone and Mineral Research. Her philosophy is that there is no singular approach to patient care. Even though many patients may carry the same diagnosis, each individual is affected by that illness in a different way. Patients are not perceived as just a number, but instead approached and treated as the unique individuals they represent.
Credentials
Specialties
- Hematology - American Board of Internal Medicine
- Internal Medicine
- Medical Oncology - American Board of Internal Medicine
Education
2000
MD | SUNY at Buffalo School of Medicine
Post-doctoral Training & Residency
07/01/2003 - 06/30/2006
Fellowship in Hematology/Oncology at University of Pittsburgh
06/30/2001 - 06/30/2003
Residency in Internal Medicine at University of Rochester Medical Center
06/30/2000 - 06/30/2001
Internship in Internal Medicine at University of Rochester Medical Center
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Awards
2014
Jacob Gitelman Award
Sponsor: Gilda's Club of Rochester
2009 - 2011
Lawrence A. Kohn Senior Teaching Fellowship Award
Location: Department of Medicine, Strong Memorial Hospital
2005
ASH Clinical Research Training Institute (ASH-CRTI) Award. Phase I Trial of Perifosine and 17-DMAG in Patients with Relapsed/Ref
2005
ASCO/AACR Workshop Methods in Clinical Cancer Research Award. A Phase II Study Evaluating the Effects of COX-2 Inhibition on Lev
2004
Cancer Education Consortium Workshop Award: Clinical Pharmacology of Anticancer Agents
2000
AMWA Janet M. Glasgow Memorial Achievement Citation
1999
Induction into Alpha Omega Alpha Society
1997
James A. Gibson Anatomical Society Award
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Clinical Trials
A Phase 3, Multicenter, Randomized, Open-Label, Active-Controlled Study of DS-8201a (Trastuzumab Deruxtecan), an Anti-HER2 Antibody Drug Conjugate (ADC), Versus Ado Trastuzumab Emtansine (T-DM1) for HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With Trastuzumab and Taxane (DS302)
Lead Researcher: Alissa Huston
This study is designed to compare the anti-tumor activity as well as the safety and efficacy of DS-8201a versus T-DM1 in HER2-positive, unresectable and/or metastatic breast cancer subjects previously treated with trastuzumab and taxane
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A Study Evaluating the Pregnancy Outcomes and Safety of Interrupting Endocrine Therapy for Young Women with Endocrine Responsive Breast Cancer who Desire Pregnancy
Lead Researcher: Alissa Huston
The best available evidence suggests that pregnancy after breast cancer does not increase a woman's risk of developing a recurrence from her breast cancer. In particular, the most recent data suggest that this is the case also in women with a hormone receptor-positive breast cancer. There is also no indication of increased risk for delivery complications or for the newborn. The aim of the study is to investigate if temporary interruption of endocrine therapy, with the goal to permit pregnancy, is associated with a higher risk of breast cancer recurrence.The study aims also to evaluate different specific indicators related to fertility, pregnancy and breast cancer biology in young women. A psycho-oncological companion study on fertility concerns, psychological well-being and decisional conflicts will be conducted in interested Centers.
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Randomized Non-Inferiority Trial Comparing Overall Survival of Patients Monitored With Serum Tumor Marker Directed Disease Monitoring (STMDDM) Versus Usual Care in Patients With Metastatic Hormone Receptor Positive Breast Cancer
Lead Researcher: Alissa Huston
This randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread to other places in the body. Using markers to prompt when scans should be ordered may be as good as the usual approach to monitoring disease.
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A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 as Adjuvant therapy for Triple Receptor-Negative Breast Cancer or Positive Lymph Nodes After Neoadjuvant Chemotherapy
Lead Researcher: Alissa Huston
The purpose of this study is to compare treated subjects' invasive disease-free survival of patients with triple-negative breast cancer after neoadjuvant chemotherapy.
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Publications
Journal Articles
8/2018
Peppone LJ, Ling M, Huston AJ, Reid ME, Janelsins MC, Puzas JE, Kamen C, Del Giglio A, Asare M, Peoples AR, Mustian KM. "The effects of high-dose calcitriol and individualized exercise on bone metabolism in breast cancer survivors on hormonal therapy: a phase II feasibility trial." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2018 Aug 0; 26(8):2675-2683. Epub 2018 Feb 22.
1/15/2018
Williams AM, Shah R, Shayne M, Huston AJ, Krebs M, Murray N, Thompson BD, Doyle K, Korotkin J, van Wijngaarden E, Hyland S, Moynihan JA, Cory-Slechta DA, Janelsins MC. "Associations between inflammatory markers and cognitive function in breast cancer patients receiving chemotherapy." Journal of neuroimmunology.. 2018 Jan 15; 314:17-23. Epub 2017 Oct 18.
7/2015
Turner BM, Skinner KA, Tang P, Jackson MC, Soukiazian N, Shayne M, Huston A, Ling M, Hicks DG. "Use of modified Magee equations and histologic criteria to predict the Oncotype DX recurrence score." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2015 Jul 0; 28(7):921-31. Epub 2015 May 01.
Books & Chapters
2007
Chapter Title: Myeloma Bone Disease
Book Title: Translational Therapeutic Strategies in Multiple Myeloma
Author List: A. Huston and G. D. Roodman
Edited By: I. M. Ghobrial and K. Anderson
Published By: Informa Healthcare, Inc. 2007
2007
Chapter Title: Skeletal Complications: Bone Metabolism and Novel Targeted Agents
Book Title: Cancer Supportive Care: Advances in Therapeutic Strategies
Author List: A. Huston
Edited By: G. H. Lyman and J. Crawford
Published By: Informa healthcare, Inc. 2007
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