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David Justin Nagel, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 275-4161

Office: (585) 275-5053

Fax: (585) 273-1171

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Setting



As a Pulmonary and Critical Care physician, I see patients in the Medical Intensive Care Units at Strong Memorial Hospital and Highland Hospital as well as in the ambulatory clinic at Strong. In the outpatient setting, I focus on patients with interstitial lung disease, including idiopathic pulmonary fibrosis, lung scarring related to autoimmune diseases, and sarcoidosis. I am a member of the URMC Pulmonary Fibrosis Foundation Care center and work closely with the multidisciplinary diagnostic team to allow a timely and accurate diagnosis for each patient.

Professional Background

Dr. Nagel was born in Rochester, NY and graduated from the University of Rochester with a bachelor's degree in Biology. He then attended graduate school at the University of Rochester School of Medicine and Dentistry and received his Doctor of Philosophy in the Department of Pharmacology and Physiology. He next attended URSMD and received his Doctor of Medicine degree in 2011. After completing his residency in Internal Medicine at Dartmouth-Hitchcock Medical Center, he stayed on as a Chief Medical resident for an additional year. He then moved back to the University of Rochester Medical Center to complete his fellowship in Pulmonary and Critical Care Medicine in 2018. He subsequently joined the Division of Pulmonary Diseases and Critical Care at URMC and is pursuing a career as an independently funded physician-scientist.


Dr. Nagel is an Assistant Professor in the Department of Medicine, Division of Pulmonary Diseases and Critical Care. His graduate work examined the pathogenesis of vascular smooth muscle remodeling and smooth muscle cell phenotype switching, specifically exploring the role of Phosphodiesterase 1A in this process. As a pulmonologist, he has translated the skills he learned as a graduate student to examine the pathology of myofibroblast differentiation signaling as it applies to the development of pulmonary fibrosis. His fellowship research focused on the interactions between a family of proton-sensing G-Protein Coupled Receptors, the extracellular matrix, and Transforming Growth Factor-Beta dependent signaling pathways. His current work examines ways in which extracellular remodeling, specifically through elastin degradation, contribute to pulmonary fibrosis. The interstitial lung disease group is also involved in several clinical trials and was one of the nation's top enrolling institutions in the Pulmonary Fibrosis Foundation patient registry.



  • Critical Care Medicine - American Board of Internal Medicine
  • Internal Medicine - American Board of Internal Medicine
  • Pulmonary Disease - American Board of Internal Medicine


MD | University of Rochester Medical Center

Post-doctoral Training & Residency

07/01/2015 - 06/30/2018
Fellowship in Pulmonary/Critical Care at University of Rochester Medical Center

07/01/2012 - 06/30/2014
Residency in Internal Medicine at Dartmouth Hitchcock Medical Center

06/18/2011 - 06/25/2012
Internship in Internal Medicine at Dartmouth Hitchcock Medical Center

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2020 - 2020
New Faculty Boot Camp
Sponsor: American Thoracic Society
Location: Philadelphia PA

Fellows Track Symposium
Sponsor: American Thoracic Society
Location: Washington DC

2016 - 2018
Fellow-in-training Member of the Cardiovascular Medicine and Surgery Network
Sponsor: American College of Chest Physicians

Department of Medicine Excellence in Teaching
Sponsor: Dartmouth-Hitchcock Medical Center
Location: Lebanon NH

Travel Award for Basic Science
Sponsor: American College of Physicians
Location: New Orleans

Medicine Library Award
Sponsor: Rochester Academy of Medicine
Location: Rochester NY

Gold Humanism Honor Society Inductee
Sponsor: Gold Humanism Honor Society

Travel Award
Sponsor: Experimental Biology Annual Meeting
Location: Washington DC

Best Poster Award
Sponsor: Gordon Research Conference
Location: Biddeford ME

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Journal Articles

Rackow AR, Nagel DJ, McCarthy C, Judge J, Lacy S, Freeberg MAT, Thatcher TH, Kottmann RM, Sime PJ. "The Self-fulfilling Prophecy of Pulmonary Fibrosis: A Selective Inspection of Pathologic Signaling Loops." The European respiratory journal.. 2020 Sep 17; Epub 2020 Sep 17.

Judge JL, Nagel DJ, Owens KM, Rackow A, Phipps RP, Sime PJ, Kottmann RM. "Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol." PloS one.. 2018 13(5):e0197936. Epub 2018 May 24.

Cai Y, Nagel DJ, Zhou Q, Li F, Pi X, Knight P, Yan C. "Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia." Circulation research.. 2015 Mar 27; 116(7):1120-32. Epub 2015 Jan 21.

Books & Chapters

Chapter Title: Acute Respiratory Failure in Chronic Interstitial Lung Disease
Book Title: Respiratory Ventilation Strategies in Acute and Chronic Respiratory Failure in Idiopathic Pulmonary Diseases. A Practical Approach
Author List: Baah S, Nagel DJ, Kalininskiy A, Kottmann RM
Edited By: Antonio Esquinas, MD
Published By: Nova Science 2020 in Hauppague NY

Chapter Title: Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Disease
Book Title: Cyclic Nucleotide Phosphodiesterases in Health and Disease
Author List: Yan C, Nagel DJ, Jeon KI
Published By: CRC Press, Taylor and Francis Group 2005 in Boca Raton