CONTACT INFORMATIONBIOGRAPHYCREDENTIALSAWARDSPATENTSPUBLICATIONSMartin S. Zand, M.D., Ph.D.Contact InformationPhone NumbersAppointment: (585) 275-7753Administrative: (585) 273-2819Office: (585) 273-2819Fax: (585) 442-9201A member of the University of Rochester Medical Faculty GroupgroupAn Accountable Health PartnerassignmentAccepting New PatientsLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 675Rochester, NY 14642Faculty AppointmentsProfessor - Department of Medicine , Nephrology (SMD) Senior Associate Dean, Clinical Research - Dean's Office M&D - Administration (SMD) Co-Director - Clinical & Translational Science InstituteDean's Professorship - Department of Medicine (SMD) Patient Care SettingsHospital Medicine, Nephrology, Organ TransplantBiographyDr. Zand is Professor of Medicine and Medical Humanities in the Division of Nephrology. He is also Co-Director of the Clinical and Translational Science Institute, Co-Director of The Center for Leading Innovation and Collaboration and Director of the Rochester Center for Health Informatics. His clinical practice is focused on the care of kidney transplant patients. His approach emphasizes holistic care of the whole person, mind and body. He brings to his practice of medicine an extensive experience in cutting edge clinical immunology, and a practical approach to wellness emphasizing exercise, diet, stress-reduction, and mindfulness. He has an active research program in the biology of antibody producing cells and their role in vaccine responses, transplant rejection, and health informatics.Professional BackgroundDr. Zand is a Professor of Medicine in the Division of Nephrology at the University of Rochester. In January 2015, Dr. Zand became Co-Director of the Clinical and Translational Science Institute (CTSI) funded by the NIH: NCATS, National Center for Advancing Translational Sciences. The CTSI develops, demonstrates and disseminates methods and approaches to advance translational research, by providing education and training, supporting transdisciplinary teams, improving quality and efficiency, and engaging community stakeholders. In July 2017, Dr. Zand became the Co-Director of the Center for Leading Innovation and Collaboration (CLIC) funded by the NIH: NCATS, National Center for Advancing Translational Sciences. CLIC offers data coordination services to collect, analyze and transform CTSA Consortium data to actionable insights that accelerate the impact of Consortium programs. It will also support effective, efficient and coordinated collaboration and team science. In the Fall of 2014, Dr. Zand founded the Rochester Center for Health Informatics, whose focus is using health informatics, graph theory, and "big data" analytics to understand how the healthcare system and the community are interconnected and interdependent, and how these connections contribute to population health. Dr. Zand graduated from Northwestern University with an undergraduate degree in Biomedical Engineering, a PhD in Cell, Molecular and Structural Biology, and an MD. He completed his residency in Internal Medicine and Fellowship in Nephrology at Beth Israel Medical Center and Harvard University in Boston. He joined University of Rochester Medical Center faculty in July 1998 as Medical Director of the Kidney and Pancreas Transplant Programs, which he led until 2014, when he became Director of the Rochester Center for Health Informatics. Dr. Zand has a clinical practice in Transplant Nephrology and Transplant Medicine, and sees patients with kidney and other solid organ transplants. He is an internationally recognized expert in B cell immunobiology in solid organ transplantation. He directs an active NIH funded research program in B cell immunobiology, vaccine biology, and computational modeling of immune responses. He leads the Rochester Center for Health Informatics, which is focused on using advanced data science methods to analyze population health data to create a "living healthcare laboratory" which improves community health and healthcare delivery.ResearchMy research is focused in two areas: Understanding how B cells respond to vaccines and organ transplants to produce antibodies, and using graph theory to understand how we can understand and improve population health and healthcare delivery. My groups use a similar core set of analytic methods in both areas, including high dimensional clustering methods, graph theory, differential equation and stochastic branching process modeling. My laboratory studies how B cells and plasma cells participate in the adaptive immune response, through antibody production, antigen presentation, and modulation of immune responses by other immune cells. Our goal is to understand how B cell differentiation and antibody production is regulated if we are to enhance B cell anti-viral and vaccine responses, or to prevent transplant rejection. We use innovative mathematical modeling and statistical analyses to gain insights from complex and large experimental data sets. Our experiments often involve daily analysis of gene expression and cellular phenotypes from single subjects over 5-10 days after vaccination. The scientific questions we are focused on include: 1. What is the timing of B cell differentiation and antibody secretion, and how can we alter the molecular and cellular events to improve vaccine responses? 2. What are the molecular gene expression signatures of a successful B cell vaccine response? 3. How can we use mathematical models to create individualized treatment protocols for kidney transplant patients with antibody mediated rejection or allosensitization? My Health Informatics Group uses advanced data science analytics to understand how people make their way through the healthcare system, and how larger factors such as employment, mental health, community engagement, and socio-economic status contribute to population health. We use network theory to investigate connections between these factors, and turn those insights into population health based research initiatives that we refer to as the "living healthcare laboratory". We collaborate with groups in the Institute for Data Science, the University of Rochester Medical Center, and numerous community and population health groups within the greater Rochester community.CredentialsEducation1992MD | Northwestern University Feinberg School of MedicinePost-doctoral Training & Residency07/01/1995 - 06/30/1998Fellowship in Nephrology at Beth Israel Deaconess Medical Center-Main Campus06/23/1992 - 06/30/1993Internship in Internal Medicine at Beth Israel Deaconess Medical Center-Main Campus07/01/1992 - 06/30/1995Residency in Internal Medicine at Beth Israel Deaconess Medical Center-Main CampusVIEW ALL expand_moreAwards2006Technology Innovation Award - Cleveland Clinic1998American Society of Transplant Physicians Young Investigator Award1986Selected Participant-Woods Hole Marine Biology Laboratory1985Northwestern University Medical Scientist Training Program Scholarship1981 - 1992Honors Program in Medical Education ScholarshipSponsor: Northwestern UniversityVIEW ALL expand_morePatentsPatent Title: Analyte-Releasing Beads and Use Thereof in Quantitative Elispot or Fluorispot Assay Patent #: 8,569,074 Issue Date: Oct 29, 2013 Country: United States Invented By: Miguel A Brown, Alicia D Henn, Martin S ZandPublicationsJournal Articles1/21/2023King SM, Bryan SP, Hilchey SP, Wang J, Zand MS. "First Impressions Matter: Immune Imprinting and Antibody Cross-Reactivity in Influenza and SARS-CoV-2." Pathogens.. 2023 Jan 21; 12(2)Epub 2023 Jan 21. 10/5/2022Chen Y, Hilchey SP, Wang J, Garigen J, Zand MS, Huang J. "Anamnestic broadly reactive antibodies induced by H7N9 virus more efficiently bind to seasonal H3N2 strains." Human vaccines & immunotherapeutics.. 2022 Oct 5; :2128014. Epub 2022 Oct 05. 9/8/2022DeWitt SB, Plumlee SH, Brighton HE, Sivaraj D, Martz EJ, Zand M, Kumar V, Sheth MU, Floyd W, Spruance JV, Hawkey N, Varghese S, Ruan J, Kirsch DG, Somarelli JA, Alman B, Eward WC. "Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-?B signaling and integrin binding." JCI insight.. 2022 Sep 8; 7(17)Epub 2022 Sep 08. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Martin S. Zand, M.D., Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Martin S. Zand, M.D., Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.