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Steven A. Goldman, M.D., Ph.D.

Neurology

Contact Information

Phone Numbers

Appointment: (585) 275-1200

Administrative: (585) 276-4595

Fax: (585) 276-2298

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester, NY

Biography

Dr. Steven A. Goldman is the URMC Distinguished Professor of Neuroscience and Neurology. He is Chief of the Department's Division of Cell and Gene Therapy, and Co-Director of Rochester's Center for Translational Neuromedicine. Goldman is Emeritus Chairman of the Department, and holds additional appointments as a Professor of Neurosurgery, and as the Dean Zutes Chair in Biology of the Aging Brain. Dr. Goldman moved to Rochester in 2003 from the Weill Medical College of Cornell University, where he was the Nathan Cummings Professor of Neurology, and Attending Neurologist at New York Presbyterian Hospital. A summa cum laude graduate of the University of Pennsylvania, he obtained his PhD with Fernando Nottebohm at the Rockefeller University in 1983, and his MD from Cornell in 1984. Dr. Goldman interned in Medicine and did his residency in Neurology under Fred Plum at New York Hospital-Cornell, and Jerome Posner at the Memorial Sloan-Kettering Cancer Center, before joining the Cornell faculty. Dr. Goldman is interested in cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. His lab focuses on the use of stem and progenitor cells for the treatment of neurodegenerative disorders such as Huntington's Disease, as well as for the treatment of glial diseases such as the pediatric leukodystrophies and multiple sclerosis He also has a strong interest in the conversion of resident cells into brain cancers, and is board certified in neuro-oncology. He has published over 200 papers in his field, over 100 as first or senior author. Dr. Goldman is a recipient of the Jacob Javits Neuroscience Investigator Award of the NIH, and has been elected to the Association of American Physicians and American Society for Clinical Investigation, as well as the American Neurological Association. Dr. Goldman remains active clinically, with subspecialty interests in stroke, myelin disease and neuro-oncology, and he is the program director for Rochester's neuro-oncology fellowship. He serves on standing committees of the NIH, and is a voting member of the FDA Cellular, Tissue and Gene Therapy Advisory Committee. His work is supported by NIH/NINDS, the Mathers and Adelson Foundations, the Department of Defense, CHDI, the National MS Society, NYSTEM, and Biogen Idec.

Research

Dr. Steven A. Goldman is the URMC Distinguished Professor of Neuroscience and Neurology. He is Chief of the Department's Division of Cell and Gene Therapy, and Co-Director of Rochester's Center for Translational Neuromedicine. Goldman is Emeritus Chairman of the Department, and holds additional appointments as a Professor of Neurosurgery, and as the Dean Zutes Chair in Biology of the Aging Brain. Dr. Goldman moved to Rochester in 2003 from the Weill Medical College of Cornell University, where he was the Nathan Cummings Professor of Neurology, and Attending Neurologist at New York Presbyterian Hospital. A summa cum laude graduate of the University of Pennsylvania, he obtained his PhD with Fernando Nottebohm at the Rockefeller University in 1983, and his MD from Cornell in 1984. Dr. Goldman interned in Medicine and did his residency in Neurology under Fred Plum at New York Hospital-Cornell, and Jerome Posner at the Memorial Sloan-Kettering Cancer Center, before joining the Cornell faculty. Dr. Goldman is interested in cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. His lab focuses on the use of stem and progenitor cells for the treatment of neurodegenerative disorders such as Huntington's Disease, as well as for the treatment of glial diseases such as the pediatric leukodystrophies and multiple sclerosis He also has a strong interest in the conversion of resident cells into brain cancers, and is board certified in neuro-oncology. He has published over 200 papers in his field, over 100 as first or senior author. Dr. Goldman is a recipient of the Jacob Javits Neuroscience Investigator Award of the NIH, and has been elected to the Association of American Physicians and American Society for Clinical Investigation, as well as the American Neurological Association. Dr. Goldman remains active clinically, with subspecialty interests in stroke, myelin disease and neuro-oncology, and he is the program director for Rochester's neuro-oncology fellowship. He serves on standing committees of the NIH, and is a voting member of the FDA Cellular, Tissue and Gene Therapy Advisory Committee. His work is supported by NIH/NINDS, the Mathers and Adelson Foundations, the Department of Defense, CHDI, the National MS Society, NYSTEM, and Biogen Idec.

Credentials

Faculty Appointments

Specialties

  • Neurology - American Board of Psychiatry and Neurology

Education

1978
BA | Univ of Pennsylvania
Biology

1983
PhD | Rockefeller University
Neurobiology

1984
MD | Cornell Univ Medical College
Medicine

Post-doctoral Training & Residency

7/1984 - 6/1985
Internship in Internal Medicine at Cornell University Medical College

7/1985 - 6/1988
Residency in Neurology at Cornell University Medical College

Awards

2002 - 2009
Jacob Javits Neurosci. Investigator Award (NIH)

1998 - 2001
Human Frontiers Scientific Program award

1997 - 2007
National Multiple Sclerosis Soc. Invest. Award

1993 - 1997
Irma T. Hirschl Career Scientist Award

1993 - 1994
American Paralysis Association Award

1992 - 1997
FIRST Award
Location: NIH/NINDS

1988 - 1997
Mathers Charitable Foundation Awards

1988 - 1993
Clinical Invest. Development Award
Location: HIH/NINDS

1988 - 1991
Cornell Scholar in Biomedical Science

1978 - 1984
Medical Scientist Training Program
Location: USPHS

1977
Phi Beta Kappa
Location: University of Pennsylvania

1974 - 1978
Benjamin Franklin Scholar, U. of Pennsylvania

1974 - 1978
Mayor's Scholar
Location: City of Philadelphia

1974 - 1978
Senatorial Scholar
Location: State of Pennsylvania

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Patents

Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
U.S. Serial #: 15/161,917
Filed: May 23, 2016
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: A Human Glial Chimeric Model for Drug Candidate Assessment in Human Gliotrophic Viral Infections and Progressive Multifocal Encephalopathy
U.S. Serial #: 14/710,144
Filed: May 12, 2015
Invented By: StevenGoldman, LeonidGorelik, YoichiKondo, MarthaWindrem

Title: Non-Human Mammal Model of Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorder (HUNTINGTON'S)
U.S. Serial #: 14/701,245
Filed: Apr 30, 2015
Invented By: StevenGoldman, MaikenNedergaard, PaulTesar, MarthaWindrem

Title: Use of Thrombin and PAR1 Inhibitors for the Treatment of Glioma
U.S. Serial #: 14/776,961
Filed: Mar 14, 2014
Invented By: RomaneAuvergne, StevenGoldman

Title: Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for the Treatment of Myelin Disorders
U.S. Serial #: 14/764,507
Filed: Feb 06, 2014
Invented By: StevenGoldman, SuWang

Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
U.S. Serial #: 13/527,099
Filed: Jun 19, 2012
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: Treating Myelin Diseases With Optimized Cell Preparations
U.S. Serial #: 12/990,874
Filed: May 07, 2009
Invented By: StevenGoldman, FraserSim

Title: Treating Myelin Diseases With Optimized Cell Preparations
U.S. Serial #: FR09743660.4
Filed: May 07, 2009
Invented By: StevenGoldman, FraserSim

Title: Treating Myelin Diseases With Optimized Cell Preparations
U.S. Serial #: DE09743660.4
Filed: May 07, 2009
Invented By: StevenGoldman, FraserSim

Title: Treating Myelin Diseases With Optimized Cell Preparations
U.S. Serial #: GB09743660.4
Filed: May 07, 2009
Invented By: StevenGoldman, FraserSim

Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
U.S. Serial #: 12/111,839
Filed: Apr 09, 2008
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: Non-Human Animals With Human-Glial Chimeric Brains
U.S. Serial #: 12/015,372
Filed: Jan 16, 2008
Invented By: StevenGoldman, MarthaWindrem

Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
U.S. Serial #: 10/368,810
Filed: Feb 14, 2003
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
U.S. Serial #: 2,476,376
Filed: Feb 14, 2003
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: Myelination of the Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
U.S. Serial #: DE03742750.7
Filed: Feb 14, 2003
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: Myelination of the Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
U.S. Serial #: GB03742750.7
Filed: Feb 14, 2003
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: Myelination of the Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
U.S. Serial #: FR12176576.2
Filed: Feb 14, 2003
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: Myelination of the Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
U.S. Serial #: DE12176576.2
Filed: Feb 14, 2003
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: Myelination of the Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
U.S. Serial #: GB12176576.2
Filed: Feb 14, 2003
Invented By: StevenGoldman, NeetaRoy, MarthaWindrem

Title: A Method for Isolating and Purifying Oligodendrocytes and Oligodendrocyte Progenitor Cells
U.S. Serial #: 09/282,239
Filed: Mar 31, 1999
Invented By: StevenGoldman, SuWang

Title: A Method for Isolating and Purifying Oligodendrocytes and Oligodendrocyte Progenitor Cells
U.S. Serial #:
Filed: Jan 01, 1899
Invented By: StevenGoldman, SuWang

Title: Disease Specific Human Glial Mouse Chimeras-Schizophrenia
U.S. Serial #:
Filed: Jan 01, 1899
Invented By: StevenGoldman, MaikenNedergaard, PaulTesar, MarthaWindrem

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Publications

Journal Articles

5/31/2017
Khakh BS, Beaumont V, Cachope R, Munoz-Sanjuan I, Goldman SA, Grantyn R. "Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease." Trends in neurosciences.. 2017 May 31; Epub 2017 May 31.

4/26/2017
Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Su Wanga NA, Benraiss A, Lou N, Goldman SA, Nedergaard M. "SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2017 Apr 26; 37(17):4493-4507. Epub 2017 Mar 23.

4/6/2017
Nevin ZS, Factor DC, Karl RT, Douvaras P, Laukka J, Windrem MS, Goldman SA, Fossati V, Hobson GM, Tesar PJ. "Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes." American journal of human genetics.. 2017 Apr 6; 100(4):617-634. Epub 2017 Mar 30.

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