Steven A. Goldman, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 275-1200

Administrative: (585) 276-4595

Fax: (585) 276-2298

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Accepting New Patients

Faculty Appointments

Professor (Part-Time) - Department of Neurology , Center for Translational Neuromedicine (SMD)
Co-Director - Department of Neurology , Center for Translational Neuromedicine (SMD)
Dean Zutes Chair in Biology of the Aging Brain - Department of Neurology (SMD)
URMC Distinguished Professor in Neurosciences - Dean's Office, SMD (SMD)
Professor (Part-Time) - Department of Neuroscience (SMD) - Joint

Patient Care Settings

Hospital Medicine, Neurology

Biography

Dr. Steven A. Goldman is the URMC Distinguished Professor of Neuroscience and Neurology, and co-Director of Rochester's Center for Translational Neuromedicine. He has a concurrent appointment as Professor of Neuroscience at the University of Copenhagen in Denmark, and as co-director of its sister Center for Translational Neuromedicine. He also serves as Senior Vice President and Head of CNS Therapy at Sana Biotechnology, in Cambridge, Massachusetts. Goldman moved to Rochester in 2003 from the Weill Medical College of Cornell University, where he was the Nathan Cummings Professor of Neurology, and Attending Neurologist at New York Presbyterian Hospital. A summa cum laude graduate of the University of Pennsylvania, he obtained his PhD with Fernando Nottebohm at the Rockefeller University in 1983, and his MD from Cornell in 1984. Dr. Goldman interned in Medicine and did his residency in Neurology at both New York Hospital-Cornell and the Memorial Sloan-Kettering Cancer Center, before joining the Cornell faculty. Goldman moved to Rochester as the Dean Zutes Chair in Biology of the Aging Brain, and as Chief of the Neurology department's Division of Cell and Gene Therapy; he subsequently served as the founding director for Rochester's neuro-oncology training program, and served as Chairman of the Department (2008-12). Dr. Goldman remains active clinically, with subspecialty interests in myelin disease and neuro-oncology, and additional research interests in stem cell-based treatment of neurological disease.

Research

Goldman is interested in cell genesis and regeneration in the adult brain, with a focus on the use of stem and progenitor cells in both modeling and treating demyelinating and neurodegenerative diseases, including targets as diverse as progressive multiple sclerosis, the leukodystrophies, Huntington Disease and schizophrenia. He also has a strong interest in the conversion of resident cells into brain cancers, and is board certified in neuro-oncology. He has published over 250 papers, over 100 as first or senior author, and holds over 30 patents in his field. Dr. Goldman is a recipient of the Novo Nordisk Foundation Laureate Award, the Jacob Javits Neuroscience Investigator Award of the NIH, and has been elected to Academia Europaea, the Association of American Physicians, the American Society for Clinical Investigation, and the American Neurological Association, and he is a fellow of the American Academy of Neurology. He serves on standing committees of the NIH, and has served as a voting member of the FDA Cellular, Tissue and Gene Therapy Advisory Committee. He is a co-founder of Oscine Therapeutics, and his work is supported by NIH/NINDS, the Adelson Medical Research Foundation, the Mathers Charitable Foundation, the Novo Nordisk Foundation, and the Lundbeck Foundation.

Credentials

Education

1984
MD | Weill Medical College of Cornell University

Post-doctoral Training & Residency

07/01/1985 - 06/30/1988
Residency in Neurology at Weill Medical College of Cornell University

07/01/1984 - 06/30/1985
Internship in Internal Medicine at Weill Medical College of Cornell University

Awards

2002 - 2009
Jacob Javits Neurosci. Investigator Award (NIH)

1998 - 2001
Human Frontiers Scientific Program award

1997 - 2007
National Multiple Sclerosis Soc. Invest. Award

1993 - 1997
Irma T. Hirschl Career Scientist Award

1993 - 1994
American Paralysis Association Award

1992 - 1997
FIRST Award
Location: NIH/NINDS

1988 - 1997
Mathers Charitable Foundation Awards

1988 - 1993
Clinical Invest. Development Award
Location: HIH/NINDS

1988 - 1991
Cornell Scholar in Biomedical Science

1978 - 1984
Medical Scientist Training Program
Location: USPHS

1977
Phi Beta Kappa
Location: University of Pennsylvania

1974 - 1978
Benjamin Franklin Scholar, U. of Pennsylvania

1974 - 1978
Mayor's Scholar
Location: City of Philadelphia

1974 - 1978
Senatorial Scholar
Location: State of Pennsylvania

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Patents

Patent Title: Treating Myelin Diseases with Optimized Cell Preparations
Patent #: 9,709,553
Issue Date: Jul 18, 2017
Country: United States
Invented By: Steven A Goldman, Fraser J Sim

Patent Title: Treating Myelin Diseases With Optimized Cell Preparations
Patent #: 2283116
Issue Date: Sep 28, 2016
Country: Europe
Invented By: Steven A Goldman, Fraser J Sim

Patent Title: Treating Myelin Diseases With Optimized Cell Preparations
Patent #: FR2283116
Issue Date: Sep 28, 2016
Country: France
Invented By: Steven A Goldman, Fraser J Sim

Patent Title: Treating Myelin Diseases With Optimized Cell Preparations
Patent #: DE2283116
Issue Date: Sep 28, 2016
Country: Germany
Invented By: Steven A Goldman, Fraser J Sim

Patent Title: Treating Myelin Diseases With Optimized Cell Preparations
Patent #: GB2283116
Issue Date: Sep 28, 2016
Country: United Kingdom
Invented By: Steven A Goldman, Fraser J Sim

Patent Title: Non-Human Mammal Model of Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorder (HUNTINGTON'S)
Patent #: 10,279,051
Issue Date: May 07, 2019
Country: United States
Invented By: Steven A Goldman

Patent Title: Non-Human Mammal Model of Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorder (HUNTINGTON'S)
Patent #: 9,724,432
Issue Date: Aug 08, 2017
Country: United States
Invented By: Steven A Goldman

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: 2114167
Issue Date: Jul 11, 2018
Country: Europe
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: DK2114167
Issue Date: Jul 11, 2018
Country: Denmark
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: FI2114167
Issue Date: Jul 11, 2018
Country: Finland
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: FR2114167
Issue Date: Jul 11, 2018
Country: France
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: DE2114167
Issue Date: Jul 11, 2018
Country: Germany
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: NL2114167
Issue Date: Jul 11, 2018
Country: Netherlands
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: SE2114167
Issue Date: Jul 11, 2018
Country: Sweden
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: CH2114167
Issue Date: Jul 11, 2018
Country: Switzerland/Liechtenstein
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: GB2114167
Issue Date: Jul 11, 2018
Country: United Kingdom
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Non-Human Animals With Human-Glial Chimeric Brains
Patent #: 7,524,491
Issue Date: Apr 28, 2009
Country: United States
Invented By: Steven A Goldman, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
Patent #: 9,371,513
Issue Date: Jun 21, 2016
Country: United States
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: 10,190,095
Issue Date: Jan 29, 2019
Country: United States
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: 2532241
Issue Date: May 11, 2016
Country: Europe
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: FR2532241
Issue Date: May 11, 2016
Country: France
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: DE2532241
Issue Date: May 11, 2016
Country: Germany
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: GB2532241
Issue Date: May 11, 2016
Country: United Kingdom
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: 1480521
Issue Date: Feb 25, 2015
Country: Europe
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: DE1480521
Issue Date: Feb 25, 2015
Country: Germany
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: GB1480521
Issue Date: Feb 25, 2015
Country: United Kingdom
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: 2,476,376
Issue Date: Oct 21, 2014
Country: Canada
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
Patent #: 8,206,699
Issue Date: Jun 26, 2012
Country: United States
Invented By: Steven A Goldman, Neeta S Roy, Martha S Windrem

Patent Title: Method for Isolating and Purifying Oligodendrocytes and Oligodendrocyte Progenitor Cells
Patent #: 8,263,402
Issue Date: Sep 11, 2012
Country: United States
Invented By: Steven A Goldman, Su Wang

Patent Title: Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for the Treatment of Myelin Disorders
Patent #: 6894941
Issue Date: Jun 08, 2021
Country: Japan
Invented By: Steven A Goldman, Su Wang

Patent Title: Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for the Treatment of Myelin Disorders
Patent #: 10,626,369
Issue Date: Apr 21, 2020
Country: United States
Invented By: Steven A Goldman, Su Wang

Patent Title: Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for the Treatment of Myelin Disorders
Patent #: 10,450,546
Issue Date: Oct 22, 2019
Country: United States
Invented By: Steven A Goldman, Su Wang

Patent Title: Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for the Treatment of Myelin Disorders
Patent #: 6541577
Issue Date: Jul 10, 2019
Country: Japan
Invented By: Steven A Goldman, Su Wang

Patent Title: Human Glial Chimeric Model for Drug Candidate Assessment in Human Gliotrophic Viral Infections and Progressive Multifocal Encephalopathy
Patent #: 10,779,519
Issue Date: Sep 22, 2020
Country: United States
Invented By: Steven A Goldman, Martha S Windrem

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Publications

Journal Articles

9/13/2023
Takasugi M, Ohtani N, Takemura K, Emmrich S, Zakusilo FT, Yoshida Y, Kutsukake N, Mariani JN, Windrem MS, Chandler-Militello D, Goldman SA, Satoh J, Ito S, Seluanov A, Gorbunova V. "CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance." Cell reports.. 2023 Sep 13; 42(9):113130. Epub 2023 Sep 13.

7/17/2023
Vieira R, Mariani JN, Huynh NPT, Stephensen HJT, Solly R, Tate A, Schanz S, Cotrupi N, Mousaei M, Sporring J, Benraiss A, Goldman SA. "Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain." Nature biotechnology.. 2023 Jul 17; Epub 2023 Jul 17.

6/13/2023
Villanueva CB, Stephensen HJT, Mokso R, Benraiss A, Sporring J, Goldman SA. "Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington's disease." Proceedings of the National Academy of Sciences of the United States of America.. 2023 Jun 13; 120(24):e2210719120. Epub 2023 Jun 06.

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