Research Bio
Dr. Steven A. Goldman is the URMC Distinguished Professor of Neuroscience and Neurology. He is Chief of the Department's Division of Cell and Gene Therapy, and Co-Director of Rochester's Center for Translational Neuromedicine. Goldman is Emeritus Chairman of the Department, and holds additional appointments as a Professor of Neurosurgery, and as the Dean Zutes Chair in Biology of the Aging Brain. Dr. Goldman moved to Rochester in 2003 from the Weill Medical College of Cornell University, where he was the Nathan Cummings Professor of Neurology, and Attending Neurologist at New York Presbyterian Hospital.
A summa cum laude graduate of the University of Pennsylvania, he obtained his PhD with Fernando Nottebohm at the Rockefeller University in 1983, and his MD from Cornell in 1984. Dr. Goldman interned in Medicine and did his residency in Neurology under Fred Plum at New York Hospital-Cornell, and Jerome Posner at the Memorial Sloan-Kettering Cancer Center, before joining the Cornell faculty. Dr. Goldman is interested in cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. His lab focuses on the use of stem and progenitor cells for the treatment of neurodegenerative disorders such as Huntington's Disease, as well as for the treatment of glial diseases such as the pediatric leukodystrophies and multiple sclerosis He also has a strong interest in the conversion of resident cells into brain cancers, and is board certified in neuro-oncology. He has published over 200 papers in his field, over 100 as first or senior author. Dr. Goldman is a recipient of the Jacob Javits Neuroscience Investigator Award of the NIH, and has been elected to the Association of American Physicians and American Society for Clinical Investigation, as well as the American Neurological Association. Dr. Goldman remains active clinically, with subspecialty interests in stroke, myelin disease and neuro-oncology, and he is the program director for Rochester's neuro-oncology fellowship. He serves on standing committees of the NIH, and is a voting member of the FDA Cellular, Tissue and Gene Therapy Advisory Committee. His work is supported by NIH/NINDS, the Mathers and Adelson Foundations, the Department of Defense, CHDI, the National MS Society, NYSTEM, and Biogen Idec.
Optimized Cell Preparations for Allogeneic Repair of Injured Human White Matter
United States Serial NO.: 12/990,874
Filed Date: May 7, 2009
Title: Treating Myelin Diseases With Optimized Cell Preparations
Invented by: Steven Goldman, Fraser Sim
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CD24 as a Brain Tumor Stem Cell Marker as a Diagnostic and Therapeutic Target in Primary Neural and Glial Tumors of the Brain
United States Serial NO.: 12/809,491
Filed Date: December 22, 2008
Title: CD24 as a Brain Tumor Stem Cell Marker as a Diagnostic and Therapeutic Target in Primary Neural and Glial Tumors of the Brain
Invented by: Steven Goldman, Fraser Sim, Romane Auvergne
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Isolating and Purifying Neuronal Stem Cells for Enrichment and Therapeutic Applications
United States Serial NO.:
Filed Date: January 1, 1899
Title: A Method for Isolating and Purifying Oligodendrocytes and Oligodendrocyte Progenitor Cells
Invented by: Steven Goldman, Su Wang
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Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
United States Serial NO.: 13/527,099
Filed Date: June 19, 2012
Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
Invented by: Steven Goldman
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Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
United States Serial NO.: 10/368,810
Filed Date: February 14, 2003
Title: Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendyocyte Progenitor Cells
Invented by: Steven Goldman
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| Jacob Javits Neurosci. Investigator Award (NIH) |
2002 - 2009 |
| Human Frontiers Scientific Program award |
1998 - 2001 |
| National Multiple Sclerosis Soc. Invest. Award |
1997 - 2007 |
| American Paralysis Association Award |
1993 - 1994 |
| Irma T. Hirschl Career Scientist Award |
1993 - 1997 |
| FIRST Award | NIH/NINDS |
1992 - 1997 |
| Cornell Scholar in Biomedical Science |
1988 - 1991 |
| Clinical Invest. Development Award | HIH/NINDS |
1988 - 1993 |
| Mathers Charitable Foundation Awards |
1988 - 1997 |
| Medical Scientist Training Program | USPHS |
1978 - 1984 |
| Phi Beta Kappa | University of Pennsylvania |
1977 |
| Mayor's Scholar | City of Philadelphia |
1974 - 1978 |
| Senatorial Scholar | State of Pennsylvania |
1974 - 1978 |
| Benjamin Franklin Scholar, U. of Pennsylvania |
1974 - 1978 |
2013 Jun 27
Auvergne RM, Sim FJ, Wang S, Chandler-Militello D, Burch J, Al Fanek Y, Davis D, Benraiss A, Walter K, Achanta P, Johnson M, Quinones-Hinojosa A, Natesan S, Ford HL, Goldman SA. "Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes." Cell reports. 2013 Jun 27; 3(6):2127-41. Epub 2013 May 30. |
2013 Jun 6
Benraiss A, Toner MJ, Xu Q, Bruel-Jungerman E, Rogers EH, Wang F, Economides AN, Davidson BL, Kageyama R, Nedergaard M, Goldman SA. "Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease." Cell stem cell.. 2013 Jun 6; 12(6):787-99. |
2013 Jun 3
Chen Z, Ye R, Goldman SA. "Testosterone modulation of angiogenesis and neurogenesis in the adult songbird brain." Neuroscience.. 2013 Jun 3; 239:139-48. Epub 2013 Jan 03. |
2013 May
Goldman SA. "White matter from fibroblasts." Nature biotechnology. 2013 May; 31(5):412-3. |
2013 Apr 3
Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. "An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Apr 3; 33(14):6181-90. |
