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Lawrence J. Saubermann, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-4711

Fax: (585) 276-0101

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Settings

Gastroenterology & Hepatology, Pediatrics

Biography

Dr. Saubermann's clinical interest is centered on taking care of adolescents and adults with Inflammatory Bowel Diseases, such as Crohn's Disease, Ulcerative Colitis, Celiac Sprue(gluten sensitive enteropathy), and microscopic /lymphocytic colitis, though he also sees patients with a variety of gastrointestinal and liver related illnesses. As part of the complex care required by these patients, he utilizes a multidisciplinary approach that sometimes involves rheumatologists, pathologists, dermatologists radiologists, ophthalmologist, and surgeons. Through his clinical trial work, he also provided access to advanced treatments that are being tested in the treatment of these disorders.

Professional Background

Dr. Lawrence Saubermann is a Gastroenterologist at Strong Memorial Hospital and Associate Professor of Medicine at the University of Rochester School of Medicine. He received a B.A. in Biology from Brandeis University, Waltham, Massachusetts. He attended medical school at the University of Texas, Southwestern Medical School in Dallas, Texas. He then completed his internship and residency in Internal Medicine at Rhode Island Hospital, and Brown University, in Providence, Rhode Island. Dr. Saubermann then completed a clinical and research fellowship in Gastroenterology at Brigham and Women's Hospital, Harvard Medical School, in Boston, Massachusetts. He was an Instructor in Medicine at the Brigham and Women's hospital for a couple of years before moving to Boston University Medical Center to establish his independent research program. While at Boston University Medical Center, he became an Assistant Professor of Medicine, and stayed there for five years as a Staff Gastroenterologist. In July 2005, he came to Strong Memorial Hospital to continue his research and clinical activities in the area of Inflammatory Bowel Disease.  He has received grants and published widely in this area, as well as written chapters in major textbooks. He enjoys teaching on the wards, in the clinics, and in the laboratory.

Research

Dr. Saubermann is interested in the intestinal mucosal immune system, and how it is involved in Inflammatory Bowel Diseases, such as Crohn's Disease, Ulcerative Colitis, Microscopic/lymphocytic colitis, and Celiac Sprue. He has a number of projects related to inflammatory bowel disease, including clinical research trials with new biologic agents, testing for novel serologic markers of disease activity, and examining the effects of environmental toxins on the mucosal immune system. He is collaborating with other clinical and basic science researchers throughout the university to better understand the mechanisms behind the disease and develop new therapies. In addition, he participates as a co-investigator on a longitudinal countywide database study of inflammatory bowel disease subjects.

Credentials

Specialties

  • Gastroenterology - American Board of Internal Medicine
  • Internal Medicine

Education

1991
MD | University of Texas Southwestern

Post-doctoral Training & Residency

07/01/1994 - 09/30/1998
Fellowship in Gastroenterology at Brigham and Women's Hospital

07/01/1992 - 06/30/1994
Residency in Internal Medicine at Rhode Island Hospital

07/01/1991 - 06/30/1992
Internship in Internal Medicine at Rhode Island Hospital

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Awards

2010
CCFA Executive Board and CMAC
Location: Rochester Chapter

2009
Fellowship in American College of Gastroenterology

2008
Chair of Education, Appointed Member
Sponsor: CCFA Medical Advisory Committee
Location: Rochester, NY

2003
Senior Research Award Crohn's and Colitis Foundation of America Senior Research Award

2002
Appointed Institutional Review Board Committee Member (Panel Purple, Active)

2002
Appointed Member of New England CCFA Medical Advisory Committee (Active)

2002
Broad Medical Research Program Award Broad Foundation

2001
Appointed Institutional Review Board Committee Member (Panel Green, Active)

1998
Mentored Clinical Scientist Development Award (K08) National Institutes of Health

1998
Physician Post-Doctoral Research Fellowship Award Howard Hughes Medical Institute

1998
Mentored Clinical Scientist Development Award K08
Sponsor: National Institute of Health

1997
Astra-Merck Advanced Research Training Award American Digestive Health Foundation

1987
cum laude Brandeis University

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Clinical Trials

A Phase 3b, Multicenter, Randomized, Blinded, Active-Controlled Study to Compare the Efficacy and Safety of Ustekinumab to that of Adalimumab in the Treatment of Biologic Naïve Subjects with Moderately-to-Severely Active Crohn’s Disease

Lead Researcher: Lawrence J Saubermann

The purpose of this study is to compare the effectiveness of the drug Ustekinumab to the drug Adalimumab in patients who have moderate to severe Crohn's disease. The study will test Ustekinumab compared to Adalimumab for 56 weeks. To determine if the effectiveness of each drug, patients will come to the clinic regularly to meet with the study team, complete questionnaires, and have blood work completed.

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A Phase II, Randomized, Parallel-Group, Double-Blind, Double-Dummy, Placebo-Controlled, Multicenter Study To Evaluate the Efficacy, Safety, and Pharmacokinetics of UTTR1147A Compared With Placebo and Compared With Vedolizumab in Patients With Moderate to Severe Ulcerative Colitis

Lead Researcher: Lawrence J Saubermann

This study is designed to evaluate the efficacy, safety, and pharmacokinetics of UTTR1147A compared with vedolizumab and with placebo in the treatment of participants with moderate to severe UC. This study will consist of two parts, Part A and Part B. Part A will test the induction of clinical remission and Part B will test the durability of clinical remission.

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A Phase 2/3, Randomized, Double-blind, Placebo- and Active-controlled, Parallel-group, Multicenter Protocol to Evaluate the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

Lead Researcher: Lawrence J Saubermann

The purpose of this program is to evaluate the efficacy and safety of guselkumab (an injection under the skin) in participants with Crohn's disease. Inclusion Criteria: Have Crohn's disease or fistulizing Crohn's disease for at least 3 months duration (a minimum of 12 weeks). Have demonstrated intolerance or inadequate response to conventional or biologic therapy for Chrohn's disease.

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Publications

Journal Articles

6/22/2020
"Human blood PIG-A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra- and inter-subject variation." Environmental and molecular mutagenesis.. 2020 Jun 22; Epub 2020 Jun 22.

3/27/2020
"Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays." Mutagenesis.. 2020 Mar 27; 35(2):161-167.

10/22/2019
Deneau M, Valentino P, Mack C, Alqoaer K, Amin M, Amir A, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, El-Matary W, Ferrari F, Furuya K, Gottrand F, Gupta N, Homan M, Jensen MK, Kamath BM, Kim KM, Kolho KL, Koot BG, Iorio R, Martinez M, Miloh T, Mohan P, Palle S, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Woynarowski M, Guthery S. "Assessing the Validity of Adult-Derived Prognostic Models for Primary Sclerosing Cholangitis Outcomes in Children." Journal of pediatric gastroenterology and nutrition.. 2019 Oct 22; Epub 2019 Oct 22.

Books & Chapters

2006
Chapter Title: Ulcerative Colitis
Book Title: Therapies of Digestive Disorders, second edition
Author List: Saubermann LJ; Farraye FA
Edited By: M.W. Wolfe, et al, Eds.
Published By: Elsevier Publishers 2006

2003
Chapter Title: Inflammatory Bowel Disease
Book Title: Cecil Essentials of Medicine
Author List: Saubermann, LJ and Farraye, FA.
Edited By: Andreoli TE et al.
Published By: W.B. Saunders Company 2003 in Philadelphia

2000
Chapter Title: Immunological Aspects of Gastroenterology
Book Title: Molecular Immunology of Mucosal T Cells
Author List: Saubermann, LJ and Blumberg RS
Published By: Kluwer Academic Press 2000

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