Dr. Guercio strives to provide compassionate, personalized, and evidence-based care to all his patients based on shared decision-making with the patient and their family. His decision to specialize in the care of patients with cancer was motivated by experiences caring for his own family members diagnosed with cancer.

His areas of expertise include the use of cutting-edge immunotherapy, chemotherapy, and hormone therapy in the treatment of genitourinary cancers, with a focus on the development of new forms of therapy through clinical trials. Dr. Guercio has authored research articles in multiple journals including the Journal of Clinical Oncology. He has received Young Investigator Awards from the Bladder Cancer Advocacy Network (BCAN) and ASCO Conquer Cancer Foundation and has been a recipient of research support from the NIH/NCI.

Dr. Guercio previously served as an Instructor of Medicine at Harvard Medical School and as a Visiting Investigator at Memorial Sloan Kettering Cancer Center.

Certified Specialties

Internal Medicine - American Board of Internal Medicine

Medical Oncology - American Board of Internal Medicine

Faculty Appointments

Assistant Professor - Department of Medicine, Hematology/Oncology (SMD)

Credentials

Residency & Fellowship

Fellowship, Hematology & Oncology, Memorial Sloan-Kettering Cancer Center. 2019 - 2022

Residency, Internal Medicine, Brigham and Women's Hospital. 2017 - 2018

Internship, Internal Medicine, Brigham and Women's Hospital. 2015 - 2016

Education

MD | Harvard Medical School. 2015

Research

Clinical Trials

A Phase II Study of Gemcitabine Plus Cisplatin Chemotherapy in Patients With Muscle-invasive Bladder Cancer With Bladder Preservation for Those Patients Whose Tumors Harbor Deleterious DNA Damage Response (DDR) Gene Alterations

Lead Researcher: Brendan J Guercio

This phase II trial studies how well gemcitabine hydrochloride and cisplatin work in treating participants with invasive bladder urothelial cancer. Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to...

A Phase 1b/2 Basket Study of ACR-368 as Monotherapy and in Combination With Gemcitabine in Adult Subjects With Platinum-Resistant Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma Based on Acrivon OncoSignature® Status

Lead Researcher: Brendan J Guercio

This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelia...

Publications

Journal Articles

Quantitative functional profiling of ERCC2 mutations deciphers cisplatin sensitivity in bladder cancer.

Börcsök J, Gopaul D, Devesa-Serrano D, Mooser C, Jonsson N, Cagiada M, Stormoen DR, Ataya MN, Guercio BJ, Kaimakliotis HZ, Iyer G, Lindorff-Larsen K, Dyrskjøt L, Mouw KW, Szallasi Z, Sørensen CS

The Journal of clinical investigation.. 2025 August 15135 (16)Epub 08/15/2025.

Circulating Tumor DNA and Response to Cisplatin-based Chemotherapy in Patients with Metastatic Urothelial Carcinoma Enrolled in CALGB 90601 (Alliance).

Guercio BJ, Whiting K, Shah RH, Ballman KV, Halabi S, Regazzi AM, Milbank JH, Bajorin DF, Beltran H, Morris MJ, Solit DB, Berger MF, Iyer G, Seshan V, Rosenberg JE

European urology open science.. 2025 May 75 :80-88. Epub 04/07/2025.

Novel metabolomic predictors of incident colorectal cancer in men and women.

Downie JM, Joshi AD, Geraghty CM, Guercio BJ, Zeleznik OA, Song M, Bever AM, Drew DA, Tabung FK, Zhang X, Jin L, Eliassen AH, Willett WC, Wu K, Kraft P, Tamimi R, Clish C, Fuchs CS, Giovannucci E, Meyerhardt JA, Chan AT

Journal of the National Cancer Institute.. 2025 March 1117 (3):517-528. Epub 1900 01 01.

Advances in diagnosis and treatment of bladder cancer.

Lopez-Beltran A, Cookson MS, Guercio BJ, Cheng L

BMJ : British medical journal. 2024 February 12384 :e076743. Epub 02/12/2024.

Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience.

Guercio BJ, Sarfaty M, Teo MY, Ratna N, Duzgol C, Funt SA, Lee CH, Aggen DH, Regazzi AM, Chen Z, Lattanzi M, Al-Ahmadie HA, Brannon AR, Shah R, Chu C, Lenis AT, Pietzak E, Bochner BH, Berger MF, Solit DB, Rosenberg JE, Bajorin DF, Iyer G

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2023 November 1429 (22):4586-4595. Epub 1900 01 01.

Current Trends in Chemotherapy in the Treatment of Metastatic Prostate Cancer.

Zhao J, Guercio BJ, Sahasrabudhe D

Cancers.. 2023 August 415 (15)Epub 08/04/2023.

Resident-Reported Impact of a Novel Oncology Curriculum for Internal Medicine Residents.

Tsai FD, Guercio B, Stuver S, Stern R, Peluso MJ, Winkler M, Piawah S, Vallurupalli M, Luskin MR, Braun D, Parent A, Glotzbecker B, Kilbridge KL

Journal of cancer education : the official journal of the American Association for Cancer Education.. 2022 December 37 (6):1879-1885. Epub 09/04/2021.

Long-term Outcomes of Local and Metastatic Small Cell Carcinoma of the Urinary Bladder and Genomic Analysis of Patients Treated With Neoadjuvant Chemotherapy.

Teo MY, Guercio BJ, Arora A, Hao X, Regazzi AM, Donahue T, Herr HW, Goh AC, Cha EK, Pietzak E, Donat SM, Dalbagni G, Bochner BH, Olgac S, Sarungbam J, Sirintrapun SJ, Chen YB, Gopalan A, Fine SW, Tickoo SK, Reuter VE, Weigelt B, Schultheis AM, Funt SA, Bajorin DF, Solit DB, Iyer G, Ostrovnaya I, Rosenberg JE, Al-Ahmadie H

Clinical genitourinary cancer.. 2022 October 20 (5):431-441. Epub 05/11/2022.

Developing Precision Medicine for Bladder Cancer.

Guercio BJ, Iyer G, Rosenberg JE

Hematology/oncology clinics of North America.. 2021 June 35 (3):633-653. Epub 04/10/2021.

IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405.

Guercio BJ, Zhang S, Ou FS, Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, Pollak MN, Nixon AB, Mullen BC, O'Neil BH, Shaw JE, Polite BN, Benson AB, Atkins JN, Goldberg RM, Brown JC, O'Reilly EM, Mayer RJ, Blanke CD, Fuchs CS, Meyerhardt JA

JNCI cancer spectrum.. 2021 February 5 (1)Epub 08/27/2020.

Treatment of Metastatic Extramammary Paget Disease with Combination Ipilimumab and Nivolumab: A Case Report.

Guercio BJ, Iyer G, Kidwai WZ, Lacouture ME, Ghafoor S, Rossi AM, Assis DN, Chen YB, Busam KJ, Janjigian YY, Jhaveri K, Feldman DR, Capozzi A, Figueroa V, Bajorin DF, Rosenberg JE, Hollmann TJ, Funt SA

Case reports in oncology.. 2021 14 (1):430-438. Epub 03/12/2021.

Body Mass Index and Weight Loss in Metastatic Colorectal Cancer in CALGB (Alliance)/SWOG 80405.

Guercio BJ, Zhang S, Venook AP, Ou FS, Niedzwiecki D, Lenz HJ, Innocenti F, Mullen BC, O'Neil BH, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg RM, Brown JC, O'Reilly EM, Mayer RJ, Blanke CD, Fuchs CS, Meyerhardt JA

JNCI cancer spectrum.. 2020 June 4 (3):pkaa024. Epub 03/31/2020.

Identification of Racial Inequities in Access to Specialized Inpatient Heart Failure Care at an Academic Medical Center.

Eberly LA, Richterman A, Beckett AG, Wispelwey B, Marsh RH, Cleveland Manchanda EC, Chang CY, Glynn RJ, Brooks KC, Boxer R, Kakoza R, Goldsmith J, Loscalzo J, Morse M, Lewis EF, Abel S, Adams A, Anaya J, Andrews EH, Atkinson B, Avutu V, Bachorik A, Badri O, Bailey M, Baird K, Bakshi S, Balaban D, Barshop K, Baumrin E, Bayomy O, Beamesderfer J, Becker N, Berg DD, Berman AN, Blum SM, Boardman AP, Boden K, Bonacci RA, Brown S, Campbell K, Case S, Cetrone E, Charrow A, Chiang D, Clark D, Cohen AJ, Cooper A, Cordova T, Cuneo CN, de Feria AA, Deffenbacher K, DeFilippis EM, DeGregorio G, Deutsch AJ, Diephuis B, Divakaran S, Dorschner P, Downing N, Drescher C, D'Silva KM, Dunbar P, Duong D, Earp S, Eckhardt C, Elman SA, England R, Everett K, Fedotova N, Feingold-Link T, Ferreira M, Fisher H, Foo P, Foote M, Franco I, Gilliland T, Greb J, Greco K, Grewal S, Grin B, Growdon ME, Guercio B, Hahn CK, Hasselfeld B, Haydu EJ, Hermes Z, Hildick-Smith G, Holcomb Z, Holroyd K, Horton L, Huang G, Jablonski S, Jacobs D, Jain N, Japa S, Joseph R, Kalashnikova M, Kalwani N, Kang D, Karan A, Katz JT, Kellner D, Kidia K, Kim JH, Knowles SM, Kolbe L, Kore I, Koullias Y, Kuye I, Lang J, Lawlor M, Lechner MG, Lee K, Lee S, Lee Z, Limaye N, Lin-Beckford S, Lipsyc M, Little J, Loewenthal J, Logaraj R, Lopez DM, Loriaux D, Lu Y, Ma K, Marukian N, Matias W, Mayers JR, McConnell I, McLaughlin M, Meade C, Meador C, Mehta A, Messenger E, Michaelidis C, Mirsky J, Mitten E, Mueller A, Mullur J, Munir A, Murphy E, Nagami E, Natarajan A, Nsahlai M, Nze C, Okwara N, Olds P, Paez R, Pardo M, Patel S, Petersen A, Phelan L, Pimenta E, Pipilas D, Plovanich M, Pong D, Powers BW, Rao A, Ramirez Batlle H, Ramsis M, Reichardt A, Reiger S, Rengarajan M, Rico S, Rome BN, Rosales R, Rotenstein L, Roy A, Royston S, Rozansky H, Rudder M, Ryan CE, Salgado S, Sanchez P, Schulte J, Sekar A, Semenkovich N, Shannon E, Shaw N, Shorten AB, Shrauner W, Sinnenberg L, Smithy JW, Snyder G, Sreekrishnan A, Stabenau H, Stavrou E, Stergachis A, Stern R, Stone A, Tabrizi S, Tanyos S, Thomas C, Thun H, Torres-Lockhart K, Tran A, Treasure C, Tsai FD, Tsaur S, Tschirhart E, Tuwatananurak J, Venkateswaran RV, Vishnevetsky A, Wahl L, Wall A, Wallace F, Walsh E, Wang P, Ward HB, Warner LN, Weeks LD, Weiskopf K, Wengrod J, Williams JN, Winkler M, Wong JL, Worster D, Wright A, Wunsch C, Wynter JS, Yarbrough C, Yau WY, Yazdi D, Yeh J, Yialamas MA, Yozamp N, Zambrotta M, Zon R

Circulation. Heart failure.. 2019 November 12 (11):e006214. Epub 10/29/2019.

Associations of Physical Activity With Survival and Progression in Metastatic Colorectal Cancer: Results From Cancer and Leukemia Group B (Alliance)/SWOG 80405.

Guercio BJ, Zhang S, Ou FS, Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, O'Neil BH, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg RM, Sato K, Ng K, Van Blarigan E, Mayer RJ, Blanke CD, O'Reilly EM, Fuchs CS, Meyerhardt JA

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2019 October 1037 (29):2620-2631. Epub 08/13/2019.

Associations of artificially sweetened beverage intake with disease recurrence and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance).

Guercio BJ, Zhang S, Niedzwiecki D, Li Y, Babic A, Morales-Oyarvide V, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Ogino S, Zoltick ES, Stampfer M, Ng K, Wu K, Willett WC, Giovannucci EL, Meyerhardt JA, Fuchs CS

PloS one.. 2018 13 (7):e0199244. Epub 07/19/2018.

Coffee Intake, Recurrence, and Mortality in Stage III Colon Cancer: Results From CALGB 89803 (Alliance).

Guercio BJ, Sato K, Niedzwiecki D, Ye X, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Hu FB, Ogino S, Wu K, Willett WC, Giovannucci EL, Meyerhardt JA, Fuchs CS

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2015 November 133 (31):3598-607. Epub 08/17/2015.

Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly individuals.

Guercio BJ, Donovan NJ, Ward A, Schultz A, Lorius N, Amariglio RE, Rentz DM, Johnson KA, Sperling RA, Marshall GA

The Journal of neuropsychiatry and clinical neurosciences.. 2015 27 (1):e22-7. Epub 11/10/2014.

Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment.

Munro CE, Donovan NJ, Guercio BJ, Wigman SE, Schultz AP, Amariglio RE, Rentz DM, Johnson KA, Sperling RA, Marshall GA

Journal of Alzheimer's disease : JAD.. 2015 46 (3):727-35. Epub 1900 01 01.

The Apathy Evaluation Scale: A Comparison of Subject, Informant, and Clinician Report in Cognitively Normal Elderly and Mild Cognitive Impairment.

Guercio BJ, Donovan NJ, Munro CE, Aghjayan SL, Wigman SE, Locascio JJ, Amariglio RE, Rentz DM, Johnson KA, Sperling RA, Marshall GA

Journal of Alzheimer's disease : JAD.. 2015 47 (2):421-32. Epub 1900 01 01.

An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction.

Desai MK, Guercio BJ, Narrow WC, Bowers WJ

Glia.. 2011 April 59 (4):627-40. Epub 02/03/2011.

Ratings & Comments

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Ratings

Care provider's discussion of any proposed treatment (options, risks, benefits, etc.)

4.9

Likelihood of recommending this care provider to others

5.0

Explanations the care provider gave you about your problem or condition

4.9

Care provider's efforts to include you in decisions about your care

4.9

Concern the care provider showed for your questions or worries

5.0