Matthew D. McGraw, M.D.

Contact Information

Phone Numbers

Administrative: (585) 275-2464

Fax: (585) 275-8706

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Accepting New Patients

Research Labs

Visit Lab Website

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 667
Rochester, NY 14642

Faculty Appointments

Assistant Professor - Department of Pediatrics , Pulmonology (SMD)
George Washington Goler Chair in Pediatrics - Department of Pediatrics (SMD)

Patient Care Settings

Hospital Medicine, Pediatrics

Biography

Dr. McGraw's primary goal as a pediatric pulmonologist is to provide excellent care for all children and adolescents with underlying lung disease. He sees all patients with pediatric lung diseases including but not limited to cystic fibrosis, chronic lung disease of prematurity, and asthma. The primary focus of his basic science is better understanding the mechanisms of rare lung diseases, such as childhood interstitial lung disease (chILD) and bronchiolitis obliterans (BO), in order to identify new medical therapies.

Professional Background

Inherent of Dr. McGraw's practice is providing thoughtful, evidence-based, family-centered care to all children and families. His primary goal is to promote the greatest developmentally appropriate growth and potential of all children, consistent with the mission of the University of Rochester's Department of Pediatrics. He works collaboratively with parents, primary and other care providers to achieve the best outcomes for children and adolescents with underlying lung disease.

Research

Dr. McGraw's research involves understanding the mechanisms of aberrant airway epithelial repair after inhalation injuries. The primary pediatric lung disease studied is bronchiolitis obliterans (BO), a devastating and often progressive fibrotic lung disease characterized by progressive luminal narrowing and obliteration of the small airways, or bronchioles. Despite BO's high morbidity and mortality, very little is known about its pathogenesis, and even less is available in terms of prevention, intervention and treatment.

Inhalation agents used to study the mechanisms of aberrant airway epithelial repair include sulfur mustard (SM), a chemical warfare inhalation agent, and diacetyl, a volatile chemical in many flavorings. Both of these inhalation agents can cause bronchiolitis obliterans in children.

Basic science techniques include: small animal model development; primary airway epithelial cell isolation; flow sorting; 3D cell culture; single cell RNA sequencing.

Credentials

Education

2012
MD | SUNY Upstate College of Health Professions

Post-doctoral Training & Residency

07/01/2015 - 06/30/2018
Fellowship in Pediatric Pulmonology at University of Colorado Hospital- GME

07/01/2013 - 06/30/2015
Residency in Pediatrics at University of Virginia-Radiology GME

07/01/2012 - 06/30/2013
Internship in Pediatrics at University of Virginia-Radiology GME

VIEW ALL

Awards

2022 - 2026
Mechanisms of Basal Cell Dysfunction in Chemical-induced Bronchiolitis Obliterans
Sponsor: NIEHS (NIH; K08ES033290)
Location: University of Rochester Medical Center

2020 - 2022
KL2 Award
Sponsor: NCATS and URMC CTSI
Location: University of Rochester, Rochester, NY

2020 - 2021
Furth Award
Sponsor: Office of the Provost, University of Rochester
Location: Rochester, NY

2019 - 2023
NIH Loan Repayment Program
Sponsor: NIEHS
Location: University of Rochester, Rochester, NY

2018
Best Research Poster, Junior Faculty
Sponsor: Department of Pediatrics, Golisano's Children's Hospital
Location: Rochester, NY

2017
Society of Toxicology's Donald E. Gardner Inhalation Toxicology Education Award 2017

2016 - 2018
NIH T32 Training Grant, University of Colorado SOM, 2016 –2018

2015
Mulholland Resident and Fellow Teaching Award, Honorable Mention, 2015

2014 - 2015
American Academy of Pediatrics, Resident CATCH Implementation Grant, 2014 – 2015

2014 - 2015
University of Virginia Pediatrics Resident Teaching Award, 2014 & 2015

2011 - 2012
Gold Humanism Honor Society

2008
Bucknell University Department of Biomedical Engineering, Magna Cum Laude

2007 - 2008
Tau Beta Pi Engineering Honor Society

2005 - 2008
Bucknell University Dean's List

VIEW ALL

Publications

Journal Articles

3/7/2023
Day NJ, Wang J, Johnston CJ, Kim SY, Olson HM, House EL, Attah IK, Clair GC, Qian WJ, McGraw MD. "Rat Bronchoalveolar Lavage Proteome Changes Following E-cigarette Aerosol Exposures." American journal of physiology. Lung cellular and molecular physiology.. 2023 Mar 7; Epub 2023 Mar 07.

1/2023
Rebuli ME, Rose JJ, Noël A, Croft DP, Benowitz NL, Cohen AH, Goniewicz ML, Larsen BT, Leigh N, McGraw MD, Melzer AC, Penn AL, Rahman I, Upson D, Crotty Alexander LE, Ewart G, Jaspers I, Jordt SE, Kligerman S, Loughlin CE, McConnell R, Neptune ER, Nguyen TB, Pinkerton KE, Witek TJ. "The E-cigarette or Vaping Product Use-Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report." Annals of the American Thoracic Society.. 2023 Jan; 20(1):1-17.

10/25/2022
Katzen J, Rodriguez L, Tomer Y, Babu A, Zhao M, Murthy A, Carson P, Barrett M, Basil MC, Carl J, Leach JP, Morley M, McGraw MD, Mulugeta S, Pelura T, Rosen G, Morrisey EE, Beers MF. "Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells." Proceedings of the National Academy of Sciences of the United States of America.. 2022 Oct 25; 119(43):e2123187119. Epub 2022 Oct 17.

VIEW ALL PUBLICATIONS