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Inna Hughes, M.D., Ph.D.

(Pronouns: she/her/hers)

Contact Information

Phone Numbers

Appointment: (585) 275-2808

Administrative: (585) 275-9403

Administrative: (585) 275-2808

Fax: (585) 275-3683

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Settings

Neurology, Pediatrics


Professional Background

Inna Hughes, MD, PhD, is an Associate Professor of Child Neurology and Epilepsy at the University of Rochester. Her clinical interests are both in pediatric epilepsy and general child neurology. Dr. Hughes completed undergraduate studies at Williams College and graduated from Washington University in St Louis School of Medicine after completion of the combined MD, PhD program. She completed her Child Neurology residency training and a Pediatric Epilepsy fellowship at the University of Rochester Medical Center in Rochester, NY.

Dr. Hughes is board certified in Neurology with Special Qualification in Child Neurology and board certified in Epilepsy. She is an active member in the American Academy of Neurology, American Epilepsy Society, and the Child Neurology Society. She has several research interests including the development and genetics of childhood onset epilepsy syndromes, dietary therapy in children and teens, transition of care for young adults with epilepsy, and development of teaching and community programs to improve education and awareness for patients with epilepsy.



MD | Washington University School of Medicine

Post-doctoral Training & Residency

07/01/2014 - 06/02/2015
Fellowship in Epilepsy at University of Rochester Medical Center

06/29/2009 - 06/30/2012
Residency at University of Rochester Medical Center

06/23/2007 - 06/26/2009
Internship in Pediatrics at Golisano Children's Hospital-University of Rochester

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Upstate New York Regional Champions
Sponsor: New York State Neurological Society, NeuroStakes

Alpha Omega Alpha Society
Sponsor: University of Rochester Medical School

Spencer T and Ann W. Olin Medical Scientist Fellow
Sponsor: Washington University School of Medicine

2004 - 2007
Ruth L. Kirschstein National Research Service Award Individual Fellowship
Sponsor: National Institutes of Health, National Institute on Deafness

Merlie Fine Sciences Travel Award
Sponsor: Washington University School of Medicine

Viktor Hamburger Award
Sponsor: Washington University School of Medicine

Graduate Student Presentation Award
Sponsor: Stowers Institute, Mid-West Developmental Biology Meeting

1999 - 2003
Medical Scientist Training Program grant
Sponsor: Washington University School of Medicine

Honors in Biology, Magna cum Laude
Sponsor: Williams College

Minority Undergraduate Summer Internship Program
Sponsor: Harvard School of Public Health

1995 - 1997
Acceleration to Excellence Scholarship
Sponsor: Simon's Rock College of Bard

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Clinical Trials

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-921352 as Adjunctive Therapy in Subjects With SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE)

Lead Researcher: Inna Hughes

The study, known as the Kayak Study, looks at how the investigational drug affects the symptoms, quality of life, severity of seizures, and frequency of seizures when compared to a placebo (inactive drug) in individuals 2-21 years of age diagnosed with SCN8A-DEE.

View Study Details


Journal Articles

Munger Clary H, Josephson SA, Franklin G, Herman ST, Hopp JL, Hughes I, Meunier L, Moura LMVR, Parker-McFadden B, Pugh MJ, Schultz R, Spanaki MV, Bennett A, Baca C. "Seizure Frequency Process and Outcome Quality Measures: Quality Improvement in Neurology." Neurology.. 2022 Apr 5; 98(14):583-590.

Poliquin S, Hughes I, Shen W, Mermer F, Wang J, Mack T, Xu D, Kang JQ. "Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD." Experimental neurology.. 2021 May 4; :113723. Epub 2021 May 04.

Patel AD, Baca C, Franklin G, Herman ST, Hughes I, Meunier L, Moura LMVR, Munger Clary H, Parker-McFadden B, Pugh MJ, Schultz RJ, Spanaki MV, Bennett A, Josephson SA. "Quality improvement in neurology: Epilepsy Quality Measurement Set 2017 update." Neurology.. 2018 Oct 30; 91(18):829-836. Epub 2018 Oct 03.