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Inna Hughes, M.D., Ph.D.

(Pronouns: she/her/hers)

Contact Information

Phone Numbers

Appointment: (585) 275-2808

Administrative: (585) 275-9403

Fax: (585) 275-3683

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Settings

Neurology, Pediatrics


Professional Background

Inna Hughes, MD, PhD, is an Assistant Professor of Child Neurology and Epilepsy at the University of Rochester. Her clinical interests are both in pediatric epilepsy and general child neurology. Dr. Hughes completed undergraduate studies at Williams College and graduated from Washington University in St Louis School of Medicine after completion of the combined MD, PhD program. She completed her Child Neurology residency training and a Pediatric Epilepsy fellowship at the University of Rochester Medical Center in Rochester, NY.

Dr. Hughes is board certified in Neurology with Special Qualification in Child Neurology and board certified in Epilepsy. She is an active member in the American Academy of Neurology, American Epilepsy Society, and the Child Neurology Society. She has several research interests including the development and genetics of childhood onset epilepsy syndromes, dietary therapy in children and teens, and development of teaching and community programs to improve education and awareness for patients with epilepsy.



  • Epilepsy - American Board of Psychiatry and Neurology
  • Neurology with Special Qualifications in Child Neurology - American Board of Psychiatry and Neurology


MD, PhD | Washington University School of Medicine

Post-doctoral Training & Residency

07/01/2014 - 06/02/2015
Fellowship in Epilepsy at University of Rochester Medical Center

06/29/2009 - 06/30/2012
Residency in at University of Rochester Medical Center

06/23/2007 - 06/26/2009
Internship in Pediatrics at Golisano Children's Hospital at Strong, University of Rochester

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Upstate New York Regional Champions
Sponsor: New York State Neurological Society, NeuroStakes

Alpha Omega Alpha Society
Sponsor: University of Rochester Medical School

Spencer T and Ann W. Olin Medical Scientist Fellow
Sponsor: Washington University School of Medicine

2004 - 2007
Ruth L. Kirschstein National Research Service Award Individual Fellowship
Sponsor: National Institutes of Health, National Institute on Deafness

Merlie Fine Sciences Travel Award
Sponsor: Washington University School of Medicine

Viktor Hamburger Award
Sponsor: Washington University School of Medicine

Graduate Student Presentation Award
Sponsor: Stowers Institute, Mid-West Developmental Biology Meeting

1999 - 2003
Medical Scientist Training Program grant
Sponsor: Washington University School of Medicine

Honors in Biology, Magna cum Laude
Sponsor: Williams College

Minority Undergraduate Summer Internship Program
Sponsor: Harvard School of Public Health

1995 - 1997
Acceleration to Excellence Scholarship
Sponsor: Simon's Rock College of Bard

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Clinical Trials

A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel Group Study with Open-Label Extension Phase of Lorcaserin as Adjunctive Treatment in Subjects with Dravet Syndrome

Lead Researcher: Inna Hughes

There is a Core Study and an Extension Phase. The Core Study will include a Pre-randomization (Baseline) and a Randomization (Treatment) Phase. The Pre-randomization Phase will include a Screening/Baseline Period (4 weeks), during which the subjects will be assessed for eligibility. Once the Screening and Baseline procedures have been completed and eligibility has been established, the subjects will be randomized to 1 of 2 treatment groups in a ratio of 1:1 and will receive lorcaserin or placebo for 14 weeks. All subjects who complete the Core Study will be eligible to enter the 16-week Open-label Extension Phase. Eligibility: Aged 2 or older with a diagnosis of Dravet syndrome.

View Study Details


Journal Articles

Poliquin S, Hughes I, Shen W, Mermer F, Wang J, Mack T, Xu D, Kang JQ. "Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD." Experimental neurology.. 2021 May 4; :113723. Epub 2021 May 04.

Patel AD, Baca C, Franklin G, Herman ST, Hughes I, Meunier L, Moura LMVR, Munger Clary H, Parker-McFadden B, Pugh MJ, Schultz RJ, Spanaki MV, Bennett A, Josephson SA. "Quality improvement in neurology: Epilepsy Quality Measurement Set 2017 update." Neurology.. 2018 Oct 30; 91(18):829-836. Epub 2018 Oct 03.

Hurle B, Marques-Bonet T, Antonacci F, Hughes I, Ryan JF, Comparative Sequencing Program N, Eichler EE, Ornitz DM, Green ED. "Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses." BMC evolutionary biology. 2011 Jan 24; 11:23. Epub 2011 Jan 24.