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Archibald S. Perkins, M.D., Ph.D.

Pathology

Contact Information

Phone Numbers

Office: (585) 276-3399

Fax: (585) 756-4468

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Cancer research, using mouse models to investigate molecular mechanisms in acute myeloid leukemia and myelodysplastic syndrome, with focus on the function of the zinc finger oncoprotein EVI1.

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Biography

Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective therapies at present. His clinical responsibilities include interpretation of bone marrow biopsies and smears, lymph node biopsies, and spleen; and laboratory analyses of coagulation disorders and hemoglobinopathies.

Professional Background

Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective thereapies at present.

Research

Dr. Perkins' current research focus is on Evi1, a complex locus that plays a critical role in both normal Hematopoiesis and myeloid leukemogenesis. Evidence indicates that Evi1 is an important player in maintenance of the leukemic stem cell compartment by increasing proliferation and prolonging survival, in part through regulation of the transcription factor Gata2 and the anti-apoptotic molecule Bc12a1. His current work encompasses embryogenesis in genetically modified mice, identification of chromosomal Evi1 binding targets, Evi1 protein-protein interactions, clinical implications of chromosomal rearrangements involving Evi1, and exploration of potential therapeutic approaches to block the function of Evi1 in leukemia.

Credentials

Faculty Appointments

Specialties

  • Anatomic Pathology - American Board of Pathology
  • Hematopathology - American Board of Pathology

Education

1979
BA | Williams College
Chemistry

1986
MD | Columbia Univ, College of Physicians & Surgeons
Medicine

1987
PhD | Columbia Univ, College of Physicians & Surgeons
Human Genetics

Post-doctoral Training & Residency

07/01/1986 - 06/30/1988
Residency in Pathology-Anatomic and Clinical at Brigham & Women's Hospital

07/01/1988 - 06/30/1992
Fellowship in Medical Genetics at National Cancer Institute

Awards

1979
Phi Beta Kappa

1979
Sigma Xi

Publications

Journal Articles

3/2014
Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS. "Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia." Bone.. 2014 Mar 0; 60:148-61. Epub 2013 Dec 04.

2014
Glass C, Wilson M, Gonzalez R, Zhang Y, Perkins AS. "The role of EVI1 in myeloid malignancies." Blood cells, molecules & diseases.. 2014 53(1-2):67-76. Epub 2014 Feb 01.

2014
Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG. "Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects." PloS one. 2014 9(2):e89397. Epub 2014 Feb 27.

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