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Stephen R. Hammes, M.D., Ph.D.

Endocrinology, Internal Medicine

Clinical Interests

Diabetes; General Endocrine, Metabolism; Polycystic Ovary Syndrome (PCOS); Transgender

Contact Information

Phone Numbers

Administrative: (585) 275-2901

Fax: (585) 273-1288

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Biography

Professional Background

Dr. Hammes received his B.A. in chemistry from Cornell University in 1985, where he worked with Dr. Barbara Baird studying the IgE receptor. Dr. Hammes then entered the MD/PhD program at Duke. For his PhD, Dr. Hammes studied retroviral gene regulation with Dr. Warner Greene. He then traveled to San Francisco, where he completed an internship and residency in General Medicine, followed by a fellowship in Endocrinology. For his postdoctoral research, Dr. Hammes again chose an alternative direction, working with a cardiologist rather than an endocrinologist. He trained with Dr. Shaun Coughlin, where he studied G protein-coupled receptors.

In 1999, Dr. Hammes left UCSF to become faculty at the UT Southwestern Medical Center in Dallas, where he started an entirely new research program, choosing to study transcription-independent, or nongenomic, steroid signaling. Specifically, Dr. Hammes studied steroid-triggered maturation (meiotic progression) of oocytes, one of the few physiologically relevant steroid-triggered processes that is generally accepted to be nongenomic. Dr. Hammes has recently expanded his work to study ovarian development and function, with a focus on diseases of androgen excess such as polycystic ovarian syndrome. He also studies hormone-sensitive cancers such as prostate cancer and the rare disease lymphangioleiomyomatosis.

Finally, in 2009 Dr. Hammes moved back to Upstate New York, where he is the Louis S. Wolk Professor of Biomedical Research and the Chief of the Division of Endocrinology at the University of Rochester Medical Center.

Research

The Hammes laboratory studies steroid signaling and steroid production, with a focus on how steroids regulate fertility as well as how steroid promote hormone-sensitive cancer such as breast and prostate cancer.

With regard to steroid signaling, the Hammes laboratory pioneered research related to rapid, extranuclear, or "nongenomic," steroid effects, demonstrating that these rapid responses that initiate at or near the membrane of cells are critical for the subsequent steroid-mediated nuclear effects on transcription. The Hammes laboratory demonstrated that extranuclear androgen signaling via classical androgen receptors located outside of the nucleus initiate rapid activation of G protein and kinase signals that modulate normal fertility in males and females, as well as prostate cancer progression in response to androgens.

The Hammes laboratory was also one of the first to use genetic mouse models to demonstrate that androgen signaling in granulosa cells of the ovary (both nuclear and extranuclear effects) is critical for normal follicle development and subsequent ovulation. Too much androgen signaling, as seen in the disease polycystic ovary syndrome, leads to excessive and unregulated follicle growth.

The Hammes laboratory has also been studying androgen effects on prostate cancer, demonstrating that these same signaling extranuclear and nuclear pathways work together to regulate prostate cancer growth. The laboratory has also recently taken an interest in inflammation and its effects on prostate cancer progression.

Finally, the Hammes laboratory studies a rare lung disease found almost exclusively in women called lymphangioleiomyomatosis, or LAM. The laboratory has developed a mouse model for this disease, and is currently examining the roles of estrogen as well as inflammation in progression of this devastating disorder.

Credentials

Faculty Appointments

Specialties

  • Endocrinology, Diabetes and Metabolism - American Board of Internal Medicine
  • Internal Medicine

Education

1985
BA | Cornell University
Chemistry

1992
MD | Duke University Sch Medicine
Medicine

1992
PhD | Duke University
Microbiology

Post-doctoral Training & Residency

07/01/1995 - 06/30/1999
Fellowship in Endocrinology at University of California, San Francisco Medical Center

07/01/1994 - 06/30/1995
Residency in Internal Medicine at University of California, San Francisco Medical Center

07/01/1994 - 06/30/1995
Residency in Internal Medicine at University of California, San Francisco Medical Center

07/01/1995 - 06/30/1999
Fellowship in Endocrinology at University of California, San Francisco Medical Center

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Publications

Journal Articles

10/30/2017
Taya M, Hammes SR. "GPNMB and Cancer: A Novel Potential Therapeutic Target." Steroids.. 2017 Oct 30; Epub 2017 Oct 30.

10/30/2017
Ma X, Hammes SR. "Paxillin Actions in the Nucleus." Steroids.. 2017 Oct 30; Epub 2017 Oct 30.

9/1/2017
Ma X, Hayes E, Biswas A, Seger C, Prizant H, Hammes SR, Sen A. "Androgens Regulate Ovarian Gene Expression Through Modulation of Ezh2 Expression and Activity." Endocrinology.. 2017 Sep 1; 158(9):2944-2954.

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Videos

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SECOND OPINION 5 | Managing Diabetes| BCBS