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Trenton J. Tollefson, M.D.

Contact Information

Phone Numbers

Appointment: (585) 341-7500

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Setting




  • Clinical Neurophysiology - American Board of Psychiatry and Neurology
  • Epilepsy - American Board of Psychiatry and Neurology
  • Neurology - General - American Board of Psychiatry and Neurology


MD | University of Minnesota Medical School Twin Cities

Post-doctoral Training & Residency

07/01/2016 - 06/30/2017
Fellowship in Epilepsy at University of Rochester Medical Center

07/01/2015 - 06/30/2016
Fellowship in Clinical Neurophysiology at University of Rochester Medical Center

07/01/2012 - 06/30/2015
Residency in Neurology at University of Rochester Medical Center

06/24/2011 - 06/23/2012
Internship in Neurology at University of Rochester Medical Center

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Humanism in Medicine Resident Teaching Award
Sponsor: Arnold P Gold Foundation
Location: University of Rochester, Rochester NY

Developing Vision Screening Skills of Augsburg Fairview Academy (AFA) Students for Use in Underserved Minneapolis Public Schools
Sponsor: Distinction in Health Improvement
Location: University of Minnesota Medical School, Minneapolis MN

2003 - 2006
Dean's List
Sponsor: College of Biological Sciences
Location: University of Minnesota, Minneapolis MN

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Clinical Trials

A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus

Lead Researcher: Trenton J Tollefson

Potential participants may be identified in the emergency department, ICU or other units in the hospital, and will be consented/assented and then screened for inclusion/exclusion criteria prior to being randomized to start IP treatment. Investigational product (ganaxalone) will be administered as a 3-minute bolus that will be started with a continuous IV infusion lasting for 36 hours and followed by a 12- hour taper. After the Investigational Product has been discontinued, the follow-up period assessments/procedures will be collected every 24 hours through 120 hours and at the time of hospital discharge followed by weekly visits/contacts at Week 1, 2, 3 and 4. Males or females aged 18 or older and admitted to the hospital in a state of status epilepticus are eligible. Patients with a history of status epilepticus may pre-consent to participate in the study.

View Study Details


Journal Articles

Tollefson TJ, Berg MJ. "Comment: Ghrelin and des-acyl ghrelin: Do they predict success of AED treatment?" Neurology.. 2018 Jul 3; 91(1):29. Epub 2018 May 25.

Garcea FE, Chernoff BL, Diamond B, Lewis W, Sims MH, Tomlinson SB, Teghipco A, Belkhir R, Gannon SB, Erickson S, Smith SO, Stone J, Liu L, Tollefson T, Langfitt J, Marvin E, Pilcher WH, Mahon BZ. "Direct Electrical Stimulation in the Human Brain Disrupts Melody Processing." Current biology : CB.. 2017 Sep 11; 27(17):2684-2691.e7. Epub 2017 Aug 24.

Thompson Stone R, Tollefson T, Epstein R, Jozefowicz RF, Mink JW. "Education Research: Positive effect of scheduled faculty modeling on clerkship student bedside skills exposure and learning." Neurology.. 2017 Jun 13; 88(24):e236-e239.

Books & Chapters

Chapter Title: Pregnancy and Epilepsy
Book Title: Neurological Diseases and Pregnancy
Author List: Tollefson T, Liu LC
Edited By: Ciafaloni E, Thornburg LL, Bushnell CD
Published By: Oxford University Press 2018