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Thomas P. Frye, D.O.

Contact Information

Phone Numbers

Appointment: (585) 275-2838

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Settings

Surgery, Urology


Thomas Frye, DO, Assistant Professor of Urology, is a Urologic Oncologist who specializes in minimally invasive urologic oncology (robotic surgery of bladder, prostate, and kidney cancers), advanced open pelvic and retroperitoneal cancer surgery, and detection and management of localized prostate cancer with magnetic resonance imaging (MRI). Dr. Frye is one of only a few providers in the United States who offers High Intensity Focused Ultrasound (HIFU) - personalized treatment of prostate cancer.

Dr. Frye joined UR Medicine Urology after completing a fellowship in Urologic Oncology within The National Cancer Institute at the National Institutes of Health (NIH) in Bethesda, Maryland. Dr. Frye completed his urology residency at Southern Illinois University School of Medicine. He received his doctor of Osteopathy degree from Midwestern University, Chicago College of Osteopathic Medicine, where he was awarded valedictorian of his class.

Dr. Frye has clinical and research interests in prostate cancer. During his fellowship, he worked extensively in optimizing and refining the use of prostate MRIs. Dr. Frye's clinical research interest also includes focal therapy of prostate cancer.

Dr. Frye is licensed to practice medicine in the District of Columbia and state of New York and is a member of the American Urological Association, Society of Urologic Oncology and American Society of Clinical Oncology.

Dr. Frye has clinical expertise in all aspects of general urology with a special emphasis on the following:

- Prostate Cancer
- Bladder Cancer
- Kidney Cancer
- Testicular Cancer
- Penile Cancer
- High Intensity Focused Ultrasound (HIFU)
- Minimally-Invasive Surgery (Robotic and Laparoscopic)
- UroNav Fusion Prostate Biopsy
- Thermotherapies for Renal Cancer



  • Urology - American Board of Urology


DO | Midwestern University - Chicago College of Osteopathic Medicine

Post-doctoral Training & Residency

07/01/2014 - 06/30/2016
Fellowship in Urologic Oncology at National Cancer Institute

06/26/2010 - 06/26/2014
Residency in Urology at Southern Illinois University School of Medicine

07/01/2009 - 06/25/2010
Internship in General Surgery at Southern Illinois University School of Medicine

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Journal Articles

Witthaus MW, Farooq S, Melnyk R, Campbell T, Saba P, Mathews E, Ezzat B, Ertefaie A, Frye TP, Wu G, Rashid H, Joseph JV, Ghazi A. "Incorporation and validation of clinically relevant performance metrics of simulation (CRPMS) into a novel full-immersion simulation platform for nerve-sparing robot-assisted radical prostatectomy (NS-RARP) utilizing three-dimensional printing and hydrogel casting technology." BJU Int. 2020; .

Mithal P, Truong M, Quarrier S, Lu D, Hollenberg G, Weinberg E, Miyamoto H, Frye T. "Cribriform pattern and perineural invasion on MR/US fusion biopsy predict failure of selection criteria for prostatic hemigland ablation" . Urol Oncol. 2020; .

Truong M, Baack Kukreja JE, Rais-Bahrami S, Barashi NS, Wang B, Nuffer Z, Park JH, Lam K, Frye TP, Nix JW, Thomas JV, Feng C, Chapin BF, Davis JW, Hollenberg G, Oto A, Eggener SE, Joseph JV, Weinberg E, Messing EM. "Multi-institutional Clinical Tool for Predicting High-risk Lesions on 3Tesla Multiparametric Prostate Magnetic Resonance Imaging" . Eur Urol Oncol. 2019; .

Books & Chapters

Chapter Title: Neuropsychology of Genitourinary Malignancies
Book Title: Neuropsychology of Cancer and Oncology
Author List: Frye TP, Miller J, Tarter TH
Published By: Springer Publishing Company 2012




Thomas Patrick Frye, D.O., UR Medicine Urology