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URMC / Alzheimers Care / Current Research Opportunities
 

Current Research Opportunities

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Following COVID-19 guidelines, the AD-CARE program has resumed in-person screening and enrollment visits. Please view below for the current studies that are open for enrollment. 

 

Active studies; open for enrollment:

 

Alzheimer Prevention Trials (APT) Webstudy

 

If you are 50 years of age or older, you can monitor your own cognitive health by participating in the Alzheimer Prevention Trials (APT) Webstudy.  The APT Webstudy is designed to identify people who may have an increased risk for developing Alzheimer’s disease, using the latest technology to monitor their cognitive performance through regular online memory testing.  Volunteers of the APT Webstudy participate at their convenience, anywhere they have access to the internet.  APT Webstudy participants benefit by:

  • Having their cognitive health assessed over time;
  • Being on the ‘fast track’ for relevant clinical trials to prevent Alzheimer’s;
  • Making an invaluable contribution to advancing Alzheimer’s research, perhaps helping those in the research field find the first Alzheimer’s survivor; and
  • Helping ensure that future generations do not experience Alzheimer’s and its difficult challenges.

 

To participate in the APT Webstudy or to learn more, please visit www.aptwebstudy.org

 

Trial Ready Cohort for the Prevention of Alzheimer’s Dementia (TRC-PAD)

 

Those identified to have a potential increased risk for memory loss caused by Alzheimer’s disease, will be referred from the APT Webstudy to the Trial Ready Cohort for the Prevention of Alzheimer’s Dementia (TRC-PAD) In-person study.  The purpose of TRC-PAD is to find as many people as possible (also called a “cohort”) who are interested in participating in clinical trials aimed at discovering treatments that will reduce the risk of developing Alzheimer’s dementia. TRC-PAD will help researchers enroll participants into these trials quickly to allow new treatments to be discovered as soon as possible.  Participants do not have to participate in the TRC-PAD study in order to participate in the online APT Webstudy.

                                                                 

ADNI – 3

Supported by the Northern California Institute for Research and Education (NCRIE) with the Alzheimer’s Therapeutic Research Institute (ATRI) through a grant from the National Institute on Aging (NIA), ADNI (Alzheimer’s Disease Neuroimaging Initiative) looks at the relationship between clinical, cognitive, imaging, genetic, and biomarker tests to better understand the full spectrum of Alzheimer’s disease. The data from this study will be used in the development of future research studies that will focus on the treatment of AD.         

 https://clinicaltrials.gov/ct2/show/NCT02854033

 

AHEAD A3-45

The AHEAD A3-45 study is funded by the National Institute on Aging (NIA) in partnership with the Alzheimer’s Clinical Trial Consortium (ACTC), Eisai Co., and collaboration with Biogen Inc. The AHEAD study will test if the investigational treatment, BAN2401, could lower brain amyloid levels and/or prevent cognitive decline in people with amyloid buildup in the brain, in individuals who do not have a diagnosis of a memory disease.

 https://www.aheadstudy.org/ 

 

 S-CITAD                                                                                                        

Sample Processing

Funded by the National Institute on Aging (NIA), this study assesses the antidepressant escitalopram, in addition to psychosocial intervention, for the treatment of agitation in people with Alzheimer’s disease.

 www.citadtrial.org

                                                                                           

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Studies coming soon

 

LIFT-AD

Sponsored by Athira Pharma with funding from the Alzheimer’s Association, this study evaluates the safety and efficacy of an investigation drug (ATH-1017) for the treatment of individuals with mild to moderate Alzheimer's disease.

https://clinicaltrials.gov/ct2/show/NCT04488419

 

INVOKE-2

Sponsored by Alector Inc. in collaboration with AbbVie, this study evaluates the efficacy and safety of an investigation drug (AL002) in individuals with early Alzheimer’s disease.

https://clinicaltrials.gov/ct2/show/NCT04592874

 

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Active studies; not open for enrollment

 

A4

(Anti-Amyloid Treatment in Asymptomatic Alzheimer's study)
 

Conducted by the Alzheimer’s Therapeutic Research Institute (ATRI) in conjunction with Eli Lilly and Company, through a grant from the National Institute on Aging (NIA), this research study focuses on whether a new investigational medication (solanezumab) can slow the progression of memory problems associated with Alzheimer’s disease.

 https://clinicaltrials.gov/ct2/show/NCT02008357

 

Clarity AD

Sponsored by Eisai Inc., in collaboration with Biogen Inc., this study assesses safety, tolerability, and efficacy of an experimental medication (BAN2401) in people with early Alzheimer’s disease.

https://clinicaltrials.gov/ct2/show/NCT03887455

 

EMBARK

Sponsored by Biogen Pharmaceuticals, this research study evaluates the long-term safety and tolerability of aducanumab.

https://clinicaltrials.gov/ct2/show/NCT04241068

 

GRADUATE II

Sponsored by Hoffman-La Roche Pharmaceuticals, this study evaluates the efficacy and safety of an investigational medication (gantenerumab) in those with early/mild Alzheimer's disease.

https://clinicaltrials.gov/ct2/show/NCT03443973?term=roche&cond=Alzheimer+Disease&cntry=US&state=US%3ANY&city=Rochester&draw=1&rank=1

 

Lauriet

Sponsored by Genentech, a member of the Roche Group, this research study evaluates the efficacy and safety of an investigational medication (MTAU9937A) in those with moderate Alzheimer’s disease. 

https://clinicaltrials.gov/ct2/show/NCT03828747

 

 

LEARN

Conducted by the Alzheimer’s Therapeutic Research Institute (ATRI) through a grant from the Alzheimer’s Association, and the National Institute on Aging (NIA), this observational study is a companion study to the A4 Trial to evaluate the rate of cognitive change in older adults that do not have elevated levels of brain amyloid.

https://clinicaltrials.gov/ct2/show/NCT02488720

 

 

TANGO

Sponsored by Biogen Pharmaceuticals, this study evaluates the safety and tolerability of an investigational medicine (BIIB092) in participants with mild to moderate Alzheimer’s disease.

https://clinicaltrials.gov/ct2/show/NCT03352557?term=tango&cond=Alzheimer+Disease&rank=2

 

 

T2 Protect AD

Sponsored by Biohaven Pharmaceuticals, in conjunction with the Alzheimer's Disease Cooperative Study (ADCS), this study assesses safety, tolerability, and efficacy of an experimental medication (Troriluzole, BHV-4157) in people with mild to moderate Alzheimer’s Disease.

https://clinicaltrials.gov/ct2/show/NCT03605667?recrs=abd&cond=Alzheimer+Disease&cntry=US&state=US%3ANY&city=rochester&draw=2&rank=6

 

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For more information, or to sign up for a study, please visit: https://www.alz.org/research/clinical_trials/find_clinical_trials_trialmatch.asp