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Christopher Beck, PhD

Christopher BeckAssociate Professor of Biostatistics
Associate Professor of Orthopaedics
Ph.D. (2005) University of Rochester

Contact Information

University of Rochester
Dept of Biostatistics and Computational Biology
265 Crittenden Boulevard, CU 420630 
Rochester, New York 14642-0630
 
Office: Saunders Research Building 4146
Phone: (585) 275-6781
Fax: (585) 273-1031
E-mail: Christopher_Beck@urmc.rochester.edu

Research Interests

The area of statistical research that most interests me is the analysis of the performance of diagnostic tests.  Most of my work in this area involves inference concerning receiver operating characteristic (ROC) curves and surfaces.  I am actively developing statistical methods for ROC surfaces that generalize the methodology associated with ROC curves to accommodate the analysis of diagnostic tests that classify experimental units into three or more categories.  My other major research interests include change-point problems and clinical trials.

Most of my collaborative work is with researchers in the Department of Neurology and the Department of Orthopaedics and Rehabilitation, where I hold a joint appointment.  I am currently involved with studies in Parkinson's disease, Huntington's disease, Batten disease, periodic paralysis, orthopaedic trauma care, smoking cessation, and cardiomyopathy.  I am a member of an international team of researchers from several disciplines and universities that conducts studies to investigate the effects of neurotoxicants such as methyl mercury on the neurodevelopment of children.

I received a B.A. in Mathematics and Statistics and an M.A. in Statistics from State University of New York at Buffalo, and an M.A. and Ph.D. in Statistics from University of Rochester.  I am a member of the American Statistical Association and the International Biometric Society (ENAR).


Full List of Publications

A complete list of recent publications is available through my URMC Profile.

Selected Publications

  • Tomizawa T, Ishikawa M, Bello-Irizarry SN, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Beck C, Matsuda S, Schwarz EM, Nishitani K. "Biofilm producing Staphylococcus epidermidis (RP62A strain) inhibits osseous integration without osteolysis and histopathology in a murine septic implant model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 Nov 6; Epub 2019 Nov 06.
  • Augustine EF, Beck CA, Adams HR, Defendorf S, Vierhile A, Timm D, Weimer JM, Mink JW, Marshall FJ. "Short-Term Administration of Mycophenolate Is Well-Tolerated in CLN3 Disease (Juvenile Neuronal Ceroid Lipofuscinosis)." JIMD reports.. 2019 43:117-124. Epub 2018 Jun 20.
  • Oh I, Muthukrishnan G, Ninomiya MJ, Brodell JD, Smith BL, Lee CC, Gill SR, Beck CA, Schwarz EM, Daiss JL. "Tracking Anti- Antibodies Produced and during Foot Salvage Therapy for Diabetic Foot Infections Reveals Prognostic Insights and Evidence of Diversified Humoral Immunity." Infection and immunity.. 2018 Dec 0; 86(12)Epub 2018 Nov 20.
  • Elson MJ, Stevenson EA, Feldman BA, Lim J, Beck CA, Beran DB, Schmidt PN, Biglan KM, Simone R, Willis AW, Dorsey ER, Boyd CM. "Telemedicine for Parkinson's Disease: Limited Engagement Between Local Clinicians and Remote Specialists." Telemedicine journal and e-health : the official journal of the American Telemedicine Association.. 2018 Sep 0; 24(9):722-724. Epub 2018 Jan 03.
  • Zareba W, Daubert JP, Beck CA, Huang DT, Alexis JD, Brown MW, Pyykkonen K, McNitt S, Oakes D, Feng C, Aktas MK, Ayala-Parades F, Baranchuk A, Dubuc M, Haigney M, Mazur A, McPherson CA, Mitchell LB, Natale A, Piccini JP, Raitt M, Rashtian MY, Schuger C, Winters S, Worley SJ, Ziv O, Moss AJ, . "Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators: The RAID Trial." Journal of the American College of Cardiology.. 2018 Aug 7; 72(6):636-645.
  • Yokogawa N, Ishikawa M, Nishitani K, Beck CA, Tsuchiya H, Mesfin A, Kates SL, Daiss JL, Xie C, Schwarz EM. "Immunotherapy synergizes with debridement and antibiotic therapy in a murine 1-stage exchange model of MRSA implant-associated osteomyelitis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2018 Jun 0; 36(6):1590-1598. Epub 2018 Feb 05.
  • Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Teriparatide (human PTH) compensates for impaired fracture healing in COX-2 deficient mice." Bone.. 2018 May 0; 110:150-159. Epub 2018 Feb 03.
  • Mammen JR, Elson MJ, Java JJ, Beck CA, Beran DB, Biglan KM, Boyd CM, Schmidt PN, Simone R, Willis AW, Dorsey ER. "Patient and Physician Perceptions of Virtual Visits for Parkinson's Disease: A Qualitative Study." Telemedicine journal and e-health : the official journal of the American Telemedicine Association.. 2018 Apr 0; 24(4):255-267. Epub 2017 Aug 01
  • Marrie RA, Beck CA. "Preventing multiple sclerosis: To (take) vitamin D or not to (take) vitamin D?" Neurology.. 2017 Oct 10; 89(15):1538-1539. Epub 2017 Sep 13.
  • Beck CA, Beran DB, Biglan KM, Boyd CM, Dorsey ER, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Aldred J, Carter J, Fraser A, Jimenez-Shahed J, Hunter C, Spindler M, Reichwein S, Mari Z, Dunlop B, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Mejia NI, Bwala G, Nance M, Shih LC, Singer C, Vargas-Parra S, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Dhall R, Hassan A, DeMello S, Riggare SS, Wicks P, Achey MA, Elson MJ, Goldenthal S, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W, . "National randomized controlled trial of virtual house calls for Parkinson disease." Neurology.. 2017 Sep 12; 89(11):1152-1161. Epub 2017 Aug 16.
  • Kutyifa V, Beck C, Brown MW, Cannom D, Daubert J, Estes M, Greenberg H, Goldenberg I, Hammes S, Huang D, Klein H, Knops R, Kosiborod M, Poole J, Schuger C, Singh JP, Solomon S, Wilber D, Zareba W, Moss AJ, . "Multicenter Automatic Defibrillator Implantation Trial-Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol." American heart journal.. 2017 Jul 0; 189:158-166. Epub 2017 May 04.
  • Nishitani K, Mietus Z, Beck CA, Ito H, Matsuda S, Awad HA, Ehrhart N, Schwarz EM. "High dose teriparatide (rPTH1-34) therapy increases callus volume and enhances radiographic healing at 8-weeks in a massive canine femoral allograft model." PloS one.. 2017 12(10):e0185446. Epub 2017 Oct 11.
  • Moss AJ, , . "Multicenter Cardiovascular Studies and Trials: Lessons Learned From 35 Years of Productive Collaboration." Journal of the American College of Cardiology.. 2016 Nov 15; 68(20):2232-2234
  • Frank S, Testa CM, Stamler D, Kayson E, Davis C, Edmondson MC, Kinel S, Leavitt B, Oakes D, O'Neill C, Vaughan C, Goldstein J, Herzog M, Snively V, Whaley J, Wong C, Suter G, Jankovic J, Jimenez-Shahed J, Hunter C, Claassen DO, Roman OC, Sung V, Smith J, Janicki S, Clouse R, Saint-Hilaire M, Hohler A, Turpin D, James RC, Rodriguez R, Rizer K, Anderson KE, Heller H, Carlson A, Criswell S, Racette BA, Revilla FJ, Nucifora F, Margolis RL, Ong M, Mendis T, Mendis N, Singer C, Quesada M, Paulsen JS, Brashers-Krug T, Miller A, Kerr J, Dubinsky RM, Gray C, Factor SA, Sperin E, Molho E, Eglow M, Evans S, Kumar R, Reeves C, Samii A, Chouinard S, Beland M, Scott BL, Hickey PT, Esmail S, Fung WL, Gibbons C, Qi L, Colcher A, Hackmyer C, McGarry A, Klos K, Gudesblatt M, Fafard L, Graffitti L, Schneider DP, Dhall R, Wojcieszek JM, LaFaver K, Duker A, Neefus E, Wilson-Perez H, Shprecher D, Wall P, Blindauer KA, Wheeler L, Boyd JT, Houston E, Farbman ES, Agarwal P, Eberly SW, Watts A, Tariot PN, Feigin A, Evans S, Beck C, Orme C, Edicola J, Christopher E. "Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial." JAMA.. 2016 Jul 5; 316(1):40-50.

  • Dorsey ER, Achey MA, Beck CA, Beran DB, Biglan KM, Boyd CM, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Ziman N, Aldred J, Carter J, Jimenez-Shahed J, Hunter C, Spindler M, Mari Z, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Bull MT, Mejia NI, Bwala G, Nance M, Shih L, Anderson L, Singer C, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Cooper J, Webb S, Dhall R, Hassan A, Weis D, DeMello S, Riggare SS, Wicks P, Smith J, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W. "National Randomized Controlled Trial of Virtual House Calls for People with Parkinson's Disease: Interest and Barriers." Telemedicine journal and e-health : the official journal of the American Telemedicine Association.. 2016 Jul 0; 22(7):590-8. Epub 2016 Feb 17.
  • Zhang L, Chang M, Beck CA, Schwarz EM, Boyce BF. "Analysis of new bone, cartilage, and fibrosis tissue in healing murine allografts using whole slide imaging and a new automated histomorphometric algorithm." Bone research.. 2016 4:15037. Epub 2016 Jan 19.
  • Nishitani K, Beck CA, Rosenberg AF, Kates SL, Schwarz EM, Daiss JL. "A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis." Clinical orthopaedics and related research.. 2015 Sep 0; 473(9):2735-49. Epub 2015 May 27.
  • Augustine EF, Adams HR, Beck CA, Vierhile A, Kwon J, Rothberg PG, Marshall F, Block R, Dolan J, Mink JW, . "Standardized assessment of seizures in patients with juvenile neuronal ceroid lipofuscinosis." Developmental medicine and child neurology.. 2015 Apr 0; 57(4):366-71. Epub 2014 Nov 11.
  • Achey MA, Beck CA, Beran DB, Boyd CM, Schmidt PN, Willis AW, Riggare SS, Simone RB, Biglan KM, Dorsey ER. "Virtual house calls for Parkinson disease (Connect.Parkinson): study protocol for a randomized, controlled trial." Trials.. 2014 Nov 27; 15:465. Epub 2014 Nov 27.
  • Ruwald AC, Schuger C, Moss AJ, Kutyifa V, Olshansky B, Greenberg H, Cannom DS, Estes NA, Ruwald MH, Huang DT, Klein H, McNitt S, Beck CA, Goldstein R, Brown MW, Kautzner J, Shoda M, Wilber D, Zareba W, Daubert JP. "Mortality reduction in relation to implantable cardioverter defibrillator programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT)." Circulation. Arrhythmia and electrophysiology.. 2014 Oct 0; 7(5):785-92. Epub 2014 Aug 18
  • Papuga, M. O., Beck, C. A., Kates, S. L., Schwarz, E. M., Maloney, M. D. (2014). Validation of GAITRite and PROMIS as High-Throughput Physical Function Outcome Measures Following ACL Reconstruction.  Journal of Orthopaedic Research 32(6):793-801.
  • Marrie, R. A., Beck, C. A. (2014).  Obesity and HLA in Multiple Sclerosis: Weighty Matters.  Neurology 82(10):826-827.
  • Dorsey, E. R., Beck, C. A., Darwin, K., Nichols, P., Brocht, A. F., Biglan, K. M., Shoulson, I. (2013). Natural History of Huntington Disease. JAMA Neurology 70(12):1520-1530.
  • Dorsey, E. R., Venkataraman, V., Grana, M. J., Bull, M. T., George, B. P., Boyd, C. M., Beck, C. A., Rajan, B., Seidmann, A., Biglan, K. M. (2013). Randomized Controlled Clinical Trial of “Virtual House Calls” for Parkinson Disease. JAMA Neurology 70(5):565-570.
  • Moss, A. J., Schuger, C., Beck, C. A., Brown, M. W., Cannom, D. S., Daubert, J. P., Estes, N. A. M., Greenberg, H., Hall, W. J., Huang, D. T., Kautzner, J., Klein, H., McNitt, S., Olshansky, B., Shoda, M., Wilber, D., Zareba, W. (2012). Reduction in Inappropriate Therapy and Mortality through ICD Programming.  New England Journal of Medicine 367(24):2275-2283.
  • George, B. P., Scoglio, N. J., Reminick, J. I., Rajan, B., Beck, C. A., Seidmann, A., Biglan, K. M., Dorsey, E. R. (2012). Telemedicine in Leading US Neurology Departments. The Neurohospitalist 2(4):123-128.
  • Kwon, J. M., Adams, H., Rothberg, P. G., Augustine, E. F., Marshall, F. J., Deblieck, E. A., Vierhile, A., Beck, C. A., Newhouse, N. J., Cialone, J., Levy, E., Ramirez-Montealegre, D., Dure, L. S., Rose, K. R., Mink, J. W. (2011). Quantifying physical decline in juvenile neuronal ceroid lipofuscinosis (Batten disease). Neurology 77:1801-1807.
  • Wolinsky, J. S., Beck, C. A. (2011). The long march to surrogates of meaningful clinical outcomes in MS trials: are we there yet? Neurology 77:1658-1659.
  • Goldenberg, I., Hall, W. J., Beck, C. A., Moss, A. J., Barsheshet, A., McNitt, S., Polonsky, S., Brown, M. W., Zareba, W. (2011). Reduction of the Risk of Recurring Heart Failure Events with Cardiac Resynchronization Therapy: The MADIT-CRT Trial. Journal of the American College of Cardiology 58:729-737.
  • Sampson, E. R., Beck, C. A., Ketz, J., Canary, K. L., Hilton, M. J., Awad, H., Schwarz, E. M., Chen, D., O’Keefe, R. J., Rosier, R. N., Zuscik, M. J. (2011). Establishment of an Index with Increased Sensitivity for Assessing Murine Arthritis. Journal of Orthopedic Research 29:1145-1151.
  • Dorsey, E. R., Deuel, L. M., Beck, C. A., Gardiner, I. F., Scoglio, N. J., Scott, J. C., Marshall, F. J., Biglan, K. M. (2011). Group patient visits for Parkinson disease: a randomized feasibility trial. Neurology 76:1542-1547.
  • Dorsey, E. R., de Roulet, J., Thompson, J. P., Reminick, J. I., Thai, A., White-Stellato, Z., Beck, C. A., George, B. P., Moses, H. (2010). Funding of US biomedical research, 2003 - 2008. Journal of the American Medical Association 303:137-143.
  • Mitsumoto, J., Dorsey, E. R., Beck, C. A., Kieburtz, K., Griggs, R. C. (2009). Pivotal studies of orphan drugs approved for neurological diseases. Annals of Neurology 66:184-190.
  • Diener, H. C., Beck, C. A. (2009). Migraine and risk of cardiovascular disease in women: Learning about relative and absolute risk. Neurology 73:576-577.
  • Beck, C. A. (2009). Selection bias in observational studies: Out of control? Neurology 72:108-109.
  • Dorsey, E. R., Van Wuyckhuyse, B. C., Beck, C. A., Passalacqua, W. P., Guzick, D. S. (2009). The Economics of New Faculty Hires in Basic Science. Academic Medicine 84:26-31.
  • Dorsey, E. R., Beck, C. A., Adams, M., Chadwick, G., de Blieck, E. A., McCallum, C., Briner, L., Deuel, L., Clarke, A., Stewart, R., Shoulson, I., Huntington Study Group TREND-HD Investigators. (2008). Communicating Clinical Trial Results to Research Participants. Archives of Neurology 65:1590-1595.
  • Reynolds, D. G., Hock, C., Shaikh, S., Jacobson, J., Zhang, X., Rubery, P. T., Beck, C. A., O’Keefe, R. J., Lerner, A. L., Schwarz, E. M., Awad, H. A. (2007). Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. Journal of Biomechanics 40:3178-3186.
  • Davidson, P. W., Weiss, B., Beck, C., Cory-Slechta, D. A., Orlando, M., Loiselle, D., Young, E. C., Sloane-Reeves, J., Myers, G. J. (2006). Development and validation of a test battery to assess subtle neurodevelopmental differences in children. NeuroToxicology 27:951-969.
  • van Wijngaarden, E., Beck, C., Shamlaye, C. F., Cernichiari, E., Davidson, P. W., Myers, G. J., Clarkson, T. W. (2006). Benchmark concentrations for methyl mercury obtained from the 9-year follow-up of the Seychelles Child Development Study. NeuroToxicology 27:702-709.