Tanzy Love, PhD

Associate Professor of Biostatistics
Ph.D. (2005) Iowa State University

URMC profile

Contact Information

University of Rochester
Dept of Biostatistics and Computational Biology
265 Crittenden Boulevard, CU 420630 
Rochester, New York 14642-0630
 
Office: Saunders Research Building 4144
Phone: (585) 276-5559
Fax: (585) 273-1031
E-mail: Tanzy_Love@urmc.rochester.edu

Research Interests

• Environmental health statistics
• Clustering and latent variable models
• Mixed membership models and model choice
• Normalization and preprocessing issues relating to gene expression
• Bayesian models for QTLs and growth curves
• Hierarchical Bayesian models for gene expression data
• Scalable parallel model-based clustering
• Proteomics: preprocessing and analysis

Selected Publications

• Engström K, Love TM, Watson GE, Zareba G, Yeates A, Wahlberg K, Alhamdow A, Thurston SW, Mulhern M, McSorley EM, Strain JJ, Davidson PW, Shamlaye CF, Myers GJ, Rand MD, van Wijngaarden E, Broberg K. "Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study." Environment International. 2016 Sep; 94:224-9. Epub 2016 Jun 02.
• Park SY, Love TM, Perelson AS, Mack WJ, Lee HY. "Molecular clock of HIV-1 envelope genes under early immune selection." Retrovirology. 2016 Jun 1; 13(1):38.

• Love TM, Park SY, Giorgi EE, Mack WJ, Perelson AS, Lee HY. "SPMM: estimating infection duration of multivariant HIV-1 infections." Bioinformatics. 2016 May 1; 32(9):1308-15. Epub 2015 Dec 31.

• Rand MD, Vorojeikina D, van Wijngaarden E, Jackson BP, Scrimale T, Zareba G, Love TM, Myers GJ, Watson G. "Methods for Individualized Determination of Methylmercury Elimination Rate and De-Methylation Status in Humans Following Fish Consumption." Toxicological Sciences : An official journal of the Society of Toxicology. 2016 Feb; 149(2):385-95. Epub 2015 Nov 15.
• Yeates AJ, Love TM, Engström K, Mulhern MS, McSorley EM, Grzesik K, Alhamdow A, Wahlberg K, Thurston SW, Davidson PW, van Wijngaarden E, Watson GE, Shamlaye CF, Myers GJ, Strain JJ, Broberg K. "Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study." Prostaglandins, Leukotrienes, and Essential Fatty Acids (PLEFA). 2015 Dec; 102-103:13-20. Epub 2015 Sep 14.
• Misra RS, Johnston CJ, Groves A, DeDiego ML, St Martin J, Reed C, Hernady E, Miller JN, Love T, Finkelstein JN, Williams JP. "Examining the Effects of External or Internal Radiation Exposure of Juvenile Mice on Late Morbidity after Infection with Influenza A." Radiation Research. 2015 Jul; 184(1):3-13. Epub 2015 Jun 26.
• Evans K, Love T, Thurston SW. "Outlier Identification in Model-Based Cluster Analysis." Journal of Classification. 2015 Apr 1; 32(1):63-84. Epub 2015 Mar 10.

• Strain J, Yeates AJ, van Wijngaarden E, Thurston SW, Mulhern MS, McSorley EM, Watson GE, Love TM, Smith TH, Yost K, Harrington D, Shamlaye CF, Henderson J, Myers GJ, Davidson PW. "Prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids: associations with child development at 20 mo of age in an observational study in the Republic of Seychelles." The American Journal of Clinical Nutrition. 2015 Mar; 101(3):530-7. Epub 2015 Jan 21.
• Love TM, Thurston SW, Davidson PW. "Finding vulnerable subpopulations in the Seychelles Child Development Study: effect modification with latent groups." Statistical Methods in Medical Research. 2014 Dec 14; Epub 2014 Dec 14.
• Orlando MS, Dziorny AC, Harrington D, Love T, Shamlaye CF, Watson GE, van Wijngaarden E, Davidson PW, Myers GJ. "Associations between prenatal and recent postnatal methylmercury exposure and auditory function at age 19 years in the Seychelles Child Development Study." Neurotoxicology and Teratology. 2014 46:68-76.
• Dumyati G, Concannon C, van Wijngaarden E, Love TM, Graman P, Pettis AM, Greene L, El-Daher N, Farnsworth D, Quinlan G, Karr G, Ward L, Knab R, Shelly M. "Sustained reduction of central line-associated bloodstream infections outside the intensive care unit with a multimodal intervention focusing on central line maintenance." American Journal of Infection Control. 2014 Jul; 42(7):723-30. Epub 2014 May 23. PMID: 24856587

• Xiao L, Thurston SW, Ruppert D, Love TM, Davidson PW. "Bayesian Models for Multiple Outcomes in Domains with Application to the Seychelles Child Development Study." Journal of the American Statistical Association. 2014 Jan 1; 109(505):1-10. PMCID: PMC3979566

• van Wijngaarden E, Davidson PW, Smith TH, Evans K, Yost K, Love T, Thurston SW, Watson GE, Zareba G, Burns CM, Shamlaye CF, Myers GJ. "Autism spectrum disorder phenotypes and prenatal exposure to methylmercury." Epidemiology. 2013 Sep; 24(5):651-9. PMCID: PMC3732522.

• Woodward, D.; Love, T.M.; Thurston, S.W.; Ruppert, D.; Sathyanarayana, S.; Swan, S.H. "Latent Factor Regression Models for Grouped Outcomes". Biometrics, 69 (3):785-94, Sep 2013. PMID: 23845121
• Watson GE, van Wijngaarden E, Love TM, McSorley EM, Bonham MP, Mulhern MS, Yeates AJ, Davidson PW, Shamlaye CF, Strain JJ, Thurston SW, Harrington D, Zareba G, Wallace JM, Myers GJ. "Neurodevelopmental outcomes at 5 years in children exposed prenatally to maternal dental amalgam: the Seychelles Child Development Nutrition Study." Neurotoxicology and Teratology. 2013 39:57-62. Epub 2013 Jul 13. PMID: 23856391

• Watson GE, Evans K, Thurston SW, van Wijngaarden E, Wallace JM, McSorley EM, Bonham MP, Mulhern MS, McAfee AJ, Davidson PW, Shamlaye CF, Strain JJ, Love T, Zareba G, Myers GJ. "Prenatal exposure to dental amalgam in the Seychelles Child Development Nutrition Study: associations with neurodevelopmental outcomes at 9 and 30 months." Neurotoxicology. 2012 Dec; 33(6):1511-7. Epub 2012 Oct 12. PMCID: PMC3576043

• Wilson KM, Wesgate SC, Pier J, Weis E, Love T, Evans K, Chhibber A. "Secondhand smoke exposure and serum cytokine levels in healthy children." Cytokine. 2012 Oct; 60(1):34-7. Epub 2012 Jul 16. PMCID: PMC3781216

• Park SY, Love TM, Nelson J, Thurston SW, Perelson AS, Lee HY. "Designing a genome-based HIV incidence assay with high sensitivity and specificity." AIDS. 2011 Oct 23; 25(16):F13-9.PMCID: PMC3319025

• Kobrosly RW, van Wijngaarden E, Galea S, Cory-Slechta DA, Love T, Hong C, Shamlaye CF, Davidson PW. "Socioeconomic position and cognitive function in the Seychelles: a life course analysis." Neuroepidemiology. 2011 36(3):162-8. Epub 2011 Apr 20.PMCID: PMC3095839
• Airoldi EM, Erosheva EA, Fienberg SE, Joutard C, Love T, Shringarpure S. "Reconceptualizing the classification of PNAS articles." Proceedings of the National Academy of Sciences of the United States of America. 2010 107(49):20899-904. Epub 2010 Nov 15. PMCID: PMC3000298

• Crossett A, Lauter N, Love TM. "An empirical method for establishing positional confidence intervals tailored for composite interval mapping of QTL." PLoS ONE. 2010 Feb 9; 5(2):e9039. Epub 2010 Feb 09. PMCID: PMC2817735

• Love TM, Thurston SW, Keefer MC, Dewhurst S, Lee HY. "Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences." Journal of Virology. 2010 Jun; 84(11):5802-14. Epub 2010 Mar 24. PMCID: PMC2876615

• Love T, Carriquiry A. "Repeated Measurements on Distinct Scales With Censoring-A Bayesian Approach Applied to Microarray Analysis of Maize." Journal of the American Statistical Association. 2009 Jun 1; 104(486):524-540.

• Airoldi, E.; Fienberg, S.; Joutard, C.; and Love, T.M. Discovery of Latent Patterns with Hierarchical Bayesian Mixed-Membership Models and the Issue of Model Choice in Data Mining Patterns, eds. P. Poncelet, F. Masseglia, and M. Teisseire, Hershey, PA: IGI Global, Chapter IX, August 2007.

• Love, T.M., Shelley, M., and Keinert, F. Redesigning Discrete Math as a web-based course: Lessons and Accomplishments Journal of STEM Education Innovations and Research, 7(3-4), 25-35, July-December 2006.

• Che P, Love TM, Frame BR, Wang K, Carriquiry AL, Howell SH. "Gene expression patterns during somatic embryo development and germination in maize Hi II callus cultures." Plant Molecular Biology. 2006 Sep; 62(1-2):1-14. Epub 2006 Jul 15.

• Cody JD, Semrud-Clikeman M, Hardies LJ, Lancaster J, Ghidoni PD, Schaub RL, Thompson NM, Wells L, Cornell JE, Love TM, Fox PT, Leach RJ, Kaye CI, Hale DE. "Growth hormone benefits children with 18q deletions." American Journal of Medical Genetics. Part A. 2005 Aug 15; 137(1):9-15.

Chapters and Invited Papers

• Hierarchical Bayesian Mixed-Membership Models and Latent Pattern Discovery. Frontiers of Statistical Decision Making and Bayesian Analysis – In Honor of James O. Berger. M.E. Chen (Ed). 1st ed. Springer Verlag, August 2010, Chapter 10.3, ISBN: 978-1-4419-6943-9. Airoldi, E., Fienberg, S., Joutard, C. and Love, T.M.
• Estimating Gene Expression Profiles Using all Available Information. The Proceedings of the Annual Conference on Applied Statistics in Agriculture, 17, 1-32, December 2005. Love, T.M. and Carriquiry, A.L.
• Hierarchical Bayesian methods for microarray data. Handbook of Statistics: Bioinformatics, C.R. Rao, R. Chakraborty, and P.K. Sen. (Eds). North Holland, Chapter 2: 12-38, 2012.Love, T.M. and Carriquiry, A.L.