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URochester Medicine / Department of Biostatistics and Computational Biology / People & Research / Faculty / Michael B. Sohn, PhD

Michael B. Sohn, PhD

Associate Professor
Ph.D., University of ArizonaMichael Sohn Photograph

Contact Information

University of Rochester
Dept of Biostatistics and Computational Biology
265 Crittenden Boulevard, CU 420630 
Rochester, New York 14642-0630
 
Office: Saunders Research Building 4.169
Phone: (585) 275-6696 *Main Office
Email: Michael_Sohn@urmc.rochester.edu

Research Interests

  • High-Dimensional Data Analysis
  • Compositional Data Analysis
  • Statistical Machine Learning
  • Causal Mediation Analysis
  • Genomics and Metagenomics

Selected Publications

  • Beblavy, R., Monaco, C.L., Newkirk, C.E., Xiao, J., and Sohn, M.B.† TSLC: Differential abundance analysis method for identifying biologically relevant known microbes. Bioinformatics Advances, 6(1):vbag297, 2026.
  • Scheible, K., Beblavy, R., Sohn, M.B., Qui, X., Gill, A.L., Narvaez-Miranda, J., Brunner, J., Miller, R.K., Barrett, E.S., O’Connor, T.G., and Gill, S.R. Affective Symptoms in Pregnancy are Associated with the Vaginal Microbiome. Journal of Affective Disorders, 368:410-419, 2025.
  • Singhal, S., Wang, Y., Dunne, R.F., Kehoe, L., Sohn, M.B., Jensen-Battaglia, M., Canin, B., Tylock, R., Mohamed, M., Khatri, J., Bearden, J., Philip, T., Mohile, S., and Loh, K.P. Nutritional impairment and trajectories of psychological health and quality of life among older adults with advanced cancer. J Am Geriatr Soc, 0:1-9, 2025.
  • Sohn, M.B.†, Monaco, C., and Gill, S.R. An optimal normalization method for high sparse compositional microbiome data. PLoS Comput Biol, 20(8):e1012338, 2024.
  • Sohn, M.B., Gao, B., Kendrick, C., Srivastava, A., Isakova, T., Gassman, J.J., Fried, L.F., Wolf, M., Cheung, A.K., Raphael, K.L., Centron-Vinales, P., Middleton, J.P., Pabalan, A., Raj, D.S., and Pilot Studies in CKD Consortium. Targeting Gut Microbiome with Prebiotic in Patients with CKD: The TarGut-CKD Study. Kidney Int Rep, 9:671-685, 2024.
  • Loh, K.P., Sanapala, C., Jensen-Battaglia, M., Rana, A., Sohn, M.B., Watson, E., Gilmore, N., Klepin, H.D., Mendler, J.H., Llesveld, J., Huselton, E., LoCastro, M., Susiarjo, M., Netherby-Winslow, C., Williams, A.M., Mustian, K., Vertino, P., and Janelsins, M.C. Exercise and epigenetic ages in older adults with myeloid malignancies. Eur J Med Res, 28:180, 2023.
  • Gao, Y., Sohn, M.B., and Wang, J. Editorial: Gut virome and human health. Front Cell Infect Microbiol, 12:1043256, 2022.
  • Belcher, E.K., Culakova, E., Gilmore, N.J., Hardy, S.J., Kleckner, A.S., Kleckner, I.R., Lei, L., Heckler, C., Sohn, M.B., Thompson, B.D., Lotta, L.T., Werner, Z.A., Geer, J., Hopkins, J.O., Corso, S.W., Rich, D.Q., van Wijngaarden, E., and Janelsins, M.C. Inflammation, Attention, and Processing Speed in Patients With Breast Cancer Before and After Chemotherapy. J Natl Cancer Inst, 114(5):712-721, 2022.
  • Gewandter, J.S., Sohn, M.B., De Guzman, R., Frazer, M.E., Chido, V., Sharma, S., Geha, P., and Markman, J.D. Predicting treatment response with sensory phenotyping in post-traumatic neuropathic pain. Pain Medicine, 23(10):1726-1732, 2022.
  • Sohn, M.B.†, Lu, J., and Li, H. A Compositional Mediation Model for Binary Outcome: Application to Microbiome Studies. Bioinformatics, 38(1):16-21, 2021.
  • Laskey, E., Chen, Y., Gruber, E., Sohn, M.B., Chojnacki, M., and Wozniak, R.A.F. Efficacy of a novel ophthalmic antimicrobial drug combination towards a large panel of Staphylococcus aureus clinical ocular isolates from around the world. Cornea, 39(10):1278-1284, 2020.
  • Sohn, M.B. and Li, H. Compositional Mediation Analysis for Microbiome Studies. Annals of Applied Statistics, 13(1):661-681, 2019.
  • Sohn, M.B. and Li, H. A GLM-Based Latent Variable Ordination Method for Metagenomic Samples. Biometrics, 74(2):448-457, 2018.
  • Sohn, M.B., Du, R., and An, L. A robust approach for identifying differentially abundant features in metagenomic samples. Bioinformatics, 31(14):2269-2275, 2015.
  • Sohn, M.B., An, L., Pookhao, N., and Li, Q. Accurate Genome Relative Abundance Estimation for Closely Related Species in a Metagenomic Sample. BMC Bioinformatics, 15:242, 2014.

Last updated: October 26, 2026