Tong Tong Wu, PhD

Associate Professor of Biostatistics and Computational Biology

Director, M.A. in Statistics and M.S. in Medical Statistics Programs
Ph.D. (2006) University of California, Los Angeles

Contact Information

University of Rochester
Dept of Biostatistics and Computational Biology
265 Crittenden Boulevard, CU 420630 
Rochester, New York 14642-0630
 
Office: Saunders Research Building 4141
Phone: (585) 276-6858
Fax: (585) 273-1031
E-mail: Tongtong_Wu@urmc.rochester.edu

Research Interests

As a biostatistician, Dr. Tong Tong Wu’s research interests include high-dimensional data analysis, survival analysis, machine learning, computational statistics, and computational biology and statistical genetics. She is also interested in statistical applications and collaborations in various health, medical, and scientific areas, such as cancer, HIV, epidemiology, psychology, and medical engineering.

Selected Publications

(*: joint first or senior authors; $: corresponding author; **: advisee/trainee of Dr. Wu)

Click here for the full list of publications

Statistical Papers

• Wang, D., Wu, T.T., and Zhao, Y. Penalized Empirical Likelihood for the Sparse Cox Regression Model. Journal of Statistical Planning and Inference, accepted.
• Ciminelli, J.T., Love, T., and Wu, T.T. Social Network Spatial Model. Spatial Statistics, accepted.
• Chang, J., Tang, C.Y., and Wu, T.T. (2018) A New Scope of Penalized Empirical Likelihood with High-Dimensional Estimating Equations. Annals of Statistics, Volume 46, 3185--3216.
• Wu, T.T.$, Li, G., and Tang, C.Y. (2015) Empirical Likelihood for Censored Linear Regression and Variable Selection. Scandinavian Journal of Statistics, Volume 42, No 3, 798–812.
        Supplementary File: Proofs of Theorems
• Tang, C.Y. and Wu, T.T.$ (2014) Nested Coordinate Descent Algorithms for Empirical Likelihood. Journal of Statistical Computation and Simulation, Volume 84, No 9, 1917-1930.
• Wu, T.T.$ and Wu, Y. (2012) Nonlinear Vertex Discriminant Analysis with Reproducing Kernels. Statistical Analysis and Data Mining, Volume 5, No 2, 167-176.
• Wu, T.T.$ and Lange, K. (2010) The MM Alternative to EM. Statistical Science, Volume 25, No 4, 492-505.
• Li, G.# and Wu, T.T.#$ (2010) (#: alphabetic order) Semiparametric Additive Risks Regression for Two-Stage Design Survival Studies. Statistica Sinica, Volume 20, No 4, 1581-1607.
• Wu, T.T.$, Chen, Y.F., Hastie, T., Sobel, E., and Lange, K. (2009) Genomewide Association Analysis by Lasso Penalized Logistic Regression. Bioinformatics, Volume 25, No 6, 714-721.
        Supplementary Data
        R package: CDLasso
• Wu, T.T.$ and Lange, K. (2008) Coordinate Descent Algorithms for Lasso Penalized Regression. Annals of Applied Statistics, Volume 2, No 1, 224-244.
        Supplementary Appendix: Weak Consistency of Lasso Penalized l1 Regression
        R package: CDLasso

Collaborative Papers

• Chen,W., Fitzpatrick, J., Monroy-Trujillo, J., Sozio, S., Jaar, B., Estrella, M.,Wu, T.T.#, Melamed, M., Parekh, R., and Bushinsky, D.A. Diabetes Mellitus Modifies the Associations of Serum Magnesium Concentration with Arterial Calcification and Stiffness in Incident Hemodialysis Patients. Kidney International Reports, accepted.
• Konkel, B., Lavin, C., Wu, T.T.#, Anderson, E., Iwamoto, A., Rashid, H., Gaitian, B., Boones, J., Cooper, M., Abrams, P., Gilbert, A., Tang, Q., Levi, M., Fujimoto, J.G., Andrews, P., and Chen, Y. Fully automated analysis of OCT imaging of human kidneys for prediction of post-transplant function. Biomedical Optics Express, accepted.
• Young, D.R., Sidell, M., Koebnick, C., Saksvig, B.I., Mohan, Y., Cohen, D., and Wu, T.T.#* Longitudinal Sedentary Time among Females from Ages 17 to 23 Years. American Journal of Preventive Medicine, accepted.
• Xiao, J., Alkhers, N., Kopycka-Kedzierawski, D.T., Billings, R., Wu, T.T.#, Castillo, D., Rasubala, L., Malmstrom, H., Ren, Y., and Eliav, E. Prenatal Oral Health Care and Early Childhood Caries Prevention: A Systematic Review and Meta-analysis. Caries Research, accepted.
• Young, D.R., Cohen, D., Koebnick, C., Mohan, Y., Saksvig, B.I., Sidell, M., and Wu, T.T.#* (2018) Longitudinal Associations of Physical Activity Among Females from Adolescence to Young Adulthood. Journal of Adolescent Health, Volume 63, 466--473.
• Chen, W., Anokhina, V., Miller, B., Dieudonne, G., Abramowitz, M.K., Kashyap, R., Yan, C., Wu, T.T., Bentley, K., and Bushinsky, D.A. (2018) Patients with Advanced Chronic Kidney Disease and Vascular Calcification Have a Large Hydrodynamic Radius of Secondary Calciprotein Particles. Nephrology Dialysis Transplantation, 1-9.
• Groth, S.W., LaLonde, A.**, Wu, T.T., and Fernandez, I.D. (2018) Obesity candidate genes, gestational weight gain and body weight changes in pregnant women. Nutrition, Volume 48, 61-66.
• Jaworski, J.P., Bryk, P., Brower, Z., Zheng, B., Hessell, A.J., Rosenberg, A.F., Wu, T.T., Sanz, I., Keefer, M.C., Haigwood, N.L., and Kobie, J.J. (2017) Pre-Existing Neutralizing Antibody Mitigates B cell Dysregulation and Enhances the Env-Specific Antibody Response  in SHIV-Infected Rhesus Macaques. PLoS One, 12(2):e0172524.
• Abu-Farsakh, S., Wu, T.T., Lalonde, A.**, Sun, J., and Zhou, Z. (2017) High expression of the Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5. BMC Gastroenterology, 17:33.
• Tang, Q., Wang, J., Frank, A., Lin, J., Li, Z., Chen, C.W., Jin, L., Wu, T.T., Greenwald, B.D., Mashimo, H., and Chen, Y. (2016) Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography. Biomedical Optics Express, Volume 7, 5218-5232.
• Ramirez, G., Proctor, A.R., Jung, K.W., Wu, T.T., Han, S., Adams, R.R., Ren, J., Byun, D.K., Madden, K.S., Brown, E.B., Foster, T.H., Farzam, P., Durduran, T., and Choe, R. (2016) Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer xenografts as measured by diffuse correlation spectroscopy. Biomedical Optics Express, Volume 7, Issue 9, 3610-3630.
• Grant, E.**, Young, D.R.*, and Wu, T.T.* (2015) Predictors for Physical Activity in Adolescent Girls Using Statistical Shrinkage Techniques for Hierarchical Longitudinal Mixed Effects Models. PLOS ONE, 10(4): e0125431.
• Young, D.R., Saksvig, B.I., Wu, T.T., Zook, K., Li, X.**, Champaloux, S., Grieser, M., Lee, S., and Treuth, M. (2014) Multilevel Correlates of Physical Activity For Early, Mid, and Late Adolescent Girls. Journal of Physical Activity & Health, Volume 11, No 5, 950-960.
• Park, C.C., Ahn, S., Bloom, J.S., Lin, A., Wang, R.T., Wu, T.T., Sekar, A., Khan, A.H., Farr, C.J., Lusis, A.J., Leahy, R.M., Lange, K., and Smith, D. (2008) Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nature Genetics, Volume 40, No 4, 421-429.
        Supplementary information