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Hongmei Yang, PhD

Hongmei.YangResearch Associate Professor
Ph.D. (2007) North Carolina State University

Contact Information

University of Rochester
Dept of Biostatistics and Computational Biology
265 Crittenden Boulevard, CU 420630 
Rochester, New York 14642-0630
Office: Saunders Research Building 4148
Phone: (585) 275-0411
Fax: (585) 273-1031

Research Interests

My research is practically driven, a combination of active collaborations in HIV, Influenza, and other diseases and independent research. In summary it falls in three areas: statistical processing of assay data (e.g., Elispot, Elisa, and Hemagglutination assays), mixed-effect models for correlated data, and variable selection for high dimensional data.

Full List of Publications

Please visit my URMC Profile for a complete list of publications.

Selected Publications

  • Yang, H., Holden-Wiltse, J., Topham, DJ., Treanor, J., "Maximum Likelihood Estimation of Titer via a Power Family of Four-Parameter Logistic Model. Journal of Biopharmaceutical Statistics.. 2018 28(3):492-500. Epub 2017 Sept 05
  • Caserta, MT., Yang, H., Gill, SR., Holden-Wiltse, J., Pryhuber, G., "Viral Respiratory Infections in Preterm Infants during and after Hospitalization." The Journal of Pediatrics.. 2017 Mar 0; 182:53-58.e3. Epub 2016 Dec 30.
  • Antwi, S., Yang, H., Enimil, A., Sarfo, AM., Gillani, FS., Ansong, D., Dompreh, A., Orstin, A., Opoku, T., Bosomtwe, D., Wiesner, L., Norman, J., Peloquin, CA., Kwara, A., "Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection." Antimicrobial agents and chemotherapy.. 2017 Feb 0; 61(2)EPUB 2017 Jan 24. 
  • Kwara, A., Enimil, A., Gillani, FS., yang, H., Sarfo, Am., Domprey, A., Osei-Tutu, L., Kwarteng Owusu, S., Wisner, L., Norman, J., Kurpewski, J., Peloquin, CA., Ansong, D., Antwi, S., "Pharmacokinetics of First-Line Antituberculosis Drugs Using WHO Revised Dosage in Children With Tuberculosis With and Without HIV Coinfection. Journal of the Pediatric Infectious Diseases Society.. 2016 Dec 0; 5(4):356-365. Epub 2015 May 26.
  • DeDiego, M., Anderson, C., Yang, H., Holden-Wiltse, J., Fitzgerald, T., Treanor, J., Topham, D.(2016) Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine mediated immune protection. Immunology PMID: 26854888.
  • Archampong, T., Lartey, M., Sagoe, K.W., Obo-Akwa, A., Kenu, E., Gillani, F.S., Yang, H., Boamah, I., Flanigan, T., Kwara, A.(2015) Proportion and Factors Associated with Hepatitis B Viremia in Antiretroviral Treatment Naïve and Experienced HIV Co-infected Ghanaian Patients. BMC Infectious Diseases DOI: 10.1186/s12879-016-1342-4.
  • Shah, K., Yang, H., Luque, A.E., Hall,W.J., Dewhurst, S. (2015) Enhancing Physical Function in HIV-Infected Older Adults: A Randomized Controlled Clinical Trial. Health Psychology PMID: 26867045.
  • Scheible, K.M., Emo, J., Yang, H., Holden-Wiltse, J., Straw, A., Huyck, H., Misra, S., Topham, D.J., Ryan, R.M., Reynolds, A.M., Mariani, T.J., and Pryhuber, G.S. (2015) Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants. Journal of Clinical Immunology PMID: 26232733.
  • Kwara, A., Enimil, A., Gillani, F.S., Yang, H., Sarfo, A., Dompreh, A., Ortsin, A., Osei-Tutu, L., Owusu, S.W.,Wiesner, L., Norman, J., Kurpewski, J., Peloquin, C.A., Ansong, D., and Antwi, S. (2015) Pharmacokinetics of First-line Antituberculosis Drugs Using WHO Revised Dosage in Children with Tuberculosis with and without HIV Coinfection. Journal of the Pediatric Infectious Diseases Society doi: 10.1093/jpids/piv035.
  • Fernandez ID; Chin NP; Devine CM; Dozier AM; Martina CA; McIntosh S; Thevenet-Morrison K; Yang H "Images of a Healthy Worksite: A Group-Randomized Trial for Worksite Weight Gain Prevention With Employee Participation in Intervention Design." American journal of public health. 2015; Epub 2015 Mar 19.
  • Yang, H., Baker, S.F., González, M.E., Topham, D.J., Martínez-Sobrido, L., Zand, M., Holden-Wiltse, J. and Wu, H. (2015) An Improved Method for Estimating Antibody Titers in Microneutralization Assay Using Green Fluorescent Protein. Journal of Biopharmaceutical Statistics PMID: 26010892.
  • Halliley, J.L., Khurana, S., Krammer, F., Fitzgerald, T., Coyle, E.M., Chung, K.Y., Baker, S.F., Yang, H., Martínez-Sobrido, L., Treanor, J.J., Subbarao, K., Golding, H., Topham, D.J., and Sangster, M. (2015) High Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine after Priming with Live Attenuated Influenza Vaccine. Journal of Infectious Diseases PMID: 25838266.
  • Morse, D.S., Cerulli, C., Bandyopadhyay, S., Guido, J.J., Yang, H.,Wilson, J.L., Taxman, F.(2014) Support, traumatization, and employment differences in drug court outcomes. Drug and Alcohol Dependence DOI: 10.1016/j.drugalcdep.2014.09.498.
  • Nayak JL; Richards KA; Yang H; Treanor JJ; Sant AJ "Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4+ T-Cell Responses." The Journal of infectious diseases. 2014; Epub 2014 Nov 06.
  • Dozier AM; Brownell E; Guido J; Yang H; Howard CA; Doniger A; Ossip D; Lawrence R "Adapting the pregnancy risk assessment monitoring survey to enhance locally available data: methods." Maternal and child health journal. 2014; 18(5):1196-204.
  • Kwara A; Cao L; Yang H; Poethke P; Kurpewski J; Tashima KT; Mahjoub BD; Court MH; Peloquin CA "Factors associated with variability in rifampin plasma pharmacokinetics and the relationship between rifampin concentrations and induction of efavirenz clearance." Pharmacotherapy. 2014; 34(3):265-71.
  • Lerman YV; Lim K; Hyun YM; Falkner KL; Yang H; Pietropaoli AP; Sonnenberg A; Sarangi PP; Kim M "Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin ?3?1-dependent." Blood. 2014; 124(24):3515-23.
  • Luque AE; Orlando MS; Leong UC; Allen PD; Guido JJ; Yang H; Wu H "Hearing function in patients living with HIV/AIDS." Ear and hearing. 2014; 35(6):e282-90.
  • Wang J; Li D; Bambara RA; Yang H; Dykes C "L74V increases the reverse transcriptase content of HIV-1 virions with non-nucleoside reverse transcriptase drug-resistant mutations L100I+K103N and K101E+G190S, which results in increased fitness." The Journal of general virology. 2013; 94(Pt 7):1597-607.
  • Sangster MY; Baer J; Santiago FW; Fitzgerald T; Ilyushina NA; Sundararajan A; Henn AD; Krammer F; Yang H; Luke CJ; Zand MS; Wright PF; Treanor JJ; Topham DJ; Subbarao K "B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination." Clinical and vaccine immunology : CVI. 2013; 20(6):867-76.
  • Nayak JL; Fitzgerald TF; Richards KA; Yang H; Treanor JJ; Sant AJ "CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine." The Journal of infectious diseases. 2013; 207(2):297-305.
  • Weaver JM; Yang H; Roumanes D; Lee FE; Wu H; Treanor JJ; Mosmann TR "Increase in IFN?(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza." PloS one. 2013; 8(3):e57275.
  • Yang H; Topham DJ; Holden-Wiltse J; Wu H "Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays." Journal of biopharmaceutical statistics. 2013; 23(4):921-36.
  • Henn AD; Wu S; Qiu X; Ruda M; Stover M; Yang H; Liu Z; Welle SL; Holden-Wiltse J; Wu H; Zand MS "High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature." Scientific reports. 2013; (3):2327.
  • Mapstone M; Hilton TN; Yang H; Guido JJ; Luque AE; Hall WJ; Dewhurst S; Shah K "Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults." Aging and disease. 2013; 4(6):311-9.
  • Henn, A.D., Laski, M., Yang, H., Qiu, X., Miao, H., Barry, C.T.,Welle, S.,Wu, H. and Zand, M.S. (2012) Functionally Distinct Subpopulations of CpG-Activated Memory B Cells. Nature Scientific Reports. doi:10.1038/srep00345.
  • Sundararajan, A., Huan, L., Richards, K.A., Marcelin, G., Alam, S., Joo, H., Yang, H., Webby, R.J., Topham, D.J., Sant, A.J. and Sangster, M.Y. (2012) Host Differences in Influenza-Specific CD4 T Cell and B Cell Responses are Modulated by Viral Strain and Route of Immunization. PLoS One. 2012;7(3):e34377.
  • Lartey M, Sagoe KW, Yang H, Kenu E, Xexemeku F, Oliver-Commey J, Boima V, Seshie M, Sagoe A, Mingle JAA, Flanigan TP, Wu H, Kwara A (2011). Viral Decay Rates are Similar in HIV-infected Patients with and without TB Coinfection during Treatment with an Efavirenz-based Regimen. Clinical Infectious Diseases 52(4): 547-550.