Skip to main content

Coronavirus (COVID-19): Visitor Restrictions, Resources, and Updates

Explore URMC
menu

Laura M. Calvi, M.D.

Contact Information

Phone Numbers

Office: (585) 275-2901

Fax: (585) 273-1288

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentNot Accepting New Patients

Research Labs

Faculty Appointments

Patient Care Setting

Endocrinology

Biography

Dr. Calvi is the endocrinologist co-director of the University of Rochester Multidisciplinary Neuroendocrinology Clinic. Dr. Calvi graduated from Union College, obtained her medical degree from Harvard Medical School, and then completed her residency in internal medicine at Massachusetts General Hospital, Harvard Medical School. Dr. Calvi then pursued fellowship training in endocrinology at MGH, where she trained in neuroendocrinology at the MGH Neuroendocrine Clinical Center and Pituitary Tumor Center. She then moved to Rochester to assume the position of Assistant Professor in the Department of Medicine, Division of Endocrinology, University of Rochester Medical Center. Together with Dr. Vates, Dr. Calvi has developed the University of Rochester Multidisciplinary Neuroendocrinology Clinic as a center of excellence for management of patients with pituitary tumors.

Research

RESEARCH
Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow

To survive throughout the life of an individual, hematopoietic stem cells (or HSC), which continuously give rise to all cellular blood components, must strictly regulate their behavioral choices. These choices include self-renewal, differentiation, quiescence or death. This essential regulation of stem cells is thought to be determined at least in part by the environment, or niche, in which these cells reside. The bone forming cells, osteoblasts, have been known to support and expand HSC in vitro and co-transplantation of osteoblasts with HSC can increase engraftment rate. Work in our laboratory and others first identified osteoblastic cells as a regulatory component in the HSC niche through genetic means. A number of molecules have since been implicated in HSC-osteoblastic interaction. In fact, it has recently become evident that osteoblasts can both stimulate and limit HSC expansion, promote quiescence, coordinate HSC mobilization and, when destroyed or mutated, initiate hematopoietic dysfunction. Therefore, increasing evidence points to osteoblasts as key regulators of HSC behavior. While the HSC niche is still poorly understood, we and others have begun to demonstrate the therapeutic potential of its manipulation in animal models. Our laboratory has demonstrated that osteoblastic activation by Parathyroid Hormone (PTH) expands HSC, and improves recovery from myeloablation. Thus, the central hypothesis pursued by my laboratory is that osteoblastic cells play a central role in orchestrating microenvironmental control of the behavior of both benign and malignant HSC, and that they can be targeted for therapeutic benefit. My laboratory therefore uniquely uses techniques that bridge bone and stem cell biology to discover the regulatory components of the bone marrow microenvironment, with the long term goal of identifying targets for therapeutic manipulation.

Current areas of research include:
1) Molecular mechanisms of osteoblastic regulation of hematopoietic stem cells,

2) Role of osteoblasts in coordinating the actions of other bone marrow cellular components (osteoclasts, endothelial cells and adipocytes) for HSC regulation,

3) Regulation of malignant stem cells by bone microenvironmental factors,

4) Role of HSC niche components in response to toxic or irradiation injury,

5) Therapeutic targeting of the HSC niche to improve HSC expansion (in vivo and in vitro), response to toxic injury and malignant stem cell eradication.

Individuals working in the laboratory can expect to learn flow cytometric analysis, pharmacologic and immunohistochemical methods for studying microenvironmental interactions in several animal and in vitro models, and the necessary computational techniques for analyzing these data.

CAREERS
We are currently accepting applications for graduate students and post-doctoral fellow positions in Calvi Lab at the University of Rochester Medical Center. Individuals interested in conducting research on the physiology and stem cell biology within the bone marrow microenvironment are encouraged to apply. Interested candidates, please e-mail your CV and a cover letter detailing your scientific background and skills to Dr. Calvi (laura_calvi@urmc.rochester.edu )

Credentials

Specialties

  • Endocrinology, Diabetes and Metabolism - American Board of Internal Medicine
  • Internal Medicine

Education

1995
MD | Harvard Medical School Children s Hospital

Post-doctoral Training & Residency

07/01/1998 - 06/30/2000
Fellowship in Endocrinology and Metabolism at Massachusetts General Hospital

06/01/1996 - 06/30/1998
Residency in Internal Medicine at Massachusetts General Hospital

06/24/1995 - 05/31/1996
Internship in Internal Medicine at Massachusetts General Hospital

VIEW ALL expand_more

Patents

Patent Title: Expansion of Hematopoietic Stem Cells
Patent #: 2094839
Issue Date: Feb 05, 2020
Country: Europe
Invented By: Laura M Calvi, Regis O'Keefe

Patent Title: Expansion of Hematopoietic Stem Cells
Patent #: FR2094839
Issue Date: Feb 05, 2020
Country: France
Invented By: Laura M Calvi, Regis O'Keefe

Patent Title: Expansion of Hematopoietic Stem Cells
Patent #: 602007059820.6
Issue Date: Feb 05, 2020
Country: Germany
Invented By: Laura M Calvi, Regis O'Keefe

Patent Title: Expansion of Hematopoietic Stem Cells
Patent #: GB2094839
Issue Date: Feb 05, 2020
Country: United Kingdom
Invented By: Laura M Calvi, Regis O'Keefe

Patent Title: Expansion of Hematopoietic Stem Cells
Patent #: 9,394,520
Issue Date: Jul 19, 2016
Country: United States
Invented By: Laura M Calvi, Regis O'Keefe

VIEW ALL expand_more

Publications

Journal Articles

1/6/2020
Calvi LM. "Improved in vivo Experimental Screening Identifies an Anabolic Analog of 1,25 Dihydroxyvitamin D3 With Minimal Bone Resorption Activity." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 Jan 6; Epub 2020 Jan 06.

12/2019
Calvi LM, Li AJ, Becker MW. "What is the role of the microenvironment in MDS?" Best practice & research. Clinical haematology.. 2019 Dec 0; 32(4):101113. Epub 2019 Oct 28.

9/6/2019
Azadniv M, Myers JR, McMurray HR, Guo N, Rock P, Coppage ML, Ashton J, Becker MW, Calvi LM, Liesveld JL. "Bone marrow mesenchymal stromal cells from acute myelogenous leukemia patients demonstrate adipogenic differentiation propensity with implications for leukemia cell support." Leukemia.. 2019 Sep 6; Epub 2019 Sep 06.

VIEW ALL PUBLICATIONS