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Clive S. Zent, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-5823

Fax: (585) 273-5761

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Faculty Appointments

Patient Care Setting



I chose this specialty because I have always had an interest in diseases of the blood. My patients can be confident knowing I provide optimal individual patient care based on precision diagnosis and targeted therapy. Although I treat many types of blood diseases, my area of expertise is chronic lymphocytic leukemia.

Conditions I Treat:

- Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL)
- Hairy cell leukemia
- Prolymphocytic leukemia
- Lymphoplasmacytic lymphoma (Waldenstrom's macroglobulinemia)
- Large granular lymphocytic leukemia

Professional Background

Dr. Clive Zent is a highly experienced hematologist and internationally recognized researcher and expert in the care of patients with chronic lymphocytic leukemia (CLL) and related lymphoid malignancies. While training in Hematology at the University of Chicago, Dr. Zent studied the molecular genetics of hematological malignancies in the laboratory of Dr. Janet Rowley. His clinical and research interest in CLL started as an attending physician at the Central Arkansas Veterans Healthcare System and continued when he joined the staff of the Mayo Clinic in Rochester MN in 2003. In 2013 he was appointed to the faculty of the Wilmot Cancer Center at the University of Rochester Medical Center as Professor of Medicine and director of the Chronic Lymphocytic Leukemia program.


Dr. Zent's research has improved our understanding of the therapeutic monoclonal antibodies used to treat CLL, use of molecular prognostic markers in the management of CLL, diagnosis of CLL and related diseases, and evaluation and management of autoimmune cytopenias and second malignancies complicating CLL. His goal as a clinician, researcher and teacher is to continue to improve treatment and outcome for patients with CLL.



  • Hematology - American Board of Internal Medicine
  • Internal Medicine


MB Bchir | University of Witwatersrand

Post-doctoral Training & Residency

7/1/1996 - 6/30/1997
Residency in Internal Medicine at University of Arkansas College of Medicine

7/1/1993 - 6/30/1996
Fellowship in Hematology at University of Chicago Medical Center

2/1/1987 - 1/31/1991
Residency in Internal Medicine at Groote Schuur Hospital - University of Cape Town

1/1/1984 - 12/31/1984
Internship in Internal Medicine at University of Witwatersrand

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Teacher of the Year in Hematology
Sponsor: Mayo Fellows Association, College of Medicine
Location: Mayo Clinic

Kaminer Fellowship (Travel Award)
Sponsor: University of Chicago
Location: Chicago, IL

Degree with Distinction
Sponsor: University of the Witwatersrand
Location: South Africa

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Journal Articles

Zent CS. "Ibrutinib Restores Tumor Specific Adaptive Immunity in Chronic Lymphocytic Leukemia." Clinical cancer research : an official journal of the American Association for Cancer Research.. 2021 Jun 9; Epub 2021 Jun 09.

Grever M, Andritsos L, Banerji V, Barrientos JC, Bhat S, Blachly JS, Call T, Cross M, Dearden C, Demeter J, Dietrich S, Falini B, Forconi F, Gladstone DE, Gozzetti A, Iyengar S, Johnston JB, Juliusson G, Kraut E, Kreitman RJ, Lauria F, Lozanski G, Parikh SA, Park J, Polliack A, Ravandi F, Robak T, Rogers KA, Saven A, Seymour JF, Tadmor T, Tallman MS, Tam CS, Tiacci E, Troussard X, Zent C, Zenz T, Zinzani PL, Wörmann B. "Hairy cell leukemia and COVID-19 adaptation of treatment guidelines." Leukemia.. 2021 May 4; Epub 2021 May 04.

Moore JE, Delibert K, Baran AM, Evans AG, Liesveld JL, Zent CS. "Targeted therapy for treatment of patients with classical hairy cell leukemia." Leukemia research.. 2021 Feb 4; 102:106522. Epub 2021 Feb 04.

Books & Chapters

Chapter Title: Chronic lymphocytic leukemia/small lymphocytic lymphoma.
Book Title: ASH-SAP American Society of Hematology Self-Assessment Program
Author List: Zent CS, Call TG
Edited By: Steensma DP, Cuker A, Kempton CL
Published By: American Society of Hematology 2016

Chapter Title: Chronic lymphocytic leukemia causing multiple mononeuropathies
Book Title: Companion to Peripheral Neuropathy: Illustrated Cases and New Developments
Author List: Mauermann ML, Zent CS, Low PA
Edited By: Dyck PJ,
Published By: Saunders/Elsevier 2010 in Philadelphia

Chapter Title: Disorders of the Blood
Book Title: Textbook of Medicine
Author List: Zent C and Polliack A
Edited By: Warrel D, Cox T, Firth J
Published By: Oxford 2010