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Clive S. Zent, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-5823

Fax: (585) 273-5761

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Patient Care Settings

Cancer, Hospital Medicine


I chose this specialty because I have always had an interest in diseases of the blood. My patients can be confident knowing I provide optimal individual patient care based on precision diagnosis and targeted therapy. Although I treat many types of blood diseases, my area of expertise is chronic lymphocytic leukemia.

Conditions I Treat:

- Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL)
- Hairy cell leukemia
- Prolymphocytic leukemia
- Lymphoplasmacytic lymphoma (Waldenstrom's macroglobulinemia)
- Large granular lymphocytic leukemia

Professional Background

Dr. Clive Zent is a highly experienced hematologist and internationally recognized researcher and expert in the care of patients with chronic lymphocytic leukemia (CLL) and related lymphoid malignancies. While training in Hematology at the University of Chicago, Dr. Zent studied the molecular genetics of hematological malignancies in the laboratory of Dr. Janet Rowley. His clinical and research interest in CLL started as an attending physician at the Central Arkansas Veterans Healthcare System and continued when he joined the staff of the Mayo Clinic in Rochester MN in 2003. In 2013 he was appointed to the faculty of the Wilmot Cancer Center at the University of Rochester Medical Center as Professor of Medicine and director of the Chronic Lymphocytic Leukemia program.


Dr. Zent's research has improved our understanding of the therapeutic monoclonal antibodies used to treat CLL, use of molecular prognostic markers in the management of CLL, diagnosis of CLL and related diseases, and evaluation and management of autoimmune cytopenias and second malignancies complicating CLL. His goal as a clinician, researcher and teacher is to continue to improve treatment and outcome for patients with CLL.



MBBCH | University of Witwatersrand (South Africa)

Post-doctoral Training & Residency

07/01/1996 - 06/30/1997
Residency in Internal Medicine at University of Arkansas College of Medicine

07/01/1993 - 06/30/1996
Fellowship in Hematology & Oncology at University of Chicago Medical Center

02/01/1987 - 01/31/1991
Residency in Internal Medicine at Groote Schuur Hospital (South Africa)

01/01/1984 - 12/31/1984
Internship in Internal Medicine at Coronation Hospital (South Africa)

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Teacher of the Year in Hematology
Sponsor: Mayo Fellows Association, College of Medicine
Location: Mayo Clinic

Kaminer Fellowship (Travel Award)
Sponsor: University of Chicago
Location: Chicago, IL

Degree with Distinction
Sponsor: University of the Witwatersrand
Location: South Africa

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Journal Articles

Hill BT, Ma S, Zent CS, Baran AM, Wallace DS, Advani AS, Winter AM, Winter JN, Gordon LI, Karmali R, Liesveld JL, Mulford DA, Rowland C, Bui A, Sportelli P, Miskin HP, Weiss MS, Friedberg JW, Barr PM. "Response-Adapted, Time-Limited Venetoclax, Umbralisib and Ublituximab for Relapsed/Refractory Chronic Lymphocytic Leukemia." Blood advances.. 2023 Oct 23; Epub 2023 Oct 23.

Van Wagoner CM, Rivera-Escalera F, Jaimes-Delgadillo NC, Chu CC, Zent CS, Elliott MR. "Antibody-mediated phagocytosis in cancer immunotherapy." Immunological reviews.. 2023 Aug 21; Epub 2023 Aug 21.

Brady MT, Laniewski N, Strawderman M, Chu CC, Kanagaiah P, Sangster MY, Topham DJ, Friedberg JW, Zent CS. "Long-term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial Bruton tyrosine kinase inhibitors therapy for chronic lymphocytic leukemia or lymphoplasmacytic lymphoma." American journal of hematology.. 2023 Jul 23; Epub 2023 Jul 23.

Books & Chapters

Chapter Title: Chronic lymphocytic leukemia/small lymphocytic lymphoma.
Book Title: ASH-SAP American Society of Hematology Self-Assessment Program
Author List: Zent CS, Call TG
Edited By: Steensma DP, Cuker A, Kempton CL
Published By: American Society of Hematology 2016

Chapter Title: Chronic lymphocytic leukemia causing multiple mononeuropathies
Book Title: Companion to Peripheral Neuropathy: Illustrated Cases and New Developments
Author List: Mauermann ML, Zent CS, Low PA
Edited By: Dyck PJ,
Published By: Saunders/Elsevier 2010 in Philadelphia

Chapter Title: Disorders of the Blood
Book Title: Textbook of Medicine
Author List: Zent C and Polliack A
Edited By: Warrel D, Cox T, Firth J
Published By: Oxford 2010