Research Networks HIV Clinical Trials Unit (CTU) and the UR Infectious Diseases Division (IDD) HIV Clinical Trials Unit (CTU) and the UR Infectious Diseases Division (IDD) have conducted high quality HIV/AIDS-related clinical research for 25 years. The IDD was an original member of the NIAID-supported Adult AIDS Clinical Trials Group (ACTG) and the HIV Vaccine Trials Network (HVTN; formerly the AIDS Vaccine Evaluation Group), and has been continuously funded as a member of these groups since their inception. HIV Vaccine Clinical Trials Network The UR IDD has been a member of the NIAID-sponsored multi-center HIV vaccine clinical trials network since 1988. Dr. Keefer has directed the site since 1991 and has assisted with network operations since 1998, providing a degree of continuity that has been helpful at the local and national levels. Over 1,500 healthy HIV-uninfected adults have been enrolled into more than 50 preventive HIV vaccine studies in Rochester since 1988, and the Rochester HVTN CRS has consistently had an overall enrollment that is among the highest in the nation. AIDS Clinical Trials Unit UR ACTG CRS investigators have a substantial history of leading and contributing to multicenter trials of antiretroviral therapies in patients at varying stages of HIV infection. The UR ACTG CRS also has a major strength in neurologic manifestations, participating in the design and execution of several trials of sensory neuropathy and cognitive impairment. Adult HIV and STD Clinics The IDD also operates the SMH Adult HIV Clinic, and the Monroe County STD Clinic, and maintains close linkages with its affiliated ACTG CRS at AIDS Care, Inc. The SMH Adult HIV Clinic provides care to over 1,100 persons living with HIV/AIDS (PLWHA) in the Greater Rochester area, and gained designation as a center for excellence in HIV/AIDS Care by the New York State Department of Health in 1987. AIDS Care AIDS Care is a comprehensive, community-based health care center for people living with HIV/AIDS that was formed in 2010, through the merger of two major HIV/AIDS community organizations in Rochester (AIDS Community Health Center and AIDS Rochester). AIDS Care has strongly supported enrollment in ACTG trials and provides medical care and other services to over 600 PLWHA in the Greater Rochester area. Pediatric Infectious Diseases and IMPAACT The Division of Pediatric Infectious Diseases (DPID) at UR SMD is an NICHD-affiilated IMPAACT site and is the sole provider of comprehensive pediatric HIV care in Monroe County and our 13 county referral area. The DPID oversees the management of the vast majority (>95%) of HIV-infected children and adolescents in the region.