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Charcot Marie Tooth (CMT)

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What is Charcot Marie Tooth (CMT) Disease?

Charcot Marie Tooth (CMT) disease is a group of inherited disorders that cause nerve damage. It is also called hereditary motor and sensory neuropathy.

CMT generally causes damage to the peripheral nerves in the arms and legs. It can result in muscle weakness, loss of sensation, difficulty walking, and foot deformities.

What Are the Symptoms of Charcot Marie Tooth Disease?

Symptoms vary based on the individual. As the disease progresses, they may spread from the legs and feet to the arms and hands. The most common symptoms include:

  • Weakness in legs, ankles, and feet
  • Loss of muscle bulk in legs and feet
  • High foot arches
  • Hammertoes – curled toes
  • Decreased ability to run
  • Footdrop – difficulty lifting foot at the ankle
  • Higher than normal step
  • Frequent tripping or falling
  • Loss of feeling in legs and feet

What Causes Charcot Marie Tooth Disease?

CMT is a genetic condition. It is caused by mutations in the genes that affect the peripheral nerves. Because it is hereditary, you have a higher risk of developing the disease if someone in your immediate family has it.

UR Medicine's Treatments for Charcot Marie Tooth (CMT)

At the Charcot Marie Tooth Inherited Neuropathy Clinic at UR Medicine, we provide excellent, specialized multidisciplinary clinical care for patients and families with CMT and other forms of Inherited Neuropathy, including TTR Amyloid Polyneuropathy.

We focus on all aspects of disease including diagnosis with genetic confirmation, genetic and family counseling, prevention and management of secondary symptoms and complications, access to clinical research studies and treatment trials, and coordination of care with schools and other providers. 

What Sets Us Apart?

Our team of experts specialize in what’s needed to care for all forms of childhood and adult neuromuscular disease. We coordinate care tailored to the needs of patients and families. 

As part of an academic medical center, our clinicians are also active in research, serving as Principal Investigators for national and international multi-center trials. UR Medicine has been home to:

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Neurology - Rochester

Ambulatory Care Center at Strong Memorial Hospital
601 Elmwood Avenue, 1st Floor
Rochester, NY 14642

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