Research
The Eastman Institute for Oral Health, consistently ranking in the top ten for NIDCR dentistry funding, continues to gain international attention for breakthrough discoveries.
We work on a wide range of projects, including oral infectious diseases, salivary gland biology, craniofacial development, and community-based disease prevention. We focus on basic-science research as well as translational, clinical and community dentistry research.
We have four specific research goals as we expand our capabilities:
- To boost our national reputation as a research institution
- To enhance clinical and translational research
- To better integrate basic with translational and clinical research efforts
- To improve the overall quality and number of research-intensive faculty
Our Recent Publications
2018
Abduljabbar, T., Al-Hamoudi, N., Al-Sowygh, Z. H., Alajmi, M., Javed, F., & Vohra, F. (2018). Comparison of peri-implant clinical and radiographic status around short (6 mm in length) dental implants placed in cigarette-smokers and never-smokers: Six-year follow-up results. Clinical Implant Dentistry and Related Research
Akram, Z., Abduljabbar, T., Hosain, M., Al-Sowygh, Z. H., Al-Hamoudi, N., Vohra, F., & Javed, F. (2018). Comparison of periodontal inflammatory parameters among habitual gutka-chewers and naswar-dippers: A split-mouth retrospective clinical study. Acta Odontologica Scandinavica
Akram, Z., Vohra, F., Bukhari, I. A., Sheikh, S. A., & Javed, F. (2018). Clinical and radiographic peri-implant parameters and proinflammatory cytokine levels among cigarette smokers, smokeless tobacco users, and nontobacco users. Clinical Implant Dentistry and Related Research
Al-Hamoudi, N., Abduljabbar, T., Mirza, S., Al-Sowygh, Z. H., Vohra, F., Javed, F., & Akram, Z. (2018). Non-surgical periodontal therapy reduces salivary adipocytokines in chronic periodontitis patients with and without obesity. Journal of Investigative and Clinical Dentistry
Caito, S. W., Jackson, B. P., Punshon, T., Scrimale, T., Grier, A., Gill, S. R., . . . Rand, M. D. (2018). Editor's highlight: Variation in methylmercury metabolism and elimination status in humans following fish consumption. Toxicological Sciences : An Official Journal of the Society of Toxicology
Cheng, C. W., Chien, C. H., Chen, C. J., & Papaspyridakos, P. (2018). Clinical results and technical complications of posterior implant-supported modified monolithic zirconia single crowns and short-span fixed dental prostheses: A 2-year pilot study. Journal of Prosthodontics : Official Journal of the American College of Prosthodontists
Heft, M. W., Litaker, M. S., Kopycka-Kedzierawski, D. T., Meyerowitz, C., Chonowski, S., Yardic, R. L., . . . National Dental PBRN Collaborative Group. (2018). Patient-centered dentinal hypersensitivity treatment outcomes: Results from the national dental PBRN. JDR Clinical and Translational Research
Herzog, C. R., Berzins, D. W., DenBesten, P., Gregory, R. L., Hargreaves, K. M., Messer, R. L. W., . . . Hu, J. C. C. (2018). Oral sciences PhD program enrollment, graduates, and placement: 1994 to 2016. Journal of Dental Research
Javed, F., Akram, Z., Barillas, A. P., Kellesarian, S. V., Ahmed, H. B., Khan, J., & Almas, K. (2018). Outcome of orthodontic palatal plate therapy for orofacial dysfunction in children with down syndrome: A systematic review. Orthodontics & Craniofacial Research
Kellesarian, S. V., Javed, F., & Romanos, G. E. (2018). Osteomyelitis arising around osseointegrated dental implants: A systematic review. Implant Dentistry
Kellesarian, S. V., Malignaggi, V. R., Kellesarian, T. V., Bashir Ahmed, H., & Javed, F. (2018). Does incorporating collagen and chondroitin sulfate matrix in implant surfaces enhance osseointegration? A systematic review and meta-analysis. International Journal of Oral and Maxillofacial Surgery
Korczeniewska, O. A., Husain, S., Khan, J., Eliav, E., Soteropoulos, P., & Benoliel, R. (2018). Differential gene expression in trigeminal ganglia of male and female rats following chronic constriction of the infraorbital nerve. European Journal of Pain (London, England)
Makhija, S. K., Robinson, M. E., Bader, J. D., Shugars, D. A., Litaker, M. S., Im, H. R., . . . National Dental PBRNCollaborative Group. (2018). Dentists' decision strategies for suspicious occlusal caries lesions in a national dental PBRN study. Journal of Dentistry
Papaspyridakos, P., Kang, K., DeFuria, C., Amin, S., Kudara, Y., & Weber, H. P. (2018). Digital workflow in full-arch implant rehabilitation with segmented minimally veneered monolithic zirconia fixed dental prostheses: 2-year clinical follow-up. Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry
Yuen, H., Rossouw, P. E., Wolford, L. M., & Wang, H. (2018). Pharyngeal airway space changes after condylar replacement and mandibular advancement surgery. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Zhu, W. Q., Ming, P. P., Qiu, J., Shao, S. Y., Yu, Y. J., Chen, J. X., . . . Tang, C. B. (2018). Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3-E1 osteoblasts. Journal of Applied Toxicology : JAT]
2017
Abduljabbar, T., Akram, Z., Vohra, F., Warnakulasuriya, S., & Javed, F. (2017). Assessment of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha levels in the peri-implant sulcular fluid among waterpipe (narghile) smokers and never-smokers with peri-implantitis. Clinical Implant Dentistry and Related Research
Akram, Z., Javed, F., Hosein, M., Al-Qahtani, M. A., Alshehri, F., Alzahrani, A. I., & Vohra, F. (2017). Photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review. Photodermatology, Photoimmunology & Photomedicine
Akram, Z., Vohra, F., & Javed, F. (2017). Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A meta-analysis. Journal of Investigative and Clinical Dentistry
Bowen, W. H., Burne, R. A., Wu, H., & Koo, H. (2017). Oral biofilms: Pathogens, matrix, and polymicrobial interactions in microenvironments. Trends in Microbiology
Castillo Pedraza, M. C., Novais, T. F., Faustoferri, R. C., Quivey, R. G.,Jr, Terekhov, A., Hamaker, B. R., & Klein, M. I. (2017). Extracellular DNA and lipoteichoic acids interact with exopolysaccharides in the extracellular matrix of streptococcus mutans biofilms. Biofouling
Cousley, R. R. J., Bainbridge, M., & Rossouw, P. E. (2017). The accuracy of maxillary positioning using digital model planning and 3D printed wafers in bimaxillary orthognathic surgery. Journal of Orthodontics]
Eliav, E. (2017). Editorial: We can do more: The role of dentists extends beyond traditional dentistry. Quintessence International (Berlin, Germany : 1985)
Free, R. D., DeRocher, K., Stock, S. R., Keane, D., Scott-Anne, K., Bowen, W. H., & Joester, D. (2017). Characterization of enamel caries lesions in rat molars using synchrotron X-ray microtomography. Journal of Synchrotron Radiation
Graham, J. W. (2017). JCO roundtable: The temporomandibular joint and craniomandibular disorders. Journal of Clinical Orthodontics
Gupta, B., Singh, S., Tallents, R. H., & Rossouw, E. (2017). Effects of bisphosphonates on orthodontic treatment and the TMJ: A systematic review. Journal of Clinical Orthodontics
Huang, X., Browngardt, C. M., Jiang, M., Ahn, S. J., Burne, R. A., & Nascimento, M. M. (2017). Diversity in antagonistic interactions between commensal oral streptococci and streptococcus mutans. Caries Research
Huang, X., Deng, M., Liu, M., Cheng, L., Exterkate, R. A. M., Li, J., . . . Ten Cate, J. M. (2017). Comparison of composition and anticaries effect of galla chinensis extracts with different isolation methods. The Open Dentistry Journal]
Javed, F., ALHarthi, S. S., BinShabaib, M. S., Gajendra, S., Romanos, G. E., & Rahman, I. (2017). Toxicological impact of waterpipe smoking and flavorings in the oral cavity and respiratory system. Inhalation Toxicology
Javed, F., Kellesarian, S. V., Abduljabbar, T., Abduljabbar, A. T., Akram, Z., Vohra, F., . . . Romanos, G. E. (2017). Influence of involuntary cigarette smoke inhalation on osseointegration: A systematic review and meta-analysis of preclinical studies. International Journal of Oral and Maxillofacial Surgery
Kellesarian, S. V., Malignaggi, V. R., de Freitas, P., Ahmed, H. B., & Javed, F. (2017). Association between prenatal maternal cigarette smoking and early childhood caries. A systematic review. Journal of Clinical and Experimental Dentistry
Kellesarian, S. V., Qayyum, F., de Freitas, P. C., Akram, Z., & Javed, F. (2017). Is antimicrobial photodynamic therapy a useful therapeutic protocol for oral decontamination? A systematic review and meta-analysis. Photodiagnosis and Photodynamic Therapy
Kellesarian, S. V., Ros Malignaggi, V., Aldosary, K. M., & Javed, F. (2017). Laser-assisted removal of all ceramic fixed dental prostheses: A comprehensive review. Journal of Esthetic and Restorative Dentistry: Official Publication of the American Academy of Esthetic Dentistry ...[Et Al.],
Khan, J., Hassun, H., Zusman, T., Korczeniewska, O., & Eliav, E. (2017). Interleukin-8 levels in rat models of nerve damage and neuropathic pain. Neuroscience Letters
Khan, J., Noboru, N., Imamura, Y., & Eliav, E. (2017). Effect of pregabalin and diclofenac on tactile allodynia, mechanical hyperalgesia and pro inflammatory cytokine levels (IL-6, IL-1beta) induced by chronic constriction injury of the infraorbital nerve in rats. Cytokine, S1043
Korczeniewska, O. A., Khan, J., Tao, Y., Eliav, E., & Benoliel, R. (2017). Effects of sex and stress on trigeminal neuropathic pain-like behavior in rats. Journal of Oral & Facial Pain and Headache
Kovacs, C. J., Faustoferri, R. C., & Quivey, R. G.,Jr. (2017). RgpF is required for maintenance of stress tolerance and virulence in streptococcus mutans. Journal of Bacteriology, 199(24), Print 2017
Laird, E., Thurston, S. W., van Wijngaarden, E., Shamlaye, C. F., Myers, G. J., Davidson, P. W., . . . Strain, J. J. (2017). Maternal vitamin D status and the relationship with neonatal anthropometric and childhood neurodevelopmental outcomes: Results from the seychelles child development nutrition study. Nutrients
Makhija, S. K., Shugars, D. A., Gilbert, G. H., Litaker, M. S., Bader, J. D., Schaffer, R., . . . National Dental Practice-Based Research Network Collaborative Group. (2017). Surface characteristics and lesion depth and activity of suspicious occlusal carious lesions: Findings from the national dental practice-based research network. Journal of the American Dental Association (1939)
Malcolm, D. W., Varghese, J. J., Sorrells, J. E., Ovitt, C. E., & Benoit, D. S. W. (2018). The effects of biological fluids on colloidal stability and siRNA delivery of a pH-responsive micellar nanoparticle delivery system. ACS Nano
McCracken, M. S., Litaker, M. S., George, A. J., Durand, S., Malekpour, S., Marshall, D. G., . . . National Dental Practice-Based Research Network Collaborative Group. (2017). Impression evaluation and laboratory use for single-unit crowns: Findings from the national dental practice-based research network. Journal of the American Dental Association (1939)
Myers, R. B. (2017). Bio-progressive therapy. Journal of Clinical Orthodontics : JCO
Poggio, C. E., Ercoli, C., Rispoli, L., Maiorana, C., & Esposito, M. (2017). Metal-free materials for fixed prosthodontic restorations. The Cochrane Database of Systematic Reviews
Ren, Y. F. (2017). Oral and maxillofacial surgery residency training in the united states: What can we learn. Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology
Saputo, S., Faustoferri, R. C., & Quivey, R. G.,Jr. (2017). A drug repositioning approach reveals that streptococcus mutans is susceptible to a diverse range of established antimicrobials and nonantibiotics. Antimicrobial Agents and Chemotherapy, 62(1), 10.1128/AAC.01674-17. Print 2018
Saputo, S., Faustoferri, R. C., & Quivey, R. G.,Jr. (2017). Vitamin D compounds are bactericidal against streptococcus mutans and target the bacitracin-associated efflux system. Antimicrobial Agents and Chemotherapy
Vohra, F., Akram, Z., Bukhari, I. A., Sheikh, S. A., & Javed, F. (2017). Short-term effects of adjunctive antimicrobial photodynamic therapy in obese patients with chronic periodontitis: A randomized controlled clinical trial. Photodiagnosis and Photodynamic Therapy
Vohra, F., Alkhudhairy, F., Al-Kheraif, A. A., Akram, Z., & Javed, F. (2017). Peri-implant parameters and C-reactive protein levels among patients with different obesity levels. Clinical Implant Dentistry and Related Research
Vorrasi, J., Calvi, R., Lv, M., & Hammond, R. (2017). What factors necessitate removal of retained ballistic fragments in the head and neck? Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Vorrasi, J. S., & Kolokythas, A. (2017). Controversies in traditional oral and maxillofacial reconstruction. Oral and Maxillofacial Surgery Clinics of North America
Wiens, J. P., Koka, S., Graser, G., White, S. N., Marinello, C. P., & Curtis, D. A. (2017). Academy of prosthodontics centennial: The emergence and development of prosthodontics as a specialty. The Journal of Prosthetic Dentistry
Xiao, J., Huang, X., Alkhers, N., Alzamil, H., Alzoubi, S., Wu, T. T., . . . Koo, H. (2017). Candida albicans and early childhood caries: A systematic review and meta-analysis. Caries Research
Yeates, A. J., Thurston, S. W., Li, H., Mulhern, M. S., McSorley, E. M., Watson, G. E., . . . Broberg, K. (2017). PUFA status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the seychelles child development study. The Journal of Nutrition]
Zhao, X., Zanetti, F., Majeed, S., Pan, J., Malmstrom, H., Peitsch, M. C., . . . Ren, Y. (2017). Effects of cigarette smoking on color stability of dental resin composites. American Journal of Dentistry
2016
Akram, Z., Safii, S. H., Vaithilingam, R. D., Baharuddin, N. A., Javed, F., & Vohra, F. (2016). Efficacy of non-surgical periodontal therapy in the management of chronic periodontitis among obese and non-obese patients: A systematic review and meta-analysis. Clinical Oral Investigations
Cross, B., Garcia, A., Faustoferri, R., & Quivey, R. G. (2016). PlsX deletion impacts fatty acid synthesis and acid adaptation in streptococcus mutans. Microbiology (Reading, England)
Kalladka, M., Nasri-Heir, C., Eliav, E., Ananthan, S., Viswanath, A., & Heir, G. (2016). Continuous neuropathic pain secondary to endoscopic procedures: Report of two cases and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Rafael, B., Sorin, T., & Eli, E. (2016). Painful traumatic trigeminal neuropathy. Oral and Maxillofacial Surgery Clinics of North America
Xiao J, Moon Y, Li L, Rustchenko E, Wakabayashi H, Zhao X, Feng C, Gill SR, McLaren S, Malmstrom H, Ren Y, Quivey R, Koo H, Kopycka-Kedzierawski DT. 2016. Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness. PLoS One