Research

The Eastman Institute for Oral Health, ranking in the top ten for NIDCR dentistry funding, continues to gain international attention for breakthrough discoveries.

We work on a wide range of projects, including oral infectious diseases, salivary gland biology, craniofacial development, and community-based disease prevention. We focus on basic-science research as well as translational, clinical and community dentistry research.

We have four specific research goals as we expand our capabilities:

• To boost our national reputation as a research institution
• To enhance clinical and translational research
• To better integrate basic with translational and clinical research efforts
• To improve the overall quality and number of research-intensive faculty

Our Recent Publications

Baker, J. L., Abranches, J., Faustoferri, R. C., Hubbard, C. J., Lemos, J. A., Courtney, M. A., & Quivey, R.,Jr. (2015). Transcriptional profile of glucose-shocked and acid-adapted strains of streptococcus mutans. Molecular Oral Microbiology

Baladhandayutham, B., Lawson, N. C., & Burgess, J. O. (2015). Fracture load of ceramic restorations after fatigue loading. The Journal of Prosthetic Dentistry

Das, S., Yu, S., Sakamori, R., Vedula, P., Feng, Q., Flores, J., . . . Gao, N. (2015). Rab8a vesicles regulate wnt ligand delivery and paneth cell maturation at the intestinal stem cell niche. Development  

Gaca, A. O., Kudrin, P., Colomer-Winter, C., Beljantseva, J., Liu, K., Anderson, B., . . . Lemos, J. A. (2015). From (p)ppGpp to (pp)pGpp: Characterization of regulatory effects of pGpp synthesized by the small alarmone synthetase of enterococcus faecalis. Journal of Bacteriology

Gilbert GH; Gordan VV; Korelitz JJ; Fellows JL; Meyerowitz C; Oates TW; Rindal DB; Gregory RJ. “Provision of specific dental procedures by general dentists in the National Dental Practice-Based Research Network: questionnaire findings.”  BMC oral health. 2015

Javed, F., Al Amri, M. D., Al-Kheraif, A. A., Qadri, T., Ahmed, A., Ghanem, A., . . . Romanos, G. E. (2015). Efficacy of non-surgical periodontal therapy with adjunct nd:YAG laser therapy in the treatment of periodontal inflammation among patients with and without type 2 diabetes mellitus: A short-term pilot study. Journal of Photochemistry and Photobiology.B, Biology

Javed, F., Al-Kheraif, A. A., Al Amri, M. D., Alshehri, M., Vohra, F., Al-Askar, M., . . . Romanos, G. E. (2015). Periodontal status and whole salivary cytokine profile among smokers and never-smokers with and without prediabetes. Journal of Periodontology

Liu, X., Wang, C., Fujita, T., Malmstrom, H. S., Nedergaard, M., Ren, Y. F., & Dirksen, R. T. (2015). External dentin stimulation induces ATP release in human teeth. Journal of Dental Research

Malmstrom, H., Xiao, J., Romanos, G., & Ren, Y. F. (2015). Two-year success rate of implant-retained mandibular overdentures by novice general dentistry residents. The Journal of Oral Implantology

McLaren, S. W., & Kopycka-Kedzierawski, D. T. (2015). Compliance with dental treatment recommendations by rural paediatric patients after a live-video teledentistry consultation: A preliminary report. Journal of Telemedicine and Telecare

Meirelles, L., Branemark, P. I., Albrektsson, T., Feng, C., & Johansson, C. (2015). Histological evaluation of bone formation adjacent to dental implants with a novel apical chamber design: Preliminary data in the rabbit model. Clinical Implant Dentistry and Related Research

Mikami, T., Kurose, A., Javed, F., & Takeda, Y. (2015). Detection of rare variant of SS18-SSX1 fusion gene and mutations of important cancer-related genes in synovial sarcoma of the lip: Gene analyses of a case and literature review. Journal of Oral and Maxillofacial Surgery

Nasri-Heir, C., Khan, J., Benoliel, R., Feng, C., Yarnitsky, D., Kuo, F., . . . Eliav, E. (2015). Altered pain modulation in patients with persistent post-endodontic pain. Pain

Quivey, R. G.,Jr, Grayhack, E. J., Faustoferri, R. C., Hubbard, C. J., Baldeck, J. D., Wolf, A. S., . . . Marquis, R. E. (2015). Functional profiling in streptococcus mutans: Construction and examination of a genomic collection of gene deletion mutants. Molecular Oral Microbiology

Romanos, G. E., & Javed, F. (2015). Laser therapy is safe but not superior to conventional treatment of peri-implantitis. The Journal of Evidence-Based Dental Practice

Saunders, R. (2015). Partial denture swallowed by patient with dementia. Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

Tsigarida, A. A., Dabdoub, S. M., Nagaraja, H. N., & Kumar, P. S. (2015). The influence of smoking on the peri-implant microbiome. Journal of Dental Research

Vohra, F., Al-Kheraif, A. A., Ab Ghani, S. M., Abu Hassan, M. I., Alnassar, T., & Javed, F. (2015). Crestal bone loss and periimplant inflammatory parameters around zirconia implants: A systematic review. The Journal of Prosthetic Dentistry

Del Castillo, R., Hernandez, A. M., & Ercoli, C. (2015). A conservative orthodontic-prosthodontic approach for excessive gingival display. A clinical report. The Journal of Prosthetic Dentistry

Galvao, L. C., Miller, J. H., Kajfasz, J. K., Scott-Anne, K., Freires, I. A., Franco, G. C., . . . Lemos, J. A. (2015). Transcriptional and phenotypic characterization of novel spx-regulated genes in streptococcus mutans. PloS One

Kajfasz, J. K., Rivera-Ramos, I., Scott-Anne, K., Gregoire, S., Abranches, J., & Lemos, J. A. (2015). Transcription of oxidative stress genes is directly activated by SpxA1 and, to a lesser extent, by SpxA2 in streptococcus mutans. Journal of Bacteriology

Myers, G. J., Davidson, P. W., Watson, G. E., van Wijngaarden, E., Thurston, S. W., Strain, J. J., . . . Bovet, P. (2015). Methylmercury exposure and developmental neurotoxicity. Bulletin of the World Health Organization

Romanos, G. E., Belikov, A. V., Skrypnik, A. V., Feldchtein, F. I., Smirnov, M. Z., & Altshuler, G. B. (2015). Uncovering dental implants using a new thermo-optically powered (TOP) technology with tissue air-cooling. Lasers in Surgery and Medicine

Aure, M. H., Konieczny, S. F., & Ovitt, C. E. (2015). Salivary gland homeostasis is maintained through acinar cell self-duplication. Developmental Cell

Carpenter, P. A., Kitko, C. L., Elad, S., Flowers, M. E., Gea-Banacloche, J. C., Halter, J. P., . . . Couriel, D. R. (2015). National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: V. the 2014 ancillary therapy and supportive care working group report. Biology of Blood and Marrow Transplantation

Elad, S., & Thierer, T. (2015). Cost-effective analysis of topical chlorhexidine in hematologic patients at risk for oral mucositis. Clinical Oral Investigations

Faustoferri, R. C., Hubbard, C. J., Santiago, B., Buckley, A. A., Seifert, T. B., & Quivey, R. G.,Jr. (2015). Regulation of fatty acid biosynthesis by the global regulator CcpA and the local regulator FabT in streptococcus mutans. Molecular Oral Microbiology

Fears, K. P., Gonzalez-Begne, M., Love, C. T., Day, D. E., & Koo, H. (2015). Surface-induced changes in the conformation and glucan production of glucosyltransferase adsorbed on saliva-coated hydroxyapatite. Langmuir: The ACS Journal of Surfaces and Colloids

Frank, K. L., Colomer-Winter, C., Grindle, S. M., Lemos, J. A., Schlievert, P. M., & Dunny, G. M. (2014). Transcriptome analysis of enterococcus faecalis during mammalian infection shows cells undergo adaptation and exist in a stringent response state. PloS One

Geminiani, A., Weitz, D. S., Ercoli, C., Feng, C., Caton, J. G., & Papadimitriou, D. E. (2015). A comparative study of the incidence of schneiderian membrane perforations during maxillary sinus augmentation with a sonic oscillating handpiece versus a conventional turbine handpiece. Clinical Implant Dentistry and Related Research

Horev, B., Klein, M. I., Hwang, G., Li, Y., Kim, D., Koo, H., & Benoit, D. S. (2015). pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence. ACS Nano

Javed, F., Al-Kheraif, A. A., Salazar-Lazo, K., Yanez-Fontenla, V., Aldosary, K. M., Alshehri, M., . . . Romanos, G. E. (2015). Periodontal inflammatory conditions among smokers and never-smokers with and without type 2 diabetes mellitus. Journal of Periodontology

Javed, F., Vohra, F., Al-Kheraif, A. A., Malmstrom, H., & Romanos, G. E. (2015). Comparison of periodontal inflammatory conditions among habitual gutka chewers and betel quid chewers. Oral Diseases

Javed, F., Yakob, M., Ahmed, H. B., Al-Huzimi, K., & Samaranayake, L. P. (2015). Oral candida carriage among individuals chewing betel-quid with and without tobacco. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Kalantar Motamedi, M. R., Heidarpour, M., Siadat, S., Motamedi, A. K., & Bahreman, A. A. (2015). Orthodontic extraction of high-risk impacted mandibular third molars in close proximity to the mandibular canal: A systematic review. Journal of Oral and Maxillofacial Surgery

Kashi, A., Gupta, B., Malmstrom, H., & Romanos, G. E. (2015). Primary stability of implants placed at different angulations in artificial bone. Implant Dentistry

Khan, J., Ramadan, K., Korczeniewska, O., Anwer, M. M., Benoliel, R., & Eliav, E. (2015). Interleukin-10 levels in rat models of nerve damage and neuropathic pain. Neuroscience Letters

Klein, M. I., Hwang, G., Santos, P. H., Campanella, O. H., & Koo, H. (2015). Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms. Frontiers in Cellular and Infection Microbiology

Miller, J. H., Aviles-Reyes, A., Scott-Anne, K., Gregoire, S., Watson, G. E., Sampson, E., . . . Abranches, J. (2015). The collagen binding protein cnm contributes to oral colonization and cariogenicity of streptococcus mutans OMZ175. Infection and Immunity

Ning, L., Malmstrom, H., & Ren, Y. F. (2015). Porous collagen-hydroxyapatite scaffolds with mesenchymal stem cells for bone regeneration. The Journal of Oral Implantology

Vohra, F., Al-Kheraif, A. A., Qadri, T., Hassan, M. I., Ahmed, A., Warnakulasuriya, S., & Javed, F. (2015). Efficacy of photodynamic therapy in the management of oral premalignant lesions. A systematic review. Photodiagnosis and Photodynamic Therapy

Zhang, Z., Han, Y., Song, J., Luo, R., Jin, X., Mu, D., . . . Liu, H. (2015). Interferon-gamma regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity. Journal of Oral Pathology & Medicine