Research The Eastman Institute for Oral Health, ranking in the top ten for NIDCR dentistry funding, continues to gain international attention for breakthrough discoveries. We work on a wide range of projects, including oral infectious diseases, salivary gland biology, craniofacial development, and community-based disease prevention. We focus on basic-science research as well as translational, clinical and community dentistry research. We have four specific research goals as we expand our capabilities: To boost our national reputation as a research institution To enhance clinical and translational research To better integrate basic with translational and clinical research efforts To improve the overall quality and number of research-intensive faculty Our Recent Publications Primary Stability of Implants Placed at Different Angulations in Artificial Bone: Kashi A, Gupta B, Malmstrom H, Romanos GE., Implant Dent 2014 BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin: Zhu XJ, Liu Y, Dai ZM, Zhang X, Yang X, Li Y, Qiu M, Fu J, Hsu W, Chen Y, Zhang Z. PLoS Genet. 2014 Periodontal Regeneration: Intrabony Defects: A Consensus Report: Reynolds MA, Kao RT, Camargo PM, Caton JG, Clem DS, Fiorellini JP, Geisinger ML, Mills MP, Nares S, Nevins ML.,J Periodontol. 2014 Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration: Fu J, Yu HM, Chiu SY, Mirando AJ, Maruyama EO, Cheng JG, Hsu W.,PLoS Genet. 2014 Comparison of Periodontal Inflammatory Conditions Among Habitual Gutka-Chewers and Betel Quid-Chewers: Javed F, Vohra F, Al-Kheraif AA, Malmstrom H, Romanos GE., Oral Dis. 2014 Maternal salivary bacterial challenge is associated with oral infection among children and predicts early childhood caries (ECC) incidence in a high-risk cohort of 36-month-old children: Kopycka-Kedzierawski DT., J Evid Based Dent Pract. 2014 Exercise-Induced Hypoalgesia Profile in Rats Predicts Neuropathic Pain Intensity Induced by Sciatic Nerve Constriction Injury: Khan J, Benavent V, Korczeniewska OA, Benoliel R, Eliav E., J Pain. 2014 Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity, Zhang Z, Han Y, Song J, Luo R, Jin X, Mu D, Su S, Ji X, Ren YF, Liu H, J Oral Pathol Med. 2014. Bacterial Composition at the Implant-Abutment Connection under Loading in vivo.: Romanos GE, Biltucci MT, Kokaras A, Paster BJ., Clin Implant Dent Relat Res. 2014. Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT): Elad S, Raber-Durlacher JE, Brennan MT, Saunders DP, Mank AP, Zadik Y, Quinn B, Epstein JB, Blijlevens NM, Waltimo T, Passweg JR, Correa ME, Dahllöf G, Garming-Legert KU, Logan RM, Potting CM, Shapira MY, Soga Y, Stringer J, Stokman MA, Vokurka S, Wallhult E, Yarom N, Jensen SB, Support Care Cancer. 2014. Pharmacokinetics of fluoride in toddlers after application of 5% sodium fluoride dental varnish: Milgrom P, Taves DM, Kim AS, Watson GE, Horst JA., Pediatrics. 2014 Regulation of fatty acid biosynthesis by the global regulator CcpA and the local regulator FabT in Streptococcus mutants: Faustoferri RC, Hubbard CJ, Santiago B, Buckley AA, Seifert TB, Quivey RG Jr., Mol Oral Microbiol. 2014. CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors: Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N., Cancer Res. 2014 Self-perceived oral health and periodontal parameters in chronic periodontitis patients with and without rheumatoid arthritis: Javed F, Ahmed HB, Mehmood A, Mikami T, Malmstrom H, Romanos GE., J Investig Clin Dent. 2014 Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice: McGee-Lawrence ME, Carpio LR, Bradley EW, Dudakovic A, Lian JB, van Wijnen AJ, Kakar S, Hsu W, Westendorf JJ., Bone 2014 In-vivo bone response to titanium screw implants anodized in sodium sulfate: Pinheiro FA, Mourão CF, Diniz VS, Silva PC, Meirelles L, Santos Junior E, Schanaider A., Acta Cir Bras. 2014 Altered structure and function in hippocampus and medial frontal cortex in patients with burning mouth syndrome: Eliav E., Pain. 2014 Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Hagen FK, Abranches J, Lemos JA., J Bacteriol. 2014 Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery.: Liao S, Klein MI, Heim KP, Fan Y, Bitoun JP, Ahn SJ, Burne RA, Koo H, Brady LJ, Wen ZT., J Bacteriol. 2014 Evaluation of bone healing on sandblasted and Acid etched implants coated with nanocrystalline hydroxyapatite: an in vivo study in rabbit femur.: Melin Svanborg L, Meirelles L, Franke Stenport V, Kjellin P, Currie F, Andersson M, Wennerberg A, Int J Dent. 2014 Streptococcus mutans NADH oxidase lies at the intersection of overlapping regulons controlled by oxygen and NAD+ levels: Baker JL, Derr AM, Karuppaiah K, MacGilvray ME, Kajfasz JK, Faustoferri RC, Rivera-Ramos I, Bitoun JP, Lemos JA, Wen ZT, Quivey RG Jr., J Bacteriol. 2014 Safety and efficacy of an intra-oral electrostimulator for the relief of dry mouth in patients with chronic graft versus host disease: Case Series: Zadik Y, Zeevi I, Luboshitz-Shon N, Dakwar N, Wolff A, Shapira MY, Or R, Elad S., Med Oral Patol Oral Cir Bucal. 2014 Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus: Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Lemos JA, Abranches J., Mol Oral Microbiol. 2014 Sex-dependent and non-monotonic enhancement and unmasking of methylmercury neurotoxicity by prenatal stress: Weston, H, Sobolewski,M., Allen, J., Weston, D, Conrad, K, Pelkowski, S, Watson, G., Zareba, G., Cory-Slechta, D., NeuroToxicology, 2014