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Eastman Institute for Oral Health, consistently ranking in the top ten for NIDCR dentistry funding, continues to gain international attention for breakthrough discoveries.

We work on a wide range of projects, including oral infectious diseases, salivary gland biology, craniofacial development, and community-based disease prevention. We focus on basic-science research as well as translational, clinical and community dentistry research.

We have four specific research goals as we expand our capabilities:

  • To boost our national reputation as a research institution
  • To enhance clinical and translational research
  • To better integrate basic with translational and clinical research efforts
  • To improve the overall quality and number of research-intensive faculty

Our Recent Publications

Eliav, E. (2019). Editorial: 50 years of clinically relevant, scientifically based publishing. Quintessence International (Berlin, Germany: 1985)

Kopycka-Kedzierawski, D. T., Billings, R. J., & Feng, C. (2018). Development of a prognostic model for caries onset and progression from early childhood caries incidence in urban preschool children. European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry

Watanabe, K., Noma, N., Sekine, N., Takanezawa, D., Hirota, C., Eliav, E., & Imamura, Y. (2018). Association of somatosensory dysfunction with microscope imagesymptom duration in burning mouth syndrome. Clinical Oral Investigations

Geminiani, A., Chochlidakis, K., Hosney, S., Corsentino, G., & Ercoli, C. (2018). Effect of framework design and firing cycle on the success rate of bilayered zirconia crowns. Quintessence International (Berlin, Germany : 1985)

Gilbert, G. H., Cochran, D. L., Fellows, J. L., Gordan, V. V., Makhija, S. K., Meyerowitz, C., & Rindal, D. B. (2018). Engaging clinicians in research. Journal of the American Dental Association (1939)

Irwin, J. L., Yeates, A. J., Mulhern, M. S., McSorley, E. M., Strain, J. J., Watson, G. E., . . . van Wijngaarden, E. (2018). Maternal gestational immune response and autism spectrum disorder phenotypes at 7 years of age in the seychelles child development study. Molecular Neurobiology

Kalladka, M., Navaneetham, A., Eliav, E., Khan, J., Heir, G., & Mupparapu, M. (2018). Presentation of cysticercosis of the lateral pterygoid muscle as temporomandibular disorder: A diagnostic and therapeutic challenge. Journal of Indian Prosthodontic Society

Mungia , R., Funkhouser, E., Buchberg Trejo, M. K., Cohen, R., Reyes, S. C., Cochran, D. L., . . . National Dental PBRN Collaborative Group. (2018). Practitioner participation in national dental practice-based research network (PBRN) studies: 12-year results. Journal of the American Board of Family Medicine : JABFM

Obamiyi , S., Malik, S., Wang, Z., Singh, S., Rossouw, E. P., Fishman, L., . . . Tallents, R. H. (2018). Radiographic features associated with temporomandibular joint disorders among african, white, chinese, hispanic, and indian racial groups. Nigerian Journal of Clinical Practice

Zeng, Y., Nikitkova, A., Abdelsalam, H., Li, J., & Xiao, J. (2018). Activity of quercetin and kaemferol against streptococcus mutans biofilm. Archives of Oral Biology

ALHarthi, S. S., BinShabaib, M., Akram, Z., Rahman, I., Romanos, G. E., & Javed, F. (2018). Impact of cigarette smoking and vaping on the outcome of full-mouth ultrasonic scaling among patients with gingival inflammation: A prospective study. Clinical Oral Investigations

Huang, L. S., Cory-Slechta, D. A., Cox, C., Thurston, S. W., Shamlaye, C. F., Watson, G. E., . . . Davidson, P. W. (2018). Analysis of nonlinear associations between prenatal methylmercury exposure from fish consumption and neurodevelopmental outcomes in the seychelles main cohort at 17 years. Stochastic Environmental Research and Risk Assessment : Research Journal

McSorley, E. M., Yeates, A. J., Mulhern, M. S., van Wijngaarden, E., Grzesik, K., Thurston, S. W., . . . Strain, J. J. (2018). Associations of maternal immune response with MeHg exposure at 28 weeks' gestation in the seychelles child development study. American Journal of Reproductive Immunology (New York, N.Y.: 1989) NOTE: Gene Watson is 12th author on this paper.

Minye, H. M., Gilbert, G. H., Litaker, M. S., Mugia, R., Meyerowitz, C., Louis, D. R., . . . National Dental PBRN Collaborative Group. (2018). Preparation techniques used to make single-unit crowns: Findings from the national dental practice-based research network. Journal of Prosthodontics : Official Journal of the American College of Prosthodontists

Nicolatou-Galitis, O., Kouri, M., Papadopoulou, E., Vardas, E., Galiti, D., Epstein, J. B., . . . MASCC Bone Study Group. (2018). Osteonecrosis of the jaw related to non-antiresorptive medications: A systematic review. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer NOTE: Sharon Elad is 7th author on this paper.

Planerova, A., Pulcino, T., & Saunders, R. (2018). Multidisciplinary dentistry for transitional care patients. Quintessence International (Berlin, Germany : 1985 NOTE: Eli Eliav is 9th author on this paper.

Sampaio, F. A., Sampaio, C. R. A., Cunha, C. O., Costa, Y. M., Alencar, P. N. B., Bonjardim, L. R., . . . Conti, P. C. R. (2018). The effect of orthodontic separator and short-term fixed orthodontic appliance on inflammatory mediators and somatosensory function. Journal of Oral Rehabilitation,

Zhang, S., Ye, D., Ma, L., Ren, Y., Dirksen, R. T., & Liu, X. (2018). Purinergic signaling modulates Survival/Proliferation of human dental pulp stem cells. Journal of Dental Research

 Abduljabbar, T., Al-Hamoudi, N., Al-Sowygh, Z. H., Alajmi, M., Javed, F., & Vohra, F. (2018). Comparison of peri-implant clinical and radiographic status around short (6 mm in length) dental implants placed in cigarette-smokers and never-smokers: Six-year follow-up results. Clinical Implant Dentistry and Related Research

Akram, Z., Abduljabbar, T., Hosain, M., Al-Sowygh, Z. H., Al-Hamoudi, N., Vohra, F., & Javed, F. (2018). Comparison of periodontal inflammatory parameters among habitual gutka-chewers and naswar-dippers: A split-mouth retrospective clinical study. Acta Odontologica Scandinavica

Akram, Z., Vohra, F., Bukhari, I. A., Sheikh, S. A., & Javed, F. (2018). Clinical and radiographic peri-implant parameters and proinflammatory cytokine levels among cigarette smokers, smokeless tobacco users, and nontobacco users. Clinical Implant Dentistry and Related Research

Al-Hamoudi, N., Abduljabbar, T., Mirza, S., Al-Sowygh, Z. H., Vohra, F., Javed, F., & Akram, Z. (2018). Non-surgical periodontal therapy reduces salivary adipocytokines in chronic periodontitis patients with and without obesity. Journal of Investigative and Clinical Dentistry

Caito, S. W., Jackson, B. P., Punshon, T., Scrimale, T., Grier, A., Gill, S. R., . . . Rand, M. D. (2018). Editor's highlight: Variation in methylmercury metabolism and elimination status in humans following fish consumption. Toxicological Sciences : An Official Journal of the Society of Toxicology

Cheng, C. W., Chien, C. H., Chen, C. J., & Papaspyridakos, P. (2018). Clinical results and technical complications of posterior implant-supported modified monolithic zirconia single crowns and short-span fixed dental prostheses: A 2-year pilot study. Journal of Prosthodontics : Official Journal of the American College of Prosthodontists

Heft, M. W., Litaker, M. S., Kopycka-Kedzierawski, D. T., Meyerowitz, C., Chonowski, S., Yardic, R. L., . . . National Dental PBRN Collaborative Group. (2018). Patient-centered dentinal hypersensitivity treatment outcomes: Results from the national dental PBRN. JDR Clinical and Translational Research

Herzog, C. R., Berzins, D. W., DenBesten, P., Gregory, R. L., Hargreaves, K. M., Messer, R. L. W., . . . Hu, J. C. C. (2018). Oral sciences PhD program enrollment, graduates, and placement: 1994 to 2016. Journal of Dental Research

Dr. EliavJaved, F., Akram, Z., Barillas, A. P., Kellesarian, S. V., Ahmed, H. B., Khan, J., & Almas, K. (2018). Outcome of orthodontic palatal plate therapy for orofacial dysfunction in children with down syndrome: A systematic review. Orthodontics & Craniofacial Research

Kellesarian, S. V., Javed, F., & Romanos, G. E. (2018). Osteomyelitis arising around osseointegrated dental implants: A systematic review. Implant Dentistry

Kellesarian, S. V., Malignaggi, V. R., Kellesarian, T. V., Bashir Ahmed, H., & Javed, F. (2018). Does incorporating collagen and chondroitin sulfate matrix in implant surfaces enhance osseointegration? A systematic review and meta-analysis. International Journal of Oral and Maxillofacial Surgery

Korczeniewska, O. A., Husain, S., Khan, J., Eliav, E., Soteropoulos, P., & Benoliel, R. (2018). Differential gene expression in trigeminal ganglia of male and female rats following chronic constriction of the infraorbital nerve. European Journal of Pain (London, England)

Makhija, S. K., Robinson, M. E., Bader, J. D., Shugars, D. A., Litaker, M. S., Im, H. R., . . . National Dental PBRNCollaborative Group. (2018). Dentists' decision strategies for suspicious occlusal caries lesions in a national dental PBRN study. Journal of Dentistry

Papaspyridakos, P., Kang, K., DeFuria, C., Amin, S., Kudara, Y., & Weber, H. P. (2018). Digital workflow in full-arch implant rehabilitation with segmented minimally veneered monolithic zirconia fixed dental prostheses: 2-year clinical follow-up. Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry

Yuen, H., Rossouw, P. E., Wolford, L. M., & Wang, H. (2018). Pharyngeal airway space changes after condylar replacement and mandibular advancement surgery. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons

Zhu, W. Q., Ming, P. P., Qiu, J., Shao, S. Y., Yu, Y. J., Chen, J. X., . . . Tang, C. B. (2018). Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3-E1 osteoblasts. Journal of Applied Toxicology : JAT]


Dr. Catherine OvittAbduljabbar, T., Akram, Z., Vohra, F., Warnakulasuriya, S., & Javed, F. (2017). Assessment of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha levels in the peri-implant sulcular fluid among waterpipe (narghile) smokers and never-smokers with peri-implantitis. Clinical Implant Dentistry and Related Research

Akram, Z., Javed, F., Hosein, M., Al-Qahtani, M. A., Alshehri, F., Alzahrani, A. I., & Vohra, F. (2017). Photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review. Photodermatology, Photoimmunology & Photomedicine

Akram, Z., Vohra, F., & Javed, F. (2017). Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A meta-analysis. Journal of Investigative and Clinical Dentistry

Bowen, W. H., Burne, R. A., Wu, H., & Koo, H. (2017). Oral biofilms: Pathogens, matrix, and polymicrobial interactions in microenvironments. Trends in Microbiology

Castillo Pedraza, M. C., Novais, T. F., Faustoferri, R. C., Quivey, R. G.,Jr, Terekhov, A., Hamaker, B. R., & Klein, M. I. (2017). Extracellular DNA and lipoteichoic acids interact with exopolysaccharides in the extracellular matrix of streptococcus mutans biofilms. Biofouling

bubblesCousley, R. R. J., Bainbridge, M., & Rossouw, P. E. (2017). The accuracy of maxillary positioning using digital model planning and 3D printed wafers in bimaxillary orthognathic surgery. Journal of Orthodontics]

Eliav, E. (2017). Editorial: We can do more: The role of dentists extends beyond traditional dentistry. Quintessence International (Berlin, Germany : 1985)

Free, R. D., DeRocher, K., Stock, S. R., Keane, D., Scott-Anne, K., Bowen, W. H., & Joester, D. (2017). Characterization of enamel caries lesions in rat molars using synchrotron X-ray microtomography. Journal of Synchrotron Radiation

Graham, J. W. (2017). JCO roundtable: The temporomandibular joint and craniomandibular disorders. Journal of Clinical Orthodontics

Gupta, B., Singh, S., Tallents, R. H., & Rossouw, E. (2017). Effects of bisphosphonates on orthodontic treatment and the TMJ: A systematic review. Journal of Clinical Orthodontics

Huang, X., Browngardt, C. M., Jiang, M., Ahn, S. J., Burne, R. A., & Nascimento, M. M. (2017). Diversity in antagonistic interactions between commensal oral streptococci and streptococcus mutans. Caries Research

Huang, X., Deng, M., Liu, M., Cheng, L., Exterkate, R. A. M., Li, J., . . . Ten Cate, J. M. (2017). Comparison of composition and anticaries effect of galla chinensis extracts with different isolation methods. The Open Dentistry Journal]

Javed, F., ALHarthi, S. S., BinShabaib, M. S., Gajendra, S., Romanos, G. E., & Rahman, I. (2017). Toxicological impact of waterpipe smoking and flavorings in the oral cavity and respiratory system. Inhalation Toxicology

Javed, F., Kellesarian, S. V., Abduljabbar, T., Abduljabbar, A. T., Akram, Z., Vohra, F., . . . Romanos, G. E. (2017). Influence of involuntary cigarette smoke inhalation on osseointegration: A systematic review and meta-analysis of preclinical studies. International Journal of Oral and Maxillofacial Surgery

Kellesarian, S. V., Malignaggi, V. R., de Freitas, P., Ahmed, H. B., & Javed, F. (2017). Association between prenatal maternal cigarette smoking and early childhood caries. A systematic review. Journal of Clinical and Experimental Dentistry

Dr. YanFang RenKellesarian, S. V., Qayyum, F., de Freitas, P. C., Akram, Z., & Javed, F. (2017). Is antimicrobial photodynamic therapy a useful therapeutic protocol for oral decontamination? A systematic review and meta-analysis. Photodiagnosis and Photodynamic Therapy

Kellesarian, S. V., Ros Malignaggi, V., Aldosary, K. M., & Javed, F. (2017). Laser-assisted removal of all ceramic fixed dental prostheses: A comprehensive review. Journal of Esthetic and Restorative Dentistry: Official Publication of the American Academy of Esthetic Dentistry ...[Et Al.],

Khan, J., Hassun, H., Zusman, T., Korczeniewska, O., & Eliav, E. (2017). Interleukin-8 levels in rat models of nerve damage and neuropathic pain. Neuroscience Letters

Khan, J., Noboru, N., Imamura, Y., & Eliav, E. (2017). Effect of pregabalin and diclofenac on tactile allodynia, mechanical hyperalgesia and pro inflammatory cytokine levels (IL-6, IL-1beta) induced by chronic constriction injury of the infraorbital nerve in rats. Cytokine, S1043  

Korczeniewska, O. A., Khan, J., Tao, Y., Eliav, E., & Benoliel, R. (2017). Effects of sex and stress on trigeminal neuropathic pain-like behavior in rats. Journal of Oral & Facial Pain and Headache

Kovacs, C. J., Faustoferri, R. C., & Quivey, R. G.,Jr. (2017). RgpF is required for maintenance of stress tolerance and virulence in streptococcus mutans. Journal of Bacteriology, 199(24), Print 2017

Laird, E., Thurston, S. W., van Wijngaarden, E., Shamlaye, C. F., Myers, G. J., Davidson, P. W., . . . Strain, J. J. (2017). Maternal vitamin D status and the relationship with neonatal anthropometric and childhood neurodevelopmental outcomes: Results from the seychelles child development nutrition study. Nutrients

Makhija, S. K., Shugars, D. A., Gilbert, G. H., Litaker, M. S., Bader, J. D., Schaffer, R., . . . National Dental Practice-Based Research Network Collaborative Group. (2017). Surface characteristics and lesion depth and activity of suspicious occlusal carious lesions: Findings from the national dental practice-based research network. Journal of the American Dental Association (1939)

Malcolm, D. W., Varghese, J. J., Sorrells, J. E., Ovitt, C. E., & Benoit, D. S. W. (2018). The effects of biological fluids on colloidal stability and siRNA delivery of a pH-responsive micellar nanoparticle delivery system. ACS Nano

Dr. Wei HsuMcCracken, M. S., Litaker, M. S., George, A. J., Durand, S., Malekpour, S., Marshall, D. G., . . . National Dental Practice-Based Research Network Collaborative Group. (2017). Impression evaluation and laboratory use for single-unit crowns: Findings from the national dental practice-based research network. Journal of the American Dental Association (1939)

Myers, R. B. (2017). Bio-progressive therapy. Journal of Clinical Orthodontics : JCO

Poggio, C. E., Ercoli, C., Rispoli, L., Maiorana, C., & Esposito, M. (2017). Metal-free materials for fixed prosthodontic restorations. The Cochrane Database of Systematic Reviews

Ren, Y. F. (2017). Oral and maxillofacial surgery residency training in the united states: What can we learn. Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology

Saputo, S., Faustoferri, R. C., & Quivey, R. G.,Jr. (2017). A drug repositioning approach reveals that streptococcus mutans is susceptible to a diverse range of established antimicrobials and nonantibiotics. Antimicrobial Agents and Chemotherapy, 62(1), 10.1128/AAC.01674-17. Print 2018

Saputo, S., Faustoferri, R. C., & Quivey, R. G.,Jr. (2017). Vitamin D compounds are bactericidal against streptococcus mutans and target the bacitracin-associated efflux system. Antimicrobial Agents and Chemotherapy

Vohra, F., Akram, Z., Bukhari, I. A., Sheikh, S. A., & Javed, F. (2017). Short-term effects of adjunctive antimicrobial photodynamic therapy in obese patients with chronic periodontitis: A randomized controlled clinical trial. Photodiagnosis and Photodynamic Therapy

Vohra, F., Alkhudhairy, F., Al-Kheraif, A. A., Akram, Z., & Javed, F. (2017). Peri-implant parameters and C-reactive protein levels among patients with different obesity levels. Clinical Implant Dentistry and Related Research

Vorrasi, J., Calvi, R., Lv, M., & Hammond, R. (2017). What factors necessitate removal of retained ballistic fragments in the head and neck? Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons

Vorrasi, J. S., & Kolokythas, A. (2017). Controversies in traditional oral and maxillofacial reconstruction. Oral and Maxillofacial Surgery Clinics of North America

Wiens, J. P., Koka, S., Graser, G., White, S. N., Marinello, C. P., & Curtis, D. A. (2017). Academy of prosthodontics centennial: The emergence and development of prosthodontics as a specialty. The Journal of Prosthetic Dentistry

Xiao, J., Huang, X., Alkhers, N., Alzamil, H., Alzoubi, S., Wu, T. T., . . . Koo, H. (2017). Candida albicans and early childhood caries: A systematic review and meta-analysis. Caries Research

Yeates, A. J., Thurston, S. W., Li, H., Mulhern, M. S., McSorley, E. M., Watson, G. E., . . . Broberg, K. (2017). PUFA status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the seychelles child development study. The Journal of Nutrition]

Zhao, X., Zanetti, F., Majeed, S., Pan, J., Malmstrom, H., Peitsch, M. C., . . . Ren, Y. (2017). Effects of cigarette smoking on color stability of dental resin composites. American Journal of Dentistry


Akram, Z., Safii, S. H., Vaithilingam, R. D., Baharuddin, N. A., Javed, F., & Vohra, F. (2016). Efficacy of non-surgical periodontal therapy in the management of chronic periodontitis among obese and non-obese patients: A systematic review and meta-analysis. Clinical Oral Investigations

Cross, B., Garcia, A., Faustoferri, R., & Quivey, R. G. (2016). PlsX deletion impacts fatty acid synthesis and acid adaptation in streptococcus mutans. Microbiology (Reading, England)

cell imageKalladka, M., Nasri-Heir, C., Eliav, E., Ananthan, S., Viswanath, A., & Heir, G. (2016). Continuous neuropathic pain secondary to endoscopic procedures: Report of two cases and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Rafael, B., Sorin, T., & Eli, E. (2016). Painful traumatic trigeminal neuropathy. Oral and Maxillofacial Surgery Clinics of North America

      Xiao J, Moon Y, Li L, Rustchenko E, Wakabayashi H, Zhao X, Feng C, Gill SR, McLaren S, Malmstrom H, Ren Y, Quivey R, Koo H, Kopycka-Kedzierawski DT. 2016. Candida albicans Carriage in Children with Severe Early      Childhood Caries (S-ECC) and Maternal Relatedness. PLoS One