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UR Medicine / Otolaryngology (ENT) / Research / Current Research

Current Research

Neurodevelopmental Research in Children

Am detectionOur group is currently studying the effects of temporary conductive hearing loss due to otitis media with effusion (OME) on long term listening strategies in children.  OME is one of the most common diseases of childhood, and is by far the most common cause of acquired conductive hearing loss in children.  OME occurs most frequently in early childhood, often before the age of 3 years, a time that overlaps significantly with the critical period for speech and language development.  Because the effects on hearing are often fluctuating or transient, they can be easily overlooked. Our lab tests children between the ages of 4-7 years on a variety of auditory tasks, aiming to compare typically developing children to those with a history of hearing loss during the critical period of speech and language development earlier in childhood.  Using an interactive touch-screen interface designed for children in a sound-proof booth, we can investigate whether measures such as amplitude modulation (AM) detection and tone in noise are impaired in children with a history of OME-related hearing loss, even after normal hearing is restored.  

  • UR-CTSI Pilot Studies Award: 06/01/2017 – 05/31/2018
    PI: Margo McKenna Benoit, MD
  • Multi-modal Vestibular Perception
    DHHS/PHS/NIH: 12/01/14 – 11/30/19
    PI: Benjamin T Crane, MD, PhD
  • Effects of Auditory Nerve Degeneration on Midbrain Coding and Perception in Noise
    DHHS/PHS/NIH: 07/01/16 – 06/30/19
    PI: Kenneth S Henry, PhD
  • Optimizing Bone Allograft in Craniofacial Defect Reconstruction
    American Academy of Facial Plastics: 07/01/16 – 06/30/17
    PI: Weitao Wang, MD

Recently Concluded Industry-Sponsored Clinical Trials

  • A Prospective, R, DB, PC, MC, Phase 3, S & E Study of OTO-104 Given as a Single Intratympanic Injection in Subjects with Unilateral Meniere’s Disease
    Otonomy, Inc.: 05/01/16 – 04/30/17
    PI: Benjamin T Crane, MD, PhD
  • A 6 Month, MC, Phase 3, OL Extension Safety Study of OTO-104 Given at 3 Month Intervals by Intratympanic Injection in Subjects with Unilateral Meniere’s Disease
    Otonomy, Inc.: 08/19/16 – 09/30/17
    PI: Benjamin T Crane, MD, PhD
  • Efficacy and Safety of AM-111 as Acute and Sudden Sensorineural Hearing Loss Treatment (ASSENT)
    Auris Medical, Inc.: 09/01/16 – 11/30/2017
    PI: Benjamin T Crane, MD, PhD