Paige Lawrence Awarded the Outstanding Senior Immunotoxicologist Award at SOT
Monday, April 5, 2021
Dr. B. Paige Lawrence
At this year’s Society of Toxicology meeting, Dr. B. Paige Lawrence was awarded the Outstanding Senior Immunotoxicologist Award presented by the Immunotoxicology Specialty Section (ISS). The award is given to a Senior Investigator whose work has made significant contributions to the field of Immunotoxicology. Dr. Lawrence is Professor and Chair of the Department of Environmental Medicine and Director of the Environmental Health Sciences Center. Her research addresses problems of human health and how our environment influences our health. Much of her work focuses on the impact of pollutants on our ability to fight infections, such as influenza viruses. Other work centers on understanding how signals from the environment affect proper development in early life, and how these developmental changes adversely impact health later in life.
She is a member of the Society of Toxicology, American Association of Immunologists, and American Association for the Advancement of Scientists, and currently serves on the Editorial Boards for Toxicological Sciences, Toxicology, The American Journal of Physiology - Lung Cellular and Molecular Physiology, The Journal of Toxicology and Environmental Health, and The American Journal of Reproductive Immunology and in 2020 was named one of three deputy editors of Environmental Health Perspectives. She provides peer review service to the National Institutes of Health and to other research organizations and agencies.
Ian Krout wins the People’s Choice award for SOT’s 3 Minute Thesis
Wednesday, March 24, 2021
Congratulations to Ian Krout for winning the People’s Choice award for SOT’s 3 Minute Thesis! Krout is a 3rd year Toxicology student, in Matt Rand's Lab, whose interests lie in both methylmercury toxicity as well as the gut microbiomes role in the field of toxicology. His research is focused on elucidating the microbial mechanisms of the gut that give rise to inter-individual differences in methylmercury elimination from person to person. It is focused on investigating the bacterial species at play in the microbiome, the mechanisms used for biotransformation, and what this means for the overall elimination rate and subsequent toxicity of differing mercury compounds.
Deborah Cory-Slechta Receives the 2021 SOT Distinguished Toxicology Scholar Award
Thursday, February 11, 2021
Deborah Cory-Slechta, PhD, has been awarded the 2021 SOT Distinguished Toxicology Scholar Award in honor of her scientific achievements and contributions to public health in the fields of environmental health sciences and toxicology.
Dr. Cory-Slechta is currently a Professor of environmental medicine, pediatrics, and public health sciences at the University of Rochester Medical Center, where she trains and mentors a number of scholastically recognized students via hands-on, project-oriented teaching, as well as offering support and mentorship to junior faculty members. She also is the Deputy Director of the Environmental Health Sciences Center at the University of Rochester Medical Center.
Dr. Cory-Slechta is a world-renowned behavioral psychologist and neurotoxicologist, and her work has provided mechanistic support for understanding the consequences of lead exposure in developing animals and humans. Her studies combine powerful hypothesis-generating screening tools with rigorous hypothesis-driven research questions to systematically test xenobiotic-induced neurotoxicity. Dr. Cory-Slechta has championed behavioral batteries for the assessment of neurotoxicity, developing new methodologies and asserting the importance of early changes in behavior as markers of aberrant neurodevelopment and neurotoxicity. She developed sensitive behavioral tasks to enable translation and validation of her animal work to human populations, which has significantly contributed to the recognition that levels of lead exposure previously thought of as safe are likely causing damage to children, particularly those that have additional risk factors. Dr. Cory-Slechta’s studies have led to a paradigm shift and recognition by federal agencies of the necessity to include developmental neurotoxicity studies in the assessment of ill effects of xenobiotics, particularly as they pertain to the nervous system.
Dr. Cory-Slechta’s scientific influence is demonstrated by an enormous number of invited research presentations worldwide as well as her sustained publication repertoire, which includes over 190 published manuscripts in high-impact journals. In addition, her laboratory since its establishment has received continual funding by the National Institutes of Health, a testament to her outstanding leadership and research.
Since joining SOT in 1983, Dr. Cory-Slechta has served as Chair of the SOT Awards Committee; as a member of the Education and Nominating Committees; as Councilor of the Metals Specialty Section; and as Councilor and President of the Neurotoxicology Specialty Section. Her efforts were recognized through her receipt of the 2017 Neurotoxicology Specialty Section Distinguished Neurotoxicologist Award. In addition to service to SOT, Dr. Cory-Slechta is on the Editorial Boards of Toxicology and Applied Pharmacology, Toxicology, and NeuroToxicology and is a reviewer for a multitude of study sections for the National Institutes of Health, US Environmental Protection Agency, and other granting bodies, among numerous other institutional commitments.
Congratulations, Debbie!Read More: Deborah Cory-Slechta Receives the 2021 SOT Distinguished Toxicology Scholar Award
Inhaled paraquat enters brain, impairs sense of smell in male mice
Tuesday, February 2, 2021
Researchers funded by NIEHS reported that inhalation of the widely used pesticide paraquat reduced the sense of smell in male mice for several months after exposure. Moreover, the chemical entered the brain and other tissues. These results underscore the importance of studying the effects of inhalation of neurotoxicants, to protect public health.
Loss of sense of smell, or olfactory impairment, is an early sign of Parkinson's disease. The findings, published Dec. 29, 2020, in the journal Toxicological Sciences, suggest paraquat may contribute to such neurodegenerative diseases.
Researchers at the University of Rochester modeled an inhalation of low concentrations of paraquat. Using the university's Inhalation Core facility, they exposed mice to aerosolized paraquat. The team then measured levels of the pesticide in lung, kidney, and four regions of the brain — olfactory bulb, striatum, midbrain, and cerebellum.
"Inhalation can provide a direct route of entry to the brain," explained first author Timothy Anderson. "If you inhale something and it goes into your nose, it can actually enter the neurons responsible for sense of smell, and travel into the brain." Anderson is a graduate student at the University of Rochester lab of Deborah Cory-Slechta, Ph.D.,where the study was conducted. Cory-Slechta is deputy director of the university's NIEHS-funded Environmental Health Sciences Center.
Co-author Kevin Welle measured the highest brain levels in the olfactory bulb, suggesting paraquat entered the brain through nasal-olfactory neurons.
"The sex-dependent olfactory impairment observed after paraquat [PQ] inhalation exposure is intriguing and parallels important features of Parkinson's disease [PD], including early loss of sense of smell and greater prevalence in males," said Jonathan Hollander, Ph.D.,health scientist administrator in the NIEHS Genes, Environment, and Health Branch. Hollander oversees research grants for neurodegenerative diseases and other areas.
"Given that paraquat is a known risk factor for PD, and inhalation is a prevalent source of exposure, this study may lead to a more useful animal model of PQ-induced neurodegeneration," he added.Read More: Inhaled paraquat enters brain, impairs sense of smell in male mice