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URMC / EHSC / Cores / EXPAND Core / Inhalation Exposure Facility / Facilities and Instruments

Overview of Inhalation Exposure Facility Capabilities

The Environmental Health Sciences Center’s Inhalation Exposure Facility was established to focus the combined skills of biology, chemistry, and aerosol physics that are critical for inhalation toxicology research.  The broad capabilities of the Facility include aerosol generation, exposure monitoring, and exposure characterization.  The latter two capabilities are also supported – depending on the nature of exposure – via coordination with the Elemental Analysis Facility.  There are very few inhalation exposure facilities in the world, each with a unique focus:  at Rochester, the specialty area is the toxicology of airborne ultrafine and nanoparticles.  However, the Facility was built to adapt to research needs, so tools are available to generate aerosols with larger particles, liquid-phase compounds, or gases, as well as mixtures thereof.  Below are descriptions of some of the Facility resources (these are examples, not an exhaustive list, so please consult with the Facility Director regarding specific capabilities):

Aerosol Generation

Wet-to-Dry Particle Dispersions

wet to dry photo

System used to aerosolize slurries of, e.g., Diesel particles or metal oxide nanoparticles.

Dry Particle Dispersions

dry particle photo

System used to aerosolize and de-agglomerate dry powders.

Freshly-generated Nanoscale/Ultrafine Particle Aerosols

spark discharge photo

Spark discharge system for the generation of dry metal/metal oxide and graphite aerosols.

Ambient Ultrafine Particle Concentrator

ultrafine photo

Harvard Ultrafine Concentrated Ambient Particles (HUCAPS) system.

Exposure Monitoring

Particle Count-Based Measurements

particle count photo

Particle concentration and size distribution in the number regime.

Particle Mass-Based Measurements

particle mass photo

Particle (concentration and) size distribution in the mass regime.