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Lupus mouse kidney glomerulus (yellow) with tubules (white)

Barnas Lab

Type III Interferon in Autoimmune Disease

Type I interferon production from nucleic acid-sensing pathways drives systemic lupus erythematosus pathogenesis according to current dogma. However, type III interferons (IFN-λ) can stimulate a similar gene expression profile utilizing a unique receptor. IFN-λ is detected in the blood, kidneys, and skin of lupus patients. The contribution of IFN-λ to lupus and lupus nephritis pathogenesis is currently unknown. The objective of this project is to identify which innate interferon pathways are dominant in the human renal microenvironment of lupus nephritis.

Immunohistochemistry and laser microdissection of patient renal biopsies will be used to assess in situ protein and RNA expression of innate interferons and their gene signatures. One working hypothesis is that nucleic acid sensors, IFN-α, and IFN-λ stimulate innate interferon production in human renal tubule epithelial cells to promote lupus pathogenesis.

Long-term goals include establishing the functional role of IFN-λ in lupus and the renal microenvironment including its contribution to renal fibrosis and end-stage kidney disease. Understanding how innate interferon pathways interconnect will allow for their therapeutic calibration for improved lupus patient outcome as well as in other autoimmune and viral diseases.

Publications

Barnas JL, Albrecht J, Meednu N, Alzamareh DF, Baker C, McDavid A, Looney RJ, Anolik JHB Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-λ in Systemic Lupus Erythematosus. Journal of immunology (Baltimore, Md. : 1950). 2021 Oct 27. 

Barnas JL, Looney RJ, Anolik JHB cell targeted therapies in autoimmune disease. Current opinion in immunology; Vol 61. 2019 Dec.

Dieudonné Y, Gies V, Guffroy A, Keime C, Bird AK, Liesveld J,Barnas JL, Poindron V, Douiri N, Soulas-Sprauel P, Martin T, Meffre E. Anolik JH, Korganow AS. Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN. Journal of autoimmunity; Vol 102. 2019 Aug.

Gao L. Slack M, Barnas JL, McDavid A, Anolik J, Looney RJ. Cell Senescence in Lupus. Current rheumatology reports; Vol 21(2). 2019 Jan 14.

Barnas JL and Ritchlin CT. Etiology and Pathogenesis of Psoriatic Arthritis. Rheum Dis Clin North Am. 2015 Nov; 41(4):643-63.

View Publications

Contact Us

  Barnas Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642