Arrayed Imaging Reflectometry
An AIR microarray image showing detection of proteins
in human serumimage.
Simple methods for detecting and quantifying proteins in a multiplex (many proteins at once) fashion would potentially have considerable utility in the construction of point-of-care diagnostic devices, as well as tools for basic studies in biology and medicine. One technique under study by our group is Arrayed Imaging Reflectometry, a method whereby an antireflective coating (
a in the image below) on a silicon chip is perturbed by protein binding (
b in the image below) resulting in reflected light that's proportional to the amount of protein bound. The image shows an example microarray of proteins detected in human serum; we’re currently working on applying the technology to several disease areas including cancer, immunology, and wound healing.
Schematic of Arrayed Imaging Reflectometry.
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