URochester Medicine / Labs / Earley Lab / Publications

Recent Publications

1. Zhu W
2. Sanchez-Solano A
3. Lavanderos B
4. Pan S
5. Feng Earley Y
6. Earley S
TRPM4 Couples Mechanical Force to Myogenic Constriction Throughout the Resistance Vasculature.; bioRxiv : the preprint server for biology. 2026 Jun 11.
1. McCarthy CG
2. Aalkjær C
3. Bagher P
4. Beyer AM
5. Boedtkjer E
6. Bomfim GF
7. Breslin JW
8. Briones AM
9. Castorena-Gonzalez JA
10. Costa TJ
11. Dai Z
12. Davel AP
13. Earley S
14. Freed JK
15. Garland C
16. Isakson BE
17. Jepps TA
18. Kalucka J
19. Lavanderos B
20. Makino A
21. Norton CE
22. Segal SS
23. Tan W
24. Trask AJ
25. Wilson C
26. Zawieja SD
27. Wenceslau CF
Guidelines for evaluating endothelial function in vascular tissue.; American journal of physiology. Heart and circulatory physiology; Vol 330(5), pp. H1600-H1672. 2026 Mar 09.
1. Santana LF
2. Earley S
Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model.; The Journal of physiology. 2026 Jan 29.
1. Davis MJ
2. Kim HJ
3. Li M
4. Castorena-Gonzalez JA
5. Pal S
6. Domeier TL
7. Scallan JP
8. Earley S
9. Zawieja SD
Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels.; bioRxiv : the preprint server for biology. 2025 Oct 07.
1. Earley S
Pericytes under pressure: TRPC3 channels as gatekeepers of capillary flow.; Science signaling; Vol 18(884), pp. eadw7185. 2025 Apr 29.
1. Navedo MF
2. Earley S
3. Isakson BE
Understanding Vascular Reactivity.; Microcirculation (New York, N.Y. : 1994); Vol 32(3), pp. e70008. 2025 Apr.
1. Zhang X
2. Shi J
3. Thakore P
4. Gonzales AL
5. Earley S
6. Chen Q
7. Zhou T
8. Feng Earley Y
Mitochondrial Small RNA Alterations Associated with Increased Lysosome Activity in an Alzheimer's Disease Mouse Model Uncovered by PANDORA-seq.; International journal of molecular sciences; Vol 26(7). 2025 Mar 26.
1. Solano AS
2. Lavanderos B
3. Metwally E
4. Earley S
Transient Receptor Potential Channels in Vascular Mechanotransduction.; American journal of hypertension; Vol 38(3), pp. 151-160. 2025 Feb 18.
1. Lavanderos B
2. Saldias MP
3. Earley S
Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries.; Cell calcium; Vol 126, pp. 103001. 2025 Feb 01.
1. Metwally E
2. Sanchez Solano A
3. Lavanderos B
4. Yamasaki E
5. Thakore P
6. McClenaghan C
7. Rios N
8. Radi R
9. Feng Earley Y
10. Nichols CG
11. Earley S
Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome.; JCI insight; Vol 9(17). 2024 Aug 01.
1. Yamasaki E
2. Thakore P
3. Ali S
4. Sanchez Solano A
5. Wang X
6. Gao X
7. Labelle-Dumais C
8. Chaumeil MM
9. Gould DB
10. Earley S
Impaired intracellular Ca2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice.; Science signaling; Vol 16(811), pp. eadi3966. 2023 Nov 14.
1. Akin EJ
2. Aoun J
3. Jimenez C
4. Mayne K
5. Baeck J
6. Young MD
7. Sullivan B
8. Sanders KM
9. Ward SM
10. Bulley S
11. Jaggar JH
12. Earley S
13. Greenwood IA
14. Leblanc N
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle.; The Journal of general physiology; Vol 155(11). 2023 Sep 13.
1. Thakore P
2. Yamasaki E
3. Ali S
4. Sanchez Solano A
5. Labelle-Dumais C
6. Gao X
7. Chaumeil MM
8. Gould DB
9. Earley S
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(35), pp. e2306479120. 2023 Aug 22.
1. Thakore P
2. Yamasaki E
3. Ali S
4. Solano AS
5. Labelle-Dumais C
6. Gao X
7. Chaumeil MM
8. Gould DB
9. Earley S
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease.; bioRxiv : the preprint server for biology. 2023 Mar 06.
1. Sullivan MN
2. Thakore P
3. Krishnan V
4. Alphonsa S
5. Li W
6. Feng Earley Y
7. Earley S
Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.; Frontiers in molecular biosciences; Vol 10, pp. 1129435. 2023 Jan 30.
1. Yamasaki E
2. Ali S
3. Sanchez Solano A
4. Thakore P
5. Smith M
6. Wang X
7. Labelle-Dumais C
8. Gould DB
9. Earley S
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(5), pp. e2217327120. 2023 Jan 24.
1. Davis MJ
2. Earley S
3. Li YS
4. Chien S
Vascular mechanotransduction.; Physiological reviews; Vol 103(2), pp. 1247-1421. 2023 Jan 05.
1. Thakore P
2. Earley S
STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma.; Cell calcium; Vol 104, pp. 102589. 2022 Apr 09.
1. Wenceslau CF
2. McCarthy CG
3. Earley S
4. England SK
5. Filosa JA
6. Goulopoulou S
7. Gutterman DD
8. Isakson BE
9. Kanagy NL
10. Martinez-Lemus LA
11. Sonkusare SK
12. Thakore P
13. Trask AJ
14. Watts SW
15. Webb RC
Reply to De Mey et al.; American journal of physiology. Heart and circulatory physiology; Vol 322(4), pp. H683-H684. 2022 Apr 01.
1. Wenceslau CF
2. McCarthy CG
3. Earley S
4. England SK
5. Filosa JA
6. Goulopoulou S
7. Gutterman DD
8. Isakson BE
9. Kanagy NL
10. Martinez-Lemus LA
11. Sonkusare SK
12. Thakore P
13. Trask AJ
14. Watts SW
15. Webb RC
Reply to Boedtkjer and Aalkjaer.; American journal of physiology. Heart and circulatory physiology; Vol 322(4), pp. H687-H688. 2022 Apr 01.
1. Krishnan V
2. Ali S
3. Gonzales AL
4. Thakore P
5. Griffin CS
6. Yamasaki E
7. Alvarado MG
8. Johnson MT
9. Trebak M
10. Earley S
STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells.; eLife; Vol 11. 2022 Feb 11.
1. Earley S
2. Santana LF
3. Lederer WJ
The physiological sensor channels TRP and piezo: Nobel Prize in Physiology or Medicine 2021.; Physiological reviews; Vol 102(2), pp. 1153-1158. 2022 Feb 07.
1. Ali S
2. Solano AS
3. Gonzales AL
4. Thakore P
5. Krishnan V
6. Yamasaki E
7. Earley S
Nitric Oxide Signals Through IRAG to Inhibit TRPM4 Channels and Dilate Cerebral Arteries.; Function (Oxford, England); Vol 2(6), pp. zqab051. 2021 Oct 09.
1. Earley S
2. Lederer WJ
Metabolic Control of Cardiac Pacemaking.; Function (Oxford, England); Vol 2(5), pp. zqab043. 2021 Aug 23.
1. Earley S
2. Kleinfeld D
PIP2 as the "coin of the realm" for neurovascular coupling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 118(21). 2021 May 25.
1. Wenceslau CF
2. McCarthy CG
3. Earley S
4. England SK
5. Filosa JA
6. Goulopoulou S
7. Gutterman DD
8. Isakson BE
9. Kanagy NL
10. Martinez-Lemus LA
11. Sonkusare SK
12. Thakore P
13. Trask AJ
14. Watts SW
15. Webb RC
Guidelines for the measurement of vascular function and structure in isolated arteries and veins.; American journal of physiology. Heart and circulatory physiology; Vol 321(1), pp. H77-H111. 2021 May 14.
1. Alvarado MG
2. Thakore P
3. Earley S
Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function.; Cells; Vol 10(5). 2021 May 11.
1. Thakore P
2. Alvarado MG
3. Ali S
4. Mughal A
5. Pires PW
6. Yamasaki E
7. Pritchard HA
8. Isakson BE
9. Tran CHT
10. Earley S
Brain endothelial cell TRPA1 channels initiate neurovascular coupling.; eLife; Vol 10. 2021 Feb 26.
1. Griffin CS
2. Alvarado MG
3. Yamasaki E
4. Drumm BT
5. Krishnan V
6. Ali S
7. Nagle EM
8. Sanders KM
9. Earley S
The intracellular Ca2+ release channel TRPML1 regulates lower urinary tract smooth muscle contractility.; Proceedings of the National Academy of Sciences of the United States of America; Vol 117(48), pp. 30775-30786. 2020 Nov 16.
1. Thakore P
2. Pritchard HAT
3. Griffin CS
4. Yamasaki E
5. Drumm BT
6. Lane C
7. Sanders KM
8. Feng Earley Y
9. Earley S
TRPML1 channels initiate Ca2+ sparks in vascular smooth muscle cells.; Science signaling; Vol 13(637). 2020 Jun 23.
1. Thakore P
2. Ali S
3. Earley S
Regulation of vascular tone by transient receptor potential ankyrin 1 channels.; Current topics in membranes; Vol 85, pp. 119-150. 2020 Feb 29.
1. Yamasaki E
2. Thakore P
3. Krishnan V
4. Earley S
Differential expression of angiotensin II type 1 receptor subtypes within the cerebral microvasculature.; American journal of physiology. Heart and circulatory physiology; Vol 318(2), pp. H461-H469. 2019 Dec 30.
1. Pritchard HAT
2. Griffin CS
3. Yamasaki E
4. Thakore P
5. Lane C
6. Greenstein AS
7. Earley S
Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility.; Proceedings of the National Academy of Sciences of the United States of America; Vol 116(43), pp. 21874-21881. 2019 Oct 07.
1. Thakore P
2. Earley S
Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling.; Comprehensive Physiology; Vol 9(3), pp. 1249-1277. 2019 Jun 12.
1. Pires PW
2. Earley S
Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke.; eLife; Vol 7. 2018 Sep 21.
1. Pritchard HAT
2. Pires PW
3. Yamasaki E
4. Thakore P
5. Earley S
Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy.; Proceedings of the National Academy of Sciences of the United States of America; Vol 115(41), pp. E9745-E9752. 2018 Sep 04.
1. Zheng H
2. Drumm BT
3. Earley S
4. Sung TS
5. Koh SD
6. Sanders KM
SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract.; Science signaling; Vol 11(534). 2018 Jun 12.
1. Peng H
2. Jensen DD
3. Li W
4. Sullivan MN
5. Buller SA
6. Worker CJ
7. Cooper SG
8. Zheng S
9. Earley S
10. Sigmund CD
11. Feng Y
Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system.; American journal of physiology. Heart and circulatory physiology; Vol 314(3), pp. H580-H592. 2017 Dec 15.
1. Pritchard HAT
2. Gonzales AL
3. Pires PW
4. Drumm BT
5. Ko EA
6. Sanders KM
7. Hennig GW
8. Earley S
Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility.; Science signaling; Vol 10(497). 2017 Sep 19.
1. Pires PW
2. Ko EA
3. Pritchard HAT
4. Rudokas M
5. Yamasaki E
6. Earley S
The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells.; The Journal of physiology; Vol 595(14), pp. 4735-4753. 2017 Jun 01.
1. Pires PW
2. Earley S
Redox regulation of transient receptor potential channels in the endothelium.; Microcirculation (New York, N.Y. : 1994); Vol 24(3). 2017 Apr.
1. Pires PW
2. Dabertrand F
3. Earley S
Isolation and Cannulation of Cerebral Parenchymal Arterioles.; Journal of visualized experiments : JoVE. 2016 May 23.
1. Pires PW
2. Earley S
No Static at All: Tuning Into the Complexities of Ca2+ Signaling in the Endothelium.; Circulation research; Vol 118(7), pp. 1042-4. 2016 Apr 01.
1. Pires PW
2. Earley S
A TRPC3 signalling complex promotes cerebral artery remodelling during hypertension.; Cardiovascular research; Vol 109(1), pp. 4-5. 2015 Nov 27.
1. Pires PW
2. Sullivan MN
3. Pritchard HA
4. Robinson JJ
5. Earley S
Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles.; American journal of physiology. Heart and circulatory physiology; Vol 309(12), pp. H2031-41. 2015 Oct 09.
1. Earley S
2. Brayden JE
Transient receptor potential channels in the vasculature.; Physiological reviews; Vol 95(2), pp. 645-90. 2015 Apr.
1. Sullivan MN
2. Gonzales AL
3. Pires PW
4. Bruhl A
5. Leo MD
6. Li W
7. Oulidi A
8. Boop FA
9. Feng Y
10. Jaggar JH
11. Welsh DG
12. Earley S
Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation.; Science signaling; Vol 8(358), pp. ra2. 2015 Jan 06.
1. Streifel KM
2. Gonzales AL
3. De Miranda B
4. Mouneimne R
5. Earley S
6. Tjalkens R
Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes.; PloS one; Vol 9(11), pp. e110996. 2014 Nov 03.
1. Pires PW
2. Earley S
TRPs in the kidney - location, location, location.; Acta physiologica (Oxford, England); Vol 213(2), pp. 296-7. 2014 Oct 18.
1. Harraz OF
2. Abd El-Rahman RR
3. Bigdely-Shamloo K
4. Wilson SM
5. Brett SE
6. Romero M
7. Gonzales AL
8. Earley S
9. Vigmond EJ
10. Nygren A
11. Menon BK
12. Mufti RE
13. Watson T
14. Starreveld Y
15. Furstenhaupt T
16. Muellerleile PR
17. Kurjiaka DT
18. Kyle BD
19. Braun AP
20. Welsh DG
Ca(V)3.2 channels and the induction of negative feedback in cerebral arteries.; Circulation research; Vol 115(7), pp. 650-61. 2014 Aug 01.