Skip to main content

Coronavirus (COVID-19): Latest Updates | Visitation PoliciesVisitation PoliciesVisitation PoliciesVisitation PoliciesVisitation Policies | COVID-19 Testing | Vaccine InformationVaccine InformationVaccine Information

menu

Goldman Lab

URMC / Labs / Goldman Lab / Patents

 

Patents

(Primarily American filings listed; most also filed in Canada and Europe; Asian filings selective)

Issued US Patents

31 issued in US; 20 pending published applications in prosecution; list does not include >100 corresponding international patents)

Method for Separating Cells
US Patent No. 6,245,564; filed 1/23/97; issued 6/12/01
Inventors: Steven Goldman and Hong Wu; Owner: Cornell Research Foundation, Inc.

Method for Separating Cells
US Patent No. 6,692,957; filed 4/17/01; issued 2/17/04
Inventors: Steven Goldman and Hong Wu; Owner: Cornell Research Foundation, Inc.

Discovery, Localization, Harvest and Propagation of an FGF2 and BDNF-Responsive Population of Neural and Neuronal Progenitor Cells in the Adult Human Forebrain
US Patent No. 6,812,027; filed 3/18/99; issued 11/2/04
Inventors: Steven Goldman and Maiken Nedergaard; Owner: Cornell Research Foundation, Inc.

Method of Inducing Neuronal production in the Brain and Spinal Cord
US Patent No. 7,037,493; filed 5/1/01; issued 5/2/06
Inventors: Steven Goldman and Abdellatif Benraiss; Owner: Cornell Research Foundation, Inc.

Telomerase-Immortalized Neural Progenitor Cells
US Patent No. 7,150,989; filed 8/9/02; issued 12/19/06
Inventors: Steven Goldman and Neeta Roy; Owner: Cornell Research Foundation, Inc.

Enriched Preparation of Human Fetal Multipotential Neural Stem Cells
US Patent No. ; filed 12/22/2000; issued 12/23/08
Inventors: Steven A. Goldman and Hideyuki Okano; Owner: Cornell Research Foundation, Inc.

Non-Human Animals with Human-Glial Chimeric Brains
US Patent No. 7,524,491; filed 1/16/08, issued 4/28/09
Inventors: Steven Goldman and Martha S. Windrem; Owner: University of Rochester

Enhancing Neurotrophin-Induced Neurogenesis by Endogenous Neural Progenitor Cells by Concurrent Overexpression of BDNF and an Inhibitor of a Pro-Gliogenic Bone Morphogenetic Protein
US Patent No. 7,576,065; filed 2/14/03; issued 8/18/09
Inventors: Steven Goldman, Eva Chmielnicki and Aris Economides; Owner: Cornell Research Foundation, Inc.

Neuronal Progenitor Cells from Hippocampal Tissue and a Method for Isolating and Purifying Them
US Patent No. 7,785,882; filed 1/18/01, issued 8/31/10
Inventor: Steven Goldman; Owner: Cornell Research Foundation, Inc. 

Method of Inducing Neuronal Production in the Caudate Nucleus and Putamen
US Patent No. 7,803,752; filed 4/3/06; issued 9/28/10
Inventors: Steven Goldman and Abdellatif Benraiss; Owner: Cornell Research Foundation, Inc. 

Method of Inducing Neuronal Production in the Brain and Spinal Cord
US Patent No. 7,807,145; filed 4/3/06; issued 10/5/10
Inventors: Steven Goldman and Abdellatif Benraiss; Owner: Cornell Research Foundation, Inc. 

Purines are Self-Renewing signals for Neural Stem cells, and Purine Receptor Antagonists Promote Neuronal and Glial Differentiation Therefrom
US Patent No.; filed 2/10/05; issued 11/9/2010
Inventors: Steven A. Goldman, Maiken Nedergaard, Jane Lin; Owner: Cornell Research Foundation, Inc.

Purine Receptor Inhibition as a Therapeutic Strategy in Spinal Cord and Brain
US Patent No. 7,923,448; filed 11/2/04; issued 4/12/11
Inventors: Steven Goldman and Maiken Nedergaard; Owner: Cornell Research Foundation, Inc. 

Myelination of Congenitally Dysmyelinated Forebrains using Oligodendrocyte Progenitor Cells
US Patent No. 8,206,699; filed 4/29/08; issued 6/26/12
Inventors: Steven Goldman, Neeta Roy and Martha Windrem; Owner: Cornell Research Foundation, Inc. 

Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
A divisional of U.S.  Patent 8,206,699, issued 6/26/12
U.S. Patent 9,371,513, issued June 21, 2016
Inventors: Steven Goldman, Neeta Roy and Martha Windrem; Owner: University of Rochester 

Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
A divisional of U.S.  Patent 9,371,513, issued June 21, 2016
U.S. Patent no. 10,190,095, issued 1/29/19
Inventors: Steven Goldman, Neeta Roy and Martha Windrem; Owner: University of Rochester 

Method for Isolating and Purifying Oligodendrocytes and Oligodendrocyte Progenitor Cells
U.S. Patent No. 8,263,402; filed 3/31/99; issued 9/11/12
Inventors: Steven Goldman and Su Wang; Owner: Cornell Research Foundation, Inc.

Enriched or Purified Population of Motor Neurons and its Preparation from a Population of Embryonic Stem Cells
U.S. Patent No. 8,263,406; filed 6/10/04; issue date 9/11/2012
Inventors: Steven Goldman, Takahiro Nakano, Neeta Roy; Owner: Cornell Research Foundation, Inc.

Regulatory Sequences that Direct Gene Expression to Spinal Motor Neurons and Uses Thereof
U.S. Patent No. 8,524,499; filed 11/9/04; issued 9/3/13
Inventors: Steven Goldman and Takahiro Nakano; Owner: Cornell Research Foundation, Inc.

Identification and Isolation of Multipotential Neural Progenitor Cells from the Subcortical White Matter of the Adult Human Brain
Patent No. 8,642,332; filed 3/4/04; issued 2/4/14
Inventors: Steven Goldman and Neeta Roy; Owner: Cornell Research Foundation, Inc.

Modulating the Production of Neurons and/or Oligodendrocytes from White Matter Progenitor Cells
U.S. Patent No. 8,945,921; filed 2/10/09; issued 2/3/2015
Inventors: Steven Goldman and Fraser Sim; Owner: Cornell Research Foundation, Inc.

Modulating the Production of Neurons and/or Oligodendrocytes from White Matter Progenitor Cells
U.S. Patent No. 10,485,807; a divisional of 8,945,921; issued 11/26/2019
Inventors: Steven Goldman and Fraser Sim 

Treating Myelin Diseases with Optimized Cell Preparations
U.S. Patent No. 9,709,553; filed 5/7/09; issued 7/18/2017
Inventors: Steven Goldman and Sim Fraser; Owner: University of Rochester 

Treating Myelin Diseases with Optimized Cell Preparations
U.S. Patent No. 11,344,582; a divisional of 9,709,553; filed 2/10/17; issued 5/31/2022
Inventors: Steven Goldman and Sim Fraser; Owner: University of Rochester

Non-Human Mammalian Model of a Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorders
U.S. Patent No. 9,724,432, issued 8/8/2017
Inventor: Steven Goldman; Owner: University of Rochester

Non-Human Mammalian Model of a Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorders
U.S. Patent No. 10,279,051 B2 (a divisional of 9,724,432, focusing on frontotemporal dementia); issued 5/7/2019
Inventor: Steven Goldman; Owner: University of Rochester 

Non-Human Mammalian Model of a Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorder
U.S. Patent No. 11,596,700 (a divisional of 9,724,432, focusing on broader indications); issued 3/7/2023
Inventor: Steven Goldman; Owner: University of Rochester

Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for the Treatment of Myelin Disorders
U.S. Patent No.: 10,450,546, issued 10/22/19
Inventors: Steven Goldman and Su Wang 

Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for Treatment of Myelin Disorders
U.S. Patent No. 10,626,369, issued 4/21/20 (a divisional of U.S. Patent No.: 10,450,546)
Inventors: Steven Goldman and Su Wang

A Human Glial Chimeric Model for Drug Candidate Assessment in Human Gliotrophic Viral Infections and Progressive Multifocal Encephalopathy (divisional filing)
US Patent No. 10,779,519, filed 5/12/15; issued 9/22/20
Inventors: Steven Goldman, Leonid Gorelick, Yoichi Kondo, and Martha Windrem; Owner: University of Rochester 

Methods of Treating Neuropsychiatric Disorders
U.S. Patent 11,690,876, filed 5/10/17; issued 7/4/23
Patent Cooperation Treaty PCT serial no.: US2018/031961, filed 5/10/2018
Inventors: Steven Goldman and Maiken Nedergaard; Owner: University of Rochester

Pending US Patent Applications

(All have corresponding PCTs and international filings)

Human iPS Cell-derived Glial Progenitor Cells for the Patient-Specific Treatment of Myelin Disorders
U.S. Application no. 61/761,584; filed 2/6/2013
U.S. Application no. 61/780,265; filed 3/13/2013 (allowed, issuance pending)
Patent Cooperation Treaty PCT serial no. PCT/US2014/015019, filed 2/6/14
Inventors: Steven Goldman; Owner: University of Rochester

Use of Thrombin and PAR1 Inhibitors for the Treatment of Glioma
U.S. Application no. 15/425,562, filed 2/6/17
A continuation of U.S. Application no. 14/776,961, filed 3/14/14
Inventors: Steven Goldman, Romane Auvergne; Owner: University of Rochester 

Methods of Treating Schizophrenia and Other Neuropsychiatric Disorders
Patent Cooperation Treaty Serial no.  PCT/US2019/037754, filed: 6/18/2019
Inventor: Steven Goldman; Owner: University of Rochester

Methods of Treating or Inhibiting Onset of Huntington's Disease
U.S. Application no. 62/688,174, filed 6/21/18
Patent Cooperation Treaty Serial no. PCT/US2019/037987, filed 6/19/2019
Inventor: Steven Goldman; Owner: University of Rochester

Cell type-specific immunoprotected cell lines
U.S. Application no. 62/875,883, filed 7/18/19
Patent Cooperation Treaty Serial no. PCT/US2020/042768, filed: 7/20/20
Inventors: Steven Goldman and Abdellatif Benraiss; Owner: University of Rochester

Identification of transplanted human glial cells (by PET)
U.S. Application no. 63/012,709, filed: 4/20/20
Patent Cooperation Treaty Serial no. PCT/US2021/028206, filed 4/20/21
Inventors: Steven Goldman, Gitte Moos Knudsen and Abdellatif Benraiss
Owners: University of Rochester and University of Copenhagen

GPR17 Promoter-Based Targeting and Transduction of Glial Progenitor Cells
U.S. Application no. 63/305,558, filed 2/1/22
Patent Cooperation Treaty Serial no. PCT/US2023/061751, filed 2/1/23
Inventors: Steven Goldman, John Mariani and Abdellatif Benraiss; Owner: University of Rochester

A Dual Macroglial-Microglial Approach Towards Therapeutic Cell Replacement in Neurodegenerative and Neuropsychiatric Disease
U.S. Application no. 63/338,698, filed 5/5/22
Patent Cooperation Treaty Serial no. pending
Inventors: Steven Goldman and Steve Schanz; Owner: University of Rochester

MicroRNA-Medicated Methods for Rejuvenating CNS Glial Populations
U.S. Application no. 17/968,984, filed 10/19/22 (as a conversion of U.S. Application no. 63/350,039, filed 6/8/22)
Patent Cooperation Treaty Serial no. PCT/US2022/047085, filed 10/19/22
Inventors: Steven Goldman and John Mariani; Owner: University of Rochester

Humanized Chimeras for the Prospective Assessment of Cell Addition and Replacement Therapies
U.S. Application no. 63/380,093, filed 10/20/21
Patent Cooperation Treaty Serial no. PCT/US2022/077825, filed 10/8/22
Inventors: Ricardo Vieira and Steven Goldman; Owner: University of Rochester and the University of Copenhagen

Gene Networks that Mediate Remyelination of the Human Brain
U.S. Application no. 62/805,202, filed 2/13/19
Patent Cooperation Treaty Serial no. PCT/US2020/017737, filed 2/11/20
Inventors: Steven Goldman and John Mariani; Owner: University of Rochester

Methods Of Generating A Population Of Neurons From Human Glial Progenitor Cells And Genetic Constructs For Carrying Out Such Methods
U.S. Application no. 63/305,570, filed 2/1/22
Patent Cooperation Treaty Serial no. PCT/US2023/061756, filed February 1, 2023
Inventors: Steven Goldman and Abdellatif Benraiss
Owner: University of Rochester

Competitive Replacement of Glial Cells
U.S. Application no. 63/482,862, filed 2/2/23
Inventors: Nguyen Huynh, John Mariani and Steven Goldman; Owner: University of Rochester

Competitive Replacement of Glial Cells
U.S. Application no. 63/493,451, filed 3/31/23 (distinct from U.S. Application no. 63/482,862)
Inventors: Nguyen Huynh, John Mariani and Steven Goldman; Owner: University of Rochester

Methods and Compositions for Rejuvenating CNS Glial Populations with BCL11A Transcription Factor Expression
U.S. Application no. 63/380,093, filed 10/19/22
Inventors: Steven Goldman, Abdellatif Benraiss, John Mariani and Benjamin Mansky
Owner: University of Rochester

Improvement of Glymphatic Delivery by Manipulating Plasma Osmolarity
U.S. Application no. 17/699,953, filed 3/21/22
Patent Cooperation Treaty Serial no. pending
Inventors: Maiken Nedergaard, Steven Goldman; Owner: University of Rochester

Compositions and Methods for Delivery of Agents to Inner Ear
U.S. Application no. 63/293,210, filed 12/23/21
Patent Cooperation Treaty Serial no. PCT/US2022/082226, filed 12/22/22
Inventors: Maiken Nedergaard, Steven Goldman; Owner: University of Rochester

Treatment of Age-Related White Matter Loss
U.S. Application no. 63/257,767, filed 10/20/21
Patent Cooperation Treaty Serial no. PCT/US2022/078344
Inventors: Ricardo Vieira and Steven Goldman; Owner: University of Rochester and University of Copenhagen

TCF7L2 Mediated Remyelination in the Brain
U.S. Application no. 63/378,092, filed 10/3/22 (a conversion of U.S. Application no. 63/274,763, filed 11/2/21)
Patent Cooperation Treaty Serial no. PCT/US2022/079028, filed 11/1/22
Inventors: Steven Goldman, Abdellatif Benraiss, John Mariani; Owner: University of Rochester

Treatment with Genetically Modified Cells, and Genetically Modified Cells Per Se, with Increased Competitive Advantage and/or Decreased Competitive Disadvantage
U.S. Application no. 63/257,853, filed 10/20/21
Patent Cooperation Treaty Serial no. PCT/US2022/078181, filed 10/16/22
Inventors: Steven Goldman, John Mariani; Owner: University of Rochester

Incomplete list of current domestic and foreign filings; also does not include pre-PCT US filings or foreign patents issued.

Broadly Issued European Patents

Non-Human Animals with Human-Glial Chimeric Brains
European Patent Office, patent no. 2,114,167, issued 7/11/18
Inventors: Steven Goldman and Martha S. Windrem; Owner: University of Rochester
Has separately issued in the UK, Denmark, Finland, France, Germany, the Netherlands, Sweden, Switzerland and Lichtenstein. All on 7/11/18.

Treating Myelin Diseases with Optimized Cell Preparations
European Patent Office, patent no. 2,283,116, issued 9/28/16
Inventors: Steven Goldman and Sim Fraser; Owner: University of Rochester
Has separately issued in France, Germany, the UK, Canada, and Korea. All on 9/28/16

Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
European Patent Office, patent no. 1,480,521, issued 2/25/15
Inventors: Steven Goldman, Neeta Roy and Martha Windrem; Owner: University of Rochester
Has separately issued in the UK as GB1480521 on 2/25/15; and Germany DE1480521, issued 10/21/15

Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
European Patent Office, patent no. 2,532,241, issued 5/11/16
Inventors: Steven Goldman, Neeta Roy and Martha Windrem; Owner: University of Rochester

Has also issued as Canada 2,476,376 on 10/21/14; and as United Kingdom GB2532241, Germany DE2532241, and France FR2532241, all issued 5/11/16

Incomplete list; individual national approvals for other issued US patents in Israel and Asia (Japan, China, Hong Kong, Korea) not listed