URochester Medicine / Labs / Goldman Lab / Publications

Recent Publications from the Goldman Lab

1. Boesen HC
2. Du T
3. Goldman SA
4. Nedergaard M
Glymphatic dysfunction: a unifying hypothesis for delirium.; Nature reviews. Neurology. 2026 Mar 30.
1. Kabbe M
2. Agirre E
3. Carlström KE
4. Dumral Ö
5. Lor YK
6. Pohl FB
7. Ruffin N
8. van Bruggen D
9. Meijer M
10. Seeker LA
11. Bestard-Cuche N
12. Lederer AR
13. Zhang J
14. Ahola V
15. Goldman SA
16. Edström E
17. Arvidsson L
18. Moreira TH
19. Bartosovic M
20. Jagodic M
21. Williams A
22. Castelo-Branco G
Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs.; Nature neuroscience. 2026 Mar 19.
1. Jiang Y
2. Ahn R
3. Huang A
4. Gonzalez PP
5. Kim J
6. Zhang G
7. Liu Z
8. He Z
9. Dudley L
10. Patel KS
11. Dzhivhuho GA
12. Crowl S
13. Przanowski P
14. Camacho LQ
15. Hao S
16. Zeng J
17. Hippenmeyer S
18. Fallahi-Sichani M
19. Janes KA
20. Naegle KM
21. Hammarskjold ML
22. Goldman SA
23. Kornblum HI
24. Yao M
25. White F
26. Zong H
Critical role of cell competition in gliomagenesis.; bioRxiv : the preprint server for biology. 2026 Jan 16.
1. Jin M
2. Ma Z
3. Zhang H
4. Dang R
5. Papetti AV
6. Stillitano AC
7. Zou L
8. Goldman SA
9. Jiang P
Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions.; Cell reports; Vol 45(1), pp. 116794. 2026 Jan 06.
1. Kipnis J
2. Benveniste H
3. Eichmann A
4. Thomas JL
5. Reich DS
6. Lewis LD
7. Tsai LH
8. Drieu A
9. Bakker ENTP
10. Kelley DH
11. Lundgaard I
12. Mestre H
13. Zott B
14. Eide PK
15. van Osch MJP
16. van Veluw SJ
17. Iliff J
18. Yang AC
19. Santambrogio L
20. Da Mesquita S
21. Daneman R
22. Rustenhoven J
23. Goldman SA
24. Nedergaard M
Resolving the mysteries of brain clearance and immune surveillance.; Neuron. 2025 Nov 24.
1. Cona A
2. Newbold E
3. Kesmen D
4. Snape R
5. Danner J
6. White N
7. Borden W
8. Iseson A
9. Schanz SJ
10. Chandler-Militello D
11. Li X
12. Cano JC
13. Mariani JN
14. Nedergaard M
15. Benraiss A
16. Goldman SA
In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells.; bioRxiv : the preprint server for biology. 2025 Jul 04.
1. Villanueva CB
2. Huynh NPT
3. Mariani JN
4. Mansky B
5. Tate A
6. Lorenzen SS
7. Chandler-Militello D
8. Benraiss A
9. Goldman SA
Human glial progenitors transplanted into Huntington disease mice normalize neuronal gene expression, dendritic structure, and behavior.; Cell reports; Vol 44(6), pp. 115762. 2025 Jun 10.
1. Cano JC
2. Mangiamele C
3. Nedergaard M
4. Benraiss A
5. Goldman SA
Newly generated striatal neurons rescue motor circuitry in a Huntington's disease mouse model.; Cell reports. 2025 Apr 05.
1. Plá V
2. Kroesbergen E
3. Deng S
4. Giannetto MJ
5. Hablitz LM
6. Newbold E
7. Ladrón-de-Guevara A
8. Esmail T
9. Gomolka RS
10. Mori Y
11. Goldman SA
12. Kelley DH
13. Thomas JH
14. Nedergaard M
A curious concept of CNS clearance.; Nature neuroscience. 2025 Mar 11.
1. Bastola S
2. Pavlyukov MS
3. Sharma N
4. Ghochani Y
5. Nakano MA
6. Muthukrishnan SD
7. Yu SY
8. Kim MS
9. Sohrabi A
10. Biscola NP
11. Yamashita D
12. Anufrieva KS
13. Kovalenko TF
14. Jung G
15. Ganz T
16. O'Brien B
17. Kawaguchi R
18. Qin Y
19. Seidlits SK
20. Burlingame AL
21. Oses-Prieto JA
22. Havton LA
23. Goldman SA
24. Hjelmeland AB
25. Nakano I
26. Kornblum HI
Endothelial-secreted Endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma.; Nature communications; Vol 16(1), pp. 471. 2025 Jan 07.
1. Kroesbergen E
2. Riesselmann LV
3. Gomolka RS
4. Plá V
5. Esmail T
6. Stenmo VH
7. Kovács ER
8. Nielsen ES
9. Goldman SA
10. Nedergaard M
11. Weikop P
12. Mori Y
Glymphatic clearance is enhanced during sleep.; bioRxiv : the preprint server for biology. 2024 Sep 15.
1. Huynh NPT
2. Osipovitch M
3. Foti R
4. Bates J
5. Mansky B
6. Cano JC
7. Benraiss A
8. Zhao C
9. Lu QR
10. Goldman SA
Shared patterns of glial transcriptional dysregulation link Huntington's disease and schizophrenia.; Brain : a journal of neurology; Vol 147(9), pp. 3099-3112. 2024 Sep 03.
1. Li C
2. Huynh NPT
3. Schanz SJ
4. Windrem MS
5. Goldman SA
JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation.; Brain : a journal of neurology. 2024 Aug 12.
1. Jin M
2. Ma Z
3. Zhang H
4. Papetti AV
5. Dang R
6. Stillitano AC
7. Goldman SA
8. Jiang P
Co-Transplantation-Based Human-Mouse Chimeric Brain Models to Study Human Glial-Glial and Glial-Neuronal Interactions.; bioRxiv : the preprint server for biology. 2024 Jul 06.
1. Kaag Rasmussen M
2. Møllgård K
3. Bork PAR
4. Weikop P
5. Esmail T
6. Drici L
7. Wewer Albrechtsen NJ
8. Carlsen JF
9. Huynh NPT
10. Ghitani N
11. Mann M
12. Goldman SA
13. Mori Y
14. Chesler AT
15. Nedergaard M
Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model.; Science (New York, N.Y.); Vol 385(6704), pp. 80-86. 2024 Jul 04.
1. Mariani JN
2. Mansky B
3. Madsen PM
4. Salinas D
5. Kesmen D
6. Huynh NPT
7. Kuypers NJ
8. Kesel ER
9. Bates J
10. Payne C
11. Chandler-Militello D
12. Benraiss A
13. Goldman SA
Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells.; Nature communications; Vol 15(1), pp. 3873. 2024 May 08.
1. Ding F
2. Sun Q
3. Long C
4. Rasmussen RN
5. Peng S
6. Xu Q
7. Kang N
8. Song W
9. Weikop P
10. Goldman SA
11. Nedergaard M
Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.; Brain : a journal of neurology. 2024 Mar 11.
1. Franklin RJM
2. Bodini B
3. Goldman SA
Remyelination in the Central Nervous System.; Cold Spring Harbor perspectives in biology. 2024 Feb 05.
1. Patel KS
2. Tessema KK
3. Kawaguchi R
4. Dudley L
5. Alvarado AG
6. Muthukrishnan SD
7. Perryman T
8. Hagiwara A
9. Swarup V
10. Liau LM
11. Wang AC
12. Yong W
13. Geschwind DH
14. Nakano I
15. Goldman SA
16. Everson RG
17. Ellingson BM
18. Kornblum HI
Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma.; Neuro-oncology advances; Vol 6(1), pp. vdae005. 2024 Jan 25.
1. Zhao L
2. Qiu Z
3. Yang Z
4. Xu L
5. Pearce TM
6. Wu Q
7. Yang K
8. Li F
9. Saulnier O
10. Fei F
11. Yu H
12. Gimple RC
13. Varadharajan V
14. Liu J
15. Hendrikse LD
16. Fong V
17. Wang W
18. Zhang J
19. Lv D
20. Lee D
21. Lehrich BM
22. Jin C
23. Ouyang L
24. Dixit D
25. Wu H
26. Wang X
27. Sloan AE
28. Wang X
29. Huan T
30. Mark Brown J
31. Goldman SA
32. Taylor MD
33. Zhou S
34. Rich JN
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism.; Nature cancer. 2024 Jan 03.
1. Goldman SA
2. Franklin RJM
3. Osorio J
Stem and progenitor cell-based therapy of myelin disorders.; Handbook of clinical neurology; Vol 205, pp. 283-295. 2024.
1. Takasugi M
2. Ohtani N
3. Takemura K
4. Emmrich S
5. Zakusilo FT
6. Yoshida Y
7. Kutsukake N
8. Mariani JN
9. Windrem MS
10. Chandler-Militello D
11. Goldman SA
12. Satoh J
13. Ito S
14. Seluanov A
15. Gorbunova V
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance.; Cell reports; Vol 42(9), pp. 113130. 2023 Sep 13.
1. Vieira R
2. Mariani JN
3. Huynh NPT
4. Stephensen HJT
5. Solly R
6. Tate A
7. Schanz S
8. Cotrupi N
9. Mousaei M
10. Sporring J
11. Benraiss A
12. Goldman SA
Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain.; Nature biotechnology. 2023 Jul 17.
1. Villanueva CB
2. Stephensen HJT
3. Mokso R
4. Benraiss A
5. Sporring J
6. Goldman SA
Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington's disease.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(24), pp. e2210719120. 2023 Jun 06.
1. Stogsdill JA
2. Harwell CC
3. Goldman SA
Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes.; Annals of the New York Academy of Sciences. 2023 May 23.
1. Khakh BS
2. Goldman SA
Astrocytic contributions to Huntington's disease pathophysiology.; Annals of the New York Academy of Sciences; Vol 1522(1), pp. 42-59. 2023 Mar 02.
1. Hussain R
2. Tithof J
3. Wang W
4. Cheetham-West A
5. Song W
6. Peng W
7. Sigurdsson B
8. Kim D
9. Sun Q
10. Peng S
11. Plá V
12. Kelley DH
13. Hirase H
14. Castorena-Gonzalez JA
15. Weikop P
16. Goldman SA
17. Davis MJ
18. Nedergaard M
Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema.; Nature. 2023 Jan 15.
1. Alvarado AG
2. Tessema K
3. Muthukrishnan SD
4. Sober M
5. Kawaguchi R
6. Laks DR
7. Bhaduri A
8. Swarup V
9. Nathanson DA
10. Geschwind DH
11. Goldman SA
12. Kornblum HI
Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma.; Cancer research communications; Vol 2(9), pp. 1049-1060. 2022 Sep 22.
1. Wang X
2. Delle C
3. Asiminas A
4. Akther S
5. Vittani M
6. Brøgger P
7. Kusk P
8. Vo CT
9. Radovanovic T
10. Konno A
11. Hirai H
12. Fukuda M
13. Weikop P
14. Goldman SA
15. Nedergaard M
16. Hirase H
Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation.; Cell reports methods; Vol 2(10), pp. 100302. 2022 Sep 21.
1. Benraiss A
2. Mariani JN
3. Tate A
4. Madsen PM
5. Clark KM
6. Welle KA
7. Solly R
8. Capellano L
9. Bentley K
10. Chandler-Militello D
11. Goldman SA
A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.; Cell reports; Vol 40(9), pp. 111291. 2022 Aug 30.
1. Rosser AE
2. Busse ME
3. Gray WP
4. Badin RA
5. Perrier AL
6. Wheelock V
7. Cozzi E
8. Martin UP
9. Salado-Manzano C
10. Mills LJ
11. Drew C
12. Goldman SA
13. Canals JM
14. Thompson LM
Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder.; Brain : a journal of neurology; Vol 145(5). 2022 Jun 03.
1. Muthukrishnan SD
2. Kawaguchi R
3. Nair P
4. Prasad R
5. Qin Y
6. Johnson M
7. Wang Q
8. VanderVeer-Harris N
9. Pham A
10. Alvarado AG
11. Condro MC
12. Gao F
13. Gau R
14. Castro MG
15. Lowenstein PR
16. Deb A
17. Hinman JD
18. Pajonk F
19. Burns TC
20. Goldman SA
21. Geschwind DH
22. Kornblum HI
P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.; Nature communications; Vol 13(1), pp. 6202. 2022 Jan 19.
1. Ghochani Y
2. Muthukrishnan SD
3. Sohrabi A
4. Kawaguchi R
5. Condro MC
6. Bastola S
7. Gao F
8. Qin Y
9. Mottahedeh J
10. Iruela-Arispe ML
11. Rao N
12. Laks DR
13. Liau LM
14. Mathern GW
15. Goldman SA
16. Carmichael ST
17. Nakano I
18. Coppola G
19. Seidlits SK
20. Kornblum HI
A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration.; Cell reports; Vol 41(3), pp. 111511. 2022 Jan 18.
1. Osorio MJ
2. Mariani JN
3. Zou L
4. Schanz SJ
5. Heffernan K
6. Cornwell A
7. Goldman SA
Glial progenitor cells of the adult human white and grey matter are contextually distinct.; Glia. 2022 Jan 05.
1. Benraiss A
2. Mariani JN
3. Osipovitch M
4. Cornwell A
5. Windrem MS
6. Villanueva CB
7. Chandler-Militello D
8. Goldman SA
Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.; Cell reports; Vol 36(1). 2021 Jul 06.
1. Li J
2. Pan L
3. Pembroke WG
4. Rexach JE
5. Godoy MI
6. Condro MC
7. Alvarado AG
8. Harteni M
9. Chen YW
10. Stiles L
11. Chen AY
12. Wanner IB
13. Yang X
14. Goldman SA
15. Geschwind DH
16. Kornblum HI
17. Zhang Y
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes.; Nature communications; Vol 12(1). 2021 Jun 25.
1. Park HJ
2. Jeon J
3. Choi J
4. Kim JY
5. Kim HS
6. Huh JY
7. Goldman SA
8. Song J
Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model.; Cell proliferation. 2021 Jun 21.
1. Hyun I
2. Clayton EW
3. Cong Y
4. Fujita M
5. Goldman SA
6. Hill LR
7. Monserrat N
8. Nakauchi H
9. Pedersen RA
10. Rooke HM
11. Takahashi J
12. Knoblich JA
ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts.; Stem cell reports; Vol 16(6). 2021 Jun 08.
1. Lovell-Badge R
2. Anthony E
3. Barker RA
4. Bubela T
5. Brivanlou AH
6. Carpenter M
7. Charo RA
8. Clark A
9. Clayton E
10. Cong Y
11. Daley GQ
12. Fu J
13. Fujita M
14. Greenfield A
15. Goldman SA
16. Hill L
17. Hyun I
18. Isasi R
19. Kahn J
20. Kato K
21. Kim JS
22. Kimmelman J
23. Knoblich JA
24. Mathews D
25. Montserrat N
26. Mosher J
27. Munsie M
28. Nakauchi H
29. Naldini L
30. Naughton G
31. Niakan K
32. Ogbogu U
33. Pedersen R
34. Rivron N
35. Rooke H
36. Rossant J
37. Round J
38. Saitou M
39. Sipp D
40. Steffann J
41. Sugarman J
42. Surani A
43. Takahashi J
44. Tang F
45. Turner L
46. Zettler PJ
47. Zhai X
ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.; Stem cell reports. 2021 May 25.
1. Kim KP
2. Li C
3. Bunina D
4. Jeong HW
5. Ghelman J
6. Yoon J
7. Shin B
8. Park H
9. Han DW
10. Zaugg JB
11. Kim J
12. Kuhlmann T
13. Adams RH
14. Noh KM
15. Goldman SA
16. Schöler HR
Donor cell memory confers a metastable state of directly converted cells.; Cell stem cell. 2021 Apr 07.
1. Escartin C
2. Galea E
3. Lakatos A
4. O'Callaghan JP
5. Petzold GC
6. Serrano-Pozo A
7. Steinhäuser C
8. Volterra A
9. Carmignoto G
10. Agarwal A
11. Allen NJ
12. Araque A
13. Barbeito L
14. Barzilai A
15. Bergles DE
16. Bonvento G
17. Butt AM
18. Chen WT
19. Cohen-Salmon M
20. Cunningham C
21. Deneen B
22. De Strooper B
23. Díaz-Castro B
24. Farina C
25. Freeman M
26. Gallo V
27. Goldman JE
28. Goldman SA
29. Götz M
30. Gutiérrez A
31. Haydon PG
32. Heiland DH
33. Hol EM
34. Holt MG
35. Iino M
36. Kastanenka KV
37. Kettenmann H
38. Khakh BS
39. Koizumi S
40. Lee CJ
41. Liddelow SA
42. MacVicar BA
43. Magistretti P
44. Messing A
45. Mishra A
46. Molofsky AV
47. Murai KK
48. Norris CM
49. Okada S
50. Oliet SHR
51. Oliveira JF
52. Panatier A
53. Parpura V
54. Pekna M
55. Pekny M
56. Pellerin L
57. Perea G
58. Pérez-Nievas BG
59. Pfrieger FW
60. Poskanzer KE
61. Quintana FJ
62. Ransohoff RM
63. Riquelme-Perez M
64. Robel S
65. Rose CR
66. Rothstein JD
67. Rouach N
68. Rowitch DH
69. Semyanov A
70. Sirko S
71. Sontheimer H
72. Swanson RA
73. Vitorica J
74. Wanner IB
75. Wood LB
76. Wu J
77. Zheng B
78. Zimmer ER
79. Zorec R
80. Sofroniew MV
81. Verkhratsky A
Reactive astrocyte nomenclature, definitions, and future directions.; Nature neuroscience. 2021 Feb 15.
1. Goldman SA
2. Mariani JN
3. Madsen PM
Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic.; Seminars in cell & developmental biology. 2021 Jan 04.
1. Feng L
2. Chao J
3. Tian E
4. Li L
5. Ye P
6. Zhang M
7. Chen X
8. Cui Q
9. Sun G
10. Zhou T
11. Felix G
12. Qin Y
13. Li W
14. Meza ED
15. Klein J
16. Ghoda L
17. Hu W
18. Luo Y
19. Dang W
20. Hsu D
21. Gold J
22. Goldman SA
23. Matalon R
24. Shi Y
Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.; Advanced science (Weinheim, Baden-Wurttemberg, Germany); Vol 7(23). 2020 Dec.
1. Nedergaard M
2. Goldman SA
Glymphatic failure as a final common pathway to dementia.; Science (New York, N.Y.); Vol 370(6512). 2020 Oct 02.
1. Zeng J
2. Dong S
3. Luo Z
4. Xie X
5. Fu B
6. Li P
7. Liu C
8. Yang X
9. Chen Y
10. Wang X
11. Liu Z
12. Wu J
13. Yan Y
14. Wang F
15. Chen JF
16. Zhang J
17. Long G
18. Goldman SA
19. Li S
20. Zhao Z
21. Liang Q
The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis.; Cell stem cell. 2020 Aug 04.
1. Goldman SA
Glial evolution as a determinant of human behavior and its disorders.; Annals of the New York Academy of Sciences; Vol 1471(1). 2020 Jul.
1. Windrem MS
2. Schanz SJ
3. Zou L
4. Chandler-Militello D
5. Kuypers NJ
6. Nedergaard M
7. Lu Y
8. Mariani JN
9. Goldman SA
Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.; Cell reports; Vol 31(7). 2020 May 19.
1. Nolbrant S
2. Giacomoni J
3. Hoban DB
4. Bruzelius A
5. Birtele M
6. Chandler-Militello D
7. Pereira M
8. Ottosson DR
9. Goldman SA
10. Parmar M
Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons.; Stem cell reports; Vol 15(4). 2020 Jan 13.
1. Dietz AG
2. Goldman SA
3. Nedergaard M
Glial cells in schizophrenia: a unified hypothesis.; The lancet. Psychiatry. 2019 Nov 05.
1. Nobuta H
2. Yang N
3. Ng YH
4. Marro SG
5. Sabeur K
6. Chavali M
7. Stockley JH
8. Killilea DW
9. Walter PB
10. Zhao C
11. Huie P
12. Goldman SA
13. Kriegstein AR
14. Franklin RJM
15. Rowitch DH
16. Wernig M
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.; Cell stem cell; Vol 25(4). 2019 Oct 03.