URMC / Labs / Goldman Lab / Publications Recent Publications Kroesbergen ERiesselmann LVGomolka RSPlá VEsmail TStenmo VHKovács ERNielsen ESGoldman SANedergaard MWeikop PMori Y Glymphatic clearance is enhanced during sleep.; bioRxiv : the preprint server for biology. 2024 Sep 15. Huynh NPTOsipovitch MFoti RBates JMansky BCano JCBenraiss AZhao CLu QRGoldman SA Shared patterns of glial transcriptional dysregulation link Huntington's disease and schizophrenia.; Brain : a journal of neurology; Vol 147(9), pp. 3099-3112. 2024 Sep 03. Li CHuynh NPTSchanz SJWindrem MSGoldman SA JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation.; Brain : a journal of neurology. 2024 Aug 12. Jin MMa ZZhang HPapetti AVDang RStillitano ACGoldman SAJiang P Co-Transplantation-Based Human-Mouse Chimeric Brain Models to Study Human Glial-Glial and Glial-Neuronal Interactions.; bioRxiv : the preprint server for biology. 2024 Jul 06. Kaag Rasmussen MMøllgård KBork PARWeikop PEsmail TDrici LWewer Albrechtsen NJCarlsen JFHuynh NPTGhitani NMann MGoldman SAMori YChesler ATNedergaard M Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model.; Science (New York, N.Y.); Vol 385(6704), pp. 80-86. 2024 Jul 04. Mariani JNMansky BMadsen PMSalinas DKesmen DHuynh NPTKuypers NJKesel ERBates JPayne CChandler-Militello DBenraiss AGoldman SA Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells.; Nature communications; Vol 15(1), pp. 3873. 2024 May 08. Ding FSun QLong CRasmussen RNPeng SXu QKang NSong WWeikop PGoldman SANedergaard M Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.; Brain : a journal of neurology. 2024 Mar 11. Franklin RJMBodini BGoldman SA Remyelination in the Central Nervous System.; Cold Spring Harbor perspectives in biology. 2024 Feb 05. Patel KSTessema KKKawaguchi RDudley LAlvarado AGMuthukrishnan SDPerryman THagiwara ASwarup VLiau LMWang ACYong WGeschwind DHNakano IGoldman SAEverson RGEllingson BMKornblum HI Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma.; Neuro-oncology advances; Vol 6(1), pp. vdae005. 2024 Jan 25. Zhao LQiu ZYang ZXu LPearce TMWu QYang KLi FSaulnier OFei FYu HGimple RCVaradharajan VLiu JHendrikse LDFong VWang WZhang JLv DLee DLehrich BMJin COuyang LDixit DWu HWang XSloan AEWang XHuan TMark Brown JGoldman SATaylor MDZhou SRich JN Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism.; Nature cancer. 2024 Jan 03. Goldman SAFranklin RJMOsorio J Stem and progenitor cell-based therapy of myelin disorders.; Handbook of clinical neurology; Vol 205, pp. 283-295. 2024. Takasugi MOhtani NTakemura KEmmrich SZakusilo FTYoshida YKutsukake NMariani JNWindrem MSChandler-Militello DGoldman SASatoh JIto SSeluanov AGorbunova V CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance.; Cell reports; Vol 42(9), pp. 113130. 2023 Sep 13. Vieira RMariani JNHuynh NPTStephensen HJTSolly RTate ASchanz SCotrupi NMousaei MSporring JBenraiss AGoldman SA Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain.; Nature biotechnology. 2023 Jul 17. Villanueva CBStephensen HJTMokso RBenraiss ASporring JGoldman SA Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington's disease.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(24), pp. e2210719120. 2023 Jun 06. Stogsdill JAHarwell CCGoldman SA Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes.; Annals of the New York Academy of Sciences. 2023 May 23. Khakh BSGoldman SA Astrocytic contributions to Huntington's disease pathophysiology.; Annals of the New York Academy of Sciences; Vol 1522(1), pp. 42-59. 2023 Mar 02. Hussain RTithof JWang WCheetham-West ASong WPeng WSigurdsson BKim DSun QPeng SPlá VKelley DHHirase HCastorena-Gonzalez JAWeikop PGoldman SADavis MJNedergaard M Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema.; Nature. 2023 Jan 15. Alvarado AGTessema KMuthukrishnan SDSober MKawaguchi RLaks DRBhaduri ASwarup VNathanson DAGeschwind DHGoldman SAKornblum HI Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma.; Cancer research communications; Vol 2(9), pp. 1049-1060. 2022 Sep 22. Wang XDelle CAsiminas AAkther SVittani MBrøgger PKusk PVo CTRadovanovic TKonno AHirai HFukuda MWeikop PGoldman SANedergaard MHirase H Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation.; Cell reports methods; Vol 2(10), pp. 100302. 2022 Sep 21. Benraiss AMariani JNTate AMadsen PMClark KMWelle KASolly RCapellano LBentley KChandler-Militello DGoldman SA A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.; Cell reports; Vol 40(9), pp. 111291. 2022 Aug 30. Rosser AEBusse MEGray WPBadin RAPerrier ALWheelock VCozzi EMartin UPSalado-Manzano CMills LJDrew CGoldman SACanals JMThompson LM Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder.; Brain : a journal of neurology; Vol 145(5). 2022 Jun 03. Muthukrishnan SDKawaguchi RNair PPrasad RQin YJohnson MWang QVanderVeer-Harris NPham AAlvarado AGCondro MCGao FGau RCastro MGLowenstein PRDeb AHinman JDPajonk FBurns TCGoldman SAGeschwind DHKornblum HI P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.; Nature communications; Vol 13(1), pp. 6202. 2022 Jan 19. Ghochani YMuthukrishnan SDSohrabi AKawaguchi RCondro MCBastola SGao FQin YMottahedeh JIruela-Arispe MLRao NLaks DRLiau LMMathern GWGoldman SACarmichael STNakano ICoppola GSeidlits SKKornblum HI A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration.; Cell reports; Vol 41(3), pp. 111511. 2022 Jan 18. Osorio MJMariani JNZou LSchanz SJHeffernan KCornwell AGoldman SA Glial progenitor cells of the adult human white and grey matter are contextually distinct.; Glia. 2022 Jan 05. Benraiss AMariani JNOsipovitch MCornwell AWindrem MSVillanueva CBChandler-Militello DGoldman SA Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.; Cell reports; Vol 36(1). 2021 Jul 06. Li JPan LPembroke WGRexach JEGodoy MICondro MCAlvarado AGHarteni MChen YWStiles LChen AYWanner IBYang XGoldman SAGeschwind DHKornblum HIZhang Y Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes.; Nature communications; Vol 12(1). 2021 Jun 25. Park HJJeon JChoi JKim JYKim HSHuh JYGoldman SASong J Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model.; Cell proliferation. 2021 Jun 21. Hyun IClayton EWCong YFujita MGoldman SAHill LRMonserrat NNakauchi HPedersen RARooke HMTakahashi JKnoblich JA ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts.; Stem cell reports; Vol 16(6). 2021 Jun 08. Lovell-Badge RAnthony EBarker RABubela TBrivanlou AHCarpenter MCharo RAClark AClayton ECong YDaley GQFu JFujita MGreenfield AGoldman SAHill LHyun IIsasi RKahn JKato KKim JSKimmelman JKnoblich JAMathews DMontserrat NMosher JMunsie MNakauchi HNaldini LNaughton GNiakan KOgbogu UPedersen RRivron NRooke HRossant JRound JSaitou MSipp DSteffann JSugarman JSurani ATakahashi JTang FTurner LZettler PJZhai X ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.; Stem cell reports. 2021 May 25. Kim KPLi CBunina DJeong HWGhelman JYoon JShin BPark HHan DWZaugg JBKim JKuhlmann TAdams RHNoh KMGoldman SASchöler HR Donor cell memory confers a metastable state of directly converted cells.; Cell stem cell. 2021 Apr 07. Escartin CGalea ELakatos AO'Callaghan JPPetzold GCSerrano-Pozo ASteinhäuser CVolterra ACarmignoto GAgarwal AAllen NJAraque ABarbeito LBarzilai ABergles DEBonvento GButt AMChen WTCohen-Salmon MCunningham CDeneen BDe Strooper BDíaz-Castro BFarina CFreeman MGallo VGoldman JEGoldman SAGötz MGutiérrez AHaydon PGHeiland DHHol EMHolt MGIino MKastanenka KVKettenmann HKhakh BSKoizumi SLee CJLiddelow SAMacVicar BAMagistretti PMessing AMishra AMolofsky AVMurai KKNorris CMOkada SOliet SHROliveira JFPanatier AParpura VPekna MPekny MPellerin LPerea GPérez-Nievas BGPfrieger FWPoskanzer KEQuintana FJRansohoff RMRiquelme-Perez MRobel SRose CRRothstein JDRouach NRowitch DHSemyanov ASirko SSontheimer HSwanson RAVitorica JWanner IBWood LBWu JZheng BZimmer ERZorec RSofroniew MVVerkhratsky A Reactive astrocyte nomenclature, definitions, and future directions.; Nature neuroscience. 2021 Feb 15. Goldman SAMariani JNMadsen PM Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic.; Seminars in cell & developmental biology. 2021 Jan 04. Feng LChao JTian ELi LYe PZhang MChen XCui QSun GZhou TFelix GQin YLi WMeza EDKlein JGhoda LHu WLuo YDang WHsu DGold JGoldman SAMatalon RShi Y Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.; Advanced science (Weinheim, Baden-Wurttemberg, Germany); Vol 7(23). 2020 Dec. Nedergaard MGoldman SA Glymphatic failure as a final common pathway to dementia.; Science (New York, N.Y.); Vol 370(6512). 2020 Oct 02. Zeng JDong SLuo ZXie XFu BLi PLiu CYang XChen YWang XLiu ZWu JYan YWang FChen JFZhang JLong GGoldman SALi SZhao ZLiang Q The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis.; Cell stem cell. 2020 Aug 04. Goldman SA Glial evolution as a determinant of human behavior and its disorders.; Annals of the New York Academy of Sciences; Vol 1471(1). 2020 Jul. Windrem MSSchanz SJZou LChandler-Militello DKuypers NJNedergaard MLu YMariani JNGoldman SA Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.; Cell reports; Vol 31(7). 2020 May 19. Nolbrant SGiacomoni JHoban DBBruzelius ABirtele MChandler-Militello DPereira MOttosson DRGoldman SAParmar M Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons.; Stem cell reports; Vol 15(4). 2020 Jan 13. Dietz AGGoldman SANedergaard M Glial cells in schizophrenia: a unified hypothesis.; The lancet. Psychiatry. 2019 Nov 05. Nobuta HYang NNg YHMarro SGSabeur KChavali MStockley JHKillilea DWWalter PBZhao CHuie PGoldman SAKriegstein ARFranklin RJMRowitch DHWernig M Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.; Cell stem cell; Vol 25(4). 2019 Oct 03. Liu ZOsipovitch MBenraiss AHuynh NPTFoti RBates JChandler-Militello DFindling RLTesar PJNedergaard MWindrem MSGoldman SA Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.; Cell reports; Vol 27(13). 2019 Jun 25. Osipovitch MAsenjo Martinez AMariani JNCornwell ADhaliwal SZou LChandler-Militello DWang SLi XBenraiss SJAgate RLampp ABenraiss AWindrem MSGoldman SA Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.; Cell stem cell; Vol 24(1). 2019 Jan 03. Mariani JNZou LGoldman SA Human Glial Chimeric Mice to Define the Role of Glial Pathology in Human Disease.; Methods in molecular biology (Clifton, N.J.); Vol 1936. 2019. Wang MQin CLuo XWang JWang XXie MHu JCao JHu TGoldman SANedergaard MWang W Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.; Theranostics; Vol 9(15). 2019. Barker RACarpenter MKForbes SGoldman SAJamieson CMurry CETakahashi JWeir G The Challenges of First-in-Human Stem Cell Clinical Trials: What Does This Mean for Ethics and Institutional Review Boards?; Stem cell reports; Vol 10(5). 2018 May 08. Goldman SA Transplanted neural progenitors bridge gaps to benefit cord-injured monkeys.; Nature medicine; Vol 24(4). 2018 Apr 10. Osório MJGoldman SA Neurogenetics of Pelizaeus-Merzbacher disease.; Handbook of clinical neurology; Vol 148. 2018. Goldman SA Patience pays in spinal repair.; The Journal of clinical investigation; Vol 127(9). 2017 Sep 01. Windrem MSOsipovitch MLiu ZBates JChandler-Militello DZou LMunir JSchanz SMcCoy KMiller RHWang SNedergaard MFindling RLTesar PJGoldman SA Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.; Cell stem cell; Vol 21(2). 2017 Aug 03. Khakh BSBeaumont VCachope RMunoz-Sanjuan IGoldman SAGrantyn R Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.; Trends in neurosciences; Vol 40(7). 2017 Jul.