URMC / Labs / Goldman Lab / Publications Recent Publications Alvarado AGTessema KMuthukrishnan SDSober MKawaguchi RLaks DRBhaduri ASwarup VNathanson DAGeschwind DHGoldman SAKornblum HI Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma.; Cancer research communications; Vol 2(9), pp. 1049-1060. 2022 Sep 22. Wang XDelle CAsiminas AAkther SVittani MBrøgger PKusk PVo CTRadovanovic TKonno AHirai HFukuda MWeikop PGoldman SANedergaard MHirase H Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation.; Cell reports methods; Vol 2(10), pp. 100302. 2022 Sep 21. Benraiss AMariani JNTate AMadsen PMClark KMWelle KASolly RCapellano LBentley KChandler-Militello DGoldman SA A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.; Cell reports; Vol 40(9), pp. 111291. 2022 Aug 30. Rosser AEBusse MEGray WPBadin RAPerrier ALWheelock VCozzi EMartin UPSalado-Manzano CMills LJDrew CGoldman SACanals JMThompson LM Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder.; Brain : a journal of neurology; Vol 145(5). 2022 Jun 03. Muthukrishnan SDKawaguchi RNair PPrasad RQin YJohnson MWang QVanderVeer-Harris NPham AAlvarado AGCondro MCGao FGau RCastro MGLowenstein PRDeb AHinman JDPajonk FBurns TCGoldman SAGeschwind DHKornblum HI P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.; Nature communications; Vol 13(1), pp. 6202. 2022 Jan 19. Ghochani YMuthukrishnan SDSohrabi AKawaguchi RCondro MCBastola SGao FQin YMottahedeh JIruela-Arispe MLRao NLaks DRLiau LMMathern GWGoldman SACarmichael STNakano ICoppola GSeidlits SKKornblum HI A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration.; Cell reports; Vol 41(3), pp. 111511. 2022 Jan 18. Osorio MJMariani JNZou LSchanz SJHeffernan KCornwell AGoldman SA Glial progenitor cells of the adult human white and grey matter are contextually distinct.; Glia. 2022 Jan 05. Benraiss AMariani JNOsipovitch MCornwell AWindrem MSVillanueva CBChandler-Militello DGoldman SA Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.; Cell reports; Vol 36(1). 2021 Jul 06. Li JPan LPembroke WGRexach JEGodoy MICondro MCAlvarado AGHarteni MChen YWStiles LChen AYWanner IBYang XGoldman SAGeschwind DHKornblum HIZhang Y Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes.; Nature communications; Vol 12(1). 2021 Jun 25. Park HJJeon JChoi JKim JYKim HSHuh JYGoldman SASong J Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model.; Cell proliferation. 2021 Jun 21. Hyun IClayton EWCong YFujita MGoldman SAHill LRMonserrat NNakauchi HPedersen RARooke HMTakahashi JKnoblich JA ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts.; Stem cell reports; Vol 16(6). 2021 Jun 08. Lovell-Badge RAnthony EBarker RABubela TBrivanlou AHCarpenter MCharo RAClark AClayton ECong YDaley GQFu JFujita MGreenfield AGoldman SAHill LHyun IIsasi RKahn JKato KKim JSKimmelman JKnoblich JAMathews DMontserrat NMosher JMunsie MNakauchi HNaldini LNaughton GNiakan KOgbogu UPedersen RRivron NRooke HRossant JRound JSaitou MSipp DSteffann JSugarman JSurani ATakahashi JTang FTurner LZettler PJZhai X ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.; Stem cell reports. 2021 May 25. Kim KPLi CBunina DJeong HWGhelman JYoon JShin BPark HHan DWZaugg JBKim JKuhlmann TAdams RHNoh KMGoldman SASchöler HR Donor cell memory confers a metastable state of directly converted cells.; Cell stem cell. 2021 Apr 07. Escartin CGalea ELakatos AO'Callaghan JPPetzold GCSerrano-Pozo ASteinhäuser CVolterra ACarmignoto GAgarwal AAllen NJAraque ABarbeito LBarzilai ABergles DEBonvento GButt AMChen WTCohen-Salmon MCunningham CDeneen BDe Strooper BDíaz-Castro BFarina CFreeman MGallo VGoldman JEGoldman SAGötz MGutiérrez AHaydon PGHeiland DHHol EMHolt MGIino MKastanenka KVKettenmann HKhakh BSKoizumi SLee CJLiddelow SAMacVicar BAMagistretti PMessing AMishra AMolofsky AVMurai KKNorris CMOkada SOliet SHROliveira JFPanatier AParpura VPekna MPekny MPellerin LPerea GPérez-Nievas BGPfrieger FWPoskanzer KEQuintana FJRansohoff RMRiquelme-Perez MRobel SRose CRRothstein JDRouach NRowitch DHSemyanov ASirko SSontheimer HSwanson RAVitorica JWanner IBWood LBWu JZheng BZimmer ERZorec RSofroniew MVVerkhratsky A Reactive astrocyte nomenclature, definitions, and future directions.; Nature neuroscience. 2021 Feb 15. Goldman SAMariani JNMadsen PM Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic.; Seminars in cell & developmental biology. 2021 Jan 04. Feng LChao JTian ELi LYe PZhang MChen XCui QSun GZhou TFelix GQin YLi WMeza EDKlein JGhoda LHu WLuo YDang WHsu DGold JGoldman SAMatalon RShi Y Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.; Advanced science (Weinheim, Baden-Wurttemberg, Germany); Vol 7(23). 2020 Dec. Nedergaard MGoldman SA Glymphatic failure as a final common pathway to dementia.; Science (New York, N.Y.); Vol 370(6512). 2020 Oct 02. Zeng JDong SLuo ZXie XFu BLi PLiu CYang XChen YWang XLiu ZWu JYan YWang FChen JFZhang JLong GGoldman SALi SZhao ZLiang Q The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis.; Cell stem cell. 2020 Aug 04. Goldman SA Glial evolution as a determinant of human behavior and its disorders.; Annals of the New York Academy of Sciences; Vol 1471(1). 2020 Jul. Windrem MSSchanz SJZou LChandler-Militello DKuypers NJNedergaard MLu YMariani JNGoldman SA Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.; Cell reports; Vol 31(7). 2020 May 19. Nolbrant SGiacomoni JHoban DBBruzelius ABirtele MChandler-Militello DPereira MOttosson DRGoldman SAParmar M Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons.; Stem cell reports; Vol 15(4). 2020 Jan 13. Dietz AGGoldman SANedergaard M Glial cells in schizophrenia: a unified hypothesis.; The lancet. Psychiatry. 2019 Nov 05. Nobuta HYang NNg YHMarro SGSabeur KChavali MStockley JHKillilea DWWalter PBZhao CHuie PGoldman SAKriegstein ARFranklin RJMRowitch DHWernig M Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.; Cell stem cell; Vol 25(4). 2019 Oct 03. Liu ZOsipovitch MBenraiss AHuynh NPTFoti RBates JChandler-Militello DFindling RLTesar PJNedergaard MWindrem MSGoldman SA Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.; Cell reports; Vol 27(13). 2019 Jun 25. Osipovitch MAsenjo Martinez AMariani JNCornwell ADhaliwal SZou LChandler-Militello DWang SLi XBenraiss SJAgate RLampp ABenraiss AWindrem MSGoldman SA Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.; Cell stem cell; Vol 24(1). 2019 Jan 03. Mariani JNZou LGoldman SA Human Glial Chimeric Mice to Define the Role of Glial Pathology in Human Disease.; Methods in molecular biology (Clifton, N.J.); Vol 1936. 2019. Wang MQin CLuo XWang JWang XXie MHu JCao JHu TGoldman SANedergaard MWang W Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.; Theranostics; Vol 9(15). 2019. Barker RACarpenter MKForbes SGoldman SAJamieson CMurry CETakahashi JWeir G The Challenges of First-in-Human Stem Cell Clinical Trials: What Does This Mean for Ethics and Institutional Review Boards?; Stem cell reports; Vol 10(5). 2018 May 08. Goldman SA Transplanted neural progenitors bridge gaps to benefit cord-injured monkeys.; Nature medicine; Vol 24(4). 2018 Apr 10. Osório MJGoldman SA Neurogenetics of Pelizaeus-Merzbacher disease.; Handbook of clinical neurology; Vol 148. 2018. Goldman SA Patience pays in spinal repair.; The Journal of clinical investigation; Vol 127(9). 2017 Sep 01. Windrem MSOsipovitch MLiu ZBates JChandler-Militello DZou LMunir JSchanz SMcCoy KMiller RHWang SNedergaard MFindling RLTesar PJGoldman SA Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.; Cell stem cell; Vol 21(2). 2017 Aug 03. Khakh BSBeaumont VCachope RMunoz-Sanjuan IGoldman SAGrantyn R Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.; Trends in neurosciences; Vol 40(7). 2017 Jul. Sun WCornwell ALi JPeng SOsorio MJAalling NWang SBenraiss ALou NGoldman SANedergaard M SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 37(17). 2017 Apr 26. Nevin ZSFactor DCKarl RTDouvaras PLaukka JWindrem MSGoldman SAFossati VHobson GMTesar PJ Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.; American journal of human genetics; Vol 100(4). 2017 Apr 06. Osorio MJRowitch DHTesar PWernig MWindrem MSGoldman SA Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.; Stem cells (Dayton, Ohio); Vol 35(2). 2017 Feb. Goldman SA Progenitor cell-based treatment of glial disease.; Progress in brain research; Vol 231. 2017. Wang YZhao ZRege SVWang MSi GZhou YWang SGriffin JHGoldman SAZlokovic BV 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.; Nature medicine; Vol 22(9). 2016 Sep. Osorio MJGoldman SA Glial progenitor cell-based treatment of the childhood leukodystrophies.; Experimental neurology; Vol 283(Pt B). 2016 Sep. Auvergne RWu CConnell AAu SCornwell AOsipovitch MBenraiss ADangelmajer SGuerrero-Cazares HQuinones-Hinojosa AGoldman SA PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo.; Oncogene; Vol 35(29). 2016 Jul 21. Zhang LHe XLiu LJiang MZhao CWang HHe DZheng TZhou XHassan AMa ZXin MSun ZLazar MAGoldman SAOlson ENRichard Lu Q Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.; Developmental cell; Vol 37(6). 2016 Jun 20. Benraiss AWang SHerrlinger SLi XChandler-Militello DMauceri JBurm HBToner MOsipovitch MJim Xu QDing FWang FKang NKang JCurtin PCBrunner DWindrem MSMunoz-Sanjuan INedergaard MGoldman SA Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.; Nature communications; Vol 7. 2016 Jun 07. Zhao CDeng YLiu LYu KZhang LWang HHe XWang JLu CWu LNWeng QMao MLi Jvan Es JHXin MParry LGoldman SAClevers HLu QR Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.; Nature communications; Vol 7. 2016 Mar 09. Nedergaard MGoldman SA BRAIN DRAIN.; Scientific American; Vol 314(3). 2016 Mar. Zhang LHe XLiu LJiang MZhao CWang HHe DZheng TZhou XHassan AMa ZXin MSun ZLazar MAGoldman SAOlson ENLu QR Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.; Developmental cell; Vol 36(3). 2016 Feb 08. Goldman SA Stem and Progenitor Cell-Based Therapy of the Central Nervous System: Hopes, Hype, and Wishful Thinking.; Cell stem cell; Vol 18(2). 2016 Feb 04. Lou NTakano TPei YXavier ALGoldman SANedergaard M Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.; Proceedings of the National Academy of Sciences of the United States of America; Vol 113(4). 2016 Jan 26. Liang QLuo ZZeng JChen WFoo SSLee SAGe JWang SGoldman SAZlokovic BVZhao ZJung JU Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.; Cell stem cell; Vol 19(5). 2016 Jan 03. Goldman SAKuypers NJ How to make an oligodendrocyte.; Development (Cambridge, England); Vol 142(23). 2015 Dec 01. Iliff JJGoldman SANedergaard M Implications of the discovery of brain lymphatic pathways.; The Lancet. Neurology; Vol 14(10). 2015 Oct.