Therapeutic Targeting of Senescent Cells in Lupus
Targeting senescent cells in patients with lupus presents a potential novel approach to disease management and improved clinical outcomes. While it is known that lupus patients possess cells with a senescence-like phenotype, it is unknown whether these cells would respond to available senolytic drugs. Studying the effects of these drugs in vitro using patient and lupus mouse model samples will further fundamental insights into the potential role of senolytic drugs in the treatment of lupus.
Richard J. Looney, M.D.
Principal Investigator
Publications
View All Publications- Gut microbial IgA coating in infants with traditional farming lifestyle and urban infants with allergic outcomes.; Frontiers in immunology; Vol 17, pp. 1793302. 2026 Apr 20.
- Update on allergen immunotherapy for asthma.; Current opinion in pulmonary medicine. 2026 Feb 20.
- Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy.; Science translational medicine; Vol 17(828), pp. eads1892. 2025 Dec 10.
- Differences in outcomes associated with ABO blood groups in recipients of IVIG.; Blood vessels, thrombosis & hemostasis; Vol 2(3), pp. 100075. 2025 May 09.
May 8, 2026
Dr. Garcia-Hernandez, PhD to Receive the Women of Distinction Award
May 8, 2026
Dr. John Looney Named a JACI 2026 Outstanding Reviewer
April 13, 2026
Mentee of Dr. Jennifer Barnas Awarded Rochester Academy of Science Student Grant
February 6, 2026
Dr. Katherine Herman Presents Medical Grand Rounds
January 23, 2026
Dr. Theresa Bingemann Presents at the AAAAI Program Directors Assembly Winter Meeting
Contact Us
Looney Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642