Publications

Ding, Y., Luan, J., Malmstrom, H.S., Luan, X., and Diekwisch, T.G.H. (2026). Mir-27 promotes periodontal regeneration via osteogenesis/angiogenesis. J. Dent Res. 105(4): 495–504.

Lyu, H., Zhou, X., Qian, Y., Liu, X., Gopinathan, G., Pandya, M., Qin, C., Luan, X., and Diekwisch, T.G.H. (2022). Long-acting PFI-2 small molecule release and multilayer scaffold design achieve extensive new formation of complex periodontal tissues with unprecedented fidelity. Biomaterials. 290: 121819.

Luan, X.,  Zhou, X., Fallah, P., Pandya, M., Lyu, H., Foyle, D., Burch, D., Diekwisch, T.G.H. (2021). MicroRNAs: Harbingers and shapers of periodontal inflammation. Semin. Cell. Dev. Biol. 124: 85-98.

Pandya, M., Saxon, M., Bozanich, J., Tillberg, C., Luan, X., and Diekwisch, T.G.H. (2021). The glycoprotein/cytokine erythropoietin promotes rapid alveolar ridge regeneration in vivo by promoting new bone extracellular matrix deposition in conjunction with couple angiogenesis/osteogenesis. Int. J. Mol. Sci. 22(6): 2788.

Ma, W., Lyu, H., Pandya, M., Gopinathan, G., Luan, X., and Diekwisch, T.G.H. (2021). Successful Application of a Galanin-Coated Scaffold for Periodontal Regeneration. J. Dent. Res. 100(10): 1144-1152.

Francis, M., Gopinathan, G., Foyle, D., Fallah, P., Gonzalez, M., Luan, X., and Diekwisch, T.G.H. (2020). Histone Methylation: Achilles Heel and Powerful Mediator of Periodontal Homeostasis. J. Dent. Res. 99(12): 1332-1340.

Francis, M., Gopinathan, G., Salapatas, A., Nares, S., Gonzales, M., Diekwisch, T.G.H. and Luan, X. (2020). SETD1 and NF-kB Regulate Periodontal Inflammation through H3K4 Trimethylation. J. Dent. Res. 99(13): 1486-1493.

Qian, Y., Zhou, X., Zhang, F., Diekwisch, T.G.H., Luan, X., and Yang, J. (2019). Triple PLGA/PCL scaffold modification including silver impregnation, collagen coating, and electrospinning significantly improve biocompatibility, antimicrobial, and osteogenic properties for orofacial tissue regeneration. ACS Appl Mater Interfaces. 11(41): 37381-37396.

Issac, A., Jivan, F., Xin, S., Hardin, J., Luan, X., Pandya, M., Diekwisch, T.G.H. and Agle, D.L., (2019). Microporous Bio-orthogonally Annealed Particle Hydrogels for Tissue Engineering and Regenerative Medicine. ACS Biomater. Sci. Eng. 5(12): 6395-6404.

Luan, X., Zhou, X., Francis, M., Nares, S., and Diekwisch, T.G.H. (2018). MicroRNAs and immunity in periodontal health and disease. Int. J. Oral Sci. 10(3): 24.

Luan, X., Zhou, X., Trombetta-eSilva, J., Francis, M. , Gaharwar, A.K., Atsawasuwan, P., Diekwisch, T.G.H.  (2017). MicroRNAs and periodontal homeostasis. J. Dent. Res. 96(5): 491-500.

Chen, Z., Yu, T., Cabay, R.J., Jin, Y., Mahjabeen, I., Luan, X., Huang, L., Dai, Y., Zhou, X. (2017). miR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma. Biomark Cancer. 9: 1-8. 

He, Q., Chen, Z., Cabay, R.J., Zhang, L., Luan, X., Chen, D., Yu, T., Wang, A., Zhou, X. (2016). microRNA-21 and microRNA-375 from oral cytology as biomarkers for oral tongue cancer detection. Oral Oncol. 57: 15-20.  

He, Q., Chen, Z., Dong, Q., Zhang, L., Chen, D., Patel, A., Koya, A., Luan, X., Cabay, R.J., Dai, Y., Wang, A., Zhou, X. (2016). MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma. BMC Cancer. 16(1): 685.

Liu, H., Yan, X., Pandya, M., Luan, X., and Diekwisch, T.G.H. (2016). Daughters of the enamel organ: Development, fate, and function of the stratum intermedium, stellate reticulum, and outer enamel epithelium. Stem Cells Dev. 25(20): 1580-1590.

Lu, X., Fukumoto, S., Yamada, Y., Evans, C.A., Diekwisch, T.G.H., and Luan, X. (2016). The Ameloblastin extracellular matrix molecule enhances bone fracture resistance and promotes rapid bone fracture healing. Matrix Biol. 52-54: 113-126.

Lu, X., Fukumoto, S., Yamada, Y., Evans, C.A., Diekwisch, T.G.H., and Luan, X. (2016). Ameloblastin, an extracellular matrix protein, affects long bone growth and mineralization. J Bone Miner Res. 31(6): 1235-1246.

Zhou, X., Luan, X., Chen, Z., Francis, M., Gopinathan, G., Li, W., Lu, X., Li, S., Wu, C., Diekwisch, T.G. (2015). MicroRNA-138 inhibits periodontal progenitor differentiation under inflammatory conditions. J. Dent. Res. 95(2): 230-237.

Chen, Y., Mohammed, A., Oubaidin, M., Evans, C.A., Zhou, X., Luan, X., Diekwisch, T.G., Atsawasuwan, P. (2015). Cyclic stretch and compression forces alter microRNA-29 expression of human periodontal ligament cells. Gene. 566(1): 13-17.

Li, Q., Reed, D.A., Min, L., Gopinathan, G., Li, S., Dangaria, S.J., Li, L., Geng, Y., Galang, M.T., Gajendrareddy, P., Zhou, Y., Luan, X., Diekwisch, T.G. (2014). Lyophilized Platelet-Rich Fibrin (PRF) promotes craniofacial bone regeneration through Runx2. Int. J. Mol. Sci. 15(5): 8509-8525.

Gopinathan G., Kolokythas, A., Luan, X., and Diekwisch, T.G.H. (2013). Epigenetic marks define the lineage and differentiation potential of two distinct neural crest-derived odontogenic progenitors. Stem Cells Dev. 22(12): 1763-1778.

Huang, J., Zhao, D., Dangaria, S.J., Luan, X., Diekwisch, T.G.H., Saiz, E., Liu, G., Tomsia, A.P. (2013). Combinatorial design of hydrolytically degradable, bone-like biocomposites based on PHEMA and hydroxyapatite. Polymer. 54(2): 909-919.

Atsawasuwan P., Lu X, Ito, Y., Evans C.A., and Luan X. (2013).  Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferation. PLoS ONE. 8(4): e52800. doi:10.1371/journal.pone.0052800

Lu X., Ito, Y., Atsawasuwan P., Dangaria S., Evans C.A., and Luan, X. (2013). Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway. BONE. 54(1): 157-168.

Atsawasuwan, P., Lu, X., Ito, Y., Gopinathan, G., Chen, Y., Evans, C.A., Kulkarni, A.B., Gibson, C.W., Luan, X., and Diekwisch, T.G.H. (2013). Enamel-related gene products in calvarial development. J. Dent. Res. 92(7): 622-628.

Pan, S., Dangaria, S.J., Yan, X., Gopinathan, G., Lu, X., Kolokythas, A., Niu, X., and Luan X. (2013). SCF promotes dental pulp progenitor migration, neovascularization, and collagen remodeling – potential applications as a homing factor in pulp regeneration. Stem Cell Rev. Rep. 9(5): 655-667.

Li, Q., Pan, S., Dangaria, S.J., Gopinathan G., Kolokythas, A., Chu, S., Geng, Y., Zhou, Y, and Luan, X. (2013). Platelet-rich fibrin (PRF) promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed. Res. Int. 2013(1): 638043.

Dangaria, S., Ito, Y., Luan, X., and Diekwisch, T.G.H. (2011). Successful periodontal ligament regeneration by periodontal progenitor pre-seeding on natural tooth root surfaces. Stem Cells Dev. 20(10): 1659-1668.

Dangaria, S., Ito, Y., Yin, L.L., Valdrè, G., Luan, X., and Diekwisch, T.G.H. (2011). Apatite microtopographies instruct signaling tapestries for progenitor-driven new attachment of teeth. Tissue Eng. Part A. 17(3-4): 279-290.

Dangaria, S., Ito, Y., Luan, X., and Diekwisch, T.G.H. (2011). Differentiation of neural crest-derived intermediate pluripotent progenitors into committed periodontal populations involves unique molecular signature changes, cohort shifts, and epigenetic modifications. Stem Cells Dev. 20(1): 39-52. Journal Cover.

Lu, X., Ito, Y, Kulkarni, A., Gibson, C., Luan, X., and Diekwisch, T.G.H. (2011). Ameloblastin-rich enamel matrix favors short and randomly oriented apatite crystals. Eur. J Oral Sci. 119 Suppl 1: 254-260.

Zhang, Y., Zhang X., Lu X., Atsawasuwan, P., and Luan, X. (2011). Ameloblastin regulates cell attachment and proliferation through RhoA and p27. Eur. J. Oral Sci. 119 Suppl 1: 280-285.

Zhang, X., Diekwisch, T.G.H., and Luan, X. (2011). Structure and function of ameloblastin as an extracellular matrix protein: Adhesion, calcium binding, and CD63-interaction in human and mouse. Eur. J Oral Sci. 119 Suppl 1: 270-279.

Dangaria, S.J., Ito, Y., Walker, C., Druzinsky, R., Luan, X., and Diekwisch, T.G.H. (2009). Extracellular matrix-mediated differentiation of periodontal progenitor cells. Differentiation. 78(2-3): 79-90.

Luan, X., Ito, Y., Dangaria, S., and Diekwisch, T.G.H. (2006). Dental follicle progenitor cell heterogeneity in the developing mouse periodontium. Stem Cells Dev. 15(4): 595-608.