URMC / Labs / MacLean Lab / Publications Recent Publications Rook MLMiaro MCouch TKneisley DLMusgaard MMacLean DM Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.; The Journal of general physiology; Vol 153(8). 2021 Aug 02. Couch TBerger KKneisley DLMcCullock TWKammermeier PMaclean DM Topography and motion of the acid-sensing ion channel intracellular domains.; eLife; Vol 10. 2021 Jul 22. Rook MLMusgaard MMacLean DM Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors.; The Journal of physiology. 2020 Apr 19. Durham RJPaudyal NCarrillo EBhatia NKMaclean DMBerka VDolino DMGorfe AAJayaraman V Conformational spread and dynamics in allostery of NMDA receptors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 117(7). 2020 Feb 18. Rook MLWilliamson ALueck JDMusgaard MMaclean DM β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery.; eLife; Vol 9. 2020 Feb 07. Carrillo EShaikh SABerka VDurham RJLitwin DBLee GMacLean DMNowak LMJayaraman V Mechanism of modulation of AMPA receptors by TARP-γ8.; The Journal of general physiology; Vol 152(1). 2020 Jan 06. McCullock TWMacLean DMKammermeier PJ Comparing the performance of mScarlet-I, mRuby3, and mCherry as FRET acceptors for mNeonGreen.; PloS one; Vol 15(2). 2020. MacLean DMDurham RJJayaraman V Mapping the Conformational Landscape of Glutamate Receptors Using Single Molecule FRET.; Trends in neurosciences; Vol 42(2). 2019 Feb. Chen JLi LChen SRChen HXie JDSirrieh REMacLean DMZhang YZhou MHJayaraman VPan HL The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.; Cell reports; Vol 22(9). 2018 Feb 27. Dolino DMChatterjee SMacLean DMFlatebo CBishop LDCShaikh SALandes CFJayaraman V The structure-energy landscape of NMDA receptor gating.; Nature chemical biology. 2017 Oct 09. Coombs IDMacLean DMJayaraman VFarrant MCull-Candy SG Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.; Cell reports; Vol 20(5). 2017 Aug 01. MacLean DMJayaraman V Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.; Proceedings of the National Academy of Sciences of the United States of America; Vol 114(12). 2017 Mar 21. Vitrac HMacLean DMKarlstaedt ATaegtmeyer HJayaraman VBogdanov MDowhan W Dynamic Lipid-dependent Modulation of Protein Topology by Post-translational Phosphorylation.; The Journal of biological chemistry; Vol 292(5). 2017 Feb 03. Shaikh SADolino DMLee GChatterjee SMacLean DMFlatebo CLandes CFJayaraman V Stargazin Modulation of AMPA Receptors.; Cell reports; Vol 17(2). 2016 Oct 04. MacLean DMJayaraman V Acid-sensing ion channels are tuned to follow high-frequency stimuli.; The Journal of physiology; Vol 594(10). 2016 May 15. Vitrac HMacLean DMJayaraman VBogdanov MDowhan W Dynamic membrane protein topological switching upon changes in phospholipid environment.; Proceedings of the National Academy of Sciences of the United States of America; Vol 112(45). 2015 Nov 10. Sirrieh REMacLean DMJayaraman V A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc.; The Journal of general physiology; Vol 146(2). 2015 Aug. Sirrieh REMacLean DMJayaraman V Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine.; The Journal of biological chemistry; Vol 290(20). 2015 May 15. MacLean DMRamaswamy SSDu MHowe JRJayaraman V Stargazin promotes closure of the AMPA receptor ligand-binding domain.; The Journal of general physiology; Vol 144(6). 2014 Dec. Lee GMacLean DMUlrich HZhao XAronowski JJayaraman V RNA based antagonist of NMDA receptors.; ACS chemical neuroscience; Vol 5(7). 2014 Jul 16. Ramaswamy SSMacLean DMGorfe AAJayaraman V Proton-mediated conformational changes in an acid-sensing ion channel.; The Journal of biological chemistry; Vol 288(50). 2013 Dec 13. Sirrieh REMacLean DMJayaraman V Amino-terminal domain tetramer organization and structural effects of zinc binding in the N-methyl-D-aspartate (NMDA) receptor.; The Journal of biological chemistry; Vol 288(31). 2013 Aug 02. MacLean DM CrossTalk opposing view: TARPs modulate AMPA receptor conformations before the gating transitions.; The Journal of physiology; Vol 591(7). 2013 Apr 01. Ramaswamy SCooper DPoddar NMacLean DMRambhadran ATaylor JNUhm HLandes CFJayaraman V Role of conformational dynamics in α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor partial agonism.; The Journal of biological chemistry; Vol 287(52). 2012 Dec 21. Maclean DMBowie D Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation.; The Journal of physiology; Vol 589(Pt 22). 2011 Nov 15. Maclean DMWong AYFay AMBowie D Cations but not anions regulate the responsiveness of kainate receptors.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 31(6). 2011 Feb 09. MacLean DM The delta2 glutamate-like receptor undergoes similar conformational changes as other ionotropic glutamate receptors.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 29(21). 2009 May 27. Wong AYMacLean DMBowie D Na+/Cl- dipole couples agonist binding to kainate receptor activation.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 27(25). 2007 Jun 20. Kuang DYao YMaclean DWang MHampson DRChang BS Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 103(38). 2006 Sep 19.