URMC / Labs / MacLean Lab / Publications Recent Publications Rook MLMcCullock TWCouch TLueck JDMacLean DM Photomodulation of the ASIC1a acidic pocket destabilizes the open state.; Protein science : a publication of the Protein Society. 2023 Jan 08. Allen JPGarber KBPerszyk RKhayat CTKell SAKaneko MQuindipan CSaitta SLadda RLHewson SInbar-Feigenberg MPrasad CPrasad ANOlewiler LMu WRosenthal LSScala MStriano PZara FMcCullock TWJauss RTLemke JRMacLean DMZhu CYuan HMyers SJTraynelis SF Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.; Human molecular genetics. 2023 Jan 07. Rook MLMiaro MCouch TKneisley DLMusgaard MMacLean DM Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.; The Journal of general physiology; Vol 153(8). 2021 Aug 02. Couch TBerger KKneisley DLMcCullock TWKammermeier PMaclean DM Topography and motion of the acid-sensing ion channel intracellular domains.; eLife; Vol 10. 2021 Jul 22. Rook MLAnanchenko AMusgaard MMacLean DM Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics.; Frontiers in cellular neuroscience; Vol 15. 2021. Rook MLMusgaard MMacLean DM Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors.; The Journal of physiology. 2020 Apr 19. Durham RJPaudyal NCarrillo EBhatia NKMaclean DMBerka VDolino DMGorfe AAJayaraman V Conformational spread and dynamics in allostery of NMDA receptors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 117(7). 2020 Feb 18. Rook MLWilliamson ALueck JDMusgaard MMaclean DM β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery.; eLife; Vol 9. 2020 Feb 07. Carrillo EShaikh SABerka VDurham RJLitwin DBLee GMacLean DMNowak LMJayaraman V Mechanism of modulation of AMPA receptors by TARP-γ8.; The Journal of general physiology; Vol 152(1). 2020 Jan 06. McCullock TWMacLean DMKammermeier PJ Comparing the performance of mScarlet-I, mRuby3, and mCherry as FRET acceptors for mNeonGreen.; PloS one; Vol 15(2). 2020. MacLean DMDurham RJJayaraman V Mapping the Conformational Landscape of Glutamate Receptors Using Single Molecule FRET.; Trends in neurosciences; Vol 42(2). 2019 Feb. Chen JLi LChen SRChen HXie JDSirrieh REMacLean DMZhang YZhou MHJayaraman VPan HL The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.; Cell reports; Vol 22(9). 2018 Feb 27. Dolino DMChatterjee SMacLean DMFlatebo CBishop LDCShaikh SALandes CFJayaraman V The structure-energy landscape of NMDA receptor gating.; Nature chemical biology. 2017 Oct 09. Coombs IDMacLean DMJayaraman VFarrant MCull-Candy SG Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.; Cell reports; Vol 20(5). 2017 Aug 01. MacLean DMJayaraman V Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.; Proceedings of the National Academy of Sciences of the United States of America; Vol 114(12). 2017 Mar 21. Vitrac HMacLean DMKarlstaedt ATaegtmeyer HJayaraman VBogdanov MDowhan W Dynamic Lipid-dependent Modulation of Protein Topology by Post-translational Phosphorylation.; The Journal of biological chemistry; Vol 292(5). 2017 Feb 03. Shaikh SADolino DMLee GChatterjee SMacLean DMFlatebo CLandes CFJayaraman V Stargazin Modulation of AMPA Receptors.; Cell reports; Vol 17(2). 2016 Oct 04. MacLean DMJayaraman V Acid-sensing ion channels are tuned to follow high-frequency stimuli.; The Journal of physiology; Vol 594(10). 2016 May 15. Vitrac HMacLean DMJayaraman VBogdanov MDowhan W Dynamic membrane protein topological switching upon changes in phospholipid environment.; Proceedings of the National Academy of Sciences of the United States of America; Vol 112(45). 2015 Nov 10. Sirrieh REMacLean DMJayaraman V A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc.; The Journal of general physiology; Vol 146(2). 2015 Aug. Sirrieh REMacLean DMJayaraman V Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine.; The Journal of biological chemistry; Vol 290(20). 2015 May 15. MacLean DMRamaswamy SSDu MHowe JRJayaraman V Stargazin promotes closure of the AMPA receptor ligand-binding domain.; The Journal of general physiology; Vol 144(6). 2014 Dec. Lee GMacLean DMUlrich HZhao XAronowski JJayaraman V RNA based antagonist of NMDA receptors.; ACS chemical neuroscience; Vol 5(7). 2014 Jul 16. Ramaswamy SSMacLean DMGorfe AAJayaraman V Proton-mediated conformational changes in an acid-sensing ion channel.; The Journal of biological chemistry; Vol 288(50). 2013 Dec 13. Sirrieh REMacLean DMJayaraman V Amino-terminal domain tetramer organization and structural effects of zinc binding in the N-methyl-D-aspartate (NMDA) receptor.; The Journal of biological chemistry; Vol 288(31). 2013 Aug 02. MacLean DM CrossTalk opposing view: TARPs modulate AMPA receptor conformations before the gating transitions.; The Journal of physiology; Vol 591(7). 2013 Apr 01. Ramaswamy SCooper DPoddar NMacLean DMRambhadran ATaylor JNUhm HLandes CFJayaraman V Role of conformational dynamics in α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor partial agonism.; The Journal of biological chemistry; Vol 287(52). 2012 Dec 21. Maclean DMBowie D Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation.; The Journal of physiology; Vol 589(Pt 22). 2011 Nov 15. Maclean DMWong AYFay AMBowie D Cations but not anions regulate the responsiveness of kainate receptors.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 31(6). 2011 Feb 09. MacLean DM The delta2 glutamate-like receptor undergoes similar conformational changes as other ionotropic glutamate receptors.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 29(21). 2009 May 27. Wong AYMacLean DMBowie D Na+/Cl- dipole couples agonist binding to kainate receptor activation.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 27(25). 2007 Jun 20. Kuang DYao YMaclean DWang MHampson DRChang BS Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 103(38). 2006 Sep 19.