Lab Members

Research Interest: Innate and adaptive immune responses and cancer immunotherapy

Research Interest: Molecular and cellular events that regulate T cell signaling and activation

Research Interest: How the vasculature, immune, inflammatory systems and cells native to a tissue interact in disease states.

Research Interest: Using high resolution quantitative microscopy and bioengineering approaches to probe mechanical interactions in cellular processes

Research Interest: Multiple roles of virus-specific Band T cells in determining the outcome of viral infection of the respiratory tract. Long term protective effect of immunological mechanisms.

Research Interest: Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system

Research Interest: Innate immunity in influenza infection, Regulation of immune responses via trail formation

Research Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.

Research Interest: We propose to develop primary mouse airway epithelial cell organoids. These will be infused with activated and memory CD8 OT-I T cells as an in vitro model of the airways to study motility. Organoids offer several advantages such as the ability to use genetically engineered epithelial cells as well as Tcells, they are optically transparent, and we seek to gather higher resolution imaging and fine measurements of T cell/EC cell behaviors related to motility that are difficult or impossible to obtain in vivo.