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Project 1: Inflammatory Cues Regulating Effector T Cell Recruitment (PI: Minsoo Kim)

Project 1 imageThe maintenance of homeostatic immune surveillance and the development of effective immune responses require that leukocytes cross tissue barriers and move throughout the body, migrating in and out of the bone marrow, lymphoid and non-lymphoid tissues, under both normal and infected or inflamed conditions.

Learn more about Project 1: Inflammatory Cues Regulating Effector T Cell Recruitment

Project 2: Regulation of Effector T Cell Migration within Inflamed Tissues (PI: Deborah Fowell, Co-PI: Jim Miller)

Project 2 imageFundamental to immune-mediated protection is the ability of leukocytes to survey barrier surfaces and quickly respond to infection or tissue damage. Signals from cytokines, chemokines and cells (immune and stromal) within the tissue provide critical cues for T cell migration at sites of inflammation, but the mechanics of T cell motility to these signals is poorly understood.

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Project 3: Dynamics of CD8 T Cell Migration in the Influenza-infected Airways Leading to Establishment of Tissue Resident Memory (PI: David Topham)

Project 3 imageInfluenza virus infects the epithelial cells that line the respiratory tract. Productive replication of the virus is restricted to this site because of the requirement for a locally expressed trypsin-like enzyme to cleave nascent viral hemagglutinin (HA) surface protein into its active conformation.

Learn more about Project 3: Dynamics of CD8 T Cell Migration in the Influenza-infected Airways Leading to Establishment of Tissue Resident Memory