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Heilbronner and Yule Receive Awards at 2016 Convocation

Monday, August 29, 2016

Sarah R. Heilbronner, PhD, will receive the Postdoctoral Achievement Award at the 2016 Convocation, on September 8. She is currently a postdoc in Dr. Suzanne Haber's lab, where she is studying the neural circuitry associated with reward processing, decision-making, and executive function.

Along with the other members of Dr. Haber's team, Sarah is working to determine the anatomical connections that are affected by neurosurgical interventions for psychiatric disorders (such as deep brain stimulation).

Professor David I. Yule, Ph.D., will also receive the Faculty Teaching Award, specifically the Trainee Academic Mentoring Award in Basic Science, as well as the Louis C. Lasagna Endowed Professorship at convocation. The Yule Lab studies intracellular calcium signaling in cells which are typically, electrically non-excitable. In cells such as the liver, exocrine, pancreas, salivary glands and various cells in the blood, increases in intracellular calcium are fundamentally important for diverse processes including secretion of digestive enzymes and fluid, glucose metabolism together with cellular growth and differentiation.

Congrats Sarah and David!

David Yule appointed Louis C. Lasagna Professor

Tuesday, July 5, 2016

David Yule sits in a lab

David Yule

David Yule, professor of pharmacology and physiology, has been appointed the Louis C. Lasagna Professor in Experimental Therapeutics for five years, effective July 1. He retains his joint appointments as professor of medicine and as professor in the Center for Oral Biology.

For the past 15 years, Yule has studied calcium’s role in disorders in which calcium signaling and secretions are disrupted, such as Sjögren’s syndrome—in which patients experience dry mouth due to a lack of saliva—and acute pancreatitis.

Using state-of-the art imaging and electrophysiological techniques, Yule’s lab monitors calcium signals to achieve a better understanding of the mechanisms that underlie these signals with the goal that the studies will give insight into the control of important physiological processes in both normal physiology and disease states.

Yule received his PhD in physiology from the University of Liverpool in the United Kingdom. His research has been published in numerous journals, including the Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, Science Signaling, and the Journal of Physiology. Yule serves on the editorial board for Gastroenterology, the preeminent journal in the field of gastrointestinal disease.

The Lasagna professorship honors Louis Lasagna, who served as chair of the Department for Pharmacology from 1970 to 1983, and brought the department to national recognition as a center of training and research. Lasagna, who was known for pioneering the study of placebos and writing an alternative Hippocratic oath, died in 2003.

Read More: David Yule appointed Louis C. Lasagna Professor

Study: The Science behind Bodily Secretions

Tuesday, April 5, 2016

The salivary gland secretes saliva that helps us chew and swallow the food we eat. The pancreas secretes digestive juices that enable our bodies to break down the fat, protein, and carbohydrates in the food. Secretions like these are important in countless activities that keep our bodies running day and night. A study published today in the journal Science Signaling uncovers a previously mysterious process that makes these secretions possible.

At the heart of the new study is calcium, which is present in all of our cells and is a gatekeeper of sorts: an increase in calcium in our cells opens up “gates” or “channels” that are required for the production and secretion of fluids like saliva. If calcium doesn’t increase inside cells the gates won’t open, a problem that occurs in diseases like Sjögren’s syndrome. Sjögren’s patients experience dry mouth due to a lack of saliva and have difficulty chewing, swallowing, and speaking, which severely hampers quality of life.

For the past 15 years David I. Yule, Ph.D., professor in the department of Pharmacology and Physiology at the University of Rochester School of Medicine and Dentistry has studied calcium’s role in Sjögren’s and other disorders in which calcium and secretions are disrupted, like acute pancreatitis. In the new study he answers an important question that has stumped scientists for years: what does it take for a particularly important calcium channel to open and start these processes?

Read More: Study: The Science behind Bodily Secretions