Haber Lab Research Overview Dr. Haber's laboratory investigates the neural network that underlies incentive-based learning and decision-making leading to the development of action plans. The cortico-basal ganglia system is at the center of this circuit and comprises a diverse group of structures involved in reward and motivation, cognition, and motor control. The consequence of basal ganglia dysfunction is emphasized in the range of diseases that involve it, including mental health disorders such as obsessive-compulsive disorder, drug abuse and addiction, and schizophrenia, and motor control disorders including Parkinson’s disease. One set of experiments in Dr. Haber's laboratory address the hypothesis that the cortico-basal ganglia network processes information through both parallel and integrative circuits. A second set of studies focus on the pathway trajectories from different prefrontal areas to their targets. A third set of experiments focus on which pathways and terminals fields are likely to be involved in the therapeutic effects of during deep brain stimulation (DBS). A fourth set of studies address the changes in terminal fields and white matter tracts during postnatal development. Basal ganglia structures Projects 1) Organization of prefrontal cortical and subcortical connectives: 1.1. The reward circuit Rewardcircuit; 1.2. Corticostriatal-basal ganglia circuits: it’s not a simple topography ctx-vs ctx-DS Monkey cortical-striatal projections. Rat cortical-striatal projections.; 1.3. Cortico-subthalamic projections: topography and topology; 1.4.Striato-nigro-striatal and cortico-thalamo-cortical circuits form reciprocal and non-reciprocal connections thalamus S-SN-S Striatal-nigral spiral; 1.5. Habenular connections. 2) Rules for prefrontal cortical pathways: how they really get their targets: 2.1 Rules for the ventral prefrontal cortex Rules vmPFC cortical & subcortical pathways. OFC cortical & subcortical pathways; 2.2 Monkey and Human ventral prefrontal fibers use the same organizational rules DTI; 2.3 The cingulate bundle carries more than you think Cingulate; 2.4 Internal capsule: an organized gateway for connections Internal capsule. 3) Terminals and pathways effected during deep brain stimulation (DBS) DBSreview Overview of deep brain stimulation. : 3.1 DBS at the internal capsule site, what it gets and what it doesn’t get DBS Model of electrode in internal capsule. 4)Postnatal development of cortical conectivities and pathways: 4.1 vmPFC cortico-striatal connections during postnatal development Recent Publications Heilbronner SR, Haber SN. Frontal cortical and subcortical projections provide a basis for segmenting the cingulum bundle: implications for neuroimaging and psychiatric disorders. J. Neurosci. 2014 Jul 23; 34(30):10041-54. Averbeck BB, Lehman J, Jacobson M, Haber SN. Estimates of Projection Overlap and Zones of Convergence within Frontal-Striatal Circuits. J. Neurosci.. 2014 Jul 16; 34(29):9497-505. Tziortzi AC, Haber SN, Searle GE, Tsoumpas C, Long CJ, Shotbolt P, Douaud G, Jbabdi S, Behrens TE, Rabiner EA, Jenkinson M, Gunn RN.Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography. Cerebral cortex (New York, N.Y. : 1991). 2014 May; 24(5):1165-77. Epub 2013 Jan 02. Haynes WIA, Haber SN. The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for basal ganglia models and deep brain stimulations. 2013, J. Neurosci. 33(11):4804-4814. Jbabdi S, Lehman J, Haber SN*, Behrens, TEJ*. Human and monkey ventral prefrontal fibers use the same organizational principles to reach their targets: tracing versus tractography. J. Neurosci., 2013, 33(7):3190-3201. *equal contributon. Mailly P, Aliane V, Groenewegen HJ, Haber SN, Deniau JM. The Rat Prefrontostriatal System Analyzed in 3D: Evidence for Multiple Interacting Functional Units. J. Neurosci., 2013. 33(13):5718-5727. McLaughlin NC, Didie ER, Machado AG, Haber SN, Eskandar EN, Greenberg BD. Improvements in anorexia symptoms after deep brain stimulation for intractable obsessive-compulsive disorder. Biological psychiatry.. 2013 May 1; 73(9):e29-31. Epub 2012 Nov 03.