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Steve N. Georas, M.D.

Steve N. Georas, M.D.

Pulmonary & Critical Care Medicine

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
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About Me

I am board certified in both Pulmonary and Critical Care Medicine, and have been caring for patients with a variety of acute and chronic lung diseases for more than twenty years. I have previous experience directing a respiratory therapy department, and currently oversee the Pulmonary Function Labs...
I am board certified in both Pulmonary and Critical Care Medicine, and have been caring for patients with a variety of acute and chronic lung diseases for more than twenty years. I have previous experience directing a respiratory therapy department, and currently oversee the Pulmonary Function Labs at URMC. I am an attending physician in the Medical Intensive Care Units at Strong Memorial and Highland Hospitals, and have extensive experience in managing patients with acute respiratory failure, pneumonia, sepsis, and multi-organ failure, using multiple ventilator modes and also patient-specific approaches to ventilator weaning. I emphasize a team approach in the MICU, and value the input provided by nurses, respiratory therapists, pharmacists, and other specialists in developing tailored care plans.

I also see outpatients with asthma at the Mary Parkes Center for Asthma and Pulmonary Care, and work closely with consultants in Allergy, ENT, and Speech Therapy to develop individualized approaches to diagnosis and management.

Professional Background

Dr. Georas was born and grew up in Providence, Rhode Island. He graduated from Brown University with a B.S. in Applied Mathematics and Biology in 1983, and then attended Brown Medical School (M.D., 1987). After Internal Medicine internship and residency at Duke University Medical Center, Dr. Geora...
Dr. Georas was born and grew up in Providence, Rhode Island. He graduated from Brown University with a B.S. in Applied Mathematics and Biology in 1983, and then attended Brown Medical School (M.D., 1987). After Internal Medicine internship and residency at Duke University Medical Center, Dr. Georas moved to Johns Hopkins University for a Fellowship in Pulmonary and Critical Care Medicine, which he completed in 1994. From 1994-2006, he was a faculty member at Johns Hopkins University in the Pulmonary & Critical Care Division with a joint appointment in the Division of Allergy & Clinical Immunology, and Department of Environmental Health Sciences. He rose to the rank of Associate Professor of Medicine and Director of Pulmonary Research. In July 2006, he moved to the University of Rochester Medical Center, where he served as Division Chief of Pulmonary & Critical Care Medicine until 2010. Dr. Georas directs a research group investigating mechanisms of immune cell activation in the lung in asthma and other diseases. He has authored numerous publications in this area, and has been invited to present his research at national and international meetings. He is active in peer review, and serves on numerous advisory panels and review groups for the NIH and other professional societies.

Certified Specialties

Internal Medicine-Critical Care Medicine - American Board of Internal Medicine

Pulmonary Disease - American Board of Internal Medicine

Faculty Appointments

Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Walter & Carmina Mary Parkes Family Distinguished Professorship - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Professor - Department of Environmental Medicine (SMD) - Joint

Professor - Department of Microbiology and Immunology (SMD) - Joint

Credentials

Residency & Fellowship

Fellowship, Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine. 1990 - 1994

Residency, Internal Medicine, Duke University Internal Medicine Program. 1988 - 1990

Internship, Internal Medicine, Duke University Medical Center. 1987 - 1988

Medical School, Brown University Program in Medicine. 1983 - 1987

Research

Dr. Georas is Professor of Medicine, Environmental Medicine. Microbiology and Immunology at the University of Rochester Medical Center. From 1994-2006, he was a faculty member at Johns Hopkins University in the Pulmonary & Critical Care Division with a joint appointment in the Division of Allergy & ...
Dr. Georas is Professor of Medicine, Environmental Medicine. Microbiology and Immunology at the University of Rochester Medical Center. From 1994-2006, he was a faculty member at Johns Hopkins University in the Pulmonary & Critical Care Division with a joint appointment in the Division of Allergy & Clinical Immunology, and Department of Environmental Health Sciences. He moved to the University of Rochester in 2006. Dr. Georas directs a research group investigating mechanisms of immune cell activation in the lung. Current studies are aimed at defining molecular pathways by which allergens and particulate matter activate epithelial cells and dendritic cells, leading to generation of maladaptive allergen-specific immune responses in asthma. A separate line of research is investigating how lysophosphatidic acid is generated in the lung, exploring the role of different LPA receptors in lung inflammation and immune responses. These studies should further our understanding of how the lung functions as an immune organ, with a long-term goal of alleviating the burden of immune-mediated lung diseases including asthma in susceptible human subjects. Dr. Georas also directs the Study of Asthma in Rochester (SOAR2), which is enrolling adult asthma patients who have frequent exacerbations in a prospective registry, with the goal of identifying new treatments for these patients who currently have limited therapeutic options.

Research Lab

Clinical Trials

Asthma Future Contact Database

Lead Researcher: Steve N Georas

The doctors and researchers in the Pulmonary and Critical Care Medicine Division at the University of Rochester are creating a database (a list) of individuals with asthma who are interested in taking part in future research studies about asthma. If...

The CHRONICLE Study

Lead Researcher: Steve N Georas

In this study, you will complete monthly surveys (12 per year) about your life and health via a dedicated web site. The first survey package will take about 45 minutes to complete. Afterward, most monthly surveys will be short and require about 5-10 ...

Asthma Future Contact Database

Lead Researcher: Steve N Georas

We are looking for asthmatic and healthy volunteers who are interested in asthma research, who would like to join the database. Joining the database means you may be contacted in the future about participating in a clinical study about asthma. Joini...

Patents

Methods of Diagnosing and Treating Fibrosis

Issue date: August 18, 2015

Patent #: 9,107,942

Country: United States

Inventors: Steve N Georas, Jia Guo, Xin Lin, Patricia Janet Sime

Publications

Journal Articles

Update on Asthma Biology.

Georas SN, Khurana S

The Journal of allergy and clinical immunology.. 2024 February 8 Epub 02/08/2024.

Response.

Baugh A, Adegunsoye A, Connolly M, Croft D, Pew K, McCormack MC, Georas SN

Chest.. 2024 February 165 (2):e62-e63. Epub 1900 01 01.

Towards a Race-Neutral System of Pulmonary Function Test Results Interpretation.

Baugh A, Adegunsoye A, Connolly M, Croft D, Pew K, McCormack MC, Georas SN

Chest.. 2023 June 17 Epub 06/17/2023.

Diagnostic Impact of a Race-Composite Pulmonary Function Test Results Interpretation Strategy.

Connolly MJ, Donohue PA, Palli R, Khurana S, Cai X, Georas SN

Chest.. 2023 June 17 Epub 06/17/2023.

IgE Sensitization Drives the Atopic March.

Beck LA, Pesonen M, Thakar J, Georas SN, Järvinen KM

American journal of respiratory and critical care medicine.. 2022 December 8 Epub 12/08/2022.

The effects of a deep breathing maneuver on standard airwave oscillometry measurements.

Donohue P, Love NC, Connolly M, Khurana S, Georas SN

Respiratory medicine and research.. 2022 December 683 :100985. Epub 12/06/2022.

Protein kinase D3 promotes neutrophil migration during viral infection.

Veazey JM, Wong GS, Eliseeva SI, Smyth TR, Chapman TJ, Lim K, Kim M, Georas SN

Immunology and cell biology.. 2022 November 1 Epub 11/01/2022.

Exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters immune response to challenge in adult mice.

O'Dell CT, Boule LA, Robert J, Georas SN, Eliseeva S, Lawrence BP

Journal of immunotoxicology.. 2021 December 18 (1):105-117. Epub 1900 01 01.

The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: an overview of Network organization, procedures and interventions.

Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Alexander LC, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P,

The Journal of allergy and clinical immunology.. 2021 November 27 Epub 11/27/2021.

Inhaled Adjuvants and Eosinophilic Airway Inflammation in Asthma: Is a Little Bit of Lipopolysaccharide the Key to Allergen Sensitization?

Georas SN

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 October 1207 (7):1699-1701. Epub 1900 01 01.

JAK inhibitors for asthma.

Georas SN, Donohue P, Connolly M, Wechsler ME

The Journal of allergy and clinical immunology.. 2021 October 148 (4):953-963. Epub 1900 01 01.

The effect of air pollution on the transcriptomics of the immune response to respiratory infection.

Croft DP, Burton DS, Nagel DJ, Bhattacharya S, Falsey AR, Georas SN, Hopke PK, Johnston CJ, Kottmann RM, Litonjua AA, Mariani TJ, Rich DQ, Thevenet-Morrison K, Thurston SW, Utell MJ, McCall MN

Scientific reports.. 2021 September 3011 (1):19436. Epub 09/30/2021.

Asthma Biologics: Real-World Effectiveness, Impact of Switching Biologics and Predictors of Response.

Abbas F, Georas S, Cai X, Khurana S

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2021 September 2 Epub 09/02/2021.

Effects of ozone and particulate matter on airway epithelial barrier structure and function: a review of and studies.

Smyth T, Georas SN

Inhalation toxicology.. 2021 August 4 :1-16. Epub 08/04/2021.

LPA and Autotaxin: Potential Drug Targets in Asthma?

Georas SN

Cell biochemistry and biophysics.. 2021 July 31 Epub 07/31/2021.

PrecISE: Precision Medicine in Severe Asthma An Adaptive Platform Trial with Biomarker Ascertainment.

Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A

The Journal of allergy and clinical immunology.. 2021 March 2 Epub 03/02/2021.

Changes in lung immune cell infiltrates after electric field treatment in mice.

Eliseeva SI, Knowlden ZA, Lester GM, Dean DA, Georas SN, Chapman TJ

Scientific reports.. 2021 January 1411 (1):1453. Epub 01/14/2021.

Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge.

Rimmer C, Hetelekides S, Eliseeva SI, Georas SN, Veazey JM

PloS one.. 2021 16 (12):e0260706. Epub 12/06/2021.

Diabetes Mellitus is Associated with Worse Outcome in Patients Hospitalized for Asthma.

Zhang P, Lopez R, Attaway AH, Georas SN, Khatri SB, Abi-Saleh S, Zein JG

The journal of allergy and clinical immunology. In practice.. 2020 November 9 Epub 11/09/2020.

Lung megakaryocytes are immune modulatory cells.

Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders Ii J, Georas SN, Veazey JM, Madere F, Tesoro Santos L, Arne AM, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons CE, Metcalf Pate KA, McGrath KE, Palis J, Morrell C

The Journal of clinical investigation.. 2020 October 20 Epub 10/20/2020.

Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin.

Smyth T, Veazey J, Eliseeva S, Chalupa D, Elder A, Georas SN

Particle and fibre toxicology.. 2020 October 1517 (1):52. Epub 10/15/2020.

The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations.

Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, Billheimer D, Bleecker ER, Cardet JC, Castro M, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Holguin F, Jain S, Kenyon NJ, Krishnan JA, Kraft M, Kumar R, Liu MC, Ly NP, Moy JN, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Wechsler ME, Wenzel SE, White SR

Journal of biopharmaceutical statistics.. 2020 September 17 :1-12. Epub 09/17/2020.

Treatment for Pneumothorax.

Baah S, Georas SN

The New England journal of medicine.. 2020 April 30382 (18):1766-1767. Epub 1900 01 01.

Invasive pulmonary aspergillosis in a patient with cirrhosis.

Clark HL, Valencia HE, Findeis-Hosey JJ, Georas SN

IDCases.. 2020 19 :e00722. Epub 02/20/2020.

Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection.

Veazey JM, Eliseeva SI, Hillman SE, Stiles K, Smyth TR, Morrissey CE, Tillotson EJ, Topham DJ, Chapman TJ, Georas SN

Frontiers in immunology.. 2020 11 :580401. Epub 12/14/2020.

Restrictive lung disease in TNF-transgenic mice: correlation of pulmonary function testing and micro-CT imaging.

Wu EK, Eliseeva S, Rahimi H, Schwarz EM, Georas SN

Experimental lung research.. 2019 September 45 (7):175-187. Epub 07/18/2019.

Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA.

Veazey JM, Chapman TJ, Smyth TR, Hillman SE, Eliseeva SI, Georas SN

PloS one.. 2019 14 (5):e0216056. Epub 05/08/2019.

The leaky lung test: A pilot study using inhaled mannitol to measure airway barrier function in asthma.

Georas S, Ransom N, Hillman S, Eliseeva S, Veazey J, Smyth T, Le K, Meddings J

The Journal of asthma : official journal of the Association for the Care of Asthma.. 2018 November 16 :1-9. Epub 11/16/2018.

Developmental Exposure to a Mixture of 23 Chemicals Associated With Unconventional Oil and Gas Operations Alters the Immune System of Mice.

Boulé LA, Chapman TJ, Hillman SE, Kassotis CD, O'Dell C, Robert J, Georas SN, Nagel SC, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2018 June 1163 (2):639-654. Epub 1900 01 01.

All plugged up - noninvasive mucus score to assess airway dysfunction in asthma.

Georas SN

The Journal of clinical investigation.. 2018 March 1128 (3):906-909. Epub 02/05/2018.

A Fatal Case of Influenza B Myocarditis with Cardiac Tamponade.

Roto D, Malnoske ML, Winters S, Georas SN

Case reports in critical care.. 2018 2018 :8026314. Epub 08/30/2018.

The role of ST2 and ST2 genetic variants in schistosomiasis.

Long X, Daya M, Zhao J, Rafaels N, Liang H, Potee J, Campbell M, Zhang B, Araujo MI, Oliveira RR, Mathias RA, Gao L, Ruczinski I, Georas SN, Vercelli D, Beaty TH, Barnes KC, Chen X, Chen Q

The Journal of allergy and clinical immunology.. 2017 November 140 (5):1416-1422.e6. Epub 02/09/2017.

A work group report on ultrafine particles (American Academy of Allergy, Asthma & Immunology): Why ambient ultrafine and engineered nanoparticles should receive special attention for possible adverse health outcomes in human subjects.

Li N, Georas S, Alexis N, Fritz P, Xia T, Williams MA, Horner E, Nel A

The Journal of allergy and clinical immunology.. 2016 August 138 (2):386-96. Epub 04/06/2016.

Sarcoidosis and T-Helper Cells. Th1, Th17, or Th17.1?

Georas SN, Chapman TJ, Crouser ED

American journal of respiratory and critical care medicine.. 2016 June 1193 (11):1198-200. Epub 1900 01 01.

Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation.

Knowlden SA, Hillman SE, Chapman TJ, Patil R, Miller DD, Tigyi G, Georas SN

American journal of respiratory cell and molecular biology.. 2016 March 54 (3):402-9. Epub 1900 01 01.

Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study.

Becerra AZ, Georas S, Brenna JT, Hopke PK, Kane C, Chalupa D, Frampton MW, Block R, Rich DQ

Journal of toxicology and environmental health. Part A.. 2016 79 (6):287-98. Epub 03/30/2016.

Future Research Directions in Asthma. An NHLBI Working Group Report.

Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC

American journal of respiratory and critical care medicine.. 2015 December 1192 (11):1366-72. Epub 1900 01 01.

Air pollution and asthma incidence: doubt no more?

Georas SN, van Wijngaarden E, Rich DQ

The Lancet. Respiratory medicine.. 2015 December 3 (12):902-3. Epub 1900 01 01.

The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA.

Block RC, Abdolahi A, Tu X, Georas SN, Brenna JT, Phipps RP, Lawrence P, Mousa SA

Prostaglandins, leukotrienes, and essential fatty acids.. 2015 May 96 :17-24. Epub 12/22/2014.

An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum.

Long X, Chen Q, Zhao J, Rafaels N, Mathias P, Liang H, Potee J, Campbell M, Zhang B, Gao L, Georas SN, Vercelli D, Beaty TH, Ruczinski I, Mathias R, Barnes KC, Chen X

PloS one.. 2015 10 (8):e0135360. Epub 08/10/2015.

Regulatory tone and mucosal immunity in asthma.

Chapman TJ, Georas SN

International immunopharmacology.. 2014 November 23 (1):330-6. Epub 06/25/2014.

Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation.

Georas SN, Rezaee F

The Journal of allergy and clinical immunology.. 2014 September 134 (3):509-20. Epub 07/29/2014.

Update in environmental and occupational lung diseases 2013.

Carlsten C, Georas SN

American journal of respiratory and critical care medicine.. 2014 May 1189 (9):1037-43. Epub 1900 01 01.

Breaking barriers. New insights into airway epithelial barrier function in health and disease.

Rezaee F, Georas SN

American journal of respiratory cell and molecular biology.. 2014 May 50 (5):857-69. Epub 1900 01 01.

The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.

Knowlden S, Georas SN

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 February 1192 (3):851-7. Epub 1900 01 01.

Environmental exposures and innate immunity in the lung.

Georas SN, Upham J

Journal of environmental immunology and toxicology.. 2014 January 2 (1):1-3. Epub 1900 01 01.

The effects of aspirin and fish oil consumption on lysophosphatidylcholines and lysophosphatidic acids and their correlates with platelet aggregation in adults with diabetes mellitus.

Abdolahi A, Georas SN, Thomas Brenna J, Cai X, Thevenet-Morrison K, Phipps RP, Lawrence P, Mousa SA, Block RC

Prostaglandins, leukotrienes, and essential fatty acids.. 2014 90 (2-3):61-8. Epub 12/18/2013.

Regulation of T cell motility in vitro and in vivo by LPA and LPA2.

Knowlden SA, Capece T, Popovic M, Chapman TJ, Rezaee F, Kim M, Georas SN

PloS one.. 2014 9 (7):e101655. Epub 07/08/2014.

Adjuvant effect of diphtheria toxin after mucosal administration in both wild type and diphtheria toxin receptor engineered mouse strains.

Chapman TJ, Georas SN

Journal of immunological methods.. 2013 December 31400-401 :122-6. Epub 11/05/2013.

Pre-existing tolerance shapes the outcome of mucosal allergen sensitization in a murine model of asthma.

Chapman TJ, Emo JA, Knowlden SA, Rezaee F, Georas SN

The Journal of immunology : official journal of the American Association of Immunologists.. 2013 October 15191 (8):4423-30. Epub 09/13/2013.

Allergic to autotaxin. A new role for lysophospholipase d and lysophosphatidic Acid in asthma?

Georas SN

American journal of respiratory and critical care medicine.. 2013 October 15188 (8):889-91. Epub 1900 01 01.

Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.

Rezaee F, Desando SA, Ivanov AI, Chapman TJ, Knowlden SA, Beck LA, Georas SN

Journal of virology.. 2013 October 87 (20):11088-95. Epub 08/07/2013.

Effects of low-dose aspirin and fish oil on platelet function and NF-kappaB in adults with diabetes mellitus.

Block RC, Abdolahi A, Smith B, Meednu N, Thevenet-Morrison K, Cai X, Cui H, Mousa S, Thomas Brenna J, Georas S

Prostaglandins, leukotrienes, and essential fatty acids.. 2013 July 89 (1):9-18. Epub 05/07/2013.

Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells.

Saatian B, Rezaee F, Desando S, Emo J, Chapman T, Knowlden S, Georas SN

Tissue barriers.. 2013 April 11 (2):e24333. Epub 1900 01 01.

Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair.

Kuo IH, Carpenter-Mendini A, Yoshida T, McGirt LY, Ivanov AI, Barnes KC, Gallo RL, Borkowski AW, Yamasaki K, Leung DY, Georas SN, De Benedetto A, Beck LA

The Journal of investigative dermatology.. 2013 April 133 (4):988-98. Epub 12/06/2012.

The effects of maternal exposure to bisphenol A on allergic lung inflammation into adulthood.

Bauer SM, Roy A, Emo J, Chapman TJ, Georas SN, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2012 November 130 (1):82-93. Epub 07/21/2012.

Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.

Emo J, Meednu N, Chapman TJ, Rezaee F, Balys M, Randall T, Rangasamy T, Georas SN

The Journal of immunology : official journal of the American Association of Immunologists.. 2012 April 15188 (8):3784-90. Epub 03/16/2012.

The Effects of EPA+DHA and Aspirin on Inflammatory Cytokines and Angiogenesis Factors.

Block RC, Dier U, Calderonartero P, Shearer GC, Kakinami L, Larson MK, Harris WS, Georas S, Mousa SA

World Journal of Cardiovascular Diseases. 2012 January 12 (1):14-19. Epub 12/30/2011.

The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.

Qi Y, Operario DJ, Georas SN, Mosmann TR

PloS one.. 2012 7 (6):e39072. Epub 06/14/2012.

The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans.

Block RC, Kakinami L, Jonovich M, Antonetti I, Lawrence P, Meednu N, Calderonartero P, Mousa SA, Thomas Brenna J, Georas S

Prostaglandins, leukotrienes, and essential fatty acids.. 2012 87 (4-5):143-51. Epub 09/25/2012.

Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells.

Rezaee F, Meednu N, Emo JA, Saatian B, Chapman TJ, Naydenov NG, Debenedetto A, Beck LA, Ivanov AI, Georas SN

The Journal of allergy and clinical immunology.. 2011 December 128 (6):1216-1224.e11. Epub 10/11/2011.

What is hypoxia-inducible factor-1 doing in the allergic lung?

Rangasamy T, Semenza GL, Georas SN

Allergy.. 2011 July 66 (7):815-7. Epub 04/11/2011.

Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis.

De Benedetto A, Slifka MK, Rafaels NM, Kuo IH, Georas SN, Boguniewicz M, Hata T, Schneider LC, Hanifin JM, Gallo RL, Johnson DC, Barnes KC, Leung DY, Beck LA

The Journal of allergy and clinical immunology.. 2011 July 128 (1):242-246.e5. Epub 04/13/2011.

Yin yang 1 is a novel regulator of pulmonary fibrosis.

Lin X, Sime PJ, Xu H, Williams MA, Larussa L, Georas SN, Guo J

American journal of respiratory and critical care medicine.. 2011 June 15183 (12):1689-97. Epub 12/17/2010.

Tight junction defects in patients with atopic dermatitis.

De Benedetto A, Rafaels NM, McGirt LY, Ivanov AI, Georas SN, Cheadle C, Berger AE, Zhang K, Vidyasagar S, Yoshida T, Boguniewicz M, Hata T, Schneider LM, Hanifin JM, Gallo RL, Novak N, Weidinger S, Beaty TH, Leung DY, Barnes KC, Beck LA

The Journal of allergy and clinical immunology.. 2011 March 127 (3):773-86.e1-7. Epub 12/15/2010.

Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo.

Bezemer GF, Bauer SM, Oberdörster G, Breysse PN, Pieters RH, Georas SN, Williams MA

Journal of innate immunity.. 2011 3 (2):150-66. Epub 11/23/2010.

Human basophils express amphiregulin in response to T cell-derived IL-3.

Qi Y, Operario DJ, Oberholzer CM, Kobie JJ, Looney RJ, Georas SN, Mosmann TR

The Journal of allergy and clinical immunology.. 2010 December 126 (6):1260-6.e4. Epub 10/30/2010.

IL-17: important for host defense, autoimmunity, and allergy?

Lee FE, Georas SN, Beck LA

The Journal of investigative dermatology.. 2010 November 130 (11):2540-2. Epub 1900 01 01.

Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract.

Rangasamy T, Williams MA, Bauer S, Trush MA, Emo J, Georas SN, Biswal S

American journal of respiratory cell and molecular biology.. 2010 September 43 (3):276-85. Epub 10/05/2009.

Dangerous allergens: why some allergens are bad actors.

Georas SN, Rezaee F, Lerner L, Beck L

Current allergy and asthma reports.. 2010 March 10 (2):92-8. Epub 1900 01 01.

T-cell activation under hypoxic conditions enhances IFN-gamma secretion.

Roman J, Rangasamy T, Guo J, Sugunan S, Meednu N, Packirisamy G, Shimoda L, Golding A, Semenza G, Georas SN

American journal of respiratory cell and molecular biology.. 2010 January 42 (1):123-8. Epub 04/16/2009.

The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin.

Block RC, Duff R, Lawrence P, Kakinami L, Brenna JT, Shearer GC, Meednu N, Mousa S, Friedman A, Harris WS, Larson M, Georas S

Prostaglandins, leukotrienes, and essential fatty acids.. 2010 82 (2-3):87-95. Epub 01/27/2010.

Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands.

Williams MA, Bauer S, Lu W, Guo J, Walter S, Bushnell TP, Lillehoj EP, Georas SN

Journal of innate immunity.. 2010 2 (2):123-43. Epub 11/02/2009.

Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunity.

Georas SN

Immunologic research.. 2009 December 45 (2-3):229-38. Epub 01/30/2009.

GSMA: Gene Set Matrix Analysis, An Automated Method for Rapid Hypothesis Testing of Gene Expression Data.

Cheadle C, Watkins T, Fan J, Williams MA, Georas S, Hall J, Rosen A, Barnes KC

Bioinformatics and biology insights.. 2009 November 241 :49-62. Epub 11/24/2009.

Resolving lung injury: a new role for Tregs in controlling the innate immune response.

Pietropaoli A, Georas SN

The Journal of clinical investigation.. 2009 October 119 (10):2891-4. Epub 09/21/2009.

Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice.

Guo J, Lu W, Shimoda LA, Semenza GL, Georas SN

International archives of allergy and immunology.. 2009 149 (2):98-102. Epub 01/06/2009.

Dangerous allergens: innate immunity, dendritic cells and allergic asthma.

Georas SN, Beck L

Expert review of clinical immunology.. 2008 November 4 (6):777-85. Epub 1900 01 01.

Epigenetic studies should focus on specific cell types.

Guo J, Williams MA, Georas SN

American journal of respiratory and critical care medicine.. 2008 October 15178 (8):882-3; author reply 883. Epub 1900 01 01.

Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter.

Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN

The Journal of immunology : official journal of the American Association of Immunologists.. 2008 October 1181 (7):4545-59. Epub 1900 01 01.

Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses.

Guo J, Lin X, Williams MA, Hamid Q, Georas SN

The Journal of allergy and clinical immunology.. 2008 July 122 (1):195-201, 201.e1-5. Epub 04/18/2008.

Analysis of CD4+ T-cell gene expression in allergic subjects using two different microarray platforms.

Hansel NN, Cheadle C, Diette GB, Wright J, Thompson KM, Barnes KC, Georas SN

Allergy.. 2008 March 63 (3):366-9. Epub 1900 01 01.

Diesel-enriched particulate matter functionally activates human dendritic cells.

Porter M, Karp M, Killedar S, Bauer SM, Guo J, Williams D, Breysse P, Georas SN, Williams MA

American journal of respiratory cell and molecular biology.. 2007 December 37 (6):706-19. Epub 07/13/2007.

TLR2 and TLR4 as Potential Biomarkers of Environmental Particulate Matter Exposed Human Myeloid Dendritic Cells.

Williams MA, Cheadle C, Watkins T, Tailor A, Killedar S, Breysse P, Barnes KC, Georas SN

Biomarker insights. 2007 May 302 :226-40. Epub 05/30/2007.

Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells.

Zhao Y, He D, Zhao J, Wang L, Leff AR, Spannhake EW, Georas S, Natarajan V

The Journal of biological chemistry.. 2007 April 6282 (14):10172-9. Epub 02/06/2007.

Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge.

Georas SN, Berdyshev E, Hubbard W, Gorshkova IA, Usatyuk PV, Saatian B, Myers AC, Williams MA, Xiao HQ, Liu M, Natarajan V

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2007 March 37 (3):311-22. Epub 1900 01 01.

Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells.

Williams MA, Porter M, Horton M, Guo J, Roman J, Williams D, Breysse P, Georas SN

The Journal of allergy and clinical immunology.. 2007 February 119 (2):488-97. Epub 12/21/2006.

Lysophosphatidic acid modulates the activation of human monocyte-derived dendritic cells.

Chen R, Roman J, Guo J, West E, McDyer J, Williams MA, Georas SN

Stem cells and development.. 2006 December 15 (6):797-804. Epub 1900 01 01.

Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cells.

Barekzi E, Roman J, Hise K, Georas S, Steinke JW

Prostaglandins, leukotrienes, and essential fatty acids.. 2006 June 74 (6):357-63. Epub 05/24/2006.

Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells.

Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, Natarajan V

The Biochemical journal.. 2006 February 1393 (Pt 3):657-68. Epub 1900 01 01.

Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells.

Rubenfeld J, Guo J, Sookrung N, Chen R, Chaicumpa W, Casolaro V, Zhao Y, Natarajan V, Georas S

American journal of physiology. Lung cellular and molecular physiology.. 2006 January 290 (1):L66-74. Epub 09/30/2005.

Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells.

Keen JC, Cianferoni A, Florio G, Guo J, Chen R, Roman J, Wills-Karp M, Casolaro V, Georas SN

Immunology.. 2006 January 117 (1):29-37. Epub 1900 01 01.

Gene expression patterns and susceptibility to allergic responses.

Williams M, Georas S

Expert review of clinical immunology.. 2006 January 2 (1):59-73. Epub 1900 01 01.

Single nucleotide polymorphisms in patients with sepsis and acute lung injury.

Sevransky, J.; Georas, S.; Barnes, K.;.

Contemp Crit Care. 2006; 3: 1-8.

T-helper cell type-2 regulation in allergic disease.

Georas SN, Guo J, De Fanis U, Casolaro V

The European respiratory journal.. 2005 December 26 (6):1119-37. Epub 1900 01 01.

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice.

Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S

The Journal of experimental medicine.. 2005 July 4202 (1):47-59. Epub 1900 01 01.

Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma.

Hansel NN, Hilmer SC, Georas SN, Cope LM, Guo J, Irizarry RA, Diette GB

The Journal of laboratory and clinical medicine.. 2005 May 145 (5):263-74. Epub 1900 01 01.

Recent advances in the treatment of septic shock

Sevransky, J.; Nour, S.; Susla, G.; Georas, S.;.

Contemp Crit Care. 2005; 3: 1-12.

Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells.

Heller NM, Matsukura S, Georas SN, Boothby MR, Rothman PB, Stellato C, Schleimer RP

American journal of respiratory cell and molecular biology.. 2004 November 31 (5):573-82. Epub 08/05/2004.

Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells.

Heller NM, Matsukura S, Georas SN, Boothby MR, Stellato C, Schleimer RP

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2004 November 34 (11):1690-700. Epub 1900 01 01.

YY1 transcription factor is not responsible for the negative regulation of hamster Muc1 transcription.

Hisatsune A, Hyun SW, Lee IJ, Georas S, Kim KC

Anticancer research.. 2004 24 (1):235-40. Epub 1900 01 01.

Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases.

Georas SN

Proceedings of the American Thoracic Society.. 2004 1 (3):215-21. Epub 1900 01 01.

Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells.

Wang L, Cummings R, Zhao Y, Kazlauskas A, Sham JK, Morris A, Georas S, Brindley DN, Natarajan V

The Journal of biological chemistry.. 2003 October 10278 (41):39931-40. Epub 07/29/2003.

New insights into ventilator management in ARDS

Sevransky, J.; Rubenfeld, J.; Fessler, H.; Georas, S.;.

Contemp Crit Care. 2003; 1: 1-10.

AMP-activated kinase regulates cytoplasmic HuR.

Wang W, Fan J, Yang X, Fürer-Galban S, Lopez de Silanes I, von Kobbe C, Guo J, Georas SN, Foufelle F, Hardie DG, Carling D, Gorospe M

Molecular and cellular biology.. 2002 May 22 (10):3425-36. Epub 1900 01 01.

What is eotaxin doing in the pleura? Insights into innate immunity from pleural mesothelial cells.

Georas SN, Beck LA, Stellato C

American journal of respiratory cell and molecular biology.. 2002 April 26 (4):384-7. Epub 1900 01 01.

Histone deacetylation inhibits IL4 gene expression in T cells.

Valapour M, Guo J, Schroeder JT, Keen J, Cianferoni A, Casolaro V, Georas SN

The Journal of allergy and clinical immunology.. 2002 February 109 (2):238-45. Epub 1900 01 01.

Yin-Yang 1 activates interleukin-4 gene expression in T cells.

Guo J, Casolaro V, Seto E, Yang WM, Chang C, Seminario MC, Keen J, Georas SN

The Journal of biological chemistry.. 2001 December 28276 (52):48871-8. Epub 10/30/2001.

Elective discontinuation of life-sustaining mechanical ventilation on a chronic ventilator unit.

Ankrom M, Zelesnick L, Barofsky I, Georas S, Finucane TE, Greenough WB

Journal of the American Geriatrics Society.. 2001 November 49 (11):1549-54. Epub 1900 01 01.

Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism.

Matsukura S, Stellato C, Georas SN, Casolaro V, Plitt JR, Miura K, Kurosawa S, Schindler U, Schleimer RP

American journal of respiratory cell and molecular biology.. 2001 June 24 (6):755-61. Epub 1900 01 01.

Selective inhibition of interleukin-4 gene expression in human T cells by aspirin.

Cianferoni A, Schroeder JT, Kim J, Schmidt JW, Lichtenstein LM, Georas SN, Casolaro V

Blood.. 2001 March 1597 (6):1742-9. Epub 1900 01 01.

Human eosinophils constitutively express nuclear factor of activated T cells p and c.

Seminario MC, Guo J, Bochner BS, Beck LA, Georas SN

The Journal of allergy and clinical immunology.. 2001 January 107 (1):143-52. Epub 1900 01 01.

Preferential activation of nuclear factor of activated T cells c correlates with mouse strain susceptibility to allergic responses and interleukin-4 gene expression.

Keen JC, Sholl L, Wills-Karp M, Georas SN

American journal of respiratory cell and molecular biology.. 2001 January 24 (1):58-65. Epub 1900 01 01.

Identification and characterization of a critical CP2-binding element in the human interleukin-4 promoter.

Casolaro V, Keane-Myers AM, Swendeman SL, Steindler C, Zhong F, Sheffery M, Georas SN, Ono SJ

The Journal of biological chemistry.. 2000 November 24275 (47):36605-11. Epub 1900 01 01.

Characterization of P5, a novel NFAT/AP-1 site in the human IL-4 promoter.

Burke TF, Casolaro V, Georas SN

Biochemical and biophysical research communications.. 2000 April 21270 (3):1016-23. Epub 1900 01 01.

Characterization of a novel negative regulatory element in the human interleukin 4 promoter.

Georas S, Cumberland J, Burke T, Park E, Ono S, Casolaro V

Leukemia.. 2000 April 14 (4):629-35. Epub 1900 01 01.

Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes.

Lee SC, Brummet ME, Shahabuddin S, Woodworth TG, Georas SN, Leiferman KM, Gilman SC, Stellato C, Gladue RP, Schleimer RP, Beck LA

The Journal of immunology : official journal of the American Association of Immunologists.. 2000 March 15164 (6):3392-401. Epub 1900 01 01.

Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter.

Chen R, Burke TF, Cumberland JE, Brummet M, Beck LA, Casolaro V, Georas SN

The Journal of immunology : official journal of the American Association of Immunologists.. 2000 January 15164 (2):825-32. Epub 1900 01 01.

Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells.

Matsukura S, Stellato C, Plitt JR, Bickel C, Miura K, Georas SN, Casolaro V, Schleimer RP

The Journal of immunology : official journal of the American Association of Immunologists.. 1999 December 15163 (12):6876-83. Epub 1900 01 01.

Pulmonary infiltrates after cytokine therapy for stem cell transplantation. Massive deposition of eosinophil major basic protein detected by immunohistochemistry.

O'Hearn DJ, Leiferman KM, Askin F, Georas SN

American journal of respiratory and critical care medicine.. 1999 October 160 (4):1361-5. Epub 1900 01 01.

Stat6 inhibits human interleukin-4 promoter activity in T cells.

Georas SN, Cumberland JE, Burke TF, Chen R, Schindler U, Casolaro V

Blood.. 1998 December 1592 (12):4529-38. Epub 1900 01 01.

Molecular mechanisms of interleukin-4 production

Casolaro, V.; Steindler, C.; Ono, S.; Georas, S.;.

Int J Immunopathol Pharmacol. 1997; 10: 1-5.

Biology and genetics of atopic disease.

Casolaro V, Georas SN, Song Z, Ono SJ

Current opinion in immunology.. 1996 December 8 (6):796-803. Epub 1900 01 01.

Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene.

Song Z, Casolaro V, Chen R, Georas SN, Monos D, Ono SJ

The Journal of immunology : official journal of the American Association of Immunologists.. 1996 January 15156 (2):424-9. Epub 1900 01 01.

Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.

Casolaro V, Georas SN, Song Z, Zubkoff ID, Abdulkadir SA, Thanos D, Ono SJ

Proceedings of the National Academy of Sciences of the United States of America.. 1995 December 592 (25):11623-7. Epub 1900 01 01.

Expression of a functional laminin receptor (alpha 6 beta 1, very late activation antigen-6) on human eosinophils.

Georas SN, McIntyre BW, Ebisawa M, Bednarczyk JL, Sterbinsky SA, Schleimer RP, Bochner BS

Blood.. 1993 November 182 (9):2872-9. Epub 1900 01 01.

Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration.

Ebisawa M, Bochner BS, Georas SN, Schleimer RP

The Journal of immunology : official journal of the American Association of Immunologists.. 1992 December 15149 (12):4021-8. Epub 1900 01 01.

Altered adhesion molecule expression and endothelial cell activation accompany the recruitment of human granulocytes to the lung after segmental antigen challenge.

Georas SN, Liu MC, Newman W, Beall LD, Stealey BA, Bochner BS

American journal of respiratory cell and molecular biology.. 1992 September 7 (3):261-9. Epub 1900 01 01.

Effect of dietary fat saturation on plasma lipoproteins and high density lipoprotein metabolism of the rhesus monkey.

Chong KS, Nicolosi RJ, Rodger RF, Arrigo DA, Yuan RW, MacKey JJ, Georas S, Herbert PN

The Journal of clinical investigation.. 1987 March 79 (3):675-83. Epub 1900 01 01.

Books

Principles of Ambulatory Medicine (2006)

Chapter: Common pulmonary problems: hemoptysis, dyspnea, chest pain, and the abnormal chest x-ray

Authors: Petrache I, Georas S

Publisher: Williams & Wilkins 2006

Principles of Ambulatory Medicine (2002)

Chapter: Common pulmonary problems: hemoptysis, dyspnea, chest pain, and the abnormal chest x-ray

Authors: Petrache I, Georas S

Publisher: Williams & Wilkins 2002

Cutaneous Medicine (2000)

Chapter: Manifestations of Immunologic Diseases: Th1 and Th2 Responses

Authors: Georas, S

Publisher: B. C. Decker, Inc. 2000

Asthma and Allergic Diseases: Physiology, Immunopharmacology and Treatment (1998)

Chapter: The molecular basis of IL-4 dysregulation in the atopic condition

Authors: Georas S, Burke T, Chen, R, Cumberland J, Casolaro V

Publisher: Academic Press 1998

Principles of Ambulatory Medicine (1998)

Chapter: Common pulmonary problems: hemoptysis, dyspnea, chest pain, and the abnormal chest x-ray

Authors: White P, Georas S

Publisher: Williams & Wilkins 1998

Adhesion Molecules and Allergic Diseases (1997)

Chapter: Adhesion molecules and cell recruitment to the skin and nose

Authors: Beck L, Georas S

Publisher: Marcel Dekker, Inc. 1997

The Proceedings of the III International Meeting on Respiratory Allergy (1993)

Chapter: The role of adhesion molecules in allergic inflammation

Authors: Bochner B, Georas S, Ebisawa M, Schleimer R

Publisher: Elsevier, Amsterdam 1993

The role of adhesion molecules and cytokines in eosinophil recruitment (1993)

Chapter: Eosinophils: Immunological and Clinical Aspects,

Authors: Schleimer R, Ebisawa M, Georas S, Bochner B

Publisher: Marcel Dekker, Inc. 1993

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