It is a privilege to care for our patients. I am committed to providing personalized radiation treatment of the highest quality, as well as compassionate care. My areas of expertise include prostate and head and neck cancers.

Conditions I Treat:

- Prostate cancer
- Head and neck can...

Faculty Appointments

Professor - Department of Radiation Oncology (SMD)

Credentials

Residency & Fellowship

Residency, Radiation Oncology, University of Rochester Medical Center. 2002 - 2006

Internship, Internal Medicine, Rochester General Hospital. 2001 - 2002

Fellowship, Case Western Reserve University Endodontics Residency. 1993 - 1994

Education

MD | Yale University. 2001

PHD | Case Western Reserve University School of Medicine. 1993

Awards

Exceptional Women In Medicine 2023. 2023

Civic Service Award, Us TOO Rochester. 2018

Health Care Achievement Awards--Health Care Innovation. 2017

AAMC Mid-Career Woman Faculty Leadership Development Seminar 12/2017. 2017

Educator of the Year. 2016

Patient- and Family- Centered ICARE High Performance Award. 2013

Educator of the Year. 2012

Patient- and Family-Centered ICARE High Performance Award. 2012

Civic Service Award, Us TOO Rochester. 2012 - 2017

Upstate New York Society of Therapeutic Radiology and Oncology Fall Meeting Resident Presenter Award. 2005

ASTRO Translational Research in Radiation Oncology Symposium Travel Grant Award. 2005

Janet M.Glasgow Memorial Achievement Citations. 2001

Clyde Swift Award for Outstanding Medical Student. 2000

Research

Clinical Trials

A Phase II Double-Blinded, Placebo-Controlled Trial of PROstate OligoMETastatic RadiotHErapy With or Without ANdrogen Deprivation Therapy in Oligometastatic Prostate Cancer (NRG Promethean)

Lead Researcher: Hong Zhang

This phase II trial tests whether relugolix and radiation therapy works to shrink tumors in patients with prostate cancer that has spread in a limited way to 1 to 5 other parts of the body (oligometastatic). Testosterone can cause the growth of prost...

Randomized Phase III Trial Incorporating Abiraterone Acetate With Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients With Node-Positive Prostate Cancer After Radical Prostatectomy,Randomized Phase III Trial Incorporating Abiraterone Acetate With Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients With Node-Positive Prostate Cancer After Radical Prostatectomy

Lead Researcher: Hong Zhang

This phase III trial studies whether adding apalutamide to the usual treatment improves outcome in patients with lymph node positive prostate cancer after surgery. Radiation therapy uses high energy x-ray to kill tumor cells and shrink tumors. Androg...

Publications

Journal Articles

Radiotherapy Use and Incidence of Locoregional Recurrence in Patients With Favorable-Risk, Node-Positive Breast Cancer Enrolled in the SWOG S1007 Trial.

Jagsi R, Barlow WE, Woodward WA, Connolly E, Mahtani R, Shumway D, Speers C, Stecklein SR, Zeidan Y, Zhang H, Sharma P, Pusztai L, Hortobagyi GN, Kalinsky K

JAMA oncology.. 2023 July 6 Epub 07/06/2023.

Stroke death in patients receiving radiation for head and neck cancer in the modern era.

Hardy SJ, Bandyopadhyay S, Yang H, Williams A, Gudina A, Cummings MA, Zhang H, Singh DP, Chen Y, Mohile NA, Janelsins MC, Milano MT

Frontiers in oncology.. 2023 13 :1111764. Epub 06/15/2023.

Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer

Kerns SL; Amidon Morlang A; Lee SM; Peterson DR; Marples B; Zhang H; Bylund K; Rosenzweig D; Hall W; De Ruyck K; Rosenstein BS; Stock RG; Gómez-Caamaño A; Vega A; Sosa-Fajardo P; Taboada-Valladares B; Aguado-Barrera ME; Parker C; Veldeman L; Fonteyne V; Bultijnck R; Talbot CJ; Symonds RP; Johnson K; Rattay T; Webb A; Lambrecht M; de Ruysscher D; Vanneste B; Choudhury A; Elliott RM; Sperk E; Herskind C; Veldwijk MR; Rancati T; Avuzzi B; Valdagni R; Azria D; Farcy Jacquet MP; Chang-Claude J; et al.

Radiother Oncol. 2022; 168: 75-82.

Increased risk of high-grade prostate cancer among testicular cancer survivors

Zhang H; Yang H; Bandyopadhyay S; Milano MT; Fung C; Messing EM; Chen Y.

PLoS One. 2022; 17(2): e0263573.

Risk of second cancer among young prostate cancer survivors.

Zhang H, Yu A, Baran A, Messing E

Radiation oncology journal.. 2021 May 39 (2):91-98. Epub 06/28/2021.

Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.

Zhang H, Doucette C, Yang H, Bandyopadhyay S, Grossman CE, Messing EM, Chen Y

PloS one.. 2021 16 (7):e0253936. Epub 07/15/2021.

Who Benefits From a Prostate Rectal Spacer? Secondary Analysis of a Phase III Trial.

Quinn TJ, Daignault-Newton S, Bosch W, Mariados N, Sylvester J, Shah D, Gross E, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, DeWeese T, Gay HA, Michalski J, Hamstra DA

Practical radiation oncology.. 2020 10 (3):186-194. Epub 01/21/2020.

Building a High-Dose-Rate Prostate Brachytherapy Program With Real-Time Ultrasound-Based Planning: Initial Safety, Quality, and Outcome Results.

Zhang H, Kang S, Ali N, Baran A, Bylund K, Gentile D, Previte G, Matloubieh A, Gray A, Marou N

Advances in radiation oncology.. 2020 5 (3):388-395. Epub 02/21/2020.

Oligometastatic breast cancer treated with hypofractionated stereotactic radiotherapy: Some patients survive longer than a decade.

Milano MT, Katz AW, Zhang H, Huggins CF, Aujla KS, Okunieff P

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2019 February 131 :45-51. Epub 12/28/2018.

Sexual quality of life following prostate intensity modulated radiation therapy (IMRT) with a rectal/prostate spacer: Secondary analysis of a phase 3 trial.

Hamstra DA, Mariados N, Sylvester J, Shah D, Gross E, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, Rossi P, DeWeese T, Daignault-Newton S, Fischer-Valuck BW, Chundury A, Gay HA, Bosch W, Michalski J

Practical radiation oncology.. 2018 8 (1):e7-e15. Epub 07/19/2017.

Continued Benefit to Rectal Separation for Prostate Radiation Therapy: Final Results of a Phase III Trial.

Hamstra DA, Mariados N, Sylvester J, Shah D, Karsh L, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, Rossi P, DeWeese T, Daignault-Newton S, Fischer-Valuck BW, Chundury A, Gay H, Bosch W, Michalski J

International journal of radiation oncology, biology, physics.. 2017 April 197 (5):976-985. Epub 12/23/2016.

Hydrogel Spacer Prospective Multicenter Randomized Controlled Pivotal Trial: Dosimetric and Clinical Effects of Perirectal Spacer Application in Men Undergoing Prostate Image Guided Intensity Modulated Radiation Therapy.

Mariados N, Sylvester J, Shah D, Karsh L, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, Rossi P, DeWeese T, Hamstra DA, Bosch W, Gay H, Michalski J

International journal of radiation oncology, biology, physics.. 2015 August 192 (5):971-977. Epub 04/23/2015.

Local control rates with five-fraction stereotactic body radiotherapy for oligometastatic cancer to the lung.

Singh D, Chen Y, Hare MZ, Usuki KY, Zhang H, Lundquist T, Joyce N, Schell MC, Milano MT

Journal of thoracic disease.. 2014 April 6 (4):369-74. Epub 1900 01 01.

Age and Racial Differences among PSA-Detected (AJCC Stage?T1cN0M0) Prostate Cancer in the U.S.: A Population-Based Study of 70,345 Men.

Zhang H, Messing EM, Travis LB, Hyrien O, Chen R, Milano MT, Chen Y

Frontiers in oncology.. 2013 3 :312. Epub 12/23/2013.

Second primary lung cancer after head and neck squamous cell cancer: population-based study of risk factors.

Milano MT, Peterson CR, Zhang H, Singh DP, Chen Y

Head & neck.. 2012 December 34 (12):1782-8. Epub 02/09/2012.

Oligometastases treated with stereotactic body radiotherapy: long-term follow-up of prospective study.

Milano MT, Katz AW, Zhang H, Okunieff P

International journal of radiation oncology, biology, physics.. 2012 July 183 (3):878-86. Epub 12/13/2011.

Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 US patients.

Zhang H, Travis LB, Chen R, Hyrien O, Milano MT, Newlands SD, Chen Y

Cancer.. 2012 March 1118 (5):1276-87. Epub 07/19/2011.

Second course of radiation for new primary head-and-neck cancer: population-based study of survival.

Milano MT, Zhang H

American journal of clinical oncology.. 2011 August 34 (4):367-71. Epub 1900 01 01.

Malignant pleural mesothelioma: a population-based study of survival.

Milano MT, Zhang H

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.. 2010 November 5 (11):1841-8. Epub 1900 01 01.

Oligometastatic breast cancer treated with curative-intent stereotactic body radiation therapy.

Milano MT, Zhang H, Metcalfe SK, Muhs AG, Okunieff P

Breast cancer research and treatment.. 2009 June 115 (3):601-8. Epub 08/22/2008.

Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization.

Zhang H, Hyrien O, Pandya KJ, Keng PC, Chen Y

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.. 2008 June 3 (6):563-8. Epub 1900 01 01.

Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors.

Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J

International journal of radiation oncology, biology, physics.. 2005 May 162 (1):273-8. Epub 1900 01 01.

Expression of a cleaved brain-specific extracellular matrix protein mediates glioma cell invasion In vivo.

Zhang H, Kelly G, Zerillo C, Jaworski DM, Hockfield S

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 April 118 (7):2370-6. Epub 1900 01 01.

Neurons produce a neuronal cell surface-associated chondroitin sulfate proteoglycan.

Lander C, Zhang H, Hockfield S

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 January 118 (1):174-83. Epub 1900 01 01.

Spinal cord oligodendrocytes develop from a limited number of migratory highly proliferative precursors.

Miller RH, Payne J, Milner L, Zhang H, Orentas DM

Journal of neuroscience research.. 1997 October 1550 (2):157-68. Epub 1900 01 01.

Density-dependent feedback inhibition of oligodendrocyte precursor expansion.

Zhang H, Miller RH

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1996 November 116 (21):6886-95. Epub 1900 01 01.

TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.

Fagan AM, Zhang H, Landis S, Smeyne RJ, Silos-Santiago I, Barbacid M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1996 October 116 (19):6208-18. Epub 1900 01 01.

Asynchronous differentiation of clonally related spinal cord oligodendrocytes.

Zhang H, Miller RH

Molecular and cellular neurosciences.. 1995 February 6 (1):16-31. Epub 1900 01 01.

Glial cell heterogeneity in the mammalian spinal cord.

Miller RH, Zhang H, Fok-Seang J

Perspectives on developmental neurobiology.. 1994 2 (3):225-31. Epub 1900 01 01.

Polysialic acid is required for optimal growth of axons on a neuronal substrate.

Zhang H, Miller RH, Rutishauser U

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1992 August 12 (8):3107-14. Epub 1900 01 01.

Books

Principles and Practice of Radiation Therapy (2009)

Chapter: Breast Cancer

Authors: Uschold G; Zhang H

Publisher: Mosby Elsevier 2009

Ratings & Reviews

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