It is both an honor and a privilege to care for our patients. I am dedicated to administering radiation treatment of the highest quality, tailored to individual needs, and underscored by compassionate support.

Conditions I Treat:

- Prostate cancer
- Head and neck cancers
- Breast...

Faculty Appointments

Professor - Department of Radiation Oncology (SMD)

Credentials

Residency & Fellowship

Residency, Radiation Oncology, University of Rochester Medical Center. 2002 - 2006

Internship, Internal Medicine, Rochester General Hospital. 2001 - 2002

Fellowship, Post-Doctoral Fellow in Neurobiology, Yale University School of Medicine. 1995 - 1997

Fellowship, Case Western Reserve University. 1993 - 1994

Education

MD | Yale University School of Medicine. 2001

PhD | Case Western Reserve University School of Medicine. 1993

Awards

Exceptional Women in Medicine. 2024

Exceptional Women In Medicine 2023. 2023

Exceptional women in oncology. 2023

Civic Service Award, Us TOO Rochester. 2018

Health Care Achievement Awards--Health Care Innovation. 2017

AAMC Mid-Career Woman Faculty Leadership Development Seminar 12/2017. 2017

Educator of the Year. 2016

Patient- and Family- Centered ICARE High Performance Award. 2013

Educator of the Year. 2012

Patient- and Family-Centered ICARE High Performance Award. 2012

Civic Service Award, Us TOO Rochester. 2012 - 2017

Upstate New York Society of Therapeutic Radiology and Oncology Fall Meeting Resident Presenter Award. 2005

ASTRO Translational Research in Radiation Oncology Symposium Travel Grant Award. 2005

Janet M.Glasgow Memorial Achievement Citations. 2001

Clyde Swift Award for Outstanding Medical Student. 2000

Research

Clinical Trials

A Phase I Study to Determine the Preferred Dose of the Angiotensin Converting Enzyme Inhibitor Lisinopril for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer

Lead Researcher: Hong Zhang

This study will establish the preferred dose of lisinopril in men with non-metastatic prostate cancer undergoing radiation treatment. This study will also evaluate the effect of lisinopril on urinary symptoms and the impact of lisinopril on biomarker...

A Phase II Double-Blinded, Placebo-Controlled Trial of PROstate OligoMETastatic RadiotHErapy With or Without ANdrogen Deprivation Therapy in Oligometastatic Prostate Cancer (NRG Promethean)

Lead Researcher: Hong Zhang

This phase II trial compares the usual treatment of radiation therapy alone to using the study drug, relugolix, plus the usual radiation therapy in patients with castration-sensitive prostate cancer that has spread to limited other parts of the body ...

Randomized Phase III Trial Incorporating Abiraterone Acetate With Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients With Node-Positive Prostate Cancer After Radical Prostatectomy,Randomized Phase III Trial Incorporating Abiraterone Acetate With Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients With Node-Positive Prostate Cancer After Radical Prostatectomy

Lead Researcher: Hong Zhang

This phase III trial studies whether adding apalutamide to the usual treatment improves outcome in patients with lymph node positive prostate cancer after surgery. Radiation therapy uses high energy x-ray to kill tumor cells and shrink tumors. Androg...

Publications

Journal Articles

Pelvic radiation in the management of pathological node-positive prostate cancer

Hong Zhang, Hongmei Yang, Sanjukta Bandyopadhyay, Joel Kruger, Kevin Bylund, Michael Cummings, Chunkit Fung, Deepak Sahasrahbudhe, Peter Van Veldhuizen, Adrienne Victor, Thomas Frye, Jean Joseph, Hani Rashid, Guan Wu, Edward M. Messing.

Trends in Cancer Research. 2024; 18: 29-38.

Radiotherapy Use and Incidence of Locoregional Recurrence in Patients With Favorable-Risk, Node-Positive Breast Cancer Enrolled in the SWOG S1007 Trial.

Jagsi R, Barlow WE, Woodward WA, Connolly E, Mahtani R, Shumway D, Speers C, Stecklein SR, Zeidan Y, Zhang H, Sharma P, Pusztai L, Hortobagyi GN, Kalinsky K

JAMA oncology.. 2023 August 19 (8):1083-1089. Epub 1900 01 01.

Stroke death in patients receiving radiation for head and neck cancer in the modern era.

Hardy SJ, Bandyopadhyay S, Yang H, Williams A, Gudina A, Cummings MA, Zhang H, Singh DP, Chen Y, Mohile NA, Janelsins MC, Milano MT

Frontiers in oncology.. 2023 13 :1111764. Epub 06/15/2023.

Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer

Kerns SL; Amidon Morlang A; Lee SM; Peterson DR; Marples B; Zhang H; Bylund K; Rosenzweig D; Hall W; De Ruyck K; Rosenstein BS; Stock RG; Gómez-Caamaño A; Vega A; Sosa-Fajardo P; Taboada-Valladares B; Aguado-Barrera ME; Parker C; Veldeman L; Fonteyne V; Bultijnck R; Talbot CJ; Symonds RP; Johnson K; Rattay T; Webb A; Lambrecht M; de Ruysscher D; Vanneste B; Choudhury A; Elliott RM; Sperk E; Herskind C; Veldwijk MR; Rancati T; Avuzzi B; Valdagni R; Azria D; Farcy Jacquet MP; Chang-Claude J; et al.

Radiother Oncol. 2022; 168: 75-82.

Increased risk of high-grade prostate cancer among testicular cancer survivors

Zhang H; Yang H; Bandyopadhyay S; Milano MT; Fung C; Messing EM; Chen Y.

PLoS One. 2022; 17(2): e0263573.

Risk of second cancer among young prostate cancer survivors.

Zhang H, Yu A, Baran A, Messing E

Radiation oncology journal.. 2021 May 39 (2):91-98. Epub 06/28/2021.

Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.

Zhang H, Doucette C, Yang H, Bandyopadhyay S, Grossman CE, Messing EM, Chen Y

PloS one.. 2021 16 (7):e0253936. Epub 07/15/2021.

Who Benefits From a Prostate Rectal Spacer? Secondary Analysis of a Phase III Trial.

Quinn TJ, Daignault-Newton S, Bosch W, Mariados N, Sylvester J, Shah D, Gross E, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, DeWeese T, Gay HA, Michalski J, Hamstra DA

Practical radiation oncology.. 2020 10 (3):186-194. Epub 01/21/2020.

Building a High-Dose-Rate Prostate Brachytherapy Program With Real-Time Ultrasound-Based Planning: Initial Safety, Quality, and Outcome Results.

Zhang H, Kang S, Ali N, Baran A, Bylund K, Gentile D, Previte G, Matloubieh A, Gray A, Marou N

Advances in radiation oncology.. 2020 5 (3):388-395. Epub 02/21/2020.

Oligometastatic breast cancer treated with hypofractionated stereotactic radiotherapy: Some patients survive longer than a decade.

Milano MT, Katz AW, Zhang H, Huggins CF, Aujla KS, Okunieff P

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2019 February 131 :45-51. Epub 12/28/2018.

Sexual quality of life following prostate intensity modulated radiation therapy (IMRT) with a rectal/prostate spacer: Secondary analysis of a phase 3 trial.

Hamstra DA, Mariados N, Sylvester J, Shah D, Gross E, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, Rossi P, DeWeese T, Daignault-Newton S, Fischer-Valuck BW, Chundury A, Gay HA, Bosch W, Michalski J

Practical radiation oncology.. 2018 8 (1):e7-e15. Epub 07/19/2017.

Continued Benefit to Rectal Separation for Prostate Radiation Therapy: Final Results of a Phase III Trial.

Hamstra DA, Mariados N, Sylvester J, Shah D, Karsh L, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, Rossi P, DeWeese T, Daignault-Newton S, Fischer-Valuck BW, Chundury A, Gay H, Bosch W, Michalski J

International journal of radiation oncology, biology, physics.. 2017 April 197 (5):976-985. Epub 12/23/2016.

Hydrogel Spacer Prospective Multicenter Randomized Controlled Pivotal Trial: Dosimetric and Clinical Effects of Perirectal Spacer Application in Men Undergoing Prostate Image Guided Intensity Modulated Radiation Therapy.

Mariados N, Sylvester J, Shah D, Karsh L, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, Rossi P, DeWeese T, Hamstra DA, Bosch W, Gay H, Michalski J

International journal of radiation oncology, biology, physics.. 2015 August 192 (5):971-977. Epub 04/23/2015.

Local control rates with five-fraction stereotactic body radiotherapy for oligometastatic cancer to the lung.

Singh D, Chen Y, Hare MZ, Usuki KY, Zhang H, Lundquist T, Joyce N, Schell MC, Milano MT

Journal of thoracic disease.. 2014 April 6 (4):369-74. Epub 1900 01 01.

Age and Racial Differences among PSA-Detected (AJCC Stage?T1cN0M0) Prostate Cancer in the U.S.: A Population-Based Study of 70,345 Men.

Zhang H, Messing EM, Travis LB, Hyrien O, Chen R, Milano MT, Chen Y

Frontiers in oncology.. 2013 3 :312. Epub 12/23/2013.

Second primary lung cancer after head and neck squamous cell cancer: population-based study of risk factors.

Milano MT, Peterson CR, Zhang H, Singh DP, Chen Y

Head & neck.. 2012 December 34 (12):1782-8. Epub 02/09/2012.

Oligometastases treated with stereotactic body radiotherapy: long-term follow-up of prospective study.

Milano MT, Katz AW, Zhang H, Okunieff P

International journal of radiation oncology, biology, physics.. 2012 July 183 (3):878-86. Epub 12/13/2011.

Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 US patients.

Zhang H, Travis LB, Chen R, Hyrien O, Milano MT, Newlands SD, Chen Y

Cancer.. 2012 March 1118 (5):1276-87. Epub 07/19/2011.

Second course of radiation for new primary head-and-neck cancer: population-based study of survival.

Milano MT, Zhang H

American journal of clinical oncology.. 2011 August 34 (4):367-71. Epub 1900 01 01.

Malignant pleural mesothelioma: a population-based study of survival.

Milano MT, Zhang H

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.. 2010 November 5 (11):1841-8. Epub 1900 01 01.

Oligometastatic breast cancer treated with curative-intent stereotactic body radiation therapy.

Milano MT, Zhang H, Metcalfe SK, Muhs AG, Okunieff P

Breast cancer research and treatment.. 2009 June 115 (3):601-8. Epub 08/22/2008.

Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization.

Zhang H, Hyrien O, Pandya KJ, Keng PC, Chen Y

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.. 2008 June 3 (6):563-8. Epub 1900 01 01.

Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors.

Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J

International journal of radiation oncology, biology, physics.. 2005 May 162 (1):273-8. Epub 1900 01 01.

Expression of a cleaved brain-specific extracellular matrix protein mediates glioma cell invasion In vivo.

Zhang H, Kelly G, Zerillo C, Jaworski DM, Hockfield S

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 April 118 (7):2370-6. Epub 1900 01 01.

Neurons produce a neuronal cell surface-associated chondroitin sulfate proteoglycan.

Lander C, Zhang H, Hockfield S

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 January 118 (1):174-83. Epub 1900 01 01.

Spinal cord oligodendrocytes develop from a limited number of migratory highly proliferative precursors.

Miller RH, Payne J, Milner L, Zhang H, Orentas DM

Journal of neuroscience research.. 1997 October 1550 (2):157-68. Epub 1900 01 01.

Density-dependent feedback inhibition of oligodendrocyte precursor expansion.

Zhang H, Miller RH

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1996 November 116 (21):6886-95. Epub 1900 01 01.

TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.

Fagan AM, Zhang H, Landis S, Smeyne RJ, Silos-Santiago I, Barbacid M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1996 October 116 (19):6208-18. Epub 1900 01 01.

Asynchronous differentiation of clonally related spinal cord oligodendrocytes.

Zhang H, Miller RH

Molecular and cellular neurosciences.. 1995 February 6 (1):16-31. Epub 1900 01 01.

Glial cell heterogeneity in the mammalian spinal cord.

Miller RH, Zhang H, Fok-Seang J

Perspectives on developmental neurobiology.. 1994 2 (3):225-31. Epub 1900 01 01.

Polysialic acid is required for optimal growth of axons on a neuronal substrate.

Zhang H, Miller RH, Rutishauser U

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1992 August 12 (8):3107-14. Epub 1900 01 01.

Books

Principles and Practice of Radiation Therapy (2009)

Chapter: Breast Cancer

Authors: Uschold G; Zhang H

Publisher: Mosby Elsevier 2009

Ratings & Comments

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.

Ratings

Care provider's discussion of any proposed treatment (options, risks, benefits, etc.)

5.0

Likelihood of recommending this care provider to others

5.0

Explanations the care provider gave you about your problem or condition

5.0

Care provider's efforts to include you in decisions about your care

5.0

Concern the care provider showed for your questions or worries

5.0

Patient Comments

5.0

Dr. Zhang has wonderful rapport with patients.

Feb 25, 2025

5.0

Dr. Zhang is terrific.

Jan 31, 2025

5.0

Excellent appointment

Jan 10, 2025

5.0

Again very pleasant and concerned

Jan 09, 2025

5.0

Whether here or later, I can say Dr. Zhang provided state of the art care with acumen and warmth.

Jan 07, 2025

5.0

The doctor was very knowledgeable and compassionate. Explained everything and answered questions . Very thorough and caring.

Jan 03, 2025

5.0

My provider made me feel valued and I felt confident in her.

Dec 06, 2024

5.0

All good

Nov 24, 2024

5.0

Very good

Oct 31, 2024

5.0

Dr Zhang was. Very through in reviewing my records and scans with me. She explained her recommended treatment and then the other options. She spend at least an hour with me.

Oct 12, 2024

5.0

Dr. Zhang absolutely provided the best care I have ever received. Just excellent.

Oct 08, 2024

5.0

Dr Zhang is incredible. She has my total confidence

Sep 30, 2024

5.0

Dr. Hong Zhang is one of the best medical professionals I have met. Thoroughly competent, AND a joy to be around!

Sep 15, 2024

5.0

Professional

Aug 22, 2024

5.0

Is one of the best

Aug 05, 2024

5.0

Dr. Zhang and her staff are phenomenal people Whom I would highly recommend

Aug 03, 2024

5.0

Dr. Zhang has always been a good listener. She tends to be very proactive In her approach to tests, scans and treatments which Is good. She also readily explains what any such procedures entail. We came to mutual agreement on a path forward after some discussion. I fully trust her assessments and recommendations. While Dr. Zhang has great knowledge and experience what I cherish most is her genuine sense of care and love she expresses.

Aug 03, 2024

5.0

Very satisfied

Jul 30, 2024

5.0

She was excellent, very empathetic giving us much time to discuss my health issue. Would highly recommend her. Truly a gifted woman. Thank her.

Jul 20, 2024

5.0

Dr. Hong Zhang, MD is one of the best medical providers I have dealt with.

Jul 05, 2024

5.0

I like the provider

Jun 19, 2024

5.0

The Dr. was great!

Jun 08, 2024

5.0

Good

May 05, 2024

5.0

I have recommended many of my friends, family & patience to Dr. Zhang. She is an incredible human being.

Mar 29, 2024

5.0

Dr. Zhang is very easy to talk with. She doesn't make me feel rushed and will spend the time necessary to address any concerns, the diagnosis and whats involved in the treatment. I feel very comfortable with her and trust her completely.

Mar 29, 2024

5.0

Dr. Zhang is very easy to talk with and she is very clear and understandable concerning my cancer and the treatment options. She was very knowledgeable about my medical history and through while explaining treatment. I have complete confidence in Dr Zhang.

Feb 21, 2024

5.0

Could not ask for a more knowledgeable and professional oncologist.

Dec 29, 2023

5.0

It has been a true blessing to have met with Dr. Zhang over the years.

Dec 09, 2023

5.0

Dr Zhang is the very best.

Nov 16, 2023

5.0

Excellent provider - Concerned, respectful, professional, courteous, knowledgeable.

Oct 17, 2023

3.5

Assured comfort.

Oct 17, 2023

5.0

Great

Oct 17, 2023

5.0

Nobody better than Dr. Zhang.

Oct 06, 2023

5.0

Dr Zhang is a complete professional and best medical professional I have ever had- and I have been blessed to have excellent doctors in my life. She - and her team - are simply the best.

Sep 29, 2023

5.0

Dr. Zhang showed me such compassion and understanding that my relief was amazing. I truly appreciate her!

Sep 06, 2023

5.0

Excellent experience

Jul 30, 2023

5.0

Excellent!

Jul 21, 2023

5.0

Dr. Zhang is the best doctor I've had [...].

Jun 17, 2023

5.0

Dr. Zhang always show concern for me as a patient. She listens well and communicates clearly and concisely. She is always courteous .

Jun 15, 2023

5.0

Dr. Zhang is the best

Jun 11, 2023

5.0

Dr. Zhang is a top shelf doctor. I trust her with my life.

Apr 27, 2023

5.0

Dr. Zhang is BY FAR the best at what she does - I'm lucky to had have her.

Apr 24, 2023

5.0

Dr. Zhang has always been compassionate, considerate and informative.

Apr 10, 2023

5.0

Always a great experience & visit with Dr. Zhang.

Apr 04, 2023

5.0

It's been a long time that I have had a perfessional who cares for patients as she does!!

Mar 20, 2023

5.0

Always excellent with Dr. Zhang

Mar 09, 2023

5.0

Dr. Zhang has always been very considerate, personal and thorough explaining my cancer situation and the course of treatment that needs to be pursued.

Mar 03, 2023

Very good

Feb 01, 2023

5.0

Dr. Zhang connected with me instantly, eased my worries, gave me hope. She is excellent!

Jan 27, 2023

5.0

Excellent experience

Dec 09, 2022

Very good reconnection

Nov 09, 2022

5.0

She has always been a very caring and compassionate person. I fully trust her recommendations and advice.

Sep 27, 2022

5.0

This provider was exceptionally caring, patient, empathetic, thorough and knowledgeable. She is one of the best providers in any specialty I have ever seen. She is what all physicians should aspire to be.

Sep 25, 2022

5.0

Dr. Zhang was outstanding in her genuine concern for my condition and my questions. She is not only extrememely knowledgeable and competent, but also emanates the human quality of goodness to an extraordinary degree. I Immediately knew I was in good hands.

Sep 11, 2022

5.0

My wife and I believe that Dr. Zhang absolutely walks on water. Her manner is amazing - the level of concern, being sure that she answers ALL your questions and you understand the necessary information. I wish we could replicate Dr. Zhang - the world would be a much better place!

Sep 09, 2022

5.0

Outstanding

Sep 08, 2022

Dr. Zhang was thorough and compassionate. She used data to show parameter effect helpful to make treatment decision. She answered questions and laid out treatment options. Factors were discussed. We appreciated her preparation and support.

Sep 05, 2022

5.0

The care provided (Dr. Zhang) was excellent.

Sep 01, 2022

5.0

Dr. Zhang is one of the best care providers I have ever experienced.

Aug 29, 2022

5.0

She is just the best !!!!

Aug 29, 2022

5.0

She was absolutely amazing!

Aug 20, 2022