Jin Xiao earned her DDS (2003), and PhD in oral microbiology (2009) from West China College of Stomatology, Sichuan University, China. She completed her last two years of PhD study (2007-2009) in the Center of Oral Biology, University of Rochester and followed by one year postdoctoral training in the Center of Oral Biology. Jin also completed an Advanced Education in General Dentistry residency (2013) in the Eastman Institute for Oral Health, University of Rochester and a General Practice Residency (2014) in the Strong Memorial Hospital. Jin has a background of oral microbiology and translational research, she intends to develop a career of bridging clinical practice and translational research and translate the research findings into innovative strategies targeting treating biofilm-related infection disease. She has published eighteen peer-reviewed articles in top-tier microbiology, oral biology and dental research journals. Additionally, she won first place in the American Association for Dental Research Hatton-Competition Award, which is the most prestigious-competitive award for young investigators conducting dental/oral research in the US/Canada. She is currently interested in investigating the virulence and three-dimensional structure of oral and peri-implant multispecies biofilms.

Languages

English, Chinese

Faculty Appointments

Associate Professor - Department of Dentistry (SMD)

Credentials

Residency & Fellowship

Residency, General Practice, Eastman Dental Center. 2013 - 2014

Residency, Dentistry, General Practice, Eastman Dental Center. 2010 - 2013

Education

PHD | West China College of Stomatology (China). 2009

DDS | West China College of Stomatology (China). 2005

Awards

American Society for Microbiology Candida and Candidiasis conference travel award. 2018

First Place of Johnson & Johnson Hatton Award Competition (Senior Category). 2011

First Place of William H. Bowen Award Competition. 2010

Outstanding Young Researcher to attend The Nobel Laureate Meetings at Lindau, Germany. 2007

The USA 100-Committee Scholarship. 2007

The Second Prize in the DENTSPLY Asia/China Dental Student Clinician Competition. 2006

Research

Publications

Journal Articles

Acceptance and Usability of an Innovative mDentistry eHygiene Model Amid the COVID-19 Pandemic Within the US National Dental Practice-Based Research Network: Mixed Methods Study.

Xiao J, Kopycka-Kedzierawski D, Ragusa P, Mendez Chagoya LA, Funkhouser K, Lischka T, Wu TT, Fiscella K, Kar KS, Al Jallad N, Rashwan N, Ren J, Meyerowitz C,

JMIR human factors.. 2023 August 1810 :e45418. Epub 08/18/2023.

The Oral Microbiome and Cross-Kingdom Interactions during Pregnancy.

Gilbert Klaczko C, Alkhars N, Zeng Y, Klaczko ME, Gill AL, Kopycka-Kedzierawski DT, Jusko TA, Sohn MB, Xiao J, Gill SR

Journal of dental research.. 2023 July 11 :220345231176459. Epub 07/11/2023.

Dose-Dependent Inhibitory Effect of Probiotic on - Cross-Kingdom Microorganisms.

Bao J, Huang X, Zeng Y, Wu TT, Lu X, Meng G, Ren Y, Xiao J

Pathogens.. 2023 June 2012 (6)Epub 06/20/2023.

Effects of Nystatin oral rinse on oral Candida species and Streptococcus mutans among healthy adults.

Aljaffary M, Jang H, Alomeir N, Zeng Y, Alkhars N, Vasani S, Almulhim A, Wu TT, Quataert S, Bruno J, Lee A, Xiao J

Clinical oral investigations.. 2023 March 24 Epub 03/24/2023.

Effect of Probiotic on and Clinical Isolates from Children with Early Childhood Caries.

Zeng Y, Fadaak A, Alomeir N, Wu Y, Wu TT, Qing S, Xiao J

International journal of molecular sciences.. 2023 February 324 (3)Epub 02/03/2023.

Novel Clustering Methods Identified Three Caries Status-Related Clusters Based on Oral Microbiome in Thai Mother–Child Dyads.

Samantha Manning, Jin Xiao, Yihong Li, Prakaimuk Saraithong, Bruce J. Paster, George Chen, Yan Wu, and Tong Tong Wu.

Genes. 2023; 14(3): 641.

Metagenomic analysis examines oral microbiome changes and interplay with immune response following prenatal total oral rehabilitation.

Tong Tong Wu, Michael Sohn, Samantha Manning, Robert Beblavy, Steven Gill, Sally Quataert, Shruti Vasani, Hoonji Jang, Yan Zeng, Jennifer Bruno, Adriana Vazquez, Kevin Fiscella, Jin Xiao.

Journal of Translational Medicine. 2023; 21: 172.

Dynamics of Oral Microbiome Acquisition in Healthy Infants: A Pilot Study

YIHONG Li, Prakaimuk Saraithong, Lanxin Zhang, Ashley Dills, Bruce J. Paster, Jin Xiao, Tong Tong Wu and Zachary Jones.

Front. Oral. Health. 2023; 4.

Anti-cariogenic Properties of Lactobacillus plantarum in the Utilization of Galacto-Oligosaccharide

Huang XY, Bao JH, Zeng Y, Meng G, Lu XY, Wu TT, Ren YF, Xiao J.

Nutrients. 2023; 15(9): 2017.

Impact of Nystatin Oral Rinse on Salivary and Supragingival Microbial Community among Adults with Oral Candidiasis

Zhang, L; Manning, S; Wu, TT; Zeng, Y; Lee, L; Wu, Y; Paster, B; Chen, G; Fiscella, K; Xiao J.

Microorganisms. 2023; 11(6): 1497.

Dual transcriptome of and interplay in biofilms.

Xiao J, Zeng Y, Rustchenko E, Huang X, Wu TT, Falsetta ML

Journal of oral microbiology.. 2023 15 (1):2144047. Epub 11/09/2022.

Study protocol: understanding pain after dental procedures, an observational study within the National Dental PBRN.

Kalenderian E, White J, Yansane AI, Urata J, Holmes D, Funkhouser K, Mungia R, Xiao J, Rauschenberger C, Ibarra-Noriega A, Tran D, Rindal DB, Spallek H, Walji M

BMC oral health.. 2022 December 922 (1):581. Epub 12/09/2022.

Effect of Nystatin on Candida albicans - Streptococcus mutans duo-species biofilms.

Alomeir N, Zeng Y, Fadaak A, Wu TT, Malmstrom H, Xiao J

Archives of oral biology.. 2022 November 9145 :105582. Epub 11/09/2022.

Interkingdom assemblages in human saliva display group-level surface mobility and disease-promoting emergent functions.

Ren Z, Jeckel H, Simon-Soro A, Xiang Z, Liu Y, Cavalcanti IM, Xiao J, Tin NN, Hara A, Drescher K, Koo H

Proceedings of the National Academy of Sciences of the United States of America.. 2022 October 11119 (41):e2209699119. Epub 10/03/2022.

American Twitter users revealed social determinant-related oral health disparities amid the COVID-19 pandemic.

Fan Y, Lyu H, Xiao J, Luo J

Quintessence international.. 2022 October 110 (0):2-14. Epub 10/11/2022.

The Effect of Er:YAG Laser Treatment on Biofilm Formation on Titanium and Zirconia Disc Surfaces.

Assery N, Alomeir N, Zeng Y, Xiao J, Tsigarida A

Journal of periodontology.. 2022 September 28 Epub 09/28/2022.

Racial and oral health disparity associated with perinatal oral health care utilization among underserved US pregnant women.

Al Jallad N, Vasani S, Wu TT, Cacciato R, Thomas M, Lababede N, Lababede A, Xiao J

Quintessence international.. 2022 June 80 (0):2-12. Epub 06/08/2022.

Lactobacillus plantarum Disrupts S. mutans–C. albicans Cross-Kingdom Biofilms

Yan Zeng, Ahmed Fadaak, Nora Alomeir, Tong Tong Wu, Elena Rustchenko, Shuang Qing, Jianhang Bao, Christie Gilbert, Jin Xiao.

Frontiers in Cellular and Infection Microbiology. 2022; .

Multimodal data integration reveals mode of delivery and snack consumption outrank salivary microbiome in association with caries outcome in Thai children.

Wu TT, Xiao J, Manning S, Saraithong P, Pattanaporn K, Paster BJ, Chen T, Vasani S, Gilbert C, Zeng Y, Li Y.

Frontiers in Cellular and Infectious Microbiology. 2022; .

Artificial intelligence-powered smartphone application, AICaries, improves at-home dental caries screening in children: Moderated and unmoderated usability test.

Al Jallad N, Mapes O, Hao P, Ruan J, Ramesh A, Luo J, Wu T, Dye T, Rashwan N, Ren J, Jang H, Mendez L, Alomier N, Bullock S, Fiscella K, Xiao J.

PLOS digital health. 2022 June. 2022; .

Editorial: The Pivotal Role of Oral Microbiota Dysbiosis and Microbiota-Host Interactions in Diseases

Xin Xu , Jin Xiao, Yulong Niu.

Front. Cell. Infect. Microbiol. 2022; .

Removable Denture Wearing as a Risk Predictor for Pneumonia Incidence and Time to Event in Older Adults.

Alzamil H, Wu TT, van Wijngaarden E, Mendoza M, Malmstrom H, Fiscella K, Kopycka-Kedzierawski DT, Billings RJ, Xiao J

JDR clinical and translational research.. 2021 October 23 :23800844211049406. Epub 10/23/2021.

Assess an innovative mDentistry eHygiene model amid the COVID-19 pandemic in the National Dental Practice-Based Research Network: Protocol for design, implementation, and usability testing.

Xiao J, Meyerowitz C, Ragusa P, Funkhouser K, Lischka T, Mendez Chagoya LA, Al Jallad N, Wu TT, Fiscella K, Ivie E, Strange M, Collins J, Kopycka-Kedzierawsk DT

JMIR research protocols.. 2021 September 22 Epub 09/22/2021.

Assess A Smartphone App (AICaries) that uses artificial intelligence to detect dental caries in children and provide interactive oral health education: Protocol for design and usability testing.

Xiao J, Luo J, Ly-Mapes O, Wu TT, Dye T, Al Jallad N, Hao P, Ruan J, Bullock S, Fiscella K

JMIR research protocols.. 2021 September 14 Epub 09/14/2021.

Oral microflora and pregnancy: a systematic review and meta-analysis.

Jang H, Patoine A, Wu TT, Castillo DA, Xiao J

Scientific reports.. 2021 August 1911 (1):16870. Epub 08/19/2021.

Changes in , and oral health conditions following Prenatal Total Oral Rehabilitation among underserved pregnant women.

Jang H, Al Jallad N, Wu TT, Zeng Y, Fadaak A, Malmstrom H, Fiscella K, Xiao J

Heliyon.. 2021 August 7 (8):e07871. Epub 08/26/2021.

Oral Candida predicts Streptococcus mutans emergence in underserved US infants

Alkhars N, Zeng Y, Alomeir N, AlJallad N, Wu TT, Aboelmagd S, Youssef M, Jang H, Fogarty C, Xiao J.

Journal of Dental Research. 2021; .

mDentistry: A powerful tool to improve oral health of a broad population in the digital era

Xiao, J; Fiscella K; Meyerowitz, C.

Journal of American Dental Association. 2021; .

(2021) Early Childhood Caries Experience Associated with Upper Respiratory Infection in US Children: Findings from a Retrospective Cohort Study.

Albelali, A, Wu, TT, Malmstrom, H, and Xiao, J.

Journal of Pediatrics & Child Health Care. 2021; 6(2): 1044.

Machine Learning Approach Identified Multi-Platform Factors for Caries Prediction in Child-Mother Dyads.

Wu TT, Xiao J, Sohn MB, Fiscella KA, Gilbert C, Grier A, Gill AL, Gill SR

Frontiers in cellular and infection microbiology.. 2021 11 :727630. Epub 08/19/2021.

Identification of Non- Streptococcus mutans Bacteria from Predente Infant Saliva Grown on Mitis-Salivarius-Bacitracin Agar

Zeng Y, Youssef M, Wang L, Alkhars N, Thomas M, Cacciato R, Qing S, Ly-Mapes O, Xiao J.

J Clin Pediatr Dent. 2020; 44(1): 28-34.

Oral microbiome: possible harbinger for children's health.

Jin Xiao; Kevin A. Fiscella; Steven R. Gill.

international journal of oral science. 2020; .

Interprofessional collaboration and smartphone use as promising strategies to improve prenatal oral health care utilization among US underserved women: results from a qualitative study

Lin Wang, Johana Ren, Kevin A Fiscella, Sherita Bullock, Mechelle R Sanders, Elizabeth L Loomis, Eli Eliav, Michael Mendoza, Rita Cacciato, Marie Thomas, Dorota T Kopycka-Kedzierawski, Ronald J Billings, Jin Xiao.

2020; .

A Smartphone-based System for Real-time Early Childhood Caries Diagnosis.

Zhang Y, Liao H, Xiao J, Al Jallad N, Ly-Mapes O, Luo J.

2020; .

Oral health and Candida carriage in socioeconomically disadvantaged US pregnant women.

Xiao J, Fogarty C, Wu TT, Alkhers N, Zeng Y, Thomas M, Youssef M, Wang L, Cowen L, Abdelsalam H, Nikitkova A

BMC pregnancy and childbirth.. 2019 December 519 (1):480. Epub 12/05/2019.

Intergenerational task: Helping expectant mothers obtain better oral health care during pregnancy.

Billings RJ, Kopycka-Kedzierawski DT, Xiao J

The Journal of the American Dental Association.. 2019 July 150 (7):565-566. Epub 1900 01 01.

Human genes influence the interaction between Streptococcus mutans and host caries susceptibility: a genome-wide association study in children with primary dentition.

Meng Y, Wu T, Billings R, Kopycka-Kedzierawski DT, Xiao J

International journal of oral science.. 2019 May 3011 (2):19. Epub 05/30/2019.

Activity of quercetin and kaemferol against Streptococcus mutans biofilm.

Zeng Y, Nikitkova A, Abdelsalam H, Li J, Xiao J

Archives of oral biology.. 2019 February 98 :9-16. Epub 11/02/2018.

Prenatal Oral Health Care and Early Childhood Caries Prevention: A Systematic Review and Meta-Analysis.

Xiao J, Alkhers N, Kopycka-Kedzierawski DT, Billings RJ, Wu TT, Castillo DA, Rasubala L, Malmstrom H, Ren Y, Eliav E

Caries research.. 2019 January 10 :1-11. Epub 01/10/2019.

Association of periodontal disease with depression and adverse birth outcomes: Results from the Perinatal database; Finger Lakes region, New York State.

Kopycka-Kedzierawski DT, Li D, Xiao J, Billings RJ, Dye TD

PloS one.. 2019 14 (4):e0215440. Epub 04/18/2019.

Association between Oral Candida and Bacteriome in Children with Severe ECC.

Xiao J, Grier A, Faustoferri RC, Alzoubi S, Gill AL, Feng C, Liu Y, Quivey RG, Kopycka-Kedzierawski DT, Koo H, Gill SR

Journal of dental research.. 2018 December 97 (13):1468-1476. Epub 07/26/2018.

Candida albicans and Early Childhood Caries: A Systematic Review and Meta-Analysis.

Xiao J, Huang X, Alkhers N, Alzamil H, Alzoubi S, Wu TT, Castillo DA, Campbell F, Davis J, Herzog K, Billings R, Kopycka-Kedzierawski DT, Hajishengallis E, Koo H

Caries research.. 2018 52 (1-2):102-112. Epub 12/21/2017.

Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface.

Xiao J, Hara AT, Kim D, Zero DT, Koo H, Hwang G

International journal of oral science.. 2017 June 9 (2):74-79. Epub 04/28/2017.

Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness.

Xiao J, Moon Y, Li L, Rustchenko E, Wakabayashi H, Zhao X, Feng C, Gill SR, McLaren S, Malmstrom H, Ren Y, Quivey R, Koo H, Kopycka-Kedzierawski DT

PloS one.. 2016 11 (10):e0164242. Epub 10/14/2016.

Success, clinical performance and patient satisfaction of direct fibre-reinforced composite fixed partial dentures - a two-year clinical study.

Malmstrom H, Dellanzo-Savu A, Xiao J, Feng C, Jabeen A, Romero M, Huang J, Ren Y, Yunker MA

Journal of oral rehabilitation.. 2015 December 42 (12):906-13. Epub 07/14/2015.

Two-Year Success Rate of Implant-Retained Mandibular Overdentures by Novice General Dentistry Residents.

Malmstrom HS, Xiao J, Romanos G, Ren YF

The Journal of oral implantology.. 2015 June 41 (3):268-75. Epub 11/04/2013.

Training needs for novice general dentists to place and restore two-implant retained mandibular overdentures

Malmstrom H, Xiao J, Romanos G, Ren YF.

Journal of Dental Education. 2014; .

Effects of compounds found in Nidus Vespae on the growth and cariogenic virulence factors of Streptococcus mutans.

Guan X, Zhou Y, Liang X, Xiao J, He L, Li J

Microbiological research.. 2012 January 20167 (2):61-8. Epub 04/17/2011.

The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm.

Xiao J, Klein MI, Falsetta ML, Lu B, Delahunty CM, Yates JR, Heydorn A, Koo H

PLoS pathogens.. 2012 8 (4):e1002623. Epub 04/05/2012.

Streptococcus mutans protein synthesis during mixed-species biofilm development by high-throughput quantitative proteomics.

Klein MI, Xiao J, Lu B, Delahunty CM, Yates JR, Koo H

PloS one.. 2012 7 (9):e45795. Epub 09/25/2012.

Role of glucosyltransferase B in interactions of Candida albicans with Streptococcus mutans and with an experimental pellicle on hydroxyapatite surfaces.

Gregoire S, Xiao J, Silva BB, Gonzalez I, Agidi PS, Klein MI, Ambatipudi KS, Rosalen PL, Bauserman R, Waugh RE, Koo H

Applied and environmental microbiology.. 2011 September 77 (18):6357-67. Epub 07/29/2011.

Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms.

Jeon JG, Pandit S, Xiao J, Gregoire S, Falsetta ML, Klein MI, Koo H

International journal of oral science.. 2011 April 3 (2):98-106. Epub 1900 01 01.

An analytical tool-box for comprehensive biochemical, structural and transcriptome evaluation of oral biofilms mediated by mutans streptococci.

Klein MI, Xiao J, Heydorn A, Koo H

Journal of visualized experiments : JoVE.. 2011 January 25 (47)Epub 01/25/2011.

Structural organization and dynamics of exopolysaccharide matrix and microcolonies formation by Streptococcus mutans in biofilms.

Xiao J, Koo H

Journal of applied microbiology.. 2010 June 108 (6):2103-13. Epub 11/04/2009.

Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms.

Koo H, Xiao J, Klein MI, Jeon JG

Journal of bacteriology.. 2010 June 192 (12):3024-32. Epub 03/16/2010.

Caries experience in individuals with cleft lip and/or palate in China.

Zhu WC, Xiao J, Liu Y, Wu J, Li JY

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 2010 January 47 (1):43-7. Epub 1900 01 01.

Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms.

Jeon JG, Klein MI, Xiao J, Gregoire S, Rosalen PL, Koo H

BMC microbiology.. 2009 October 289 :228. Epub 10/28/2009.

Structural and molecular basis of the role of starch and sucrose in Streptococcus mutans biofilm development.

Klein MI, Duarte S, Xiao J, Mitra S, Foster TH, Koo H

Applied and environmental microbiology.. 2009 February 75 (3):837-41. Epub 11/21/2008.

Extracellular polysaccharides matrix--an often forgotten virulence factor in oral biofilm research.

Koo H, Xiao J, Klein MI.

Int J Oral Sci. 2009; 1(4): 229-34.

Activity of Nidus Vespae extract and chemical fractions against Streptococcus mutans biofilms.

Xiao J, Zhou XD, Feng J, Hao YQ, Li JY

Letters in applied microbiology.. 2007 November 45 (5):547-52. Epub 10/04/2007.

Effects of Nidus Vespae extract and chemical fractions on glucosyltransferases, adherence and biofilm formation of Streptococcus mutans.

Xiao J, Zuo Y, Liu Y, Li J, Hao Y, Zhou X

Archives of oral biology.. 2007 September 52 (9):869-75. Epub 03/23/2007.

The prevalence of tooth discolouration and the self-satisfaction with tooth colour in a Chinese urban population.

Xiao J, Zhou XD, Zhu WC, Zhang B, Li JY, Xu X

Journal of oral rehabilitation.. 2007 May 34 (5):351-60. Epub 1900 01 01.

Effects of Nidus Vespae extract and chemical fractions on the growth and acidogenicity of oral microorganisms.

Xiao J, Liu Y, Zuo YL, Li JY, Ye L, Zhou XD

Archives of oral biology.. 2006 September 51 (9):804-13. Epub 05/24/2006.

Books

Designing Bioactive Polymeric Materials For Restorative Dentistry (2020)

Chapter: Nanotechnology and Delivery System for Bioactive Antibiofilm Dental Materials

Authors: Jin Xiao, Yuan Liu, Marlise I. Klein, Anna Nikikova, Yanfang Ren

Publisher: Taylor & Francis Group 2020

Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria. (2016)

Chapter: Acid-adaptive responses of Streptococcus mutans, and mechanisms of integration with oxidative stress.

Authors: Quivey G, Faustoferri R, Santiago B, Baker J, Cross B, Xiao J

Publisher: Wiley-Blackwell 2016

Oral Microbial Ecology: Current Research and New Perspectives. (2013)

Chapter: The Role of Extracellular Polysaccharides Matrix in Virulent Oral biofilms

Authors: Klein MI, Falsetta ML, Xiao J, Bowen WH, Koo H

Publisher: Cambs UK, Caister Academic Press 2013