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Paul Geha, M.D.

Paul Geha, M.D.


Appointment (585) 225-5767

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About Me

Faculty Appointments

Associate Professor - Department of Psychiatry, Research (SMD)

Associate Professor - Department of Neurology, General Neurology (SMD) - Joint

Associate Professor - Department of Neuroscience (SMD) - Joint


Post-doctoral Training & Residency

Fellowship, Psychiatry, VA Connecticut Healthcare System West Haven GME. 2012 - 2014

Residency, Psychiatry, Yale New Haven Hospital. 2009 - 2012

Internship, Internal Medicine, Psychiatry, Yale New Haven Hospital. 2008 - 2009

Fellowship, Clinical Neurophysiology, Northwestern Memorial Hospital. 2003 - 2008


MD | American University of Beirut. 2003


Seymour L. Lustman Award for Psychiatric Research, Dept. of Psychiatry, Yale University School of Medicine. 2013


I have expertise in the neuroscience of pain, hedonics and feeding, and multimodal neuroimaging. I use a broad range of neuroimaging techniques, and behavioral testing to study the neurobiology of acute and chronic pain, analgesia, and obesity. My research program focuses on understanding mechanisms...
I have expertise in the neuroscience of pain, hedonics and feeding, and multimodal neuroimaging. I use a broad range of neuroimaging techniques, and behavioral testing to study the neurobiology of acute and chronic pain, analgesia, and obesity. My research program focuses on understanding mechanisms of neuro-adaptation in chronic pain and obesity, neural response to analgesic treatment, and brain derived long-term predictors of clinical outcomes. My current focus is mapping the brain signature of different chronic pain conditions using different imaging modalities to discover and validate these signatures. My laboratory has recently published (PNAS 2020) the first brain signature of chronic back pain that is highly reproducible across chronic back pain patients' cohorts collected in different laboratories. I have used neuroimaging and behavioral tools in cross-sectional, longitudinal and therapeutic designs to identify brain biomarkers of chronic pain and modulate these biomarkers with analgesic interventions.


Journal Articles

Identification of central amygdala and trigeminal motor nucleus connectivity in humans: An ultra-high field diffusion MRI study.

Kaya B, Geha P, de Araujo I, Cioffi I, Moayedi M

Human brain mapping.. 2022 October 11 Epub 10/11/2022.

Predicting treatment response with sensory phenotyping in post-traumatic neuropathic pain.

Gewandter JS, Sohn MB, De Guzman R, Frazer ME, Chiodo V, Sharma S, Geha P, Markman JD

Pain medicine : the official journal of the American Academy of Pain Medicine.. 2022 March 21 Epub 03/21/2022.

Brain Imaging Biomarkers for Chronic Pain

Zhengwu Zhang, Jennifer S. Gewandter and Paul Geha.

Frontiers in Neurology. 2022; .

Chronic pain precedes disrupted eating behavior in low-back pain patients.

Lin Y, De Araujo I, Stanley G, Small D, Geha P

PloS one.. 2022 17 (2):e0263527. Epub 02/10/2022.

Functional brain mapping in patients with chronic back pain shows age-related differences.

Baran TM, Lin FV, Geha P

Pain.. 2021 November 15 Epub 11/15/2021.

Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study.

Murray K, Lin Y, Makary MM, Whang PG, Geha P

Molecular pain. 2021 17 :1744806921990938. Epub 1900 01 01.

Decision Models and Technology Can Help Psychiatry Develop Biomarkers.

Barron DS, Baker JT, Budde KS, Bzdok D, Eickhoff SB, Friston KJ, Fox PT, Geha P, Heisig S, Holmes A, Onnela JP, Powers A, Silbersweig D, Krystal JH

Frontiers in psychiatry.. 2021 12 :706655. Epub 09/09/2021.

Brain Imaging Biomarkers for Chronic Pain.

Zhang Z, Gewandter JS, Geha P

Frontiers in neurology. 2021 12 :734821. Epub 01/03/2022.

Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain.

Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P

Proceedings of the National Academy of Sciences of the United States of America.. 2020 May 5117 (18):10015-10023. Epub 04/20/2020.

Brain activity associated with pain in inherited erythromelalgia: stimulus-free pain engages brain areas involved in valuation and learning.

Geha P, Schulman BR, Dib-Hajj SD, Waxman SG

Neurobiology of pain.. 2018 3 :8-14. Epub 01/31/2018.

Ketamine Treatment and Global Brain Connectivity in Major Depression.

Abdallah CG, Averill LA, Collins KA, Geha P, Schwartz J, Averill C, DeWilde KE, Wong E, Anticevic A, Tang CY, Iosifescu DV, Charney DS, Murrough JW

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2017 May 42 (6):1210-1219. Epub 09/08/2016.

Sodium channels in pain disorders: pathophysiology and prospects for treatment.

Dib-Hajj SD, Geha P, Waxman SG

Pain.. 2017 April 158 Suppl 1 :S97-S107. Epub 1900 01 01.

Reorganization of brain connectivity in obesity.

Geha P, Cecchi G, Todd Constable R, Abdallah C, Small DM

Human brain mapping.. 2017 March 38 (3):1403-1420. Epub 11/16/2016.

Chronic Pain and Chronic Stress: Two Sides of the Same Coin?

Abdallah CG, Geha P

Chronic stress.. 2017 February 1 Epub 06/08/2017.

Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder.

Murrough JW, Abdallah CG, Anticevic A, Collins KA, Geha P, Averill LA, Schwartz J, DeWilde KE, Averill C, Jia-Wei Yang G, Wong E, Tang CY, Krystal JH, Iosifescu DV, Charney DS

Human brain mapping.. 2016 September 37 (9):3214-23. Epub 05/04/2016.

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.

Geha P, Yang Y, Estacion M, Schulman BR, Tokuno H, Apkarian AV, Dib-Hajj SD, Waxman SG

JAMA neurology.. 2016 June 173 (6):659-67. Epub 1900 01 01.

Pain Perception: Multiple Matrices or One?

Geha P, Waxman SG

JAMA neurology.. 2016 June 173 (6):628-30. Epub 1900 01 01.

Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans.

Matuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot JD, Chen J, Wanyiri J, Najafzadeh S, Ropchan J, Geha P, Huang Y, Potenza MN, Neumeister A, Carson RE, Malison RT

Biological psychiatry.. 2014 November 1576 (10):816-22. Epub 11/28/2013.

Decreased food pleasure and disrupted satiety signals in chronic low back pain.

Geha P, deAraujo I, Green B, Small DM

Pain.. 2014 April 155 (4):712-722. Epub 12/31/2013.

Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger.

Nolan-Poupart S, Veldhuizen MG, Geha P, Small DM

Appetite.. 2013 January 60 (1):168-174. Epub 10/12/2012.

Altered hypothalamic response to food in smokers.

Geha PY, Aschenbrenner K, Felsted J, O'Malley SS, Small DM

The American journal of clinical nutrition.. 2013 January 97 (1):15-22. Epub 12/12/2012.

Orosensory and Homeostatic Functions of the Insular Taste Cortex.

de Araujo IE, Geha P, Small DM

Chemosensory perception.. 2012 March 15 (1):64-79. Epub 1900 01 01.

Brain activity for chronic knee osteoarthritis: dissociating evoked pain from spontaneous pain.

Parks EL, Geha PY, Baliki MN, Katz J, Schnitzer TJ, Apkarian AV

European journal of pain : EJP.. 2011 September 15 (8):843.e1-14. Epub 02/10/2011.

Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain.

Baliki MN, Geha PY, Fields HL, Apkarian AV

Neuron.. 2010 April 1566 (1):149-60. Epub 1900 01 01.

Towards a theory of chronic pain.

Apkarian AV, Baliki MN, Geha PY

Progress in neurobiology.. 2009 February 87 (2):81-97. Epub 10/05/2008.

Parsing pain perception between nociceptive representation and magnitude estimation.

Baliki MN, Geha PY, Apkarian AV

Journal of neurophysiology.. 2009 February 101 (2):875-87. Epub 12/10/2008.

The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions.

Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish TB, Apkarian AV

Neuron.. 2008 November 2660 (4):570-81. Epub 1900 01 01.

A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis.

Baliki MN, Geha PY, Jabakhanji R, Harden N, Schnitzer TJ, Apkarian AV

Molecular pain. 2008 October 254 :47. Epub 10/25/2008.

Brain dynamics for perception of tactile allodynia (touch-induced pain) in postherpetic neuralgia.

Geha PY, Baliki MN, Wang X, Harden RN, Paice JA, Apkarian AV

Pain.. 2008 September 15138 (3):641-656. Epub 04/01/2008.

Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics.

Baliki MN, Geha PY, Apkarian AV, Chialvo DR

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 February 628 (6):1398-403. Epub 1900 01 01.

Spontaneous pain and brain activity in neuropathic pain: functional MRI and pharmacologic functional MRI studies.

Baliki MN, Geha PY, Apkarian AV

Current pain and headache reports.. 2007 June 11 (3):171-7. Epub 1900 01 01.

Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy.

Geha PY, Baliki MN, Chialvo DR, Harden RN, Paice JA, Apkarian AV

Pain.. 2007 March 128 (1-2):88-100. Epub 10/25/2006.

Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain.

Baliki MN, Chialvo DR, Geha PY, Levy RM, Harden RN, Parrish TB, Apkarian AV

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2006 November 2226 (47):12165-73. Epub 1900 01 01.

Brain imaging findings in neuropathic pain.

Geha PY, Apkarian AV

Current pain and headache reports.. 2005 June 9 (3):184-8. Epub 1900 01 01.


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