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Chad R. Heatwole, M.D.

Neurology

Clinical Interests

Neuromuscular Disease

Contact Information

Phone Numbers

Appointment: (585) 275-2559

Fax: (585) 273-1255

Office: (585) 275-2559

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Chad Heatwole, MD, MS-CI is a neuromuscular clinician and researcher from the University of Rochester. He has an engineering degree from Virginia Tech, a medical degree from the Medical College of Virginia, a master's degree in clinical investigation, and has completed a University of Rochester neurology residency, electrophysiology fellowship, and NIH-funded neuromuscular experimental therapeutics fellowship. His research funding has included a National Institute of Arthritis and Musculoskeletal and Skin Diseases K23 award, a Muscular Dystrophy Association TRIG award, and a New York State ECRIP award (among other awards). Dr. Heatwole's research has led to the development of an international network dedicated to improving the quality-of-life of neuromuscular patients through patient-centered clinical research. His primary professional interests include providing optimal care to patients with neuromuscular disorders, performing electrodiagnostic studies, training medical personnel, evaluating novel experimental therapeutics for neurological diseases though clinical trials, and developing an improved infrastructure to utilize disease-specific, patient-relevant endpoint measures for use in clinical trials and patient monitoring. As a neurologist with sub-specialty training in neuromuscular medicine, electrophysiology, and experimental therapeutic development I am committed to: 1) providing optimal care to patients with neurological and neuromuscular disease; 2) teaching students, residents, and fellows; and, 3) training faculty in therapeutics and outcome measure development research. My main focus is in the management and diagnosis of patients with muscular dystrophy. Working in a well-established Neuromuscular Disease clinic at URMC, I have been able to develop a patient referral base from across the United States and from multiple countries throughout the world. My "myotonia clinic" now forms a key resource for patient recruitment and therapeutic care at the University of Rochester. In addition, I am partnering with patients and potential donors to develop a myotonic dystrophy type-2 research and clinical care center of excellence at the University of Rochester.

Professional Background

As a neurologist with sub-specialty training in neuromuscular medicine, electrophysiology, and experimental therapeutic development I am committed to: 1) providing optimal care to patients with neurological and neuromuscular disease; 2) teaching students, residents, and fellows; and, 3) training faculty in therapeutics and outcome measure development research. My main focus is in the management and diagnosis of patients with muscular dystrophy. Working in a well-established Neuromuscular Disease clinic at URMC, I have been able to develop a patient referral base from across the United States and from multiple countries throughout the world. My "myotonia clinic" now forms a key resource for patient recruitment and therapeutic care at the University of Rochester. In addition, I am partnering with patients and potential donors to develop a myotonic dystrophy type-2 research and clinical care center of excellence at the University of Rochester.v

Research

One of my primary research interests is in the development, validation, and analysis of patient relevant outcome measures for use in drug labeling trials. Current work from my laboratory involves the development of disease-specific, relevant, valid, responsive, reliable, clinical trial instruments for myotonic dystrophy type-1 (DM1), myotonic dystrophy type-2 (DM2), congenital myotonic dystrophy (CMD), juvenile myotonic dystrophy (JMD), Charcot-Marie Tooth 1a (CMT1a), inclusion body myositis (IBM), and facioscapulohumeral muscular dystrophy (FSHD). My research is also focused on the development, evaluation, and testing of novel experimental therapeutics for neuromuscular disease. We are currently running a single-center, FDA-funded, placebo-controlled study of mexiletine for myotonic dystrophy type-1. Our group has also evaluated recombinant human insulin-like growth factor 1 for muscular dystrophy, IVIG vs. plasma exchange for myasthenia gravis, thymectomy for non-thymomatous myasthenia gravis, and performed a comparative analysis of multiple immunosuppressive agents for dermatomyositis. Most recently I have received NIH U01 funding to longitudinally study FSHD patients over a 3 year period to develop responsive and meaningful outcome measures for this population. As a natural extension of this study, I have applied for NIH U34 funding (decision date: Spring of 2014) to test combination therapy of two promising endocrine therapies in this population. Prior work has shown that multimodality treatment with testosterone and rHGH has potential as a mechanism to bolster strength, lean body mass, and function in select populations; yet this promising treatment strategy has not been evaluated in FSHD. This planning award, conducted with experienced investigators, will allow for a multicenter clinical trial to evaluate the benefit and tolerance of this promising treatment for FSHD patients. If gains in muscular and physical function are of similar magnitude in FSHD as they have been in other populations, this discovery would significantly improve therapeutic options for FSHD patients and may provide an option for patients with other musculoskeletal disorders.

Credentials

Faculty Appointments

Specialties

  • Neuromuscular Medicine - American Board of Psychiatry and Neurology
  • Neurology - American Board of Psychiatry and Neurology

Education

1997
BS | Virginia Polytech Inst & St U
Engineering

2001
MD | Medical College of Virginia
Medicine

2010
Masters Degree | University of Rochester
Clinical Investigation (MS-CI)

Post-doctoral Training & Residency

06/01/2002 - 06/30/2005
Residency in Neurology at University of Rochester Medical Center

07/01/2005 - 07/01/2006
Fellowship in Neurology: Clinical Neurophysiology at University of Rochester Medical Center

06/24/2001 - 5/31/2002
Internship in at University of Rochester Medical Center

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Awards

2016
University of Rochester Master Mentors Program.

2015
Myotonic Dystrophy Foundation (MDF) Travel Award to Facilitate Myotonic Dystrophy Health Index (MDHI) Translational Research

2013
Chairman of Ethical-Legal-Social Issues in Myotonic Dystrophy Session. IDMC-9
Location: . San Sebastian Spain

2013
Chairman of DM1 Clinical Trials & Biomarkers Session. IDMC-
Location: San Sebastian Spain.

2013
Chairman of Patient Reported Outcome Measures for Myotonic Dystrophy; OMMYD Meeting
Location: San Sebastian Spain

2012 - 2014
Myotonic Dystrophy Foundation Research Grant (Supervising Mentor for Dr. Nick Johnson)
Sponsor: Myotonic Dystrophy Foundation

2011 - 2015
FDA Research Grant: Mexiletine Treatment in Myotonic Dystrophy Type-1 (Co-Investigator)
Sponsor: FDA

2010 - 2012
NIH Clinical Research Loan REpayment Grant REnewal Recipient
Sponsor: NIH

2010
Clinical Research Loan Repayment Grant Renewal Recipient
Sponsor: NIH

2008 - 2013
NIH K23 Career Development Grant Award Winner (NIAMS)
Sponsor: NIH

2008 - 2011
2008 Muscular Dystrophy Association Translational Research Infrastructure Grant Award Winner (Funding from 2008-2011)

2008 - 2010
NIH Clinical Research Loan Repayment Grant Recipient
Sponsor: NIH

2008 - 2010
ECRIP (Empire Clinical Research Investigator Program) Grant Award Winner (

2008
Paul Wellstone Muscular Dystrophy Cooperative Research Center Umbrella Center
Sponsor: MDCRC

2008
Clinical Research Loan Repayment Grant Renewal Recipient
Sponsor: NIH

2007
NIH Clinical and Translational Science Institute K12 Award Recipient
Sponsor: NIH

2006 - 2008
NIH Clinical Research Loan Repayment Grant Recipient
Sponsor: NIH

2006 - 2007
NIH Experimental Therapeutics Grant Recipient for
Sponsor: NIH

2005 - Present
Ad Hoc editor for Neurology

2004
American Neurology Association Scholarship Winner, Toronto 2004
Sponsor: American Neurology Association

2003
UCB Pharma, Inc. Neurology Resident Scholar. 2003

2003
UCB Pharma, Inc. Neurology Resident Scholar

1999
Student Elective Term Scholarship Winner (MMA) 1999

1998 - 1999
S.O.M. State Discretionary Scholarship Winner 1998, 1999

1998 - 1999
S.O.M. State Discretionary Scholarship Winner

1997
Awarded Virginia Tech's Best ESM 1997 Ind. Senior Project Presentation


Dean's List (General Engineering, and in ESM)


Student Elective Term Scholarship Winner (MMA) 1999


Strong Star Award for Exceptional Service and Displaying Compassion and Respect to Patients, Familes and Co-workers


Patient and Family Centered Care Award
Sponsor: University of Rochester


Awarded Virginia Tech's Best ESM Ind. Senior Project Presentation 1997
Sponsor: Virginia Tech


Patient and Family-Centered Care award (2011)
Location: The University of Rochester


Golden Key Member


Board of Supervisors Academic Excellence Award


Board of Supervisors Academic Excellence Award


Dean's List (General Engineering, and in ESM)


Golden Key Member


American Neurology Association Scholarship Winner 2004
Location: Toronto


Tau Beta Pi National Engineering Honor Society


Tau Beta Pi National Engineering Honor Society

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Patents

Title: The Spinal Muscular Atrophy Health Index (SMAHI)
U.S. Serial #: 1-4057983352
Filed: Oct 06, 2016
Invented By: ChadHeatwole

Title: The Myotonic Dystrophy Health Index Short Form (MDHI-SF)
U.S. Serial #: 1-3280622886
Filed: Apr 07, 2016
Invented By: ChadHeatwole

Title: The CMT-Health Index (CMT-HI)
U.S. Serial #: 1-3280623002
Filed: Apr 07, 2016
Invented By: ChadHeatwole, DavidHerrmann, NicholasJohnson

Title: Congenital and Childhood Mytonic Dystrophy Research Survey: Instrument for Children Ages 5 to 7
U.S. Serial #: 1-961836392
Filed: Dec 08, 2014
Invented By: ChadHeatwole, JoannaHeatwole, NicholasJohnson

Title: Congenital and Childhood Myotonic Dystrophy Health Index: Parent Proxy Instrument
U.S. Serial #: 1-1731860561
Filed: Sep 09, 2014
Invented By: ChadHeatwole, NicholasJohnson

Title: Congenital and Childhood Myotonic Dystrophy Health Index: Instrument for Children Ages 12 to 17
U.S. Serial #: 1-732766692
Filed: Sep 09, 2014
Invented By: ChadHeatwole, NicholasJohnson

Title: Congenital and Childhood Myotonic Dystrophy Health Index: Instrument for Children Ages 8 to 11
U.S. Serial #: 1-1732766808
Filed: Sep 09, 2014
Invented By: ChadHeatwole, NicholasJohnson

Title: The FSHD-Health Index
U.S. Serial #: 1-932503543
Filed: May 08, 2013
Invented By: ChadHeatwole

Title: The Myotonic Dystrophy Health Index (MDHI)
U.S. Serial #: 1-906336621
Filed: Mar 26, 2013
Invented By: ChadHeatwole

Title: The Myotonic Dystrophy Health Index (MDH)
U.S. Serial #: 1-625245648
Filed: May 26, 2011
Invented By: ChadHeatwole

Title: The Myotonic Dystrophy Health Index (MDHI) Italian Version
U.S. Serial #:
Filed: Jan 01, 1899
Invented By: ChadHeatwole

Title: Facioscapulohumeral Dystrophy Composite Outcome Measure (FSHD-COM)
U.S. Serial #:
Filed: Jan 01, 1899
Invented By: KatyEichinger, ChadHeatwole, JefferyStatland, Al-RabiTawil

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Publications

Journal Articles

10/2016
Statland JM, Heatwole C, Eichinger K, Dilek N, Martens WB, Tawil R. "Electrical impedance myography in facioscapulohumeral muscular dystrophy." Muscle & nerve.. 2016 Oct 0; 54(4):696-701. Epub 2016 May 25.

8/11/2016
Wolfe GI, Kaminski HJ, Aban IB, Minisman G, Kuo HC, Marx A, Ströbel P, Mazia C, Oger J, Cea JG, Heckmann JM, Evoli A, Nix W, Ciafaloni E, Antonini G, Witoonpanich R, King JO, Beydoun SR, Chalk CH, Barboi AC, Amato AA, Shaibani AI, Katirji B, Lecky BR, Buckley C, Vincent A, Dias-Tosta E, Yoshikawa H, Waddington-Cruz M, Pulley MT, Rivner MH, Kostera-Pruszczyk A, Pascuzzi RM, Jackson CE, Garcia Ramos GS, Verschuuren JJ, Massey JM, Kissel JT, Werneck LC, Benatar M, Barohn RJ, Tandan R, Mozaffar T, Conwit R, Odenkirchen J, Sonett JR, Jaretzki A, Newsom-Davis J, Cutter GR, . "Randomized Trial of Thymectomy in Myasthenia Gravis." The New England journal of medicine.. 2016 Aug 11; 375(6):511-22.

7/2016
Johnson NE, Ekstrom AB, Campbell C, Hung M, Adams HR, Chen W, Luebbe E, Hilbert J, Moxley RT, Heatwole CR. "Parent-reported multi-national study of the impact of congenital and childhood onset myotonic dystrophy." Developmental medicine and child neurology.. 2016 Jul 0; 58(7):698-705. Epub 2015 Oct 28.

Books & Chapters

2014
Chapter Title: Myotonic Dystrophy Health Index: Initial Evaluation of a Disease-Specific Outcome Measure
Book Title: AANEM
Author List: Heatwole, C
Published By: AANEM podcast2014

2012
Chapter Title: Channelopathies: Myotonic Disorders and Periodic Paralysis.
Book Title: Swaiman's Pediatric Principles and Practice 5th edition.
Author List: Heatwole, C; Moxley, R.
Published By: Elsevier Saunders2012

2011
Chapter Title: Myotonic Dystrophies
Book Title: Neuromuscular Disorders
Author List: Johnson, N; Heatwole, C
Published By: Blackwell Publishing Ltd2011

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