Chad R. Heatwole, M.D.

Chad R. Heatwole, M.D.

Contact Information

919 Westfall Rd, Clinton Crossings Bldg C, Suite 220
Rochester, NY 14618

Office: (585) 275-2559
Fax: (585) 273-1255

Professional Bio

As a neurologist with sub-specialty training in neuromuscular medicine, electrophysiology, and experimental therapeutic development I am committed to: 1) providing optimal care to patients with neurological and neuromuscular disease; 2) teaching students, residents, and fellows; and, 3) training faculty in therapeutics and outcome measure development research. My main focus is in the management and diagnosis of patients with muscular dystrophy. Working in a well-established Neuromuscular Disease clinic at URMC, I have been able to develop a patient referral base from across the United States and from multiple countries throughout the world. My "myotonia clinic"

now forms a key resource for patient recruitment and therapeutic care at the University of Rochester. In addition, I am partnering with patients and potential donors to develop a myotonic dystrophy type-2 research and clinical care center of excellence at the University of Rochester.v

Research Bio

One of my primary research interests is in the development, validation, and analysis of patient relevant outcome measures for use in drug labeling trials. Current work from my laboratory involves the development of disease-specific, relevant, valid, responsive, reliable, clinical trial instruments for myotonic dystrophy type-1 (DM1), myotonic dystrophy type-2 (DM2), congenital myotonic dystrophy (CMD), juvenile myotonic dystrophy (JMD), Charcot-Marie Tooth 1a (CMT1a), inclusion body myositis (IBM), and facioscapulohumeral muscular dystrophy (FSHD).

My research is also focused on the development, evaluation, and testing of novel experimental therapeutics for neuromuscular disease. We are currently running a single-center, FDA-funded, placebo-controlled study of mexiletine for myotonic dystrophy type-1. Our group has also evaluated recombinant human insulin-like growth factor 1 for muscular dystrophy, IVIG vs. plasma exchange for myasthenia gravis, thymectomy for non-thymomatous myasthenia gravis, and performed a comparative analysis of multiple immunosuppressive agents for dermatomyositis. Most recently I have received NIH U01 funding to longitudinally study FSHD patients over a 3 year period to develop responsive and meaningful outcome measures for this population.



As a natural extension of this study, I have applied for NIH U34 funding (decision date: Spring of 2014) to test combination therapy of two promising endocrine therapies in this population. Prior work has shown that multimodality treatment with testosterone and rHGH has potential as a mechanism to bolster strength, lean body mass, and function in select populations; yet this promising treatment strategy has not been evaluated in FSHD. This planning award, conducted with experienced investigators, will allow for a multicenter clinical trial to evaluate the benefit and tolerance of this promising treatment for FSHD patients. If gains in muscular and physical function are of similar magnitude in FSHD as they have been in other populations, this discovery would significantly improve therapeutic options for FSHD patients and may provide an option for patients with other musculoskeletal disorders.

Awards & Honors (National)

Myotonic Dystrophy Foundation Research Grant (Supervising Mentor for Dr. Nick Johnson) | Myotonic Dystrophy Foundation 2012 - 2014
Clinical Research Loan Repayment Grant Renewal Recipient | NIH 2010
NIH Clinical Research Loan Repayment Grant Recipient | NIH 2008 - 2010
Clinical Research Loan Repayment Grant Renewal Recipient | NIH 2008
NIH K23 Career Development Grant Award Winner (NIAMS) | NIH 2008 - 2013
NIH Clinical and Translational Science Institute K12 Award Recipient | NIH 2007
NIH Clinical Research Loan Repayment Grant Recipient | NIH 2006 - 2008
NIH Experimental Therapeutics Grant Recipient for | NIH 2006 - 2007
American Neurology Association Scholarship Winner, Toronto 2004 | American Neurology Association 2004
Tau Beta Pi National Engineering Honor Society
American Neurology Association Scholarship Winner 2004 | Toronto

Awards & Honors (Local)

University of Rochester Master Mentors Program. 2016
Myotonic Dystrophy Foundation (MDF) Travel Award to Facilitate Myotonic Dystrophy Health Index (MDHI) Translational Research 2015
Chairman of Patient Reported Outcome Measures for Myotonic Dystrophy; OMMYD Meeting | San Sebastian Spain 2013
Chairman of DM1 Clinical Trials & Biomarkers Session. IDMC- | San Sebastian Spain. 2013
Chairman of Ethical-Legal-Social Issues in Myotonic Dystrophy Session. IDMC-9 | . San Sebastian Spain 2013
FDA Research Grant: Mexiletine Treatment in Myotonic Dystrophy Type-1 (Co-Investigator) | FDA 2011 - 2015
NIH Clinical Research Loan REpayment Grant REnewal Recipient | NIH 2010 - 2012
Paul Wellstone Muscular Dystrophy Cooperative Research Center Umbrella Center | MDCRC 2008
2008 Muscular Dystrophy Association Translational Research Infrastructure Grant Award Winner (Funding from 2008-2011) 2008 - 2011
ECRIP (Empire Clinical Research Investigator Program) Grant Award Winner ( 2008 - 2010
Ad Hoc editor for Neurology 2005 - Present
UCB Pharma, Inc. Neurology Resident Scholar 2003
UCB Pharma, Inc. Neurology Resident Scholar. 2003 2003
Student Elective Term Scholarship Winner (MMA) 1999 1999
S.O.M. State Discretionary Scholarship Winner 1998 - 1999
S.O.M. State Discretionary Scholarship Winner 1998, 1999 1998 - 1999
Awarded Virginia Tech's Best ESM 1997 Ind. Senior Project Presentation 1997
Student Elective Term Scholarship Winner (MMA) 1999
Awarded Virginia Tech's Best ESM Ind. Senior Project Presentation 1997 | Virginia Tech
Golden Key Member
Dean's List (General Engineering, and in ESM)
Board of Supervisors Academic Excellence Award
Tau Beta Pi National Engineering Honor Society
Golden Key Member
Dean's List (General Engineering, and in ESM)
Board of Supervisors Academic Excellence Award
Patient and Family-Centered Care award (2011) | The University of Rochester
Patient and Family Centered Care Award | University of Rochester
Strong Star Award for Exceptional Service and Displaying Compassion and Respect to Patients, Familes and Co-workers

Patents

The Myotonic Dystrophy Type-1 Health Index (MDHI)

United States Serial NO.: 1-906336621
Filed Date: March 26, 2013
Title: The Myotonic Dystrophy Health Index (MDHI)
Invented by: Chad Heatwole
The Myotonic Dystrophy Type-1 Health Index (MDHI)

United States Serial NO.: 1-625245648
Filed Date: May 26, 2011
Title: The Myotonic Dystrophy Health Index (MDH)
Invented by: Chad Heatwole
The Facioscapulohumeral Muscular Dystrophy Health Index

United States Serial NO.: 1-932503543
Filed Date: May 8, 2013
Title: The FSHD-Health Index
Invented by: Chad Heatwole
Congenital and Childhood Myotonic Dystrophy Health Index: Parent Proxy Instrument

United States Serial NO.: 1-1731860561
Filed Date: September 9, 2014
Title: Congenital and Childhood Myotonic Dystrophy Health Index: Parent Proxy Instrument
Invented by: Chad Heatwole, Nicholas Johnson
Congenital and Childhood Myotonic Dystrophy Health Index: Instrument for Children Ages 12 to 17

United States Serial NO.: 1-732766692
Filed Date: September 9, 2014
Title: Congenital and Childhood Myotonic Dystrophy Health Index: Instrument for Children Ages 12 to 17
Invented by: Chad Heatwole, Nicholas Johnson
Congenital and Childhood Myotonic Dystrophy Health Index: Instrument for Children Ages 8 to 11

United States Serial NO.: 1-1732766808
Filed Date: September 9, 2014
Title: Congenital and Childhood Myotonic Dystrophy Health Index: Instrument for Children Ages 8 to 11
Invented by: Chad Heatwole, Nicholas Johnson
Congenital and Childhood Myotonic Dystrophy Research Survey: Instrument for Children Ages 5 to 7

United States Serial NO.: 1-961836392
Filed Date: December 8, 2014
Title: Congenital and Childhood Mytonic Dystrophy Research Survey: Instrument for Children Ages 5 to 7
Invented by: Chad Heatwole, Nicholas Johnson, Joanna Heatwole
The Myotonic Dystrophy Health Index Short Form (MDHI-SF)

United States Serial NO.: 1-3280622886
Filed Date: April 7, 2016
Title: The Myotonic Dystrophy Health Index Short Form (MDHI-SF)
Invented by: Chad Heatwole
The Myotonic Dystrophy Health Index (MDHI) Italian Version

United States Serial NO.:
Filed Date: January 1, 1899
Title: The Myotonic Dystrophy Health Index (MDHI) Italian Version
Invented by: Chad Heatwole
The CMT-Health Index (CMT-HI)

United States Serial NO.: 1-3280623002
Filed Date: April 7, 2016
Title: The CMT-Health Index (CMT-HI)
Invented by: Chad Heatwole, David Herrmann, Nicholas Johnson

Recent Journal Articles

Showing the 5 most recent journal articles. 49 available »

2016 Oct
Statland JM, Heatwole C, Eichinger K, Dilek N, Martens WB, Tawil R. "Electrical impedance myography in facioscapulohumeral muscular dystrophy." Muscle & nerve. 2016 Oct; 54(4):696-701. Epub 2016 May 25.
2016 Aug 11
Wolfe GI, Kaminski HJ, Aban IB, Minisman G, Kuo HC, Marx A, Ströbel P, Mazia C, Oger J, Cea JG, Heckmann JM, Evoli A, Nix W, Ciafaloni E, Antonini G, Witoonpanich R, King JO, Beydoun SR, Chalk CH, Barboi AC, Amato AA, Shaibani AI, Katirji B, Lecky BR, Buckley C, Vincent A, Dias-Tosta E, Yoshikawa H, Waddington-Cruz M, Pulley MT, Rivner MH, Kostera-Pruszczyk A, Pascuzzi RM, Jackson CE, Garcia Ramos GS, Verschuuren JJ, Massey JM, Kissel JT, Werneck LC, Benatar M, Barohn RJ, Tandan R, Mozaffar T, Conwit R, Odenkirchen J, Sonett JR, Jaretzki A, Newsom-Davis J, Cutter GR, . "Randomized Trial of Thymectomy in Myasthenia Gravis." The New England journal of medicine. 2016 Aug 11; 375(6):511-22.
2016 Jul
Johnson NE, Ekstrom AB, Campbell C, Hung M, Adams HR, Chen W, Luebbe E, Hilbert J, Moxley RT, Heatwole CR. "Parent-reported multi-national study of the impact of congenital and childhood onset myotonic dystrophy." Developmental medicine and child neurology. 2016 Jul; 58(7):698-705. Epub 2015 Oct 28.
2016 Feb
Heatwole C, Bode R, Nicholas Johnson , Dekdebrun J, Dilek N, Eichinger K, Hilbert JE, Logigian E, Luebbe E, Martens W, McDermott MP, Pandya S, Puwanant A, Rothrock N, Thornton C, Vickrey BG, Victorson D, Moxley RT. "Myotonic dystrophy health index: Correlations with clinical tests and patient function." Muscle & nerve. 2016 Feb; 53(2):183-90. Epub 2015 Dec 29.
2016
Johnson, N; Butterfield, R; Berggren K; Hung, M; Chen, W; Dibella D; Dixon, M; Hayes, H; Pucillo, E; Bounsanga, J; Heatwole, C; Campbell, C. "Disease burden and functional outcomes in congenital myotonic dystrophy: A cross-sectional study." Neurology. 2016; 12 87(2)(87(2)): 160-7.

Current Appointments

Associate Professor - Department of Neurology, NMD (SMD) - Primary

Specialties

Neuromuscular Medicine - American Board of Psychiatry and Neurology
Neurology - American Board of Psychiatry and Neurology

Education

Masters Degree | Clinical Investigation (MS-CI) | University of Rochester2010
MD | Medicine | Medical College of Virginia2001
BS | Engineering | Virginia Polytech Inst & St U1997

Post-Doctoral Training & Residency

Fellowship in Neurophysiology at University of Rochester Medical Center07/01/2005 - 07/01/2006
Residency in Neurology at University of Rochester Medical Center06/01/2002 - 06/30/2005
Internship at University of Rochester Medical Center06/24/2001 - 5/31/2002