Biography
I am board certified in both Pulmonary and Critical Care Medicine, and have been caring for patients with a variety of acute and chronic lung diseases for more than twenty years. I have previous experience directing a respiratory therapy department, and currently oversee the Pulmonary Function Labs at URMC. I am an attending physician in the Medical Intensive Care Units at Strong Memorial and Highland Hospitals, and have extensive experience in managing patients with acute respiratory failure, pneumonia, sepsis, and multi-organ failure, using multiple ventilator modes and also patient-specific approaches to ventilator weaning. I emphasize a team approach in the MICU, and value the input provided by nurses, respiratory therapists, pharmacists, and other specialists in developing tailored care plans.
I also see outpatients with asthma at the Mary Parkes Center for Asthma and Pulmonary Care, and work closely with consultants in Allergy, ENT, and Speech Therapy to develop individualized approaches to diagnosis and management.
Professional Background
Dr. Georas was born and grew up in Providence, Rhode Island. He graduated from Brown University with a B.S. in Applied Mathematics and Biology in 1983, and then attended Brown Medical School (M.D., 1987). After Internal Medicine internship and residency at Duke University Medical Center, Dr. Georas moved to Johns Hopkins University for a Fellowship in Pulmonary and Critical Care Medicine, which he completed in 1994. From 1994-2006, he was a faculty member at Johns Hopkins University in the Pulmonary & Critical Care Division with a joint appointment in the Division of Allergy & Clinical Immunology, and Department of Environmental Health Sciences. He rose to the rank of Associate Professor of Medicine and Director of Pulmonary Research. In July 2006, he moved to the University of Rochester Medical Center, where he served as Division Chief of Pulmonary & Critical Care Medicine until 2010. Dr. Georas directs a research group investigating mechanisms of immune cell activation in the lung in asthma and other diseases. He has authored numerous publications in this area, and has been invited to present his research at national and international meetings. He is active in peer review, and serves on numerous advisory panels and review groups for the NIH and other professional societies.
Research
Dr. Georas is Professor of Medicine, Environmental Medicine. Microbiology and Immunology at the University of Rochester Medical Center. From 1994-2006, he was a faculty member at Johns Hopkins University in the Pulmonary & Critical Care Division with a joint appointment in the Division of Allergy & Clinical Immunology, and Department of Environmental Health Sciences. He moved to the University of Rochester in 2006. Dr. Georas directs a research group investigating mechanisms of immune cell activation in the lung. Current studies are aimed at defining molecular pathways by which allergens and particulate matter activate epithelial cells and dendritic cells, leading to generation of maladaptive allergen-specific immune responses in asthma. A separate line of research is investigating how lysophosphatidic acid is generated in the lung, exploring the role of different LPA receptors in lung inflammation and immune responses. These studies should further our understanding of how the lung functions as an immune organ, with a long-term goal of alleviating the burden of immune-mediated lung diseases including asthma in susceptible human subjects. Dr. Georas also directs the Study of Asthma in Rochester (SOAR2), which is enrolling adult asthma patients who have frequent exacerbations in a prospective registry, with the goal of identifying new treatments for these patients who currently have limited therapeutic options.
Clinical Trials
IAST2201SG(Passage)
Lead Researcher: Steve N Georas
Adult and adolescent participants may be eligible if they have severe asthma with 2 or more exacerbations in the last 12 months. The study consists of 15 in-person visits (1 to 3 hours each). Visit 1 will be for eligibility screening. The study drug, tezepelumab, will be given at visits 2-14. Visit 15 will be for follow-up examination.
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The CHRONICLE Study
Lead Researcher: Steve N Georas
In this study, you will complete monthly surveys (12 per year) about your life and health via a dedicated web site. The first survey package will take about 45 minutes to complete. Afterward, most monthly surveys will be short and require about 5-10 minutes to complete. In addition to these brief surveys, there will be longer surveys every 3 months that will require an additional 15-30 minutes to complete. You can expect to complete surveys for up to 5 years over the duration of the study. When you first join the study - as well as every 6 months after - we will ask your doctor to report information about your past/current health status and clinical observations. Eligibility: Must have severe, uncontrolled asthma, seeing a pulmonologist or allergist at the study doctor's site, and be on high-dose inhaled therapy or on a monoclonal antibody therapy for asthma.
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Publications
Journal Articles
6/17/2023
Baugh A, Adegunsoye A, Connolly M, Croft D, Pew K, McCormack MC, Georas SN. "Towards a Race-Neutral System of Pulmonary Function Test Results Interpretation." Chest.. 2023 Jun 17; Epub 2023 Jun 17.
6/17/2023
Connolly MJ, Donohue PA, Palli R, Khurana S, Cai X, Georas SN. "Diagnostic Impact of a Race-Composite Pulmonary Function Test Results Interpretation Strategy." Chest.. 2023 Jun 17; Epub 2023 Jun 17.
12/8/2022
Beck LA, Pesonen M, Thakar J, Georas SN, Järvinen KM. "IgE Sensitization Drives the Atopic March." American journal of respiratory and critical care medicine.. 2022 Dec 8; Epub 2022 Dec 08.
Books & Chapters
2006
Chapter Title: Common pulmonary problems: hemoptysis, dyspnea, chest pain, and the abnormal chest x-ray
Book Title: Principles of Ambulatory Medicine
Author List: Petrache I, Georas S
Published By: Williams & Wilkins 2006
2002
Chapter Title: Common pulmonary problems: hemoptysis, dyspnea, chest pain, and the abnormal chest x-ray
Book Title: Principles of Ambulatory Medicine
Author List: Petrache I, Georas S
Published By: Williams & Wilkins 2002
2000
Chapter Title: Manifestations of Immunologic Diseases: Th1 and Th2 Responses
Book Title: Cutaneous Medicine
Author List: Georas, S
Published By: B. C. Decker, Inc. 2000
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